the regulation of fsap activity is of major importance
Báo cáo khoa học: The N-terminal hybrid binding domain of RNase HI from Thermotoga maritima is important for substrate binding and Mg2+-dependent activity pot
... °CÆmin)1. The thermal denaturation of these proteinswas fully reversible under this condition. The temperature of the midpoint of the transition, Tm, was calculated fromcurve fitting of the resultant ... Mn2+for activity, and specifically loses most of the Mg2+-depen-dent activity on removal of the HBD and 87% of it by the mutation at the HBD. Tma-CD lost the ability to suppress the RNase ... regardless of the metalcofactor. Binding analyses of the proteins to the substrate using surfaceplasmon resonance indicate that the binding affinity of Tma-RNase HI is greatly reduced on removal of the...
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Báo cáo khoa học: The Vps4 C-terminal helix is a critical determinant for assembly and ATPase activity and has elements conserved in other members of the meiotic clade of AAA ATPases pdf
... not the b domain. The distinguishing feature of members of the meioticclade of AAA ATPases is the SRH motif, which dif-fers from that of other AAA ATPases [24]. The pair of Arg residues in the ... in the absence of ATP, Vps4p–E233Q has amolecular mass of 92 kDa, which is consistent with the size of a dimer. However, in the presence of ATP, the shift in the elution profile is consistent ... bytheir first three amino acids. The TRP sequence(TRPTVNEDDLLK) is at the start of the helix,whereas the RDF sequence (RDFGQEGN) is at the end of the helix (Fig. 1B,C). To determine whether the b...
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Tài liệu The Influence of Human Activity on the Environment ppt
... sulphur dioxide and other greenhouse gases• carbon dioxide traps heat in the atmosphere and causes the temperature of the earth to rise.• This leads to disruption of the weather patterns eg ... pollute the water• They may even end up in the food chain• Bacteria decay the dead plants and in so doing use up oxygen from the water• This means the fish suffocate and die• This process is ... as they are replacing the nutrients removed from the soil by plants• However, if too much fertiliser is added and it then rains, the fertiliser finds its way into rivers and lakes• This...
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Tài liệu Evaluation of physical activity programmes for elderly people - a descriptive study using the EFQM’ criteria ppt
... participated in the coordination of the study and supervised the drafting and editing of manuscript. JC participated in the design of the questionnaires/interviewsand coordination and management of the ... validity. The expert s pointed outtheir level of accordance with the relevance of the items,ease of understanding and adequacy as an instrument tocharacterise the management models of the PA ... regarding thiscriterion, most of the leaders of our study reported thateverybody had full access to the information about the mission and objectives of the PA programme. In the field of Higher...
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Tài liệu Báo cáo khoa học: The central role of CDE/CHR promoter elements in the regulation of cell cycle-dependent gene transcription pdf
... mutation of the CHRleads to a more pronounced deregulation than the alteration of the CDE [40].Another gene tested for its cell cycle regulation is the cellular inhibitor of apoptosis protein ... not only the CCAAT-boxes them-selves, but also their distance, is conserved [7,25,58]. The particular distance with approximately three turns of the DNA double helix yields binding of the two ... analysis in reporterassays shows that this element is responsible for cellcycle-dependent expression of the gene. Surprisingly,deregulation of the promoter does not lead to loss of its activity...
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Tài liệu Báo cáo khoa học: Roles of AP-2 transcription factors in the regulation of cartilage and skeletal development doc
... AP-2expression is completely downregulated after treatment of the chick face with RA, and this is accompanied byan increase in apoptosis [73]. The authors of this studyascribe the regulation of outgrowth ... outgrowth of limb buds andpatterning of the digits to the chicken AP-2. The role of AP-2a was further studied in zebrafish.It was confirmed that AP-2a is an essential regulator of the development of ... expres-sion in the face and limbs. In a follow-up study, theyfound that this conserved cis-acting sequence serves tomaintain a level of AP-2a expression that limits the size of the hand plate and the...
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Tài liệu Báo cáo khoa học: The splicing factor ASF/SF2 is associated with TIA-1-related/ TIA-1-containing ribonucleoproteic complexes and contributes to post-transcriptional repression of gene expression doc
... expression. Aseach step of the RNA metabolism is tightly regulated, the regulation of mRNA export, stability and transla-tion rate is essential for the control of the expression of mRNAs coding for ... tethering of TTP to the same reportermRNA. These results indicate that ASF ⁄ SF2 is apotent repressing factor in the absence of competingfactors. It is worth noting that the deletion of the ... interactions. The capacity of ASF ⁄ SF2 to down-regulate mRNAexpression was further confirmed by artificial tethering of a reporter mRNA to the 3¢ UTR. In this assay, the down-regulating activity of ASF...
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Tài liệu Báo cáo khoa học: A role of miR-27 in the regulation of adipogenesis ppt
... homeostasis in adult tissues.Recently, miRNAs have emerged as a class of epigenetic regulators of metabolism and energy homeostasis. We have investigated the role of miRNAs in the regulation of adipogenic ... miR-27 expression in the adipose tissue of ob ⁄ ob mice thus led us to hypothesizethat hypoxia may play a role in the regulation of miR-27 expression. To test this hypothesis, we examinedmiR27amiR27b ... in the regulation of miR-27 expression. Ourdata suggest that the miR-27 gene family is potentiallyan important class of negative regulators of adipogene-sis and may play a role in the regulation...
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Tài liệu Báo cáo khoa học: Osmosensing and signaling in the regulation of mammalian cell function docx
... signals involved in the regulation of metabolism, gene expression and the susceptibilityto different kinds of stress [6]. For example, the inhibi-tion of autophagic proteolysis by insulin, glutamineand ... insu-lin-induced hepatocyte swelling is registrated by the integrin system, leading to a Src-dependent activation of the p38-type MAPK and thereby inhibition of autophagic proteolysis [14]. Thus, integrin-dependentcell ... Thus, the apoptotic volumedecrease may further disarrange the balance betweensurvival and death signals, thereby promoting execu-tion of the apoptotic program.Concluding remarksIt is well...
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Tài liệu Báo cáo khoa học: Glucuronate, the precursor of vitamin C, is directly formed from UDP-glucuronate in liver pptx
... 20%, despite the presence of ATP-Mg. It is shown below that this is due to loss of the inhibitory effect of ATP-Mg, consequent to the removal of a heat-stable cofactor present in the high-speed ... orientedtowards the lumen of the vesicles and that disruption of the vesicular membrane increases accessibility toUDP-glucuronate. Some of the detergents exerted inhi-bition of the enzymatic activity ... stimulator of the UDP-glucuronidase activity of ‘GT2P’ [35]). Under the ‘best’ conditions, the UDP-glucuronidase activity amounted to 0.4% of the UDP-glucuronosyltransferase activity, which is ...
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Tài liệu Báo cáo khoa học: Second messenger function and the structure–activity relationship of cyclic adenosine diphosphoribose (cADPR) doc
... cyclization between the anomericC1 of this ribose moiety (commonly termed ‘northernribose’ while the ribose linked to N9 of adenine is called the ‘southern’ ribose; Fig. 1) and the N1 of the adenine ... diphosphoribose. The development of novel cADPR analogues revealed new insights into the structure activity relationship. Substitution of either the northern ribose orboth the northern and southern ribose resulted ... Ca2+release [56]. This situation is unique for the northern ribose since replacement of the oxygen by a carbocyclic bridge in the southern ribosein the molecule termed cyclic aristeromycin diphos-phoribose...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các nguyên tắc biên soạn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ rôto dây quấn hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25