... (2001) Nitricoxide synthases: structure, function and inhibition Biochem J 357, 593–615 ´ Roman LJ, Martasek P & Masters BS (2002) Intrinsic and extrinsic modulation ofnitricoxidesynthase ... nitric- oxidesynthase by a dual mechanism Activation of intra- and interdomain electron transfer J Biol Chem 269, 1179–1190 Chen PF, Tsai AL, Berka V & Wu KK (1996) Endothelial nitric- oxidesynthase ... (1997) Calcium binding sites of calmodulin and electron transfer by neuronal nitricoxidesynthase Biochemistry 36, 12337–12345 11 Ghosh DK & Salerno JC (2003) Nitricoxide synthases: domain structure...
... regulationofnitricoxide synthases and their allosteric regulators in heart and vessels of hypertensive rats Cardiovasc Res 57, 456–467 Thomas SR, Chen K & Keaney JF Jr (2002) Hydrogen peroxide ... Involvement of the proteasome in activation of endothelial nitricoxidesynthase Life Sci 73, 2225–2236 Musial A & Eissa T (2001) Inducible nitric- oxidesynthase is regulated by the proteasome degradation ... Ubiquitination of neuronal nitric- oxidesynthase in vitro and in vivo J Biol Chem 275, 17407–17411 Hajimohammadreza I, Raser KJ, Nath R, Nadimpalli R, Scott M & Wang KKW (1997) Neuronal nitricoxide synthase...
... University of Genoa References Kone BC, Kuncewicz T, Zhang W & Yu Z (2003) Protein interaction with nitricoxide synthases: controlling the right time, the right place, and the right amount ofnitricoxide ... degradation ofnitricoxide synthase: effect of inhibitors and role of HSP90-based chaperones J Pharmacol Exp Ther 304, 493–497 13 Govers R, de Bree P & Rabelink TJ (2003) Involvement of the proteasome ... (2002) Ubiquitination of inducible nitricoxidesynthase is required for its degradation Proc Natl Acad Sci USA 99, 12315–12320 15 Musial A & Eissa T (2001) Inducible nitric- oxidesynthase is regulated...
... iNOS, inducible nitricoxide synthase; MAPK, mitogen activated protein kinase; NF-κB, nuclear factor kappa B; NGF, nerve growth factor; NO, nitric oxide; nNOS, neuronal nitricoxide synthase; NTR, ... Mechanism of selective motor neuronal death after exposure of spinal cord to glutamate: Involvement of glutamate induced nitricoxide in motor neuron toxicity and nonmotor neuron protection Annals of ... nitricoxide and dementia of the Alzheimer's type Brain Res Brain Res Rev 2001, 35:73-96 de la Monte SM, Lu BX, Sohn YK, Etienne D, Kraft J, Ganju N, Wands JR: Aberrant expression ofnitric oxide...
... of constitutive and inducible forms ofnitricoxidesynthase in autoimmune encephalomelitis 27 28 29 30 31 32 33 34 35 36 37 38 Induction ofnitricoxidesynthase activity in human astrocytes ... Fujimura, H and Yanagihara, T Nitricoxide via an inducible isoform ofnitricoxidesynthase is a possible factor to eliminate inflammatory cells from the central nervous system of mice with experimental ... Inhibition ofnitricoxidesynthase for treatment of experimental autoimmune encephalomyelitis J Immunol 1997, 158(6), 2940-2946 Buisson, A., Plotkine, M and Boulu, R G The neuroprotective effect of nitric...
... monoclonal anti-endothelial nitricoxidesynthase (eNOS) antibody, rabbit anti-inducible nitricoxidesynthase (iNOS) antisera, and rabbit anti-neuronal nitricoxidesynthase (nNOS) antisera (all ... Immunohistochemical localization of neuronal (nNOS), endothelial (eNOS), and inducible (iNOS) isoforms ofnitricoxidesynthase (NOS) in the ovaries of pigs The intensity of staining is indicated by ... Enhanced expression of constitutive and inducible forms ofnitricoxidesynthase in autoimmune encephalomyelitis J Vet Sci 2000, 1, 11-17 Knowles RG, Moncada S Nitricoxide synthases in mammals...
... Abramson SB: The expression and regulationofnitricoxidesynthase in human osteoarthritis-affected chondrocytes: evidence for an inducible "neuronal-like" nitricoxidesynthase J Exp Med 1995, 182:2097-2102 ... FY: Production ofnitricoxide in the synovial membrane of rheumatoid and osteoarthritis patients J Exp Med 1996, 184:1519-1524 42 Stefanovic-Racic M, Stadler J, Evans CH: Nitricoxide and arthritis ... effect of ASU on clinical symptoms of knee and hip OA, with a carryover effect that persists after termination of treatment [10-12] The primary aim of the present study was to explore the effects of...
... calcium-regulated isoforms ofnitricoxidesynthase J Biol Chem 272, 29769–29777 Daff S, Sagami I & Shimizu T (1999) The 42-amino acid insert in the FMN domain of neuronal nitricoxide synthase exerts ... Function of the reductase unit ofnitricoxide synthase: catalytic model NitricOxide 19, S50 Presta A, Weber-Main AM, Stankovich MT & Stuehr D (1998) Comparative effects of substrates and pterin cofactor ... activity of endothelial nitricoxidesynthase Proc Natl Acad Sci USA 104, 9254–9259 Stuehr DJ, Wei CC, Santolini J, Wang Z, Aoyagi M & Getzoff ED (2004) Radical reactions ofnitricoxide synthases...
... subcellular distribution of the human inducible nitricoxidesynthase in an intestinal cell line: evidence for post-translational regulation In The Biology ofNitricOxide Part 7, (Moncada S, ... assembly of inducible NO synthase into an active dimer J Biol Chem 274, 930–938 Kuncewicz T, Balakrishnan P, Snuggs MB & Kone BC (2001) Specific association ofnitricoxide synthase- 2 with Rac isoforms ... Decreased activity of inducible nitricoxidesynthase type and modulation of the expression of glutathione S-transferase alpha, bcl-2, and metallothioneins during the differentiation of CaCo-2 cells...
... substrates for nitricoxide synthases Bioorg Med Chem 10, 3049–3055 Jia Q, Cai T, Huang M, Li H, Xian M, Poulos TL & Wang PG (2003) Isoform-selective substrates ofnitricoxidesynthase J Med ... binding of arginine analogs to nitricoxide synthases NitricOxide Biol Chem 5, 442–452 13 Ghosh S, Wolan D, Adak S, Crane BR, Kwon NS, Tainer JA, Getzoff ED & Stuehr DJ (1999) Mutational analysis of ... in the biosynthesis ofnitricoxide from l-arginine J Biol Chem 266, 6259–6263 Klatt P, Schmidt K, Uray G & Mayer B (1993) Multiple catalytic functions of brain nitricoxidesynthase Biochemical...
... (2003) Regulationof the expression of inducible nitricoxidesynthase Biol Chem 384, 1343–1364 10 Kleinert H, Pautz A, Linker K & Schwarz PM (2004) Regulationof the expression of inducible nitric ... (2000) Differential anti-inflammatory effects of immunosuppressive drugs: cyclosporin, rapamycin and FK-506 on inducible nitricoxide synthase, nitric oxide, cyclooxygenase-2 and PGE2 production ... lipopolysaccharidestimulated nitricoxide production in macrophages via interferon-beta J Leukoc Biol 67, 405–414 Xie Q (1997) A novel lipopolysaccharide-response element contributes to induction ofnitricoxide synthase...
... when it binds to the CaM-binding domain of endothelial nitricoxidesynthase (eNOS) [33] The second example is when the C-terminal lobe of Ca2+-CaM binds part of the target peptide This is shown ... that of Ca2+-CaM [10,11,25,26], and therefore adversely affects binding of CaM to the Ca2+-CaM-binding domain of nNOS CaM is not only essential for the operation of nNOS and the other NOS isoforms, ... formation of NO by neuronal nitricoxidesynthase (nNOS) [10] These particular amphibian peptides (e.g the caerins and splendipherin [11]), are basic and hinged, and inhibit the operation of nNOS...
... three-dimensional structures of certain domains ofnitricoxidesynthase isoforms are known [53±57], we are not aware of the three-dimensional structure of the calmodulin binding sites of any isoform being reported ... comparison of the calmodulinbinding domains ofnitricoxide synthases J.Biol Chem 271, 6435±6440 43 Lee, S.J & Stull, J.T (1998) Calmodulin-dependent regulationof inducible and neuronal nitricoxidesynthase ... peptides, unlike the majority of the other members of the genus Litoria Instead, it produces a neuropeptide that inhibits the formation ofnitricoxide by neuronal nitricoxidesynthase (nNOS) We next...
... constitutively express neuronal nitricoxidesynthase mRNA NitricOxide 1998, 2, 203-212 Hooper, D.C., Ohnishi, S.T., Kean, R., Numagami, Y., Dietzschold, B and Koprowski, H Local nitricoxide production in ... expression of constitutive and inducible forms ofnitricoxidesynthase in autoimmune encephalomyelitis J Vet Sci., 2000, 1, 11-17 11 Moncada, S., Palmer, R.M.J and Higgs, E.A Nitric oxide: physiology, ... Magnification A and B, ×66 C and D, ×132 Immunohistochmical study ofnitricoxidesynthase in the central nervous system of goat Enhanced expression of nNOS and iNOS in L monocytogenes-infected brain At...
... Ivana D Stevanović et al 18 19 20 21 22 23 24 25 26 27 28 29 reduces expression of neuronal nitricoxidesynthase and of soluble guanylate cyclase and impairs glutamatergic neurotransmission in rat ... shaped, and is still refining, the nature of oxidative signaling in terms of regulating the milieu of inflammatory mediators, ostensibly via the modulation of oxygen- and redox-responsive transcription ... factors Hence, they are termed redox(y)-sensitive cofactors [12] Also, anti-oxidative defense includes both of the superoxide dismutase (SOD)-isoforms (Mn-SOD, Cu/ZnSOD), which are induced to prevent...
... expression profile of aggrecan mimicked that of type II collagen but with a slight delay of a couple of days The decline in expression of both chondrocyte markers coincided with the onset of late-stage ... (JAK)2 inhibition blocks leptin/IL-1-induced nitricoxide (NO) production and nitricoxidesynthase (NOS) type II protein expression expression Effect of tyrphostin AG490 and Tkip on NO production ... Figure Involvement of (NOS) oxidesynthase phosphatidylinositol 3-kinase (PI3K), mitogen-activated protein kinase kinase (MEK)-1 and p38-kinase in leptin/IL-1-induced nitricoxidesynthase (NOS)...
... Abramson SB: The expression and regulationofnitricoxidesynthase in human osteoarthritis-affected chondrocytes: evidence for up regulated neuronal nitricoxidesynthase J Exp Med 1995, 182:2097-102 ... induction ofnitricoxidesynthase by interleukin-1β in rat glomerular mesangial cells J Biol Chem 1999, 274:36200-36206 69 Taylor BS, Geller DA: Molecular regulationof the human inducible nitricoxide ... expression in bovine articular chondrocytes NitricOxide 2002, 6:35-44 66 LaPointe MC, Isenovic E: Interleukin-1β regulationof inducible nitricoxidesynthase and cyclooxygenase-2 involves the...