apoptotic self renewal and differentiation functions in central nervous system
Báo cáo y học: "Biology of adult mesenchymal stem cells: regulation of niche, self-renewal and differentiation" potx
... lineage differentiation in MSCs Future investigations should incorporate combinatorial knockdown approaches using inducible and stable expression systems to address redundancy in signaling functions, ... crucial to understanding the link between extracellular and intracellular signaling networks Finally, alterations in the MSC niche will help to determine the intrinsic and extrinsic specificity ... promoting MSC adipogenesis while repressing osteogenesis [52] The binding of PPARγ to various ligands, including longchain fatty acids and thiazolidinedione compounds, induces the transactivation and...
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Báo cáo khoa học: " Experimental concepts for toxicity prevention and tissue restoration after central nervous system irradiation" ppt
... phase where chemokines, cytokines and growth factors play important roles in intra- and intercellular communication CNS radiotherapy induces the production of inflammatory cytokines and mediators ... of radiation necrosis of the brain and spinal cord Initial events are similar to those described in the pathogenesis section, including inflammatory changes and increased vessel permeability Studies ... density [72] However, even in theory finding the right dose, timing and maybe combination and sequence of different growth factors in an individual patient appears very challenging, not to mention that...
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Identification of factors involved in the maintenance of embryonic stem cell self renewal and pluripotency 2
... critical in maintaining ES cell self renewal The use of a synthetic pharmacological inhibitor of GSK3 in ES cells has been reported by Sato et al to sustain the short term pluripotency and self- renewal ... Supplementing Lefty2 RNAi cultures with recombinant Lefty1 protein was able to block reduction in level of alkaline phosphatase staining induced by Lefty2 RNAi Alkalline phosphatase staining was ... enzymes and cellular machinery required to process Lefty2 are present in ES cells and assures us that Lefty2 processing is indeed active in ES cells and that mature Lefty2 proteins are secreted into...
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Identification of factors involved in the maintenance of embryonic stem cell self renewal and pluripotency 3
... cell fates is also not entirely clear Conflicting roles of Nodal signaling in both the maintenance of ES cell self renewal and induction of ES cell differentiation have both previously been reported ... factors and pathways that are important for the maintenance of ES cell self- renewal To achieve this aim, a candidate gene approach was adopted and 70 candidates were shortlisted An RNAi screen in ... elicit effects in embryos in a dose dependent manner In this thesis, the possibility that Nodal signaling might, as in the in vivo scenario, likewise influence ES cell fate decision in a dose dependent...
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Identification of factors involved in the maintenance of embryonic stem cell self renewal and pluripotency 4
... Protein extraction and western blotting To obtain protein extracts, cells were trypsinized from culture dishes harvested in chilled PBS, centrifuged at 10,000g for at °C, washed again in PBS and incubated ... maintained on uncoated cell culture dishes in E14 proliferative medium containing DMEM/20% ES FBS (Invitrogen,Carlsbad, CA), 0.1 mM MEM nonessential amino acids (Invitrogen), 2mM L-glutamine (Invitrogen), ... C-terminus of Lefty2 was chosen instead of the N-terminus because tagging at N-terminus may result in the V5 tag being cleaved off during LEFTY2 processing and secretion The insert was amplified by PCR,...
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Identification of factors involved in the maintenance of embryonic stem cell self renewal and pluripotency 5
... neural and metabolic defects and results in perinatal death Development 121, 1283-1299 Goldin, S N., and Papaioannou, V E (2003) Paracrine action of FGF4 during periimplantation development maintains ... Oct-3/4 defines differentiation, dedifferentiation or self- renewal of ES cells Nat Genet 24, 372376 Nomura, M., and Li, E (1998) Smad2 role in mesoderm formation, left-right patterning and craniofacial ... Ying, Q L., Nichols, J., Chambers, I., and Smith, A (2003) BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self- renewal in collaboration with STAT3 Cell 115,...
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Identification of factors involved in the maintenance of embryonic stem cell self renewal and pluripotency
... morphogenetic protein (BMP) and wingless-type MMTV integration site (WNT) have been established as important pathways maintaining ES cell self renewal and preventing cell differentiation Intracellularly, ... mouse, chick and human while nodal related ligands exist in frogs (XNR1-6) and in zebrafish (cyclops and squint) Nodal ligands bind to type I serine-threonine kinase receptors (ALK4/5/7) and type ... lines The derivation of pluripotent cell lines from blastocysts was first achieved in the murine system in 1981 by Martin Evans and Matthew Kaufman and independently by Gail R Martin (Evans and...
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Appendix identification of factors involved in the maintenance of embryonic stem cell self renewal and pluripotency
... Member of TGFsuperfamily Involved in Nodal signaling Nodal antagonist • • • • • Rex2 • Zinc finger protein • • • Zfx • • • a-catenin • Zinc finger protein Transcription factor Link to canonical Wnt ... -catenin (Catnb) Dot1l Lef1 Gata3 • • • • • • • • complex Involved in Wnt signaling Subunit of Cadherin protein complex Intracellular mediator of canonical Wnt signaling Non-SET domain protein Histone ... experiments involving elevation of Nodal signaling Gene Fgf5 Nestin Pax6 Ngn1 Ngn2 Gfap NeuroD1 Sox1 Msi1 Otx2 Nkx2.2 Claudin6 Mixl1 Gooscoid Nodal Fgf8 E-cadherin Cerberus1 Eomesodermin Cadherin11...
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Báo cáo khoa học: "Self-Disclosure and Relationship Strength in Twitter Conversations" pot
... of initial getting-to-know conversations in Twitter They welcome and greet each other about kids and pets, and offer sympathies about feeling bad One interesting way to use our analysis is in ... automatically analyzing self- disclosure behaviors using topic modeling This is ongoing work, and we are looking to improve methods for analyzing relationship strength and self- disclosure, especially ... Research Y Jo and A.H Oh 2011 Aspect and sentiment unification model for online review analysis In Proceedings of International Conference on Web Search and Data Mining S Kim, J Bak, and A Oh 2012...
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báo cáo hóa học: " Temporal expression and cellular origin of CC chemokine receptors CCR1, CCR2 and CCR5 in the central nervous system: insight into mechanisms of MOG-induced EAE" pptx
... expressed within inflammatory brain lesions in MS [18,39-41], and CCL3 has been demonstrated in cerebrospinal fluid of MS patients with relapsing-remitting disease course [42] In Interestingly and consistent ... < 0.05) and CCR5 (P < 0.05) within the so called IADM (inactive and demyelinated) lesions areas characterized by complete demyelination and low inflammatory and demyelinating activity In these ... (Fig 3E) corresponding to areas undergoing demyelination (Fig 3F) A strong labelling for CCR1 and CCR5 mRNA was observed over cells within the inflammatory and demyelinating areas in rats with acute...
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Báo cáo toán học: "Grothendieck bialgebras, Partition lattices, and symmetric functions in noncommutative variables" doc
... non-commuting variables) corresponding to the disjoint union of X and Y , together with the total order obtained from X and Y placing all Y after all X (That is, x < y for all x in X and all y in Y ... forms an inverse system in the category of graded algebras Let NCSym be its inverse limit in this category We call NCSym the algebra of symmetric functions in an in nite number of non-commuting variables ... (commutative) symmetric functions More progress in understanding this space was made in [7, 8] where it was considered as a Hopf algebra In the Hopf algebra Sym of (commutative) symmetric functions, the...
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Báo cáo khoa học: "Immunohistochemical study of constitutive neuronal and inducible nitric oxide synthase in the central nervous system of goat with natural listeriosis" potx
... nNOS and iNOS in neurons increased when bacterial encephalitis occurred This is the first study of NOS expression in the goat brain with listeriosis The involvement of iNOS in bovine and caprine ... expression of nNOS and iNOS in the nonneurological control brain Both nNOS and iNOS immunoreactivity was recognized in the brain of control goats No inflammatory cells were found in the brain sections ... blocked, and the primary antisera were reacted for 60 min, followed by biotinylated antisera (Zymed) for 15 minutes and [strept]avidin- biotin peroxidase (Zymed) for 15 minutes Staining was done using...
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Báo cáo toán học: "Partitions, rooks, and symmetric functions in noncommuting variables" pdf
... partition πx where j and k are in the same block of πx if and only if ij = ik in x, i.e., the the electronic journal of combinatorics 18(2) (2011), #P3 indices in the jth and kth positions are ... boards by letting the unit rook correspond to the empty partition Consider the vector space QR of all formal linear combinations of rooks in R ˆ By both extending ⊕ linearly and letting the unit ... Tevlin, L., Thibon, J.-Y., Thiem, N., Venkateswaran, V., Vinroot, C R., Yan, N., and Mike, Z Supercharacters, symmetric functions in noncommuting variables, and related Hopf algebras Preprint...
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Homo-binding character of LMO2 isoforms and their both synergic and antagonistic functions in regulating hematopoietic-related target genes potx
... LMO2-S can interact with all these partners including LDB1, GATA1, TAL1 and E47 in a similar manner, but the binding affinity can vary for LDB1[18] It remains uncharacterized in detail regarding how ... element arrangements within a typical LMO2 binding site (A) Sequences of promoter regions of GPA, VE-Cadherin and miR-142 Letters bigger and in red were indicated as E-box, and in blue as GATA site ... amino-acid sequence between LMO2-L and LMO2-S is in their Nterminal, it could be speculated that the N-terminal of LMO2-L/-S was involved in their homo-interaction and was important for their functions...
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báo cáo khoa học: "Extensive central nervous system involvement in Merkel cell carcinoma: a case report and review of the literature" docx
... carcinoma of the spine J Clin Neurosci 2010, 17(8):1069-1071 doi:10.1186/1752-1947-5-35 Cite this article as: Abul-Kasim et al.: Extensive central nervous system involvement in Merkel cell carcinoma: ... report in the literature of spinal intradural metastases of MCC, which further contributed to worsening the patient’s prognosis because it restrained a debulking and decompressive laminectomy ... showed high intratumoral CBV MR spectroscopy showed high choline:N-acetylaspartate and choline:creatine ratios (9.5 and 15, respectively) as well as occurrence of lactate and lipid peak in the tumor...
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Báo cáo khoa học: "Central nervous system Toll-like receptor expression in response to Theiler''''s murine encephalomyelitis virus-induced demyelination disease in resistant and susceptible mouse strains" ppsx
... given with myelin protein in order to incite a self- response to myelin in the rodent Another model that is gaining importance is the Theiler murine encephalomyelitis virus-induced demyelination disease ... direct or indirect (by the induction of cytokines and chemokines) involvement of TLRs in the initiation of TMEV-IDD in C57BL/6 resistant mice following LPS stimulation The involvement of TLRs in the ... essential role of interleukin1beta in mediating NF-kappaB activity and COX-2 transcription in cells of the blood-brain barrier in response to a systemic and localized inflammation but not during endotoxemia...
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Báo cáo y học: "Invasive pulmonary and central nervous system aspergillosis following slops aspiration in a trauma patient" pot
... Burik JA, Wingard JR, Patterson TF; Infectious Diseases Society of America: Treatment of aspergillosis: clinical practice guidelines of the Infectious Diseases Society of America Clin Infect Dis ... JH, Shin C: Combination therapy of disseminated coccidioidomycosis with caspofungin and fluconazole BMC Infect Dis 2006, 6:26 doi:10.1186/cc9228 Cite this article as: Zhang M, et al.: Invasive ... lung and the brain White arrows, progression of encephalomalacia in the left frontal lobe Lin SJ, Schranz J, Teutsch SM: Aspergillosis case-fatality rate: systematic review of the literature Clin...
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Báo cáo y học: "MicroRNAs show a wide diversity of expression profiles in the developing and mature central nervous system" docx
... miRNAs1expressed in proliferating and/ or differentiating cells in the developing and adult zebrafish brain miRNAs expressed in proliferating and/ or differentiating cells in the developing and adult ... 20, and Table D in Additional data file 27) In contrast, miR-34 expression is absent from forebrain and midbrain and present only in the caudal ventral and lateral isthmus and hindbrain, including ... cells and is detected in most differentiated cells throughout the adult brain as in the larval brain (compare Vd in Figure 1h and Sd in Figure 1b; Additional data file 7, and Tables B and G in Additional...
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