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Báo cáo y học: " A Novel Variable Number of Tandem Repeat of the Natriuretic Peptide Precursor B gene’s 5’-Flanking Region is Associated with Essential Hypertension among Japanese Females"
... models with a deletion of this gene develop disorders that resemble the symptoms of subjects with a deleted allele in the 5’-untranslated region of NPRA. We previously iso-lated a missense ... 5’-flanking region of the NPPB gene was discovered. This poly-morphism was associated with EH in female subjects. However, this finding does not necessarily imply that there is a relationship ... accession number AB265677). This VNTR polymorphism is a tandem repeat of the 4-nucleotide sequence TTTC (Fig. 1A). There were 8 alleles of this VNTR polymorphism, ranging from 9-repeat to...
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Tài liệu Báo cáo khoa học: The splicing factor ASF/SF2 is associated with TIA-1-related/ TIA-1-containing ribonucleoproteic complexes and contributes to post-transcriptional repression of gene expression doc
... control of gene expression. Aseach step of the RNA metabolism is tightly regulated,the regulation of mRNA export, stability and transla-tion rate is essential for the control of the expression of ... andreflect the capacity of TIAR to be associated with polysomes. Although the association of DDX21 with TIAR relies on RNA intermediate, DDX5, hnRNP Mand ASF ⁄ SF2 are associated with TIAR by protein–protein ... family of RNA-binding-proteins. It is a shuttling protein [5] involved in multiple aspects of RNA metabolism. In the nucleus, this protein acts as aregulator of the alternative splicing of diverse...
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Tài liệu Báo cáo khoa học: Down-regulation of heme oxygenase-2 is associated with the increased expression of heme oxygenase-1 in human cell lines docx
... cultured humancells.DiscussionWe have shown that the selective knockdown of HO-2expression with each of two different siRNAs is consis-tently associated with increased expression of HO-1mRNA and ... influence the expression of HO-1. The dominant expression of HO-2 protein, incomparison with the low expression of HO-1 protein,in H146 small cell lung cancer cells is of particularinterest ... It is the MARE site that is bound by Nrf2,a transcription activator, or Bach1, a transcriptionrepressor, each of which functions as a heterodimer with a member of the Maf family [46]. Bach1 is...
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Báo cáo khoa học: Muramyl-dipeptide-induced mitochondrial proton leak in macrophages is associated with upregulation of uncoupling protein 2 and the production of reactive oxygen and reactive nitrogen species docx
... as MB, is capable of inducing mitochondrial proton leak in the spleen andliver of injected mice. Moreover, it is of importance tonote that the maximum in vivo effect of MDP andsome of its ... infections,potentiation of anti-tumour activity of macrophages,manipulation of cytokine release and restoration of haematopoiesis [18–20]. The parent molecule of thisfamily is muramyl dipeptide (MDP), which ... effects with those of the parentmolecule MDP. The results reported establish thesafety of MB, the absence of undesirable effects on thecentral nervous system, and the lack of induction of inflammatory...
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Báo cáo khoa học: Cellular refractoriness to the heat-stable enterotoxin peptide is associated with alterations in levels of the differentially glycosylated forms of guanylyl cyclase C pdf
... absence of differentially glycosylated forms of GC-C.It is possible that the reappearance of the 145 kDa formfollowing removal of ST peptide was a consequence of further glycosylation of the ER -associated ... The absence of GC-C desensitization (which is correlated with removal of the 145 kDa form of GC-C from cells) in HEK293-GC-Ccells could be due to lack of a cellular factor that is present inT84 ... long-termtreatment of cells with ST. As the 130 kDa form of GC-C is still on the surface after prolonged ST treatment, it is notclear at this time whether the 130 kDa form alone is recycled, or...
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Báo cáo khoa học: N-Methylation in polylegionaminic acid is associated with the phase-variable epitope of Legionella pneumophila serogroup 1 lipopolysaccharide pptx
... of only one isomer.Molecular modelling data ( not shown) suggested t hat thisisomer is 2-E with trans orientation of N1to C5 as 2- Zwould be s terically hindered b y interaction of one of ... stereoisomerism). The lower-đeld1H NMR signal of 3 belonged to the N-methyl group at N2in the E isomer and t he higher-đeld signal t o that in t heZ isomer, in which N1 is in trans and cis ... carefulNMR spectroscopic analysis was used to elucidate thestructure of N-methylated derivatives of legionaminic acid.Comparison of the1H N MR spectra of the OPS of poolIII from all three investigated...
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Báo cáo khoa học: Suppression of urokinase receptor expression by bikunin is associated with inhibition of upstream targets of extracellular signal-regulated kinase-dependent cascade pptx
... possibly through suppression of upstreamtargets of ERK. Thus, one of the functions of bikunin is theregulation of uPA synthesis and uPA binding by modulat-ing uPAR. It is most likely that the PMA-induced ... invasiveness is a complex, multistep process thatinvolves cell attachment, the proteolysis of matrix compo-nents, and the migration of cells through the disrupted matrix[1]. Activation of receptor-bound ... invasion andmetastasis [2]. In a number of cancers, the expression of theuPA and uPAR is required for the invasive phenotype [3,4].uPAR binds uPA with high affinity with a Kd of 0.5 nM[5,6]....
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Báo cáo khoa học: The unique pharmacology of the scorpion a-like toxin Lqh3 is associated with its flexible C-tail pdf
... FEBS His15 and His66 seem to contribute to the differentialinteraction of Lqh3 with channel receptors of variousorigin.In total, the bioactive surface of Lqh3 is composed of two distinct ... 6B).DiscussionInsight into the molecular basis of preferential interac-tions of scorpion a-toxins with insect or mammalianNavs was thus far obtained mainly from mutagenesisand comparison of ... 3). Whereas substitutions of His15, His36 and His43 did not reduce Lqh3 sensitiv-ity to pH, substitutions of His66 had a clear impact with the utmost decrease obtained with H66R(Table 3). Unexpectedly,...
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Báo cáo khoa học: A distinct sequence in the adenine nucleotide translocase from Artemia franciscana embryos is associated with insensitivity to bongkrekate and atypical effects of adenine nucleotides on Ca2+ uptake and sequestration pdf
... alignment of the Artemia ANT p roteinsequence with that of other species (Xenopus, Drosophila,mouse isoforms 1, 2, and 4, rat isoforms 1 and 2,bovine isoforms 1, 2, 3, and 4, and human isoforms ... compared with the known structure of bovine ANT.Comparison of the predicted three-dimensionalstructure of Artemia ANT with that of bovineANTThe structure of bovine ANT (isoform 1) is known(structure: ... mitochondria isolated from embryos of A. francis-cana. It is of note that, in the presence of oligomycinand ADP, addition of Ca2+failed to induce anincrease in light scattering (Fig. 2A), consistent...
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Báo cáo khoa học: Homologous desensitization of guanylyl cyclase A, the receptor for atrial natriuretic peptide, is associated with a complex phosphorylation pattern pot
... phosphorylation of thisresidue in the inhibitory regulation of GC-A activity.To follow this hypothesis, we tested the influence of the substitution of Ser487 with glutamate on the pro-cess of homologous ... top). This suggests that thisphosphorylation site, in contrast with the others, is phosphorylated during homologous desensitization.Hence, homologous desensitization of GC-A is associ-ated with ... accomplished usingmultiquant 1.0 software (Applied Biosystems) [33]. Esti-mates of the relative abundance of phosphorylated trypticpeptides of GC-A isolated from HEK293 cells treated with ANP...
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Báo cáo khoa học: Mutation of epidermal growth factor receptor is associated with MIG6 expression docx
... pathway[14,15] and its loss is associated with ErbB2 ⁄ HER-2oncogenic potency leading to Herceptin resistance[16]. Furthermore, its overexpression is associated with down-regulation of phosphorylated-ErbB2 ... transcriptional regulation of this mutant is of clinical importance in terms of con-tributing towards our understanding of patient sensi-tivity to Iressa, as well as side effects and drugresistance. The ... factor receptor (EGFR) is a mem-brane tyrosine kinase that is involved in the regulation of a wide variety of biological processes [1]. Controlledactivation of EGFR is systemically and evolutionarilyguaranteed...
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báo cáo hóa học:" Higher percentage of CD133+ cells is associated with poor prognosis in colon carcinoma patients with stage IIIB" pptx
... percentage of CD133+ tumor cells andthe prognosis of colorectal cancer patients. This studyshowed that the percentage of CD133+ tumor cells was associated with the prognosis among patients with ... function of CD133 is unknown, preliminary evidence proposedthat expression of CD133 is associated with the activation of stemness-related signal pathway, resistance to apopto-sis and bioenergetic ... percentage of cancer stem cells is associated with the prognosis of cancer patients, the over-population hypothesis would be substantially supported.By now, the relationship between the percentage of CD133...
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