nitric oxide toxicity in central nervous system cultures
Báo cáo khoa học: "Immunohistochemical study of constitutive neuronal and inducible nitric oxide synthase in the central nervous system of goat with natural listeriosis" potx
Ngày tải lên :
07/08/2014, 14:23
... observed in inflammatory microabscesses Counterstained with hematoxylin Magnification: ×132 C: Immunohistochemical staining of inducible NOS in the caprine brain with natural listeriosis shows that iNOS ... were fixed in 10% buffered formalin, embedded in paraffin, sectioned at microns, and stained with hematoxylin and eosin by routine histopathologic techniques Brainstem sections of paraffin-embedded ... reacted for 60 min, followed by biotinylated antisera (Zymed) for 15 minutes and [strept]avidin- biotin peroxidase (Zymed) for 15 minutes Staining was done using a LAB-SA Kit (Zymed) according to the...
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báo cáo hóa học: " Temporal expression and cellular origin of CC chemokine receptors CCR1, CCR2 and CCR5 in the central nervous system: insight into mechanisms of MOG-induced EAE" pptx
Ngày tải lên :
19/06/2014, 22:20
... foci in the spinal cord of rats with EAE, thus identifying potential determinants for trafficking of these cells to the CNS These findings are discussed in relation to therapeutic strategies to interfere ... Kista, Sweden) and injected subcutaneously at the base of the tail with 0.2 ml inoculum, containing 20 μg recombinant rat MOG (amino acids 1–125) in saline, emulsified (1:1) with Incomplete Freund's ... recombinant rat MOG in incomplete Freund's adjuvant The arrows indicate selected time-points at which subsequent kinetic analyses were performed Rats (n = 3/time-point) which conformed in the clinical...
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Báo cáo sinh học: "Systemic 5-fluorouracil treatment causes a syndrome of delayed myelin destruction in the central nervous system" doc
Ngày tải lên :
06/08/2014, 18:21
... without myelin (arrows) longitudinal sections of CC displayed scattered foci of demyelinated axons, including partial or complete loss of myelin sheaths and increases in inter-laminar splitting of ... myelin sheaths; single arrows indicate inter-laminar splitting of the myelin sheaths; and double arrows indicate myelin debris (b) Two axons with damaged myelin sheaths (asterisks), myelin debris ... counterstaining to visualize nuclear profiles To combine TUNEL staining with immunofluorescence staining for different cell lineage markers, TUNEL staining was performed first, followed by labeling...
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Báo cáo khoa học: " Experimental concepts for toxicity prevention and tissue restoration after central nervous system irradiation" ppt
Ngày tải lên :
09/08/2014, 10:21
... years Histopathologic findings include diffuse spongiosis and demyelination as well as dissiminated miliar necrosis Clinical confirmatory data Prevention strategies Sustaining toxicity that may impair ... death in the developing brain is resistant to erythropoietin treatment and caspase inhibition Cell Death Differ 2004, 11:1166-1178 Hossain M, Atkinson S, Li YQ, Wong CS: Systemically administered ... radiation-induced Schematic concept of the time course of radiation-induced reactions in cancer patients treated with ionizing radiation via portals exposing some part of the central nervous system...
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Báo cáo y học: "Cerebrospinal fluid neopterin: an informative biomarker of central nervous system immune activation in HIV-1 infection" ppt
Ngày tải lên :
10/08/2014, 05:21
... cyclosporin-A, and Th2-type cytokines including interleukin-4 and -10 counteract the production of neopterin [21] The same is true for anti-inflammatory compounds including certain HMG-CoA reductase inhibitors ... these findings indicate and how neopterin might be used in the future While CSF neopterin has been known to be elevated in HIV infection and further increased in ADC/HIVE and CNS opportunistic infections ... lineage Figure Induction of neopterin formation in brain cells Pro-inflammatory cytokines like interferon-γ (IFN-γ) induce expression of GTP-cyclohydrolase I in various brain cells As an intermediate...
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báo cáo khoa học: "In vivo observation of gold nanoparticles in the central nervous system of Blaberus discoidalis" potx
Ngày tải lên :
11/08/2014, 00:22
... changes in noise and vibration in the building Although proteins not break into ions, introducing charged particles into the nervous system causes an imbalance in the signal transmission that links ... eliminated by using only young males in this study The effects of temperature, humidity, and wind were diminished by maintaining them in a controlled environment However, the fluctuations in Rocha ... the nanoparticles will interact with the proteins present in the biological system, i.e the material surrounding the nanoparticles are proteins present in the nervous system of the cockroach...
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báo cáo khoa học: "Extensive central nervous system involvement in Merkel cell carcinoma: a case report and review of the literature" docx
Ngày tải lên :
11/08/2014, 03:20
... carcinoma of the spine J Clin Neurosci 2010, 17(8):1069-1071 doi:10.1186/1752-1947-5-35 Cite this article as: Abul-Kasim et al.: Extensive central nervous system involvement in Merkel cell carcinoma: ... report in the literature of spinal intradural metastases of MCC, which further contributed to worsening the patient’s prognosis because it restrained a debulking and decompressive laminectomy ... metastasis in the left inguinal region Thereafter, FDG-PET showed total regression of the FDG uptake in the lymph nodes, which previously had shown increased uptake A planned MRI of the brain about...
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Báo cáo khoa học: "Central nervous system Toll-like receptor expression in response to Theiler''''s murine encephalomyelitis virus-induced demyelination disease in resistant and susceptible mouse strains" ppsx
Ngày tải lên :
12/08/2014, 04:21
... given with myelin protein in order to incite a self-response to myelin in the rodent Another model that is gaining importance is the Theiler murine encephalomyelitis virus-induced demyelination disease ... the induction of cytokines and chemokines) involvement of TLRs in the initiation of TMEV-IDD in C57BL/6 resistant mice following LPS stimulation The involvement of TLRs in the TMEV-IDD is well ... of the pDCs in the resistant strain of mice Interestingly, pDCs are one of the main therapeutic targets for MS[16], and thus the involvement of TLRs in the processing of self-DNA in these cells...
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Báo cáo y học: "Macrophage migration inhibitory factor in cerebrospinal fluid from patients with central nervous system infection" potx
Ngày tải lên :
13/08/2014, 16:21
... Anti-inflammatory therapy with corticosteroids is beneficial in bacterial meningitis [8], suggesting that MIF may also influence the course of central nervous system (CNS) infections Cerebrospinal ... concentration in CSF than in blood in the only encephalitis patient in whom we obtained corresponding CSF and blood samples Also corroborating the findings of previous studies [13], in a limited ... purulent meningitis and encephalitis than in patients with lymphocytic meningitis and patients suspected of having meningitis but without evidence of CNS infection In accordance with our findings,...
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Báo cáo y học: "Invasive pulmonary and central nervous system aspergillosis following slops aspiration in a trauma patient" pot
Ngày tải lên :
13/08/2014, 21:21
... America Clin Infect Dis 2008, 46:327-360 Park DW, Sohn JW, Cheong HJ, Kim WJ, Kim MJ, Kim JH, Shin C: Combination therapy of disseminated coccidioidomycosis with caspofungin and fluconazole BMC Infect ... Troke P, Thiel E: Improved outcome in central nervous system aspergillosis, using voriconazole treatment Blood 2005, 106:2641-2645 Walsh TJ, Anaissie EJ, Denning DW, Herbrecht R, Kontoyiannis ... Segal BH, Steinbach WJ, Stevens DA, van Burik JA, Wingard JR, Patterson TF; Infectious Diseases Society of America: Treatment of aspergillosis: clinical practice guidelines of the Infectious Diseases...
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Báo cáo y học: "MicroRNAs show a wide diversity of expression profiles in the developing and mature central nervous system" docx
Ngày tải lên :
14/08/2014, 08:20
... miRNAs1expressed in proliferating and/or differentiating cells in the developing and adult zebrafish brain miRNAs expressed in proliferating and/or differentiating cells in the developing and adult ... in maturing cells of the CMZ (which are likely to still be proliferative) but expression is maintained only in amacrine cells of the inner nuclear layer (INL in Figure 2d) These patterns indicate ... thezebrafish brain miR-181a providingthe the zebrafishbrain miR-153a usedfiguresinthe zebrafishnucleic miR-138 testother inthedpf information acid miR-137 expressionininthezebrafish brain about miR-135cexpressionthespecificity...
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The role of hydrogen sulfide in the central nervous system implications in the treatment of alzheimers disease
Ngày tải lên :
09/09/2015, 08:17
... precursor protein cleaving enzyme cAMP 3'-5'-Cyclic adenosine monophosphate; CAT Cysteine aminotransferase CBS Cystathionine-β-synthase CNS Central nervous system CO Carbon monoxide COX-2 Cyclooxygenase-2 ... neurotransmitter in the brain The interaction of glutamate with the N-methyl-D-aspartate (NMDA) receptor is important in the workings of memory and learning In AD an increase in glutamate activity results in ... tissues including liver, pancreas, uterus and intestine (Kimura, 2011) It is the main H2S-generating enzyme in the cardiovascular system (Zhao et al., 2001, Bian et al., 2006) CSE was detected in...
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Chemical drug assisted gene transfer a sensible approach to improve transgene expression in the central nervous system
Ngày tải lên :
12/09/2015, 10:15
... containing μg DNA was used in each injection The rate of injection was μl/min and the needle was allowed to remain in situ for mins before being slowly retracted at the end of each injection The intrathecal ... ATP-dependent chromatin remodeling protein (Johnstone, 2002) HATs acetylate lysine residues on histone tails inducing chromatin remodeling in an open conformation, while HDACs function in opposition ... applications, CyD has been explored in combining with other polymers to produce cyclodextrin-containing polymers since 1980s, after when cross-linked structures, linear structures, pendent structures...
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Role of central nervous system ceramides and free radicals in a mouse model of orofacial pain
Ngày tải lên :
14/09/2015, 08:42
... acid, capsaicin and resiniferatoxin, leading to burning pain or itch It is found that NGF and bradykinin can induce changes in TRPV1 by activating of cAMP-dependent (cyclic adenosine monophosphate-dependent) ... specific pain pathway which carries the information from pain receptors in the peripheral skin to pain center in the brain, indicating that a simple block of the pathway would result in the alleviation ... of any injury In this case, pain turns to a manifestation of pathological change in the nervous system Two mechanisms are known to be involved in pain hypersensitivity — peripheral and central...
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Effects of central nervous system free fatty acids, prostaglandins and lysophospholipids on allodynia in a mouse model of orofacial pain
Ngày tải lên :
05/10/2015, 13:53
... of systemic disease 20 Brainstem Mechanism in Trigeminal Nociception Nuclear Localization of Nociceptive Responses Clinical findings are consistent with the findings in experimental animals indicating ... result in rapid, short-lasting, acute pain responses similar in duration to the formalin method In the inflammation model elicited by injection of carrageenan into the footpad, the cutaneous inflammation ... state is maintained in which there is a close correlation between injury and pain But changes induced by nociceptive input or by changes in the environment can result in variations in the quality...
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INVESTIGATION OF MEMBRANE PROPERTIES IN THE CENTRAL NERVOUS SYSTEM OF DROSOPHILA MELANOGASTER STUDIED BY FLUORESCENCE CORRELATION SPECTROSCOPY
Ngày tải lên :
12/10/2015, 17:36
... lymphocyte protein CD8 ix nSMase neutral sphingomyelinase PBS phosphate buffered saline PS presenilin rFlot2 rat flotillin-2 siRNA small interfering ribonucleic acid SMase sphingomyelinase TLC thin layer ... contains phosphoethanolamine ceramide (PE-cer) as the major constituent instead of sphingomyelin (PE-cer has phosphoethanolamine as the head group, instead of the phosphocholine head group in SM) ... phosphoinositol) Drosophila’s sphingolipids also contain a shorter acyl chain on the sphingoid base than those in mammalians The reason for this may be that Drosophila being cold-blooded maintains...
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Báo cáo khoa học: Transport of L-arginine and nitric oxide formation in human platelets pdf
Ngày tải lên :
08/03/2014, 02:20
... and resuspended in pH 7.4 Hepes buffer in the absence (continuous lines) or in the presence (dotted lines) of 1.0 mM L-arginine The L-arginine efflux via system y+ (d) was determined as difference ... L-arginine transport mainly Fig L-Arginine uptake in the presence or absence of Na+ in the external medium L-Arginine uptake was measured in washed platelets (2.0 · 108 platelets) resuspended in ... total in ux; m, in ux via system y+L, determined experimentally by treating platelets with 200 lM N-ethylmaleimide d, In ux via system y+ which was obtained by subtracting the in ux via system...
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Cancer of the Brain and Other Central Nervous System doc
Ngày tải lên :
22/03/2014, 17:20
... Brain and Nervous System Histologic Type of Tumor Classification NOS, C716 - Cerebellum, NOS, C717 - Brain Stem, C718 - Overlapping lesion of brain and C719 - Brain, NOS; SPINE: C701 - Spinal ... of the Brain & Other Central Nervous System: Number of Cases and Exclusions, 12 SEER Areas, 1988-2001 Brain Other CNS Number Selected/ Remaining Number Excluded Number Selected/ Remaining Number ... Brain Stem, C718 - Overlapping lesion of brain and C719 - Brain, NOS For other CNS cancers, primary site of tumor is classified as the following: BRAIN: C700 - Cerebral meninges, C709 - Meninges,...
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Báo cáo khoa học: Planarian peptidylglycine-hydroxylating monooxygenase, a neuropeptide processing enzyme, colocalizes with cytochrome b561 along the central nervous system pptx
Ngày tải lên :
30/03/2014, 15:20
... planarians in this study were derived from a single worm of Dugesia japonica collected in the Irima River in Gifu, Japan and maintained as described (clonal strain: GI) [58] Cloning and sequencing of ... domain have been reported previously [41,47] The structure shows two copper-binding domains connected by a three-residue linker Domain binds one copper (CuH also termed as CuA) with three histidine ... morphologically distinct structures, two longitudinal VNC and an anterior brain The brain forms independent, inverted U-shaped lobes located dorsally to the VNC The brain contains FEBS Journal 272...
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Section III - Drugs Acting on the Central Nervous System docx
Ngày tải lên :
12/07/2014, 20:21
... residual cholinergic signaling Catecholamines The brain contains separate neuronal systems that utilize three different catecholamines— dopamine, norepinephrine, and epinephrine Each system is anatomically ... considered for central roles were acetylcholine and norepinephrine, largely because of their established roles in the somatic motor and autonomic nervous systems In the 1960s, serotonin, epinephrine, and ... Treatment of Central Nervous System Degenerative Disorders) Norepinephrine There are relatively large amounts of norepinephrine within the hypothalamus and in certain zones of the limbic system, such...
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