long term consequences and latent susceptibility to central nervous system disorders
Báo cáo sinh học: "The long term effects of chemotherapy on the central nervous system" docx
Ngày tải lên :
06/08/2014, 18:21
... from Noble and colleagues’ study [1] that chemotherapy is potentially as neurotoxic as radiation, and much closer attention needs to be paid to the long term follow-up of both children and adults ... attention has been paid to the possible contribution of the chemotherapy to the cognitive decline Note that a nitrosourea (BCNU) and CDDP were found to be toxic to neural progenitor cells even in low ... The response of investigators has been to reduce the dose and/ or volume of radiation and, in some cases, to eliminate radiation entirely, adding combination chemotherapy to the treatment regimens...
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báo cáo hóa học: " Temporal expression and cellular origin of CC chemokine receptors CCR1, CCR2 and CCR5 in the central nervous system: insight into mechanisms of MOG-induced EAE" pptx
Ngày tải lên :
19/06/2014, 22:20
... mechanisms leading to demyelination and tissue injury are not fully understood, activated macrophages and microglia seem to play a central role in the destructive process both in MS and in EAE [6,7] ... a microtome and stained with haematoxylin and eosin (H&E), Luxol fast blue (LFB)/periodic acid Schiff'(PAS) and Bielschowsky silver impregnation to assess inflammation, demyelination, and axonal ... receptors could all potentially activate and recruit both resident microglia and infiltrating haematogenous cells to sites of CNS inflammation, and provide several potential chemokine receptor...
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Báo cáo khoa học: " Experimental concepts for toxicity prevention and tissue restoration after central nervous system irradiation" ppt
Ngày tải lên :
09/08/2014, 10:21
... chemokines, cytokines and growth factors play important roles in intra- and intercellular communication CNS radiotherapy induces the production of inflammatory cytokines and mediators such as ... apoptotic vascular and glial cells in the CNS [6] Spinal cord experiments suggest that other growth factors, such as platelet-derived growth factor (PDGF) can increase the long- term radiation tolerance ... senescence and apoptosis, and differentiation in the mammalian CNS are complex and well regulated, e.g., by Sonic Hedgehog, Polycomb family members, cell cycle regulators, and environmental factors...
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Báo cáo lâm nghiệp: "Temperate forest trees and stands under severe drought: a review of ecophysiological responses, adaptation processes and long-term consequences" ppt
Ngày tải lên :
07/08/2014, 16:20
... related to the short and long term acclimation of trees to drought need be better understood Finally, nitrogen nutrition and cycling is likely to be modied by drought [48], and the impact of nutrient ... Vulnerability to cavitation and stomatal conductance: coupling liquid and vapour uxes Stomatal control of leaf transpiration and loss of hydraulic conductivity in twigs have been monitored in parallel ... species and over several years to detect potential changes in carbon allocation to tree compartments and to physiological functions (respiration, growth, storage) Other processes related to the...
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Báo cáo khoa học: " Renal histomorphology in dogs with pyometra and control dogs, and long term clinical outcome with respect to signs of kidney disease" pptx
Ngày tải lên :
12/08/2014, 18:21
... secondary to pyometra, although data is scarce and inconclusive [1113] Obel et al [14] examined renal tissue from 27 dogs with pyometra by light and electron microscopy and immunohistochemical ... electron microscopy and immunohistochemistry The prevalence and severity of glomerular and tubular morphological changes detected by light microscopy were similar in dogs with pyometra and control animals ... studies were (Study 1) to compare renal histomorphology in dogs with pyometra from the above original study [9] retrospectively to control dogs of comparable age, and (Study 2) to report the results...
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Long-term Performance and Community Analysis of Spirodela Polyrrhiza–bacteria Association Treating Phenol-contaminated Water
Ngày tải lên :
05/09/2013, 10:15
... test systems A and C were periodically monitored and analyzed by high-performance liquid chromatography (HPLC) over the 15 cycles After the 15th cycle, the addition of phenol to test systems A and ... test system C The labels a, b, and c are PCR-DGGE banding patterns of 16S rRNA gene in test systems A, B, and C, respectively; d, e, and f are PCR-DGGE banding patterns of C12O gene in test systems ... systems A, B, and C, respectively; and g, h, and i are PCR-DGGE banding patterns of C23O gene in test systems A, B, and C, respectively PCR products of C12O gene in test system C at the 1st and 2nd...
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báo cáo hóa học: " Health-related Quality of Life in Vacuum-Assisted Breast Biopsy: short-term effects, long-term effects and predictors" ppt
Ngày tải lên :
18/06/2014, 19:20
... according to our previous work, VABB seems to exhibit fairly distinct long- term effects, when compared to other biopsy methods in terms of compliance [5] Given the above, it is rational to anticipate ... and 10 cm3 1% lidocaine with epinephrine (deep) were administered The biopsy was performed according to a standard protocol to assure quality control Compression bandages were applied so as to ... subsequent hematoma formation and infection were recorded after VABB The histology of the lesion was classified according to the system first proposed by Dupont and Page [14] and adopted by the...
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Báo cáo khoa học: " Long-term outcome and patterns of failure in patients with advanced head and neck cancer" pps
Ngày tải lên :
09/08/2014, 09:20
... radiochemotherapy between 1992 and 2005 for primarily inoperable advanced oro -and hypopharyngeal squamous Long- term side effects Most common long- term side effects documented were xerostomia and alterations ... Documented long- term side effects were classified according to the RTOG/EORTC Late Radiation Morbidity Scoring Scheme (Appendix IV, CTC Version 2.0) Results Response to treatment and loco-regional ... 3-, 5- and 10-year-OS was 42%, 28% and 15%, respectively) a borderline significantly longer OS compared to patients with N3 disease (median 11 months, 3-, 5- and 10-year-OS was 29%, 22% and 11%,...
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Báo cáo khoa học: "Central nervous system Toll-like receptor expression in response to Theiler''''s murine encephalomyelitis virus-induced demyelination disease in resistant and susceptible mouse strains" ppsx
Ngày tải lên :
12/08/2014, 04:21
... central nervous system of SJL/J and C57BL/6 mice after infection with Expression of Toll-like receptors for viral Expression of Toll-like receptors for viral elements in the central nervous system ... single stranded RNA genome of TMEV is believed to bind to TLR7 and its double stranded replication intermediate to TLR3 located the endosomes and lysosomes of host cells[2] Since LPS is known to up-regulate ... receptors for bacterial with Theiler's Toll-likeencephalomyelitis virus elements in the central nervous system of SJL/J and C57BL/6 mice after infection Expression Expression of Toll-like receptors...
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Báo cáo y học: "Immunodepression in the surgical patient and increased susceptibility to infection" doc
Ngày tải lên :
12/08/2014, 18:21
... factor (quantitative flow cytometry, allowing counting of molecules per cell), and T-cell cytokine profiling (differentiation of type 1/2 cytokine patterns by intracellular cytokine staining and ... perioperative systemic inflammation contributes to longlasting immune depression Therefore, it makes sense to attempt to prevent extensive counter-regulation by blocking systemic inflammation Angele and ... directly and indirectly by induction of immunomodulatory cytokines (e.g IL-10) IL-10 also deactivates T cells, in particular type cytokine-secreting T cells This interaction between immune and central...
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Báo cáo khoa học: " Prognosis for long-term survival and renal recovery in critically ill patients with severe acute renal failure: a population-based stud" pps
Ngày tải lên :
12/08/2014, 23:20
... the incidence of and quantify the risk factors for developing sARF, and to establish the long- term outcome and its determinants in a large well-defined population Materials and methods R701 Available ... was 8.1 (3.4 to 16) and 22 (9 to 40) days, respectively Of those who survived to hospital discharge, the median (IQR) ICU and hospital length of stay was 8.4 (3.6 to 19) and 37 (22 to 62) days, ... prone to selection and information bias due to inclusion of patients receiving only CRRT and incomplete ascertainment of long- term survival status for the entire cohort [6] This was unlikely to...
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Báo cáo y học: "Ethics review: Long-term outcomes and clinical predictors of hospital mortality in very long stay intensive care unit patients: a cohort study" pptx
Ngày tải lên :
12/08/2014, 23:23
... home' refers to a patient from a long- term care institution without a permanent tracheostomy c'Tracheostomy' refers to a nonventilated patient with a permanent tracheostomy from a long- term care ... return to their previous place of residence), and the remaining 14% were discharged to long- term care institutions with the expectation that these patients would require care in these long- term ... study may be more similar to longer term outcomes in hospital systems commonly used in the USA, where patients are discharged from an acute care hospital to a long- term acute care or weaning...
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Báo cáo khoa học: " Long-term outcome and quality of life of patients treated in surgical intensive care: a comparison between sepsis and trauma" doc
Ngày tải lên :
13/08/2014, 03:20
... stayed longer on the general ward (35 ± 44 days versus 17 ± 24 days; P < 0.001) Mortality analysis was separated into short -term mortality (surgical ICU and in-hospital mortality) and long- term ... surgical ICU, and the patients with sepsis (76%) were mostly admitted after major abdominal surgery and had abdominal sepsis Haraldsen and Andersson [22] retrospectively evaluated long- term outcomes ... First, patients with sepsis treated in the surgical ICU have higher short -term (surgical ICU and in-hospital) and long- term (posthospital) mortality than trauma patients Not surprisingly, cumulative...
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Báo cáo y học: " Multiple organ failure after trauma affects even long-term survival and functional status" pdf
Ngày tải lên :
13/08/2014, 08:20
... simple usage of the SOFA score to categorise trauma patients into MOF or not enables us to identify patients at risk of both impaired longterm survival and impaired long- term functional status Functional ... characteristics and selected ICU treatments for the three groups according to degree of organ failure are presented in Table Patients with MOF were older and had a higher SAPS II and ISS, and a longer ... score and SOFA score at ICU admission), and ISS, with the same adjustment variables In these regressions, admission and maximum SOFA score (p < 0.001) were significantly related to long- term survival,...
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Báo cáo y học: "Health care costs, long-term survival, and quality of life following intensive care unit admission after cardiac arrest" pdf
Ngày tải lên :
13/08/2014, 11:22
... survivor, costs per long- term (5 years) survivor, costs per life year gained, and costs per QALY gained To obtain costs per survivor and costs per long- term survivor, total ICU, hospital, and post-hospital ... the study, and analyzed the raw data CM helped to develop the design of the study K-CK helped to develop the design of the study and to analyze the raw data GSD, ER, and UJ helped to analyze ... respond to the questionnaire and telephone contact could not be established, the family doctor and/ or relatives of the patients were contacted to provide the correct address of the patient or to confirm...
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Báo cáo y học: "Long-term outcome and prognosis of dissociative disorder with onset in childhood or adolescence" pot
Ngày tải lên :
13/08/2014, 18:21
... the first investigating the long- term course of juvenile dissociative disorder with respect not only to dissociative symptomatology but also to Axis I and II disorders and psychosocial functioning ... refer to the statements of patients and controls with respect to their family of origin, to friendship and social contacts as well as to partnership and sexuality Most of the patients and controls ... history, clinical symptomatology and the course of dissociative disorder, psychopathology, therapy and outcome A diagnosis according to ICD-10 on the basis of the case records was limited to...
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Genetic engineering and surface modification of baculovirus derived vectors for improved gene delivery to the central nervous system
Ngày tải lên :
14/09/2015, 11:28
... into double-stranded DNA which can then integrate randomly into the host cell genome The use of retrovirus vectors for gene delivery to the nervous system has been limited by their ability to ... “gutless” vectors in rats However, the high antigenicity of the Ad virion and toxicity of the virion penton proteins remain as potential complicating factors with this vector system Retrovirus vectors ... development and modification of baculovirus-based vectors in order to achieve improved gene delivery to the Central Nervous System There are many important requirements for an ideal gene delivery system, ...
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Development of hybrid promoters and viral vectors for improved gene delivery to the central nervous system
Ngày tải lên :
16/09/2015, 08:30
... type (AAV-2) and baculovirus vectors to drive in vitro and in vivo transgene expression A high level, neuron-specific and long- term transgene expression was achieved in rat striatum and substantia ... structure and high risk, etc (Hsich et al., 2002) The core issue and also a huge challenge for gene therapy of CNS disorders is to build up a safe and efficient delivery system to temporally and spatially ... considerations, special attention has to be paid to the gene delivery system, especially to the safety issue which is related to the vector and the temporal and spatial control of the transgene...
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The long term performance and survival patterns of canadian IPOs
Ngày tải lên :
30/09/2015, 16:44
... articles on long- term performance of Canadian IPOs are by Kooli, L ’Her and Suret (2003) and Jog (1997) Jog (1997) documented long- term performance of 308 IPOs listing in Toronto Stock Exchange ... from 1986 to 2000 and used matching firms based on market capitalization and book -to- market ratio as benchmark They documented threeaftermarket year IPOs performance and found that long- term performance ... focuses on the empirical investigation of long- term performance and survival patterns of Canadian firms that issued their initial public offerings in Toronto Stock Exchange during the period 1971...
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Long term relationship and short term dynamics between property stock prices and net asset values in asian pacific region
Ngày tải lên :
10/11/2015, 11:07
... useful to institutional investors and portfolio managers who are interested in securitized real estate investments and need to understand the long- term and short -term behavior of property stock ... on the nature and extent of the relationship between property company stock prices and NAVs both in the long run and short run 2.4 The Long- term Relationship between Stock Prices and Fundamental ... 16 Fama and French (1988b) propose dividends per share (DPS) as being significant in explaining stock returns Santoni and Dwyer (1990) examine long- run data on stock prices and dividends and found...
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