... oxidative stress in OA cartilage, as discussed above, we postulated that oxidative stress induces telomere instability and dysfunction in chondrocytes, subsequently resulting in cartilage ageing and ... pathogenesis of OA from the viewpoint of oxidative stress induced genomic instability, especially telomere erosion, and chondrocyte senescence Our findings clearly show the presence of oxidative stress in ... increases the telomere shortening rate by up to one order of magnitude [46] From these findings, we postulated that oxidative stress directly induces chondrocyte telomere instability in OA cartilage...