... illustrates redundancy in the chemokine system. Although some ofthe data on the role of CCR5 in the pathogenesis of MS and EAE appears to beconflicting, the weight of evidence identifies CCR5 ... purposes)macrophages and resident microglia to sites of CNS inflammation. Detailed knowledge of expression patterns is crucialfor the understanding of therapeutic modulation andthe validation of CCR1, CCR2 and ... immu-noneutralization of CCL3 [44], DNA vaccination [45], orgenomic deletion ofthe CCR1 gene [22], reduces clinicaldisease. Taken together, the results ofthe present study and from previous ones on the role of...
... various combinations of chemotherapy and cranial radiation. The excellentcorrelation ofthe in vitro and in vivo results of Noble and colleagues’ study [1] raises the hope that the techniqueused ... G:Abnormal CT scans ofthe brain in asymptomatic childrenwith acute lymphocytic leukemia after prophylactic treat-ment ofthecentralnervoussystem with radiation and intrathecal chemotherapy. ... this veryyoung, and hence vulnerable, population of patients.Chemotherapy-induced cognitive decline in the absence of radiation The best data on the cognitive effects of chemotherapy alonehave...
... thatshould prove of great value in the discovery and evaluation of therapies that either allow selective killing of cancer cellsor offer selective protection to thenormal cells ofthe body.MMaatteerriiaallss ... markedlydecreased levels of MBP in the CC and in the white-mattertracts ofthe striatum of treated animals (Figure 10). Inagreement with the majority ofthe cell bodies in the matureCC belonging ... oligodendrocytes and extensive myelin pathology. Functional analysis also provided the first demonstration of delayed effects of chemotherapy on the latency of impulse conduction in the auditory system, offering...
... cover of only 48 examples out of the 92 variants in the corpus. The active corpus treated separately requires 38 examples out of 46 andthe passive corpus requires 28 out of 46. Treating the ... for inducing the language. Though the minimal number of examples is of course unique, the set of particular strings in the covering sample is not necesm~rily Imique. INFERENCE OFTHE ENGLISH ... overgeneralizes the full corpus as well as the active and passive corpora treated as separate languages. For the active corpus, zero-reversible inference groups the forms of do with the other modals. The...
... the emer-gence ofthe Plathelminthes in the evolutionary his-tory. The eye ofthe planarian is one ofthe most ancestral and primitive types of visual systems in animals and is of particular ... one ofthe simplest animal groups with a central nervous system. Their primitive centralnervoussystem produces large quantities of a variety of neuropeptides, of which many are amidated at theirC ... in the planarian cen-tral nervoussystem to support the PHM activity and that it predates the emergence of Plathelminthes in the evolutionary history.AbbreviationsAsA, ascorbic acid; CNS, central...
... amounts of norepinephrine within the hypothalamus and in certain zones of the limbic system, such as thecentral nucleus ofthe amygdala andthe dentate gyrus ofthe hippocampus. However, this ... Management ofthe anesthetic interplays constantly with the general physiologyofthe patient. Historically, and continuing to the present, the great majority of cases involves the administration of ... loss ofthe agent from the arterial blood to all the tissues ofthe body. Obviously, the concentration in neural tissues is of greatest importance. The details ofthe uptake and distribution of...
... afterinjection. They found a more persistent suppression of proliferation in regions ofthe brain where proliferation isessential to normal function (the subventricular zone, the dentate gyrus ofthe hippocampus ... also found that the agents causedincreased cell death and decreased cell division in the subventricular zone, the dentate gyrus ofthe hippocampus and the corpus callosum in mice. These effects ... understanding ofthe mechanisms of acute and, importantly, progressive and delayed injury to the brain from clinically relevant short-term exposure to awidely used chemotherapy agent. Furthermore,...
... Barnholtz-Sloan, Andrew E. Sloan, and Ann G. SchwartzChapter 25Cancer ofthe Brain and Other CentralNervous System Chapter 25 Cancer ofthe Brain andNervous System National Cancer Institute ... patterns of care of brain tumor patients in the United States: a study ofthe Brain Tumor Section ofthe AANS andthe CNS andthe Commission on Cancer ofthe ACS. Clin Neurosurg 1990;36:347-52.12. ... Chapter 25 Cancer ofthe Brain andNervous System other. For all race specific analyses, only white and black patients are used because the other category is made up of a mix of racial groups....