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Báo cáo y học: " A Novel Variable Number of Tandem Repeat of the Natriuretic Peptide Precursor B gene’s 5’-Flanking Region is Associated with Essential Hypertension among Japanese Females"
... models with a deletion of this gene develop disorders that resemble the symptoms of subjects with a deleted allele in the 5’-untranslated region of NPRA. We previously iso-lated a missense ... levels. Thus, it is possible that the plasma BNP level is not an accurate reflection of the function of the NPPB gene. In the present study, the overall distribution of the VNTR genotype and the ... School of Medicine, Tokyo, Ja-pan 3. Division of General Medicine, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan Correspondence to: Tomohiro Nakayama M.D., Division of...
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Tài liệu Báo cáo khoa học: The splicing factor ASF/SF2 is associated with TIA-1-related/ TIA-1-containing ribonucleoproteic complexes and contributes to post-transcriptional repression of gene expression doc
... control of gene expression. Aseach step of the RNA metabolism is tightly regulated,the regulation of mRNA export, stability and transla-tion rate is essential for the control of the expression of ... andreflect the capacity of TIAR to be associated with polysomes. Although the association of DDX21 with TIAR relies on RNA intermediate, DDX5, hnRNP Mand ASF ⁄ SF2 are associated with TIAR by protein–protein ... family of RNA-binding-proteins. It is a shuttling protein [5] involved in multiple aspects of RNA metabolism. In the nucleus, this protein acts as aregulator of the alternative splicing of diverse...
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Tài liệu Báo cáo khoa học: Down-regulation of heme oxygenase-2 is associated with the increased expression of heme oxygenase-1 in human cell lines docx
... cultured humancells.DiscussionWe have shown that the selective knockdown of HO-2expression with each of two different siRNAs is consis-tently associated with increased expression of HO-1mRNA and ... influence the expression of HO-1. The dominant expression of HO-2 protein, incomparison with the low expression of HO-1 protein,in H146 small cell lung cancer cells is of particularinterest ... It is the MARE site that is bound by Nrf2,a transcription activator, or Bach1, a transcriptionrepressor, each of which functions as a heterodimer with a member of the Maf family [46]. Bach1 is...
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Tài liệu Báo cáo khoa học: Hu-K4 is a ubiquitously expressed type 2 transmembrane protein associated with the endoplasmic reticulum ppt
... Ashort variant of about 1700 nucleotides is abundantlypresent in brain. Lower amounts of this variant andalso of a longer isoform of about 2200 nucleotideswere ubiquitiously expressed with lowest ... pressureon this sequence and supporting the hypothesis thatthis part of the mRNA is translated.Eleven exons encode the ORF of human Hu-K4(Fig. 4A, exon 5–15). The analysis of more than 100GenBank ... proteincolocalizing with protein disulfide isomerase, a marker of the endoplasmicreticulum. Glycosylation of Hu-K4 as shown by treatment with peptideN-glycosidase F or tunicamycin indicates that Hu-K4 has a type...
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Báo cáo khoa học: Muramyl-dipeptide-induced mitochondrial proton leak in macrophages is associated with upregulation of uncoupling protein 2 and the production of reactive oxygen and reactive nitrogen species docx
... as MB, is capable of inducing mitochondrial proton leak in the spleen andliver of injected mice. Moreover, it is of importance tonote that the maximum in vivo effect of MDP andsome of its ... infections,potentiation of anti-tumour activity of macrophages,manipulation of cytokine release and restoration of haematopoiesis [18–20]. The parent molecule of thisfamily is muramyl dipeptide (MDP), which ... effects with those of the parentmolecule MDP. The results reported establish thesafety of MB, the absence of undesirable effects on thecentral nervous system, and the lack of induction of inflammatory...
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Báo cáo khoa học: Cellular refractoriness to the heat-stable enterotoxin peptide is associated with alterations in levels of the differentially glycosylated forms of guanylyl cyclase C pdf
... absence of differentially glycosylated forms of GC-C.It is possible that the reappearance of the 145 kDa formfollowing removal of ST peptide was a consequence of further glycosylation of the ER -associated ... The absence of GC-C desensitization (which is correlated with removal of the 145 kDa form of GC-C from cells) in HEK293-GC-Ccells could be due to lack of a cellular factor that is present inT84 ... all derived from different types of coloniccarcinomas. T84 cells are derived from lung metastasis of apatient with colonic carcinoma and exhibit many charac-teristics of polarized epithelial...
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Báo cáo khoa học: N-Methylation in polylegionaminic acid is associated with the phase-variable epitope of Legionella pneumophila serogroup 1 lipopolysaccharide pptx
... of only one isomer.Molecular modelling data ( not shown) suggested t hat thisisomer is 2-E with trans orientation of N1to C5 as 2- Zwould be s terically hindered b y interaction of one of ... stereoisomerism). The lower-đeld1H NMR signal of 3 belonged to the N-methyl group at N2in the E isomer and t he higher-đeld signal t o that in t heZ isomer, in which N1 is in trans and cis ... carefulNMR spectroscopic analysis was used to elucidate thestructure of N-methylated derivatives of legionaminic acid.Comparison of the1H N MR spectra of the OPS of poolIII from all three investigated...
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Báo cáo khoa học: Suppression of urokinase receptor expression by bikunin is associated with inhibition of upstream targets of extracellular signal-regulated kinase-dependent cascade pptx
... possibly through suppression of upstreamtargets of ERK. Thus, one of the functions of bikunin is theregulation of uPA synthesis and uPA binding by modulat-ing uPAR. It is most likely that the PMA-induced ... reported that bikunin expression is associated with a less malignant phenotype [24]. There is evidence that bikunin significantly prevented pulmonarymetastasis of mouse Lewis lung carcinoma 3LL cells ... twice with similar results.Ó FEBS 2002 Suppression of uPAR by bikunin (Eur. J. Biochem. 269) 3951 Suppression of urokinase receptor expression by bikunin is associated with inhibition of upstream...
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Báo cáo khoa học: The unique pharmacology of the scorpion a-like toxin Lqh3 is associated with its flexible C-tail pdf
... FEBS His15 and His66 seem to contribute to the differentialinteraction of Lqh3 with channel receptors of variousorigin.In total, the bioactive surface of Lqh3 is composed of two distinct ... 6B).DiscussionInsight into the molecular basis of preferential interac-tions of scorpion a-toxins with insect or mammalianNavs was thus far obtained mainly from mutagenesisand comparison of ... 3). Whereas substitutions of His15, His36 and His43 did not reduce Lqh3 sensitiv-ity to pH, substitutions of His66 had a clear impact with the utmost decrease obtained with H66R(Table 3). Unexpectedly,...
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Báo cáo khoa học: "WHAT A TYPE OF INTERACTION IS IT TOBE HT" potx
... impacts on this aspect of the exchange of talk. It is one reason for wondering whether retention of ordinary conversation as the target of this enterprise is appro- priate. For some of the contemplated ... "interactionality" is the sequential organiza- tion of the talk; that is, the construction of units of participation with specific respect to the details of what has preceded, and thereby ... matters right. This is a major safe- guard of "intersubjectivity," a retention of a sense that the "sa~ thing" is being understood as what is being spoken of. The requirements...
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Báo cáo khoa học: A distinct sequence in the adenine nucleotide translocase from Artemia franciscana embryos is associated with insensitivity to bongkrekate and atypical effects of adenine nucleotides on Ca2+ uptake and sequestration pdf
... alignment of the Artemia ANT p roteinsequence with that of other species (Xenopus, Drosophila,mouse isoforms 1, 2, and 4, rat isoforms 1 and 2,bovine isoforms 1, 2, 3, and 4, and human isoforms ... compared with the known structure of bovine ANT.Comparison of the predicted three-dimensionalstructure of Artemia ANT with that of bovineANTThe structure of bovine ANT (isoform 1) is known(structure: ... mitochondria isolated from embryos of A. francis-cana. It is of note that, in the presence of oligomycinand ADP, addition of Ca2+failed to induce anincrease in light scattering (Fig. 2A), consistent...
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Tìm thêm: xác định các mục tiêu của chương trình khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo gắn với các giáo trình cụ thể điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 sự cần thiết phải đầu tư xây dựng nhà máy phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008