immune response and cns injury
báo cáo hóa học: " Increased circulating leukocyte numbers and altered macrophage phenotype correlate with the altered immune response to brain injury in metallothionein (MT) -I/II null mutant mice" doc
Ngày tải lên :
19/06/2014, 22:20
... neurotoxic and can impede the resolution of brain injury [19-21] It is feasible that the number of immune cells entering the CNS can influence the progression of brain injury but the phenotype of the immune ... NIMP-R14, Iba1 and CD3 positive cells were only counted within the injury site Cell counts within the injury site were standardised to the area of the injury site in that section in mm The injury border ... observed after brain injury and local T cell specific cytokines were undetectable so Th1 and Th2 responses could not be compared directly in wild type and MT-I/ II-/- mouse injury sites To assess...
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Báo cáo y học: "Circulating adenosine increases during human experimental endotoxemia but blockade of its receptor does not influence the immune response and subsequent organ injury" pdf
Ngày tải lên :
14/08/2014, 07:21
... [25,26] and in vivo [27] and that caffeine exacerbates tissue injury during inflammation [5,24] In contrast to these results, in our human endotoxemia model, caffeine did not augment the immune response ... of its receptor does not influence the immune response and subsequent organ injury Critical Care 2011 15:R3 Submit your next manuscript to BioMed Central and take full advantage of: • Convenient ... (IL)-6, IL-1receptor antagonist (IL1RA), and IL-10 were measured in samples taken at baseline and at 30, 60, 120, 240, and 480 minutes after LPS administration and subsequently analyzed batch-wise...
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Báo cáo sinh học: " Recombinant HPV16 E7 assembled into particles induces an immune response and specific tumour protection administered without adjuvant in an animal model Linda Petrone1, Maria G Ammendolia2, Armando" ppt
Ngày tải lên :
18/06/2014, 19:20
... and cell mediated immune response Methods Protein expression and purification Freshly streaked bacterial colonies, containing the E7 plasmid [30], were inoculated in 25 ml LB medium (DIFCO) and ... immunization and progressively increased in mice immunized and times, reaching 1:8000 and 1:16000 respectively The presence of IgM and IgA was analysed in comparison with the IgG and the results ... analysis and interpretation of the data, in critical revision of the manuscript and in acquisition of funding PDB conceived and designed the study, analysed and interpreted the data and drafted...
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báo cáo hóa học: " Strain-dependent variation in the early transcriptional response to CNS injury using a cortical explant system" doc
Ngày tải lên :
19/06/2014, 22:20
... neurological disease and injury [16-18] This included pro-inflammatory cytokines, chemokines, CD74, and antisecretory factor CD74 is differentially regulated among inbred strains following CNS injury [4,19] ... levels nervous system (CNS) tissue occur among mouse strains Message for several genes involved in CNS injury and neurological diseases with autoimmunity or chronic innate immune activation were ... Experimental autoimmune encephalomyelitis is a widely studied autoimmune model, and involves infiltration of CD4+ lymphocytes and immunological activation of microglia within the CNS [21,22,29]...
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báo cáo hóa học:" Recombinant HPV16 E7 assembled into particles induces an immune response and specific tumour protection administered without adjuvant in an animal model" doc
Ngày tải lên :
20/06/2014, 03:20
... and cell mediated immune response Methods Protein expression and purification Freshly streaked bacterial colonies, containing the E7 plasmid [30], were inoculated in 25 ml LB medium (DIFCO) and ... immunization and progressively increased in mice immunized and times, reaching 1:8000 and 1:16000 respectively The presence of IgM and IgA was analysed in comparison with the IgG and the results ... analysis and interpretation of the data, in critical revision of the manuscript and in acquisition of funding PDB conceived and designed the study, analysed and interpreted the data and drafted...
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Báo cáo y học: "Bench-to-bedside review: Functional relationships between coagulation and the innate immune response and their respective roles in the pathogenesis of sepsis" ppsx
Ngày tải lên :
12/08/2014, 19:21
... to the innate immune response, and its activation and regulation is dependent on local and systemic immune responses The simultaneous activation of clotting and the innate immune response is a ... innate immune response and their major known natural ligands Receptor or related structure Cell type or soluble factor CD14 Myeloid cells and soluble forms PAMPs from bacterial, fungal, and mycobacterial ... host response to tissue injury Functional interrelationships between clotting and the innate immune response The close ancestral and functional linkage between clotting and inflammation is readily...
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Mechanisms and functions of lymphangiogenesis in regulating the immune response and inflammation resolution 2
Ngày tải lên :
09/09/2015, 18:48
... cortical and medullary sinuses and VEGF-A was ascertained to occur at interfaces - VEGF-A was present at the surface and inside reticular fibers (Fig 5.2B) While the observation of VEGF-A within and ... Expansion of LECs population in WT and µMT mice following immunization (C) Immunofluorescence analysis of WT and µMT LN sections (D and E) Expansion of the BEC (D) and FRC (E) populations in inflamed ... WT (5-fold over control) (Fig 6.3B) and was sustained for 90 days 122 Figure 6.2 Myeloid cells and neutrophil populations in WT and µMT LNs at baseline and day 14 after immunization as revealed...
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Mechanisms and functions of lymphangiogenesis in regulating the immune response and inflammation resolution 1
Ngày tải lên :
09/09/2015, 18:48
... access of APCs to corneal antigens and the traffic of immune cells and inflammatory mediators to the regional LNs where an immune response may be primed (Patel and Dana, 2009) During inflammation, ... dedicate this journey and thesis to my family I want to thank my parents who have been loving, supportive and understanding in their usual understated and unwavering manner And to my siblings, ... inflammation……………………………11 1.3.3.1 Lymphatics and immune cells trafficking……………………………………… 11 1.3.3.2 Lymphatics and inflammation resolution……………………………………… 13 1.3.3.3 Lymphatics and immune tolerance………………………………………………15...
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Báo cáo khoa học: Proteolytic activation and function of the cytokine Spatzle in the innate immune response of a lepidopteran insect, Manduca sexta ppt
Ngày tải lên :
06/03/2014, 09:22
... solution Med Chem Res 10, 493–501 Ferrandon D, Imler JL, Hetru C & Hoffmann JA (2007) The Drosophila systemic immune response: sensing and signalling during bacterial and fungal infections Nat Rev Immunol ... synthesis in larvae of Manduca sexta Arch Insect Biochem Physiol 8, 147–164 Kanost MR & Nardi JB (2009) Innate immune responses of Manduca sexta In Molecular Biology and Genetics of Lepidoptera ... mixtures were subjected to SDS-PAGE and immunoblotting using Spatzle antibodies The ¨ ¨ sizes and positions of molecular weight standards are indicated on the left Bands representing proSpatzle precursors,...
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báo cáo hóa học:" Whole blood assessment of antigen specific cellular immune response by real time quantitative PCR: a versatile monitoring and discovery tool" potx
Ngày tải lên :
18/06/2014, 15:20
... Routine monitoring of immune responses is usually limited to the detection of humoral responsiveness and the capability of inducing adequate antibody titers represents the gold standard for virtually ... Smith Kline, Münchenbuchsee, Switzerland) and influenza (Inflexal, Berna Biotech, Bern, Switzerland) commercial vaccine preparations were used to monitor T-cell responses to vaccination Cell cultures ... Glutamax and non-essential amino acids (all from GIBCO Paisley, Scotland), thereafter referred to as complete medium, and 5% (v/v) human serum (Blutspendezentrum, University Hospital Basel, Switzerland)...
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Báo cáo hóa học: " HPV vaccine: an overview of immune response, clinical protection, and new approaches for the future" pdf
Ngày tải lên :
18/06/2014, 16:20
... innate and adaptive immune responses] and they also remain high over time; VLPs generate a heterogeneous or polyclonal immune response: immunodominant and nonimmunodominat; neutralizing and non-neutralizing; ... natural HPV infection the immune response is weak and typespecific Conversely, after administrating the HPV vaccine a strong and, although partially, cross-reactive immune- response was detected The ... vascular and lymphatic channels and to lymph nodes where immune responses are initiated; most DNA viruses have mechanisms for inhibiting interferon synthesis and receptor signaling, and papillomaviruses...
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Báo cáo sinh học: " Clearance of an immunosuppressive virus from the CNS coincides with immune reanimation and diversification" pptx
Ngày tải lên :
18/06/2014, 18:20
... initially expanded with similar kinetics in the spleen, liver and CNS, although the magnitude of the response was reduced in clone 13 infected hosts, especially within the CNS (Fig 4C) Within the CNS ... replication and the responding adaptive immune response in the highly specialized CNS These studies provide a framework for understanding how a host successfully purges a persistent infection from the CNS ... CTL response regained functionality in all tissues, a major shift in the composition of the CNS immune repertoire was observed Most notably, CD4 T and B cells increased both in frequency and...
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báo cáo hóa học: " Neuronal oxidative damage and dendritic degeneration following activation of CD14-dependent innate immune response in vivo" doc
Ngày tải lên :
19/06/2014, 22:20
... robust innate immune response This same response can occur in response to endogenous ligands that also activate the CD14/TLR-4 pathway [2,3] Indeed, several endogenous CD14/TLR ligands have received ... generated by NADPH oxidase and myeloperoxidase (MPO), as well as cytokines and chemokines that can attract an adaptive immune response Although originally identified as part of the response to exogenous ... CD14-dependent innate immune response in macrophages While none of these data point to CD14 or innate immune response as etiological in neurodegenerative disorders, these findings from in vitro and cell culture...
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báo cáo hóa học: " Wallerian degeneration: the innate-immune response to traumatic nerve injury" potx
Ngày tải lên :
19/06/2014, 22:20
... Wallerian degeneration since innate -immune cells, functions and molecules that are produced by immune and non -immune cells are involved The innate -immune response helps to turn the peripheral ... regulate innate -immune functions in immune cells (e.g phagocytosis and production of cytokines by macrophages) However, some cytokines further modulate immune and non -immune functions in non -immune cells ... production of TNFa and IL-1a mRNAs and proteins; the secretion of TNFa and IL-1a proteins is detected within to hours after injury Schwann cells also express and produce IL-1b mRNA and protein, the...
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Báo cáo hóa học: " Clearance of an immunosuppressive virus from the CNS coincides with immune reanimation and diversification" pptx
Ngày tải lên :
20/06/2014, 01:20
... initially expanded with similar kinetics in the spleen, liver and CNS, although the magnitude of the response was reduced in clone 13 infected hosts, especially within the CNS (Fig 4C) Within the CNS ... replication and the responding adaptive immune response in the highly specialized CNS These studies provide a framework for understanding how a host successfully purges a persistent infection from the CNS ... CTL response regained functionality in all tissues, a major shift in the composition of the CNS immune repertoire was observed Most notably, CD4 T and B cells increased both in frequency and...
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Báo cáo khoa học: "Enhanced immune response with foot and mouth disease virus VP1 and interleukin-1 fusion genes" potx
Ngày tải lên :
07/08/2014, 18:21
... suriv esaesid htuom dna toof eht gnidocne seniccav AND dimsalp ehT noitaniccav lanoitnevnoc ot evitanretla tneiciffe dna efas a sedivorp noitazinummi AND erutcurts citnehtua eht ni sepotipe lanoitamrofnoc ... esaesid htuom-dna-toof tsniaga eniccav AND A Y eiX ,TZ gnehS ,WE nahC ,WF niS ,CS gnehC ,TH gnoW 31 9471-5471 ,952 ,3991 ecneicS nietorp lariv a gnidocne AND fo noitcejni yb azneulfni tsniaga ... secnahne eniccav AND VDVB fo ycnavujda enikotyC EM snilloC ,J eilnworB ,I nospmohT ,I noriboN 777-567 ,81 ,9991 eniccaV stcepsorp dna ssergorp ,selpicnirp :seniccav desab-ANR dna AND PN ofitseR...
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Báo cáo khoa học: "Efficiency of Matricaria chamomilla CH12 and number of doses of rabies vaccine on the humoral immune response in cattle" potx
Ngày tải lên :
07/08/2014, 23:22
... mixed with the mineral salt and were vaccinated with one and two doses of rabies vaccine, respectively Cattle from groups V1 and V2 had only mineral salt and one and two doses of rabies vaccine, ... typically used to evaluate the humoral immune response in cattle after rabies vaccination [1,8,11,12] Moreover, it is recommended by the Centers for Disease Control and Prevention (USA) The first serum ... Gharagozloo and Ghaderi [5] in humans, did not occur in cattle for rabies immunization Fig Mean rabies-neutralizing antibody titers from Nelore cattle on days 30 and 60 Cattle from groups FEV1 and FEV2...
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Báo cáo y học: "Interactions among type I and type II interferon, tumor necrosis factor, and -estradiol in the regulation of immune response-related gene expressions in systemic lupus erythematosus" potx
Ngày tải lên :
09/08/2014, 01:22
... with 20 ng/ ml TNF, 15 ng/ml IFN, ng/ml E2, and 500 U/ml IFN or null, and were co-stimulated with TNF and IFN, with IFN and IFN, or with E2 and IFN PBMCs were cultured at a final concentration ... downregulated genes in functional category of immune response Network-based analysis of downregulated genes in the the functional category of immune response (a) Network and (b) Network constructed by downregulated ... as IFIT1, IFIT3, OAS1, ISG15 and IRF7, and IL8RA were upregulated in vivo, but IFIT1, IFIT3, OAS1 and IL8RA were downregulated, while ISG15 and IRF7 showed almost no response to TNF in vitro These...
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Báo cáo khoa học: "The evolution of rectal and urinary toxicity and immune response in prostate cancer patients treated with two three-dimensional conformal radiotherapy techniques" ppt
Ngày tải lên :
09/08/2014, 09:20
... difference in the occurrence and evolution of acute and particularly late GU and GI toxicity between the two observed 3DCRT techniques To evaluate the association of immune response and toxicity level, ... of resting and terminally differentiated NK cells correlated with several dosimetric parameters, and GI and GU toxicity Table summarizes the Pearson’s correlations between the immune and dosimetric ... patient characteristics and main disorders are summarized in Table Acute and late GI and GU toxicities were studied in order to identify the treatment-related, clinical and patient characteristics...
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Báo cáo y học: "Celastrus aculeatus Merr. suppresses the induction and progression of autoimmune arthritis by modulating immune response to heat-shock protein 65" pptx
Ngày tải lên :
09/08/2014, 10:20
... changes in the immune response to Bhsp65 Furthermore, both the cellmediated and the antibody responses to Bhsp65 were affected AA is driven by pro-inflammatory cytokines (IFN-γ and Page of 10 ... Nitric oxide and the immune response Nat Immunol 2001, 2:907-916 31 Kim HR, Kim EY, Cerny J, Moudgil KD: Antibody responses to mycobacterial and self heat shock protein 65 in autoimmune arthritis: ... setting, and that this beneficial anti-arthritic effect of Celastrus is attributable in part to modulation both of the immune response to the disease-related antigen Bhsp65 [22-25] and one of...
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