... immunemediator production following traumaticbrain injury. In Shock,Sepsis, and Organ Failure -Brain Damage Secondary to Hemor-rhagic -Traumatic Shock, Sepsis, and TraumaticBrain Injury: FifthWiggers ... dysfunction inseveretraumaticbrain injury. Crit Care Med 2005, 33:654-660.3. Zygun DA, Doig CJ: Measuring organ dysfunction. In Yearbookof Intensive Care and Emergency Medicine Edited by: Vincent ... for citation purposes)14. McKeating EG, Andrews PJ, Signorini DF, Mascia L: Transcranialcytokine gradients in patients requiring intensive care afteracute brain injury. Br J Anaesth 1997, 78:520-523.15....
... whether norepinephrine-stimulated plateletsmight induce additional brain damage warrant furtherinvestigations.Introduction In clinical routine, norepinephrine is used to increase andmaintain arterial ... pressure; ICU = intensive care unit; IL = interleukin; PRP = platelet-rich plasma; SjvO2 = jugular venous oxygen saturation; sTBI = severetraumaticbrain injury; TBI = traumaticbrain injury; TRAP ... with the rate of norepinephrine infusion dur-ing steady-state conditions of the norepinephrine infusionperiod. The average norepinephrine dose infused in the pres-ently investigated patients...
... limits is controversial in patients with severetraumaticbrain injury, because decreasedblood glucose levels can induce and aggravate underlying brain injury. Methods In 228 propensity matched ... in arterial blood glucose, insulin and norepinephrine dose, and ICP. Shown are changes in arterial blood glucose, insulin and norepine-phrine dose, and intracranial pressure (ICP) in surviving ... [7,8].These positive findings are in contrast to the present findingsof sustained haemodynamic instability and increased infec-tions (bacteraemia and urinary tract infections) in patientssubjected...
... by traumaticbrain injury. Exp Neurol 2002, 178:59-67.14. Pettus EH, Wright DW, Stein DG, Hoffman SW: Progesteronetreatment inhibits the inflammatory agents that accompany traumatic brain injury. ... recently been shown in avariety of animal models, including ischemic and traumatic brain insult models [3-6]. Postinjury administration of proges-terone in experimental models of head injury confers ... and reproduction in any medium, provided the original work is properly cited.AbstractBackground Severetraumaticbraininjury (TBI) has beenincreasing with greater incidence of injuries from...
... decreased brain tissue pH inversely correlated with ele-vated brain lactate and pCO2 during the first posttraumaticday [52]. Brain pH can either be determined directly by insert-ing specialised ... cortical spreading depression and peri-infarctdepolarisations in the acutely injured human brain. Clin Neu-rophysiol 2008, 119:1973-1984.12. Park E, Bell JD, Baker AJ: Traumaticbrain injury: can ... management was guidedby SjvO2 maintaining SjvO2 above 60%. Brain temperaturewas maintained between 35 and 36.0°C using cooling blan-kets or an intravenous cooling system (CoolGard3000; Alsius;15770...
... refractory intracranial hyper-tension after traumaticbrain injury. Child Nerv Syst 2006;22:1268-1274. 47. Dickerman RD, Morgan JT, Mitller MA. Decompressive cra-niectomy for traumaticbrain injury: ... Craniectomy, TraumaticBrainInjury Introduction Decompressive craniectomy, which is performed worldwide for the treatment of severe traum a t i c b r a i n injury (TBI), is a surgical procedure in ... craniectomy in decreasing ICP and improving pr o g n o sis in patients wi th refractory in- tracranial hypertension after TBI.2-8 Presently, th e European BrainInjury Consortium and Brain Trauma Foundation...
... time-point, and TBI group Fig.Kinetics of body weight changes for up to 7 days after trau-matic braininjury (TBI)Figure 5Kinetics of body weight changes for up to 7 days after traumatic braininjury ... PF: Elevated intracranial IL-18 in humansand mice after traumaticbraininjury and evidence of neuro-protective effects of IL-18-binding protein after experimen-tal closed head injury. J Cereb ... receptor type 1-related protein y, IgG1-linked murine recombinant fusion protein; MBP, mannose-binding protein; rVCP, recombinant Vaccinia virus complement control protein; sCR1, soluble complement...
... Post -In jury (hours) Brain Water Content (%)Figure 3 Increase inbrain edema does not differ in traumatic axonal injury rats with or without hypoxia. Brain water contentwas determined ... Post -Injury (hours) Brain IL-1 (pg/mg protein)0.00.20.40.60.8S 2 24 48 72 96Time Post -Injury (hours) Brain IL-2 (pg/mg protein)0246S 2 24 48 72 96Time Post -Injury (hours) Brain IL-10 ... Cristina Morganti-Kossmann1,2*AbstractBackground: The combination of diffuse braininjury with a hypoxic insult is associated with poor outcomes in patients with traumaticbrain injury. In this...
... far-reaching consequences considering their essential importance in maintaining inhibitory balance and their extensive impact on neuronal function.Background Traumatic braininjury (TBI) disrupts neuronal ... outcome after traumatic braininjuryin rats. Brain Res 2000, 861:325-332.33. Jensen ML, Timmermann DB, Johansen TH, Schousboe A, Varming T, Ahring PK: The beta subunit determines the ion selectivity ... haveresulted in an incomplete understanding of their contri-bution to injury- induced pathology, but have indicatedthat the receptor is affected by injury. Sihver et al. [12]found a decrease in GABAAR...
... outcome of a mild traumaticbrain injury. Brain Injury 1996, 10(8):551-566.25. Anson K, Ponsford J: Evaluation of a coping skills group following traumatic brain injury. BrainInjury 2006, 20:167-178.26. ... mind after traumaticbrain injury. Neuropsychologia 2005, 43:99-114.134. Havet-Thomassin V, Allain P, Etcharry-Bouyx F, Le Gall D: What abouttheory of mind after severebrain injury? BrainInjury ... factors inbrain injury- associatedpersonality change. BrainInjury 1994, 8(3):265-276.132. Turkstra LS, Dixon TM, Baker KK: Theory of Mind and social beliefs in adolescents with traumaticbrain injury. ...
... N, Singh D, Varma N, Mathuriya SN:Change in tissue thromboplastin content of brain followingtrauma. Neurol India 2005, 53:178-182.35. Stein SC, Smith DH: Coagulopathy intraumaticbrain injury. Neurocrit ... et al.: EBICguidelines for management of severe head injuryin adults.Acta Neurichir 1997, 139:286-294.20. Vincent JL, Berré J: Primer on medical management of severe brain injury. Crit Care ... component in whomrFVIIa treatment was reported to be effective in controlling theevolution of intracerebral brain contusion and bleeding. Fourpatients presented with a penetrating head injury, ...
... first year post -injury, of non-fatal traumatic braininjury (TBI) in motorcycle users not wearing helmets in Hanoi, Vietnam. The costs arecalculated from the perspective of the injured patients ... year after traumaticbrain injury: A mul-ticenter analysis. Arch Phys Med Rehabil 1997, 78:125-31.14. Ruffolo CF, Friedland JF, Dawson DR, Colantonio A, Lindsay PH: Mild traumatic braininjury ... possible, households were strategic in mini-mizing the loss of household income by selectingTable 1: One-year costs associated with treatment by level of traumaticbraininjury (Unit: USD, 1USD = 15,850...
... intraumaticbrain injury: acomplex struggle against the nature of biology. Curr Opin CritCare 2007, 13:134-142.5. Wang KK, Larner SF, Robinson G, Hayes RL: Neuroprotectiontargets after traumatic ... [6-8].Competing interestsSMM is an investigator in the TraumaticBrainInjury ClinicalTrials Network. JDK is a Principal Investigator in the Resusci-tation Outcomes Consortium.References1. ... to clinical realityare vital to those of us seeking to expand our armamentariumof therapeutic options in the treatment of these injuries [6-8].Competing interestsSMM is an investigator in the...