damage immune deficiency and immunotherapeutics
NBS1 deficiency promotes genome instability by affecting DNA damage signaling pathway and impairing telomere integrity
... 2003) ATM and ATR are at the central of DNA damage signaling pathways About 25 substrates of ATM and ATR have been identified, and many of them have been revealed as candidates in DNA damage signaling ... 1.1 NBS and NBS1 protein 1.2 MRN complex 1.3 ATM and ATR kinases 1.4 DNA damage response 10 1.5 1.4.1 DNA damage sensing 10 1.4.2 DNA damage ... 84 4.1 NBS1 deficiency affects the DNA damage response 84 4.2 NBS1 deficiency compromises telomere integrity 92 IV 4.3 NBS1 deficiency promotes genome instabilities and is implicated...
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NBS1 deficiency promotes genome instability by affecting DNA damage signaling pathway and impairing telomere integrity
... 2003) ATM and ATR are at the central of DNA damage signaling pathways About 25 substrates of ATM and ATR have been identified, and many of them have been revealed as candidates in DNA damage signaling ... 1.1 NBS and NBS1 protein 1.2 MRN complex 1.3 ATM and ATR kinases 1.4 DNA damage response 10 1.5 1.4.1 DNA damage sensing 10 1.4.2 DNA damage ... 84 4.1 NBS1 deficiency affects the DNA damage response 84 4.2 NBS1 deficiency compromises telomere integrity 92 IV 4.3 NBS1 deficiency promotes genome instabilities and is implicated...
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Tài liệu Báo cáo khoa học: Pyruvate reduces DNA damage during hypoxia and after reoxygenation in hepatocellular carcinoma cells pptx
... single-strand and double-strand breaks Pyruvate reduces DNA damage during ⁄ after hypoxia Cells cultivated in Petri dishes (25 mm in diameter) were suspended in 0.5 mL of NaCl ⁄ Pi, and cell density ... causes DNA damage in hepatocytes Transplant Proc 26, 907–909 Moller P, Loft S, Lundby C & Olsen NV (2001) Acute hypoxia and hypoxic exercise induce DNA strand breaks and oxidative DNA damage in ... As both hypoxia and reoxygenation have been reported to induce DNA damage [30–32], we examined the effects of pyruvate addition during hypoxia and after reoxygenation on DNA damage HepG2 cells...
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Innate Immune Regulation and Cancer Immunotherapy pot
... discusses innate immune signaling and inflammatory responses to pathogens and cancer Chapters and introduce innate lymphocytes, including NKT and gamma–delta T cells and their roles in innate immune response ... the concept of immune regulation and cell-mediated immune suppression Chapters and provide overviews of our current understanding of human and mouse dendritic cell (DC) subsets and their regulatory ... Double-Stranded RNA and Activation of Innate Immunity by RIG-I-Like Receptors Mitsutoshi Yoneyama and Takashi Fujita 51 Innate Immune Signaling and Negative Regulators in Cancer Helen Y Wang and...
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Báo cáo Y học: A new siglec family member, siglec-10, is expressed in cells of the immune system and has signaling properties similar to CD33 docx
... vector, Gibco/BRL, Grand Island, NY, USA) for several splice variants were obtained from Incyte and sequenced Sequencing and alignment Individual clone colonies were cultured and DNA was isolated ... II and Nco I The amplified fragment was cloned into pd19 by digesting the fragment with HindIII and Bgl II and the plasmid with HindIII and Bam HI The fragment was ligated into the plasmid and ... by standard transformation methods B-cell lymphoblastomas Ramos, Raji, Daudi and HSB-2, a T-cell lymphoblastoma Jurkat, a erythroblastic leukemia cell line HEL and monocytic cell lines U973 and...
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Báo cáo khoa học: Differential regulation of fatty acid amide hydrolase promoter in human immune cells and neuronal cells by leptin and progesterone pdf
... Fig Effect of leptin and progesterone on FAAH activity and expression (A) Effect of leptin on the activity of FAAH in human U937 and CHP100 cells and on the protein content and the mRNA of FAAH ... seems noteworthy that leptin [42,43] and progesterone [44,45] play roles in survival, death and proliferation of immune and neuronal cells; processes in which AEA and the endocannabinoid system are ... activity and expression was additive, in fact treatment of U937 cells for 24 h with 10 nM leptin and lM progesterone enhanced FAAH activity, protein level and mRNA content up to 500%, 450% and 490%...
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Báo cáo hóa học: " First-line chemoimmunotherapy in metastatic breast carcinoma: combination of paclitaxel and IMP321 (LAG-3Ig) enhances immune responses and antitumor activity" pptx
... and FT conceived the study, and participated in its design and coordination and helped draft the manuscript All authors read and approved the final manuscript Competing interests CB, CG, MM and ... guidelines, and all applicable local laws and regulations The study protocol and amendments were approved by an institutional review board and an independent ethics committee Study design and treatments ... status, as here, but in randomized phase II and III clinical trials with standard chemotherapy as a control arm If successful this will confirm the idea that chemotherapy and immunotherapy can form...
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Báo cáo sinh học: " Clearance of an immunosuppressive virus from the CNS coincides with immune reanimation and diversification" pptx
... understanding of clone 13 distribution kinetics and tropism within the CNS, we infected adult C57BL/6 mice intravenously with × 106 PFU clone 13 and then monitored viral spread in spleen, liver and ... P14 cells produced IL-2 (compared to 3.0% in the spleen and 1.5% in the liver) and ~28% produced TNF-α (compared to 2.5% and 0.9% in spleen and liver, respectively) (Fig 5A,B) In addition, no significant ... adaptive immune repertoire, which includes the mobilization of CD4+ T cells and B cells, is responsible for the eventual clearance of clone 13 from the CNS, and, quite possibly, the periphery Immune...
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Báo cáo sinh học: " Recombinant HPV16 E7 assembled into particles induces an immune response and specific tumour protection administered without adjuvant in an animal model Linda Petrone1, Maria G Ammendolia2, Armando" ppt
... immunization and progressively increased in mice immunized and times, reaching 1:8000 and 1:16000 respectively The presence of IgM and IgA was analysed in comparison with the IgG and the results ... analysis and interpretation of the data, in critical revision of the manuscript and in acquisition of funding PDB conceived and designed the study, analysed and interpreted the data and drafted ... E7 in different aggregation forms and cell compartments could affect E7 processing and presentation by MHC I and II molecules, determining both the strength and quality of the host’s anti-HPV...
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Báo cáo hóa học: " Clearance of an immunosuppressive virus from the CNS coincides with immune reanimation and diversification" pptx
... understanding of clone 13 distribution kinetics and tropism within the CNS, we infected adult C57BL/6 mice intravenously with × 106 PFU clone 13 and then monitored viral spread in spleen, liver and ... P14 cells produced IL-2 (compared to 3.0% in the spleen and 1.5% in the liver) and ~28% produced TNF-α (compared to 2.5% and 0.9% in spleen and liver, respectively) (Fig 5A,B) In addition, no significant ... adaptive immune repertoire, which includes the mobilization of CD4+ T cells and B cells, is responsible for the eventual clearance of clone 13 from the CNS, and, quite possibly, the periphery Immune...
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báo cáo hóa học:" Recombinant HPV16 E7 assembled into particles induces an immune response and specific tumour protection administered without adjuvant in an animal model" doc
... immunization and progressively increased in mice immunized and times, reaching 1:8000 and 1:16000 respectively The presence of IgM and IgA was analysed in comparison with the IgG and the results ... analysis and interpretation of the data, in critical revision of the manuscript and in acquisition of funding PDB conceived and designed the study, analysed and interpreted the data and drafted ... E7 in different aggregation forms and cell compartments could affect E7 processing and presentation by MHC I and II molecules, determining both the strength and quality of the host’s anti-HPV...
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Chapter 071. Vitamin and Trace Mineral Deficiency and Excess (Part 1) pot
... vitamins and trace minerals in diseases: (1) deficiencies of vitamins and minerals may be caused by disease states such as malabsorption; (2) both deficiency and excess of vitamins and minerals ... vitamin C (scurvy), and niacin (pellagra) overt deficiencies Body stores of vitamins and minerals vary tremendously For example, vitamin B12 and vitamin A stores are large, and an adult may not ... excess of vitamins and minerals can cause disease in and of themselves (e.g., vitamin A intoxication and liver disease); and (3) vitamins and minerals in high doses may be used as drugs (e.g.,...
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Chapter 071. Vitamin and Trace Mineral Deficiency and Excess (Part 2) ppt
... renal failure, dermatitis, pulmonary cancer ND Element Deficiency Toxicity Tolerable Upper (Dietary) Intake Level Fluoride Dental caries Dental and skeletal fluorosis, osteosclerosis Iodine Thyroid ... Thyroid T4, dysfunction, 10 labor, maternal Element Deficiency Toxicity Tolerable Upper (Dietary) Intake Level mortality Manganese Impaired growth and General: 11 mg/d skeletal Neurotoxicity, Parkinson- ... lipid and Occupational: carbohydrate Encephalitis-like metabolism; upper body syndrome, Parkinson-like rash syndrome, psychosis, pneumoconiosis Molybdenum Severe neurologic Reproductive and fetal...
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Chapter 071. Vitamin and Trace Mineral Deficiency and Excess (Part 3) potx
... grains, and nuts Milled rice or grains contain little thiamine, if any Thiamine deficiency is therefore more common in cultures that rely heavily on a rice-based diet Tea, coffee (regular and decaffeinated), ... fish, and shellfish contain thiaminases, which can destroy the vitamin Thus, drinking large amounts of tea or coffee can theoretically lower thiamine body stores Deficiency Most dietary deficiency ... countries, the primary causes of thiamine deficiency are alcoholism and chronic illness, such as cancer Alcohol interferes directly with the absorption of thiamine and with the synthesis of thiamine...
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Chapter 071. Vitamin and Trace Mineral Deficiency and Excess (Part 4) docx
... anemia, and personality changes have been described with riboflavin deficiency Deficiency and Excess Riboflavin deficiency is almost always due to dietary deficiency Milk, other dairy products, and ... riboflavin deficiency are nonspecific and similar to those of other B vitamin deficiencies Riboflavin deficiency is manifested principally by lesions of the mucocutaneous surfaces of the mouth and skin ... nicotinic acid and nicotinamide and their biologically active derivatives Nicotinic acid and nicotinamide serve as precursors of two coenzymes, nicotinamide adenine dinucleotide (NAD) and NAD phosphate...
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Chapter 071. Vitamin and Trace Mineral Deficiency and Excess (Part 5) ppt
... tachyphylaxis and often improves with time Nausea, vomiting, and abdominal pain also occur at similar doses of niacin Hepatic toxicity is the most serious toxic reaction due to niacin and may present ... in all food groups Deficiency Symptoms of vitamin B6 deficiency include epithelial changes, as seen frequently with other B vitamin deficiencies In addition, severe vitamin B deficiency can lead ... peripheral neuropathy, abnormal electroencephalograms, and personality changes including depression and confusion In infants, diarrhea, seizures, and anemia have been reported Microcytic, hypochromic...
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Chapter 071. Vitamin and Trace Mineral Deficiency and Excess (Part 6) ppsx
... hemorrhages); inflamed and bleeding gums; and manifestations of bleeding into joints, the peritoneal cavity, pericardium, and the adrenal glands In children, vitamin C deficiency may cause impaired ... pregnancy, and stress (e.g., infection, trauma) appear to increase vitamin C requirements Deficiency Vitamin C deficiency causes scurvy In the United States, this is seen primarily among the poor and ... dopamine to norepinephrine, and the synthesis of many peptide hormones Vitamin C is also important for connective tissue metabolism and crosslinking (proline hydroxylation), and it is a component of...
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Chapter 071. Vitamin and Trace Mineral Deficiency and Excess (Part 7) pot
... paresthesia, anorexia, and nausea A scaling, seborrheic, and erythematous rash may occur around the eyes, nose, and mouth as well as on the extremities In infants, biotin deficiency presents as ... devoid of choline Deficiency results in fatty liver, elevated transaminase levels, and skeletal muscle damage with high creatine phosphokinase values The diagnosis of choline deficiency is currently ... Pantothenic acid is a component of coenzyme A and phosphopantetheine, which are involved in fatty acid metabolism and the synthesis of cholesterol, steroid hormones, and all compounds formed from isoprenoid...
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- vitamin d deficiency and parkinsons disease
- vitamin c deficiency and asthma
- a discourse analysis of news items on storm damage in english and vietnamese electronic newspapers
- innate immune signaling and negative regulators in cancer
- role of tgf b in immune suppression and inflammation
- androgen deficiency and its management in elderly men
- skin disease caused by changes in the immune system and infection
- glucose 6 phosphate dehydrogenase deficiency and malaria a method to detect primaquine induced
- potential immune responses and allergenicity induced
- iron deficiency and iron loading anemias
- acquired immune deficiency syndrome
- resistance evasion of the immune response and aids pathogenesis
- pauci immune focal and segmental necrotizing glomerulonephritis
- immune response and cns injury
- hiv and acquired immune deficiency syndrome aids
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