Cognitive rehabilitation of attention deficits in traumatic brain injury using action video games: A controlled trial

... III, Eberwine JH, Meaney DF, McIntosh TK: Traumatic injury induces differential expression of cell death genes in organotypic brain slice cultures determined by complementary DNA array hybridization ... neuroprotective potential in both in vitro models of ischemia and traumatic brain injury Protection was observed with three different concentrations of argon (25, 50 and 74%), either directly applied after ... of xenon and helium in an in vitro model of traumatic brain injury Crit Care Med 2008, 36:588-595 Dingley J, Tooley J, Porter H, Thoresen M: Xenon provides shortterm neuroprotection in neonatal...

... The added value of ordinal analysis in clinical trials: an example in traumatic brain injury Critical Care 2011 15:R127 Submit your next manuscript to BioMed Central and take full advantage of: ... non-significant, those obtained with ordinal analysis were highly significant With ordinal analysis, a 2- to 2.5-fold gain in information density was demonstrated, compared to the dichotomized analysis ... overall significant treatment effect Inefficient analysis of trials may contribute this the failure • Dichotomous analysis of an ordinal outcome scale in clinical trials results in loss of information...

... results of phase III trials with progesterone in traumatic brain injury In the meantime, the scientific community needs to continue to pursue similar, early phase trials with other candidate neuroprotective ... citation purposes) Schouten JW: Neuroprotection in traumatic brain injury: a complex struggle against the nature of biology Curr Opin Crit Care 2007, 13:134-142 Wang KK, Larner SF, Robinson G, Hayes ... promise to clinical reality are vital to those of us seeking to expand our armamentarium of therapeutic options in the treatment of these injuries [6-8] Competing interests SMM is an investigator in...

... days after brain injury in the intensive glycemic control group This unexpected worsening of mortality is cause for great concern among those who advocate intensive glycemic control in brain ... during the second week after injury in the intensive control group, the preponderance of data points against the use of intensive glycemic control This finding stands in sharp contrast to the ... Vespa intensive glycemic control is beneficial overall Specifically, the authors report that the incidence of hypoglycemia and intracranial hypertension is higher in those patients undergoing intensive...

... Seow WT, Ng I: Barbiturate therapy for patients with refractory intracranial hypertension following severe traumatic brain injury: its effects on tissue oxygenation, brain temperature and autoregulation ... after the trauma - the opportunity for the drugs to prevent secondary injury has passed Alternatively, it is plausible that only specific pathophysiologic and cerebral hemodynamic profiles will respond ... is better than the other, the future for barbiturates still looks bright Early combination therapy of barbiturates with hypothermia or progesterone, in concert with multimodality invasive neuromonitoring,...

... secondary brain injury in determining outcome from severe head injury J Trauma 1993, 34:216-222 20 Saatman KE, Duhaime AC, Bullock R, Maas AI, Valadka A, Manley GT: Classification of traumatic brain ... study, a follow-up examination was performed six months after trauma The APACHE II and SAPS were employed to evaluate physiological status The mean APACHE II score was 20.9 and mean SAPS was 45.3 ... Subdural haematoma, Epidural haematoma, Traumatic subarachnoid haemorrhage, skull fracture, skull base fracture, spine fracture Fentanyl, remifentanyl, midazolam, propofol, ketamin, esketamin,...

... attenuated by hypothermia [15] In models of post -traumatic injury, hypothermia has also been shown to reduce BBB permeability Hypothermia may be attenuating BBB permeability by altering matrix ... global ischemia Brain Res Mol Brain Res 2001, 86:34-47 33 Lyeth BG, Jiang JY, Robinson SE, Guo H, Jenkins LW: Hypothermia blunts acetylcholine increase in CSF of traumatically brain injured rats ... mechanism Hypothermia significantly attenuates the activation of both astrocytes and microglia [17-20] Combination therapy including the anti -in ammatory cytokine interleukin-10 and hypothermia therapy...

... and in most reports the involved patient populations are small, these experiences are valuable At present, in the absence of definite proof of the efficacy of decompressive craniectomy in the treatment ... enough for the enlargement of dura in during decompressive craniectomy, and forms a pedicle of temporal fascia that maintains the blood supply Brain herniation via the craniectomy defect may lead ... for the underlying brain tissue may increase the risk of several secondary surgical complications, such as brain herniation through the craniectomy defect,21, 22 epilepsy,23, 24 intracranial infection,4...

... this article as: Gibson et al., Traumatic brain injury and the effects of diazepam, diltiazem, and MK-801 on GABA-A receptor subunit expression in rat hippocampus Journal of Biomedical Science ... abundant subunits in the brain typically form a limited number of receptor combinations [23] Reportedly, the following subunits combine to form nearly 80% of the GABAAR combinations in the rat brain: ... JT: The effects of traumatic brain injury on inhibition in the hippocampus and dentate gyrus Brain Res 1997, 757:119-132 Page 10 of 11 17 Stelzer A, Shi H: Impairment of GABAA receptor function...

... Kuwayama N, Naruse Y, Takaku A: Elevation of platelet activating factor, inflammatory cytokines, and coagulation factors in the internal jugular vein of patients with subarachnoid hemorrhage ... Kossmann T, Hans VHJ, Lenzlinger PM: Analysis of immune mediator production following traumatic brain injury In Shock, Sepsis, and Organ Failure -Brain Damage Secondary to Hemorrhagic -Traumatic ... Alberta, Canada The Department of Critical Care Medicine TRACER database prospectively records organ dysfunction (SOFA and MOD) scores on all patients admitted to the ICU for each day of their...

... [19,20], arresting bleeding and maintaining hemodynamic stability are of even greater importance in hemodynamically unstable patients with TBI In addition, rFVIIa may prevent the expansion of traumatic ... hemodynamically stable patients with TBI A doseescalation study aimed primarily at assessing the safety of rFVIIa in TBI has recently been completed, and data analysis is ongoing interpretation of ... standard treatment for injuries and bleeding at the participating hospitals Traumatic brain injury post hoc subanalysis In accordance with protocol inclusion criteria, all patients were hemodynamically...

... likely that the burden caused by TBI to the country is significant, given the very low use of motorcycle helmets and the dominance of motorcycles as the main form of transport Mandatory motorcycle ... quality have been raised This study estimates the costs of non-fatal TBI in motorcycle users not wearing helmets in Hanoi, Vietnam, in their first year post -injury The study examined costs from the ... post -injury at the time of interview While all patients shared the same disability weight of zero pre -injury, the disparity post injury reflected the level of severity (Figure 2) In term of intangible...