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Báo cáo sinh học: "Membranous expression of Her3 is associated with a decreased survival in head and neck squamous cell carcinoma" pot
... primary HNSCC tissues, 20 matching metastatic tissues and 17 recurrent HNSCC tissues The clinical information of these patients was obtained from the University of Immunohistochemistry and scoring ... clear[27,30,36] In case of breast cancer, membranous staining is the criterion for positivity[17] Another interesting finding is that Her2 expression was associated with histological grade, with the most ... Special thanks to Ms Angela Miller of the Biorepository and Tissue Research Facility of The University of Virginia for construction of the TMAs used in this study This research was supported by the...
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báo cáo hóa học:" Membranous expression of Her3 is associated with a decreased survival in head and neck squamous cell carcinoma" doc
... primary HNSCC tissues, 20 matching metastatic tissues and 17 recurrent HNSCC tissues The clinical information of these patients was obtained from the University of Immunohistochemistry and scoring ... clear[27,30,36] In case of breast cancer, membranous staining is the criterion for positivity[17] Another interesting finding is that Her2 expression was associated with histological grade, with the most ... Special thanks to Ms Angela Miller of the Biorepository and Tissue Research Facility of The University of Virginia for construction of the TMAs used in this study This research was supported by the...
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báo cáo khoa học: "Down-regulation of TM4SF is associated with the metastatic potential of gastric carcinoma TM4SF members in gastric carcinoma" ppt
... protein levels were inversely associated with lymph node metastasis of gastric carcinoma Furthermore, the reduction of CD9 protein was associated with distant metastasis of gastric cancer Our results ... decreased levels of CD9 are strongly associated with an increased risk of recurrence, especially in patients with N0 nodal status and M0 metastatic status These findings are consistent with previous ... levels of CD63 were associated with distant metastasis and CD63 protein correlated lymph node status Taken together, these results suggested that decreased levels of CD63 were associated with a...
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Báo cáo y học: "Relaxin''''s induction of metalloproteinases is associated with the loss of collagen and glycosaminoglycans in synovial joint" ppsx
... fibrocartilaginous disc explants Our findings are consistent with the hypothesis that relaxin-mediated induction of MMPs is associated with the loss of matrix macromolecules that could compromise tissue function ... this is the first study to demonstrate a similar targeting of fibrocartilaginous tissues from the synovial TMJ, and may implicate this hormone in the pathogenesis of TMJ disease in a subset of ... values of the control hemisection within each animal and the fold changes were plotted as histograms The statistical significance of differences was determined by single-factorial analysis of variance...
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Báo cáo y học: "High nuclear expression of STAT3 is associated with unfavorable prognosis in diffuse large B-cell lymphoma" doc
... immunoreactivity Statistics The Chi-square test was used to analyze the consistence of expressions of STAT3 in nucleus and P-STAT3 Correlation analysis of the STAT3 expression and the PSTAT3 level with clinicopathological ... doi:10.1186/1756-8722-4-31 Cite this article as: ZL et al.: High nuclear expression of STAT3 is associated with unfavorable prognosis in diffuse large B-cell lymphoma Journal of Hematology & Oncology ... (25.7%) with strong nuclear staining of STAT3, and 24 cases (32.4%) with strong nuclear staining of P-STAT3 Representative staining outcomes were shown in Figure There existed a consistence between...
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Báo cáo y học: " Risk of malnutrition is associated with mental health symptoms in community living elderly men and women: The Tromsø Study" pdf
... category of BMI 25-27.4 kg/m2 Discussion In this study, we found that mental health symptoms were strongly associated with the risk of malnutrition in elderly individuals Both the risk of malnutrition ... level of education, and a smaller proportion had a history of smoking Mean BMI was 27.0 kg/m2 in both genders Risk of malnutrition (combining medium and high risk) was found in 7.1% (222/3112) of ... SCL-10 the assessment of the relationship between risk of malnutrition and mental health Increased risk of malnutrition (combining medium and high risk) was found in 7.1% of the individuals in...
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Báo cáo y học: " Activated mammalian target of rapamycin is associated with T regulatory cell insufficiency in nasal polyps" pps
... results show that rapamycin administration is associated with elevated Foxp3+ Tregs in cultured nasal polyps Inhibition of mTOR signaling by rapamycin is associated with enhanced Foxp3 expression ... Infiltration of pmTOR+ cells and Foxp3+CD4+ cell in nasal tissues by histologic examination Infiltration of pmTOR+ cells and Foxp3+CD4+ cell in nasal tissues by histologic examination The number of pmTOR+ ... polyps is of significant interest In the present study, we investigated the phosphorylation status of mTOR in a group of Chinese CRSwNP patients by immunohistochemistry, and the infiltration of Foxp3+CD4+...
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Báo cáo y học: "Intensivists'''' base specialty of training is associated with variations in mortality and practice patterns" docx
... System (TISS) over first 24 hours of admission to ICU, year of admission, time of year of admission (by 28-day block to coincide with trainees' length of rotation), level of care at time of admission ... file is available with the online version of this paper; it contains a total of 12 tables providing more detailed results of the analyses Tables S1 and S2 list the variables associated with ICU ... DNR) and discharge, admission diagnosis, Intensivist gender, Intensivist base specialty of training, years since completion of Critical Care Medicine Fellowship, and ICU occupancy at admission and...
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Báo cáo y học: "Chronic development of collagen-induced arthritis is associated with arthritogenic antibodies against specific epitopes on type II collagen" ppt
... development of arthritis has not been perfectly correlated with serum titers of antibodies against CII because high titers of antibodies not always lead to severe arthritis [29] This is also observed ... noted to occur spontaneously during the course of the disease, is capable of inducing severe arthritis The question arises whether this phenomena is unique to the mouse, whether we can use the ... described above Statistical analysis The Statview software program was used for the statistical analysis The Mann-Whitney U (MW) test was applied to evaluate comparisons of antibody titres and...
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Báo cáo y học: " A Novel Variable Number of Tandem Repeat of the Natriuretic Peptide Precursor B gene’s 5’-Flanking Region is Associated with Essential Hypertension among Japanese Females"
... models with a deletion of this gene develop disorders that resemble the symptoms of subjects with a deleted allele in the 5’-untranslated region of NPRA We previously isolated a missense mutation of ... (GenBank accession number AB265677) This VNTR polymorphism is a tandem repeat of the 4-nucleotide sequence TTTC (Fig 1A) There were alleles of this VNTR polymorphism, ranging from 9-repeat to 19-repeat ... genotype and the BMI among the Table Genotype distribution in NT subjects and EH patients Table The association between genotype and phenotype Table Plasma BNP levels for patients with or without...
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Tài liệu Báo cáo khoa học: The splicing factor ASF/SF2 is associated with TIA-1-related/ TIA-1-containing ribonucleoproteic complexes and contributes to post-transcriptional repression of gene expression doc
... control of gene expression As each step of the RNA metabolism is tightly regulated, the regulation of mRNA export, stability and translation rate is essential for the control of the expression of ... Tris, pH 8.0) in the presence of RNAse A (10 lgÆmg)1 extract) After 15 h of binding at °C, beads were washed twice with mL of IgG BB and once with mL of Tev cleavage buffer (Tev CB: 25 mm Tris, ... whereas the RS domain is dispensable Moreover, RRM1 but not RRM2 is necessary and sufficient to promote this cytoplasmic redistribution However, in the context of the wild -type ASF ⁄ SF2 protein,...
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Tài liệu Báo cáo khoa học: Down-regulation of heme oxygenase-2 is associated with the increased expression of heme oxygenase-1 in human cell lines docx
... cultured human cells Discussion We have shown that the selective knockdown of HO-2 expression with each of two different siRNAs is consistently associated with increased expression of HO-1 mRNA and ... measurement of heme content is useful for evaluation of heme dynamics in cultured cells Role of heme metabolism in cellular heme content Regulatory role of free heme in expression of HO-1 To evaluate ... influence the expression of HO-1 The dominant expression of HO-2 protein, in comparison with the low expression of HO-1 protein, in H146 small cell lung cancer cells is of particular interest because...
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Tài liệu Báo cáo khoa học: Hu-K4 is a ubiquitously expressed type 2 transmembrane protein associated with the endoplasmic reticulum ppt
... short variant of about 1700 nucleotides is abundantly present in brain Lower amounts of this variant and also of a longer isoform of about 2200 nucleotides were ubiquitiously expressed with lowest ... evolutionary pressure on this sequence and supporting the hypothesis that this part of the mRNA is translated Eleven exons encode the ORF of human Hu-K4 (Fig 4A, exon 5–15) The analysis of more than 100 ... efficiently translated than the larger isoforms which predominate in other tissues 1721 Hu-K4 A Munck et al Table Putative start codons of Hu-K4 Comparison of the optimal translational start site...
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Báo cáo khoa học: Muramyl-dipeptide-induced mitochondrial proton leak in macrophages is associated with upregulation of uncoupling protein 2 and the production of reactive oxygen and reactive nitrogen species docx
... enhancement of non-specific resistance to viral and bacterial infections, potentiation of anti-tumour activity of macrophages, manipulation of cytokine release and restoration of haematopoiesis [18–20] ... that the activity of UCP2 is consistent with the level of free radicals Results In vitro effect of muramyl peptides and lipopolysaccharide on respiratory mitochondrial activity of murine peritoneal ... as MB, is capable of inducing mitochondrial proton leak in the spleen and liver of injected mice Moreover, it is of importance to note that the maximum in vivo effect of MDP and some of its derivatives...
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Báo cáo khoa học: Cellular refractoriness to the heat-stable enterotoxin peptide is associated with alterations in levels of the differentially glycosylated forms of guanylyl cyclase C pdf
... all derived from different types of colonic carcinomas T84 cells are derived from lung metastasis of a patient with colonic carcinoma and exhibit many characteristics of polarized epithelial cells ... differentially glycosylated forms of GC-C It is possible that the reappearance of the 145 kDa form following removal of ST peptide was a consequence of further glycosylation of the ER -associated 130 kDa form, ... synthesis was not required, and a pool of ER -associated GC-C is available to replenish the ligand-activable form of the receptor, lost from the cell surface on ST addition The levels of cGMP...
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Báo cáo khoa học: N-Methylation in polylegionaminic acid is associated with the phase-variable epitope of Legionella pneumophila serogroup 1 lipopolysaccharide pptx
... careful NMR spectroscopic analysis was used to elucidate the structure of N-methylated derivatives of legionaminic acid Comparison of the 1H NMR spectra of the OPS of pool III from all three investigated ... nitrogen of an N-acetimidoyl group, i.e that an (N,N-dimethylacetimidoyl)amino group is present (Fig 8, structure 2) This group is linked to C5 of a legionaminic acid residue, which is substituted with ... stereoisomers, E and Z, with regard to the partial double bond at N2, while the NMR spectra showed the presence of only one isomer Molecular modelling data (not shown) suggested that this isomer is...
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Báo cáo khoa học: Suppression of urokinase receptor expression by bikunin is associated with inhibition of upstream targets of extracellular signal-regulated kinase-dependent cascade pptx
... reported that bikunin expression is associated with a less malignant phenotype [24] There is evidence that bikunin significantly prevented pulmonary metastasis of mouse Lewis lung carcinoma 3LL cells ... possibly through suppression of upstream targets of ERK Thus, one of the functions of bikunin is the regulation of uPA synthesis and uPA binding by modulating uPAR It is most likely that the PMA-induced ... increased level of phosphorylated ERK is associated with increased level of cell-surface uPAR, which results in enhanced invasion [10] To determine the role of bikunin in the regulation of ERK1/2 phosphorylation,...
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Báo cáo khoa học: The unique pharmacology of the scorpion a-like toxin Lqh3 is associated with its flexible C-tail pdf
... isomerization of the P9-E10 peptide-bond was most likely unrelated to the pH dependence of Lqh3 To test the possibility that the pH-dependent binding of Lqh3 is associated with protonation of surface histidines ... 6B) Discussion Insight into the molecular basis of preferential interactions of scorpion a-toxins with insect or mammalian Navs was thus far obtained mainly from mutagenesis and comparison of bioactive ... populations (His66, His43; Fig 7C,D), such a conformational change may provide the basis for the dependence of Lqh3 binding on pH This hypothesis is supported by the decreased sensitivity to pH of the...
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Báo cáo khoa học: "WHAT A TYPE OF INTERACTION IS IT TOBE HT" potx
... Throughout these notes, we are at a very general tevel of discourse The real pay-offs, however, w i l l come from discussing specifics For t h a t , i n t e r a c t i o n w i l l be...
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Báo cáo khoa học: A distinct sequence in the adenine nucleotide translocase from Artemia franciscana embryos is associated with insensitivity to bongkrekate and atypical effects of adenine nucleotides on Ca2+ uptake and sequestration pdf
... alignment of the Artemia ANT protein sequence with that of other species (Xenopus, Drosophila, mouse isoforms 1, 2, and 4, rat isoforms and 2, bovine isoforms 1, 2, 3, and 4, and human isoforms ... compared with the known structure of bovine ANT Comparison of the predicted three-dimensional structure of Artemia ANT with that of bovine ANT The structure of bovine ANT (isoform 1) is known ... PTP As shown in Fig 2A, this was not observed in mitochondria isolated from embryos of A franciscana It is of note that, in the presence of oligomycin and ADP, addition of Ca2+ failed to induce...
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