the role of nitric oxide in regulating cell differentiation self renewal and apoptosis
Báo cáo y học: " Central role of nitric oxide in the pathogenesis of rheumatoid arthritis and systemic lupus erythematosus" potx
... for increased endogenous NO synthesis, suggesting that overproduction of NO may be important in the pathogenesis of RA The in amed joint in RA is the predominant source of NO [45,46] Several investigators ... threonine protein kinase and a sensor of the Page of mitochondrial transmembrane potential that regulates protein synthesis, cell growth, cell proliferation and survival [32] The activity of mTOR ... chain expression of T cells [62] in a GSH-precursor-sensitive way, showing the role of redox balance in the regulation of TCR ζ chain expression TCRζ overexpression does not restore signaling in...
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The role of interferon gamma in regulating antigen specific CD8 t cell responses in a mouse model of influenza
... The HA and the NA are the two large spike-like glycoproteins on the surface of the virus HA is a lectin that mediates the binding of the virus to target cells and facilitates the entry of the virus ... leads to initial shrinkage and vacuolization of the cells hence leading to necrosis and desquamation of the cells in the luminal space The lung interstitium may show signs of congestion as the airspaces ... secretions and the lung epithelium In the lung, the first line of protection against the influenza virus is provided by the mucus lining of the respiratory tract which contains sialic-acid bearing...
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The role of nitric oxide and other gaseous mediators in cardiovascular disease models; emphasis on septic shock
... 2: Biology of Nitric Oxide (NO) 2.1 Biosynthesis In mammalian cells, nitric oxide (NO) arises from the enzymatic oxidation of a terminal guanidino nitrogen of the amino acid, L-arginine (Furchgott ... by the host in the course of severe sepsis and septic shock 2.3 Evidence for the involvement of NO in sepsis and septic shock 2.3.1 In vivo overproduction of NO in sepsis The strength of the ... both the heterogeneity of the clinical situations involved and the extreme complexity of the host response to overwhelming infection As such, the need to assess which animal model of inducing...
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The role of nitric oxide and prostaglandin e2 in prolonged hemorrhagic shock 2
... production of PGs On the other hand, COX-2 is an inducible isoform that is induced by cytokines, mitogens, and endotoxins in inflammatory cells and is responsible for the elevated production of PG during ... rat model: The role of NO and the therapeutics effects of conservative fluids and NOS inhibitors 24 3.1 Introduction Hemorrhagic shock is implicated in the induction of inducible nitric oxide synthase ... concentrations of NO and superoxide ion, produced apoptosis and necrosis in certain types of neuronal cells in the central nervous system (Szabo, 1996) PPP In recent years, the effect of iNOS inhibitors...
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The role of nitric oxide and prostaglandin e2 in prolonged hemorrhagic shock 1
... shock model: the role of NO and angiotensin II and the therapeutics effects of conservative fluids, NOS donor and inhibitors Paper Chapter 6: Role of NOS inhibitors in rats following combined fluid-percussion ... and eosin stain of Kidneys 62 Figure 4.4.2 Hemotoxylin and eosin stain of Lungs 63 Figure 4.4.3 Hemotoxylin and eosin stain of Livers 64 Figure 4.4.4 Hemotoxylin and eosin stain of Cerebral cortex ... Shirhan Md Mercaptoethylguandine inhibition of inducible nitric oxide synthase and cyclooxygenase-2 expressions induced in rats following fluid-percussion brain injury Journal of Trauma 59(2), 2005...
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Role of nitric oxide in wound healing facilitatory effects of nitrosoglutathione a nitric oxide donor on the extracellular matrix deposition characteristics of wound healing
... keratinocytes, and fibroblasts Similar to the IL-1s Table 1.2: Growth factors regulating wound healing The cellular origin and the target cell of action of the growth factors in wound healing are shown in ... requiring the collaborative efforts of many different tissues and cell lineages The behavior of each of the contributing cell types during the phases of proliferation, migration, matrix synthesis, and ... response They ingest the microbial flora, acting as the first line of defense The neutrophils are predominant in the early inflammatory phase and later replaced by the monocytes This marks the end of...
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THE ROLE OF DNA METHYLATION IN REGULATING LHX3 GENE EXPRESSION
... protein-protein interactions by increasing the affinity of interacting proteins, as well as altering the subcellular localization of modified proteins (Lomeli and Vazquez, 2011) The addition of the SUMO ... the LHX3 protein isoforms contain a DNA-binding homeodomain, two LIM domains, which participate in protein-protein interactions, and a carboxyl terminus (C-terminus) trans-activation domain The ... identify proteins that interact with the C-terminus Results from the screen indicated that chromatin -regulating proteins interact with the LHX3 C-terminus However, a general understanding of epigenetics...
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THE ROLE OF SWI/SNF IN REGULATING SMOOTH MUSCLE DIFFERENTIATION
... depends on the relative orientation in coordinate space of the PC and variable axes.30 The factor loading is determined by taking the cosine of the angle between the variable axis and the PC axis ... Projections of the data in the second and third principal component 27 A factor loadings plot, seen in Figure 2.7, plots the cosine of the angles between the original variables and principal ... that creates linear combinations of the original variables Inherent groupings of the data can be visualized if a significant portion of the variation in the data set can be explained in two or three...
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THE ROLE OF SWI/SNF IN REGULATING SMOOTH MUSCLE DIFFERENTIATION
... expression of SRF and vinculin in SW13 cells as well as in HeLa cells Although Egr-1 was not induced by MRTFA in either of these two cell types, the basal expression of Egr-1 appeared higher in SW13 cells ... my husband Sunyong Tang for his understanding and love from the bottom of my heart iv Abstract Min Zhang THE ROLE OF SWI/SNF IN REGULATING SMOOTH MUSCLE DIFFERENTIATION There are many clinical ... blocks the ability of myocardin to increase SRF binding to the promoters of smooth muscle-specific genes within chromatin 80 Figure 18 Myocardin, SRF and Brg1 form a complex in vivo and Brg1 binds...
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Elucidating the role of dok 3 in b cell receptor signaling using gene knockout mice 2
... stage) and contributes to the tissues of the developing animal including the germ line Successful microinjection of ES cells into the blastocysts results in an embryo comprised of cells from the ... pertaining to the studies of Dok-1 and were mainly explored in cells of hematopoietic origin for the following reasons Hematopoietic cells, in particular T cells, mast cells, 31 macrophages and ... mouse B lymphoma cell line or the DT40 chicken B cell line Although these studies indicate a role for Dok-3 in negative signaling of the BCR, a definitive role of Dok-3 in primary B cells has yet...
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Elucidating the role of dok 3 in b cell receptor signaling using gene knockout mice
... from the Biological Resource Centre who had help in the microinjection of Dok-3 ES cells, maintaining and changing the many cages of mice, and the staffs from DNA Sequencing Facility for their ... Cloning of targeting construct Culturing of mouse embryonic fibroblasts Culturing of ES cells Preparation of DNA for transfection Transfection and selection of ES cells Picking and freezing down ... expression profiles, are structurally similar, containing tandem Nterminus Pleckstrin (PH) and Phospho-tyrosine binding (PTB) domains as well as multiple potential Src-homology (SH2) and SH3 binding sites...
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Báo cáo y học: " The role of vitamin D in pulmonary disease: COPD, asthma, infection, and cancer" ppsx
... http://respiratory-research.com/content/12/1/31 epithelial cells is able to modulate the inflammatory profile after a viral infection by blocking the poly(I: C) induced chemokine and cytokine production while maintaining the antiviral activity ... the review, all authors contributed in writing and reviewing the paper All authors read and approved the final manuscript Competing interests The authors declare that they have no competing interests ... of VitD have been discovered, indicating that VitD regulates many cellular processes and is potentially involved in the development of many diseases Since the discovery of VDRs in a variety of...
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Báo cáo khoa học: " Pichinde virus induces microvascular endothelial cell permeability through the production of nitric oxide" pot
... endothelial cell monolayers The ability of PIC to induce the production of NO and TNF-α in response to viral infection; correlating with the induction of vascular leak was also determined Inhibitors ... virus infection of endothelial cells in vitro Serum samples from AHF patients confirm the increase in NO in vivo By comparing these results to endothelial cells infected with nonvirulent Junin virus, ... for NO in the increase in PIC-induced leak in HMEC-1 Effect of NO and L-NAME on PIC viral dynamics In order to determine the effect of NO production and inhibition on PIC replication in HMEC-1,...
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THE REGULATORY ROLE OF MATRIX METALLOPROTEINASES IN T CELL ACTIVATION
... IL-10 Interleukin-10 IL-1β Interleukin-1 beta IL-12 Interleukin-12 IL-13 Interleukin-13 xxii IL-21 Interleukin-21 IL-22 Interleukin-22 IL-23 Interleukin-23 IFN-γ Interferon gamma ITK IL-2 inducible ... pro-form and MMP9 as a 92kDa pro15 form These enzymes are in an inactive state due to the thiol (SH-) group of the cysteine residue within the pro-domain interacting with the Zn2+ ion in the catalytic ... exception of the constitutive expression of MMP2 in the endothelium During infection and inflammatory disease, bronchial epithelial cells, Clara cells, alveolar type II cells, smooth muscle cells and...
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the role of fgfr3 mutation in tumour initiation, progression and invasion of urothelial cell carcinoma in mice
... node invasion; N1 indicates cells in one lymph node in the pelvic area; N2 in more than one lymph node in the pelvis; and N3 in one or more lymph nodes in the groin or other parts of the body The ... The role of FGFR3 mutation in tumour initiation, progression and invasion of urothelial cell carcinoma in mice Mona Foth Submitted in fulfilment of the requirements for the Degree of PhD ... may merge at the signalling downstream Thirdly, we examined the role of the most common mutation in FGFR3, S249C, in the urothelium and in tumour progression and invasion by subjecting Fgfr3 mutant...
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Role of SPHK2S1P signalling in regulating mitochondrial function in the MPTP induced mouse model of parkinsons disease and in the MPP treated MN9D cells
... Possible role of sphingosine kinase 2/S1P signaling in promoting mitochondrial function in the MPTPinduced mouse model of Parkinson’s disease and in MPP+- treated MN9D cells (Manuscript in Press) in ... Samuel, Sam Wah Tay* Role of sphingosine kinase and sphingosine kinase in apoptotic cell death evoked by 1-Methyl-4-Phenylpyridinium (MPP+) in the MN9D cells in vitro Manuscript in preparation Conference ... implicated in PD pathogenesis, the expression pattern of TNFα and iNOS in the SNc of the MPTP-induced mouse model was analysed It was observed that there was an increase in the levels of XX TNF and iNOS...
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The role of p38 MAPK in cell cycle checkpoint control following DNA damage
... regulators of the cell cycle, including Cdc2/cyclinB complex, now known CDK1 (100) The main goal of cells in the G1 phase of the cell cycle is to prepare for DNA synthesis in the ensuing S phase The ... changes in the intracellular domain of the receptor, which facilitates recruitment and binding (84) The key intracellular adaptor proteins for the TNF receptor family are the RIP protein and the ... One of the main roles of the APC/cyclosome complex in mitosis is the destruction of cyclin B1 and inactivation of CDK1 (167) Destruction of cyclin B1 generally marks the end of metaphase and the...
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The role of prion protein in breast cancer cell metabolism
... overview of the role of PrP in breast cancer metabolism in the study model Picture showing different lactate production in normal and cancer situation Schematic overview of the role of PrP in cancer ... aspects of PrP In humans, PrP is initially synthesized as a pre-pro-PrP of 253 amino acids in the cytosol PrP contains a hydrophobic N-terminal signal peptide of 22 amino acids while the last 22 amino ... focused on the role of PrP in neurodegenerative diseases, its function outside the nervous system remains unclear Some of the hypothesized functions of PrP include protection against apoptosis and oxidative...
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The role of caspase 1 in a murine model of influenza pneumonitis, and studies on cell death inhibitors in vitro
... immunopathology of influenza infection of the lung in an in vivo murine model A detailed understanding of the mechanisms that undermine pathogenicity and the host-virus interactions that influence the outcome ... of potassium from the cell (step 5a) resulting in a fall in intracellular levels of potassium (step 5b) The fall in intracellular potassium levels triggers the assembly of the components of the ... increasing the likelihood of a pandemic 1.4 Clinical manifestations and pathology of influenza infection Influenza viruses can infect people of all age groups In addition, infants, the aged and...
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