pauci immune focal and segmental necrotizing glomerulonephritis
Innate Immune Regulation and Cancer Immunotherapy pot
Ngày tải lên :
05/03/2014, 23:20
... discusses innate immune signaling and inflammatory responses to pathogens and cancer Chapters and introduce innate lymphocytes, including NKT and gamma–delta T cells and their roles in innate immune response ... the concept of immune regulation and cell-mediated immune suppression Chapters and provide overviews of our current understanding of human and mouse dendritic cell (DC) subsets and their regulatory ... Double-Stranded RNA and Activation of Innate Immunity by RIG-I-Like Receptors Mitsutoshi Yoneyama and Takashi Fujita 51 Innate Immune Signaling and Negative Regulators in Cancer Helen Y Wang and...
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Báo cáo Y học: A new siglec family member, siglec-10, is expressed in cells of the immune system and has signaling properties similar to CD33 docx
Ngày tải lên :
24/03/2014, 04:21
... vector, Gibco/BRL, Grand Island, NY, USA) for several splice variants were obtained from Incyte and sequenced Sequencing and alignment Individual clone colonies were cultured and DNA was isolated ... II and Nco I The amplified fragment was cloned into pd19 by digesting the fragment with HindIII and Bgl II and the plasmid with HindIII and Bam HI The fragment was ligated into the plasmid and ... by standard transformation methods B-cell lymphoblastomas Ramos, Raji, Daudi and HSB-2, a T-cell lymphoblastoma Jurkat, a erythroblastic leukemia cell line HEL and monocytic cell lines U973 and...
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Báo cáo khoa học: Differential regulation of fatty acid amide hydrolase promoter in human immune cells and neuronal cells by leptin and progesterone pdf
Ngày tải lên :
30/03/2014, 15:20
... Fig Effect of leptin and progesterone on FAAH activity and expression (A) Effect of leptin on the activity of FAAH in human U937 and CHP100 cells and on the protein content and the mRNA of FAAH ... seems noteworthy that leptin [42,43] and progesterone [44,45] play roles in survival, death and proliferation of immune and neuronal cells; processes in which AEA and the endocannabinoid system are ... activity and expression was additive, in fact treatment of U937 cells for 24 h with 10 nM leptin and lM progesterone enhanced FAAH activity, protein level and mRNA content up to 500%, 450% and 490%...
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Báo cáo hóa học: " First-line chemoimmunotherapy in metastatic breast carcinoma: combination of paclitaxel and IMP321 (LAG-3Ig) enhances immune responses and antitumor activity" pptx
Ngày tải lên :
18/06/2014, 16:20
... and FT conceived the study, and participated in its design and coordination and helped draft the manuscript All authors read and approved the final manuscript Competing interests CB, CG, MM and ... guidelines, and all applicable local laws and regulations The study protocol and amendments were approved by an institutional review board and an independent ethics committee Study design and treatments ... status, as here, but in randomized phase II and III clinical trials with standard chemotherapy as a control arm If successful this will confirm the idea that chemotherapy and immunotherapy can form...
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Báo cáo sinh học: " Clearance of an immunosuppressive virus from the CNS coincides with immune reanimation and diversification" pptx
Ngày tải lên :
18/06/2014, 18:20
... understanding of clone 13 distribution kinetics and tropism within the CNS, we infected adult C57BL/6 mice intravenously with × 106 PFU clone 13 and then monitored viral spread in spleen, liver and ... P14 cells produced IL-2 (compared to 3.0% in the spleen and 1.5% in the liver) and ~28% produced TNF-α (compared to 2.5% and 0.9% in spleen and liver, respectively) (Fig 5A,B) In addition, no significant ... adaptive immune repertoire, which includes the mobilization of CD4+ T cells and B cells, is responsible for the eventual clearance of clone 13 from the CNS, and, quite possibly, the periphery Immune...
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Báo cáo sinh học: " Recombinant HPV16 E7 assembled into particles induces an immune response and specific tumour protection administered without adjuvant in an animal model Linda Petrone1, Maria G Ammendolia2, Armando" ppt
Ngày tải lên :
18/06/2014, 19:20
... immunization and progressively increased in mice immunized and times, reaching 1:8000 and 1:16000 respectively The presence of IgM and IgA was analysed in comparison with the IgG and the results ... analysis and interpretation of the data, in critical revision of the manuscript and in acquisition of funding PDB conceived and designed the study, analysed and interpreted the data and drafted ... E7 in different aggregation forms and cell compartments could affect E7 processing and presentation by MHC I and II molecules, determining both the strength and quality of the host’s anti-HPV...
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Báo cáo hóa học: " Clearance of an immunosuppressive virus from the CNS coincides with immune reanimation and diversification" pptx
Ngày tải lên :
20/06/2014, 01:20
... understanding of clone 13 distribution kinetics and tropism within the CNS, we infected adult C57BL/6 mice intravenously with × 106 PFU clone 13 and then monitored viral spread in spleen, liver and ... P14 cells produced IL-2 (compared to 3.0% in the spleen and 1.5% in the liver) and ~28% produced TNF-α (compared to 2.5% and 0.9% in spleen and liver, respectively) (Fig 5A,B) In addition, no significant ... adaptive immune repertoire, which includes the mobilization of CD4+ T cells and B cells, is responsible for the eventual clearance of clone 13 from the CNS, and, quite possibly, the periphery Immune...
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báo cáo hóa học:" Recombinant HPV16 E7 assembled into particles induces an immune response and specific tumour protection administered without adjuvant in an animal model" doc
Ngày tải lên :
20/06/2014, 03:20
... immunization and progressively increased in mice immunized and times, reaching 1:8000 and 1:16000 respectively The presence of IgM and IgA was analysed in comparison with the IgG and the results ... analysis and interpretation of the data, in critical revision of the manuscript and in acquisition of funding PDB conceived and designed the study, analysed and interpreted the data and drafted ... E7 in different aggregation forms and cell compartments could affect E7 processing and presentation by MHC I and II molecules, determining both the strength and quality of the host’s anti-HPV...
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Báo cáo y học: "Neural immune pathways and their connection to inflammatory diseases" ppsx
Ngày tải lên :
09/08/2014, 01:23
... induces the expression and release of glucocorticoids from the adrenal glands Glucocorticoids regulate a wide variety of immune- related genes and immune cell expression and function For example, ... factors connecting and modulating the immune and neuroendrocrine systems Cytokines and their receptors are expressed in the neuroendocrine system and exert their effects both centrally and peripherally ... CRH, and vasoactive intestinal polypeptide These molecules are released from nerve endings or synapses, or they may be synthesized and released by immune cells and have immunomodulatory and generally...
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Báo cáo y học: "Henoch-Schönlein purpura in an older man presenting as rectal bleeding and IgA mesangioproliferative glomerulonephritis: a case report" ppt
Ngày tải lên :
10/08/2014, 23:22
... contributions WC, CBH, and RMR were involved in the diagnosis and treatment of the patient WC and TJ drafted the manuscript CBH and RMR revised the manuscript All authors read and approved the final ... edematous and thickened sigmoid colon and probably the rectum with surrounding inflammation The possibilities of infectious colitis, ischemic colitis, and vasculitis such as small vessel and drug-induced ... inhibitors, and antibiotics such as vancomycin and cefuroxime), food allergies, vaccinations, and insect bites The clinical manifestations of HSP may develop over the course of days to weeks and may...
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Báo cáo y học: " PAKs supplement improves immune status and body composition but not muscle strength in resistance trained individuals" pps
Ngày tải lên :
11/08/2014, 23:21
... nutrients and formulas that are widely used by athletes and sports enthusiasts These supplements can decrease the time needed to improve muscle hypertrophy and body composition and maintain the immune ... Nutrition and Performance, São Paulo, Brazil Authors’ contributions FAM developed the training routines and RANP organized the diets PCM helped to develop and adapt the immune system evaluation and ... and FGR, FSL and ECC conducted the research, collected and tabulated data All authors Page of discussed results and helped to write the discussion and conclusion All authors read and approved...
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báo cáo khoa học:" Circulating Immune Complexes and trace elements (Copper, Iron and Selenium) as markers in oral precancer and cancer : a randomised, controlled clinical trial" pot
Ngày tải lên :
11/08/2014, 23:22
... documented the role of immune complexes as modulators of both cellular and humoral immune response The occurrence of circulating immune complexes (CIC) as a marker for tumor burden and prognosis in ... (Table No and Figure No 4) Correlation among the CIC and serum copper(Figure No 5) copper and iron, CIC and age was found to be significant in the precancer group Correlation among the CIC and serum ... associated antigen and antibody in cancer In Immune complexes and human cancer Penguin Publishing Corp; 1985:62 Deshpande VA, Jussawalla DJ: Evaluation of cancer risk in tobacco chewers and smokers...
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Báo cáo khoa học: " Characterisation of immune responses and protective efficacy in mice after immunisation with Rift Valley Fever virus cDNA constructs" pot
Ngày tải lên :
12/08/2014, 04:21
... and a human virus isolate of RVFV attenuated in cell culture by 5-fluorouracil treatment, MP12 [13,14] Although Clone 13 and MP12 were shown to be safe and immunogenic in mice and in cattle and ... glycopolyprotein GN/GC, and the separate GC and GN proteins were analysed The N and the GN/GC constructs displayed the most promising results regarding the elicited immune response and were evaluated ... induced immune responses and the conferred protection in mice after genetic immunisation with cDNA encoding the structural proteins of RVFV The elicited immune responses towards the N, GN, GC and...
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Báo cáo y học: "Bench-to-bedside review: Functional relationships between coagulation and the innate immune response and their respective roles in the pathogenesis of sepsis" ppsx
Ngày tải lên :
12/08/2014, 19:21
... related to the innate immune response, and its activation and regulation is dependent on local and systemic immune responses The simultaneous activation of clotting and the innate immune response is ... innate immune response and their major known natural ligands Receptor or related structure Cell type or soluble factor CD14 Myeloid cells and soluble forms PAMPs from bacterial, fungal, and mycobacterial ... Localized and controlled immune responses to discrete, focal infectious processes are clearly advantageous to the host This contains the infection, eliminates the microbial pathogens, and initiates...
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Báo cáo y học: "Innate immune recognition and activation during HIV infectio" doc
Ngày tải lên :
13/08/2014, 01:20
... activities and immune activation Concluding remarks and perspectives The interactions between HIV and the innate immune system have only recently caught the attention of HIV researchers, and as a ... glycoprotein, and the association of two copies of genomic ssRNA and cellular tRNA molecules finally promote cellular budding and virion release [75] Genomic RNA, mRNA and various viral structural and ... DNA, as well as by TLRs 7/8, and sensing single-stranded (ss) RNA and doublestranded (ds) RNA, respectively [55-59] In addition, CLRs, such as DC-SIGN, Dectin-1, and mannose receptor, have emerged...
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Báo cáo y học: "Circulating immune complexes and complement C3 and C4 levels in a selected group of patients with rhinitis in Lebanon" pot
Ngày tải lên :
13/08/2014, 13:22
... CIC and determine the serum levels of C3 and C4 in patients and to see if a correlation existed between these parameters and allergic rhinitis Methods Subjects and blood specimens One hundred and ... Research Board and is in compliance with the Helsinki Declaration Results and discussion Earlier we reported on the frequency of causative allergens in groups of perennial asthmatics and rhinitics ... (Dpt) was the causative allergen in 62, Dermatophagoides farinae (Df) in 58, cat hair dander in 23 and dog hair dander in patients (some patients were allergic to more than one allergen) The presence...
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Báo cáo y học: "Circulating adenosine increases during human experimental endotoxemia but blockade of its receptor does not influence the immune response and subsequent organ injury" pdf
Ngày tải lên :
14/08/2014, 07:21
... (IL)-6, IL-1receptor antagonist (IL1RA), and IL-10 were measured in samples taken at baseline and at 30, 60, 120, 240, and 480 minutes after LPS administration and subsequently analyzed batch-wise ... after LPS infusion, and between and hours after LPS infusion During the sampling period, urine was kept on ice Urine was processed, and GSTA1-1 (glutathione Stransferase alpha 1-1) and GSTP1-1 (glutathione ... supervised the genetic analyses and the writing of the manuscript WHMP performed the GSTA1-1 and GSTP1-1 analyses PP, NPR, and PS supervised the conduct of the study and the writing of the paper...
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Báo cáo y học: "Tumor microenvironments, the immune system and cancer survival" ppt
Ngày tải lên :
14/08/2014, 14:21
... signaling cascade, and B-cell associated transcription factors) The third group was termed ‘host response’ (HR) and had expression of a suite of immune components such as T/NK-cell receptor and activation ... different cell types of the immune system (indicated by round cells) may lead to elimination of the cancerous cells (b) If elimination is unsuccessful, the immune system and the cancer can reach ... inhibit the immune system The cancer can then grow unchecked Figure modified from [2] CD4+, CD8+, CD4+CD25+ Treg, γδ and NKT cells are all types of T cell; Mφ cells are macrophages and NK cells...
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Mechanisms and functions of lymphangiogenesis in regulating the immune response and inflammation resolution 2
Ngày tải lên :
09/09/2015, 18:48
... cortical and medullary sinuses and VEGF-A was ascertained to occur at interfaces - VEGF-A was present at the surface and inside reticular fibers (Fig 5.2B) While the observation of VEGF-A within and ... Expansion of LECs population in WT and µMT mice following immunization (C) Immunofluorescence analysis of WT and µMT LN sections (D and E) Expansion of the BEC (D) and FRC (E) populations in inflamed ... WT (5-fold over control) (Fig 6.3B) and was sustained for 90 days 122 Figure 6.2 Myeloid cells and neutrophil populations in WT and µMT LNs at baseline and day 14 after immunization as revealed...
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