... Sentence stress organizes the words inthe sentence into logically connected
thought groups by joining the unstressed syllables to the main stressed
syllable inthe group and marking the end ofthe ... lose their stress. The most important words in
the sentence receive stronger stress. The last stressed word inthe sentence
receives the strongest stress with the help of falling or rising intonation. ... distinguish between four levels of stress: major
sentence stress, major word stress, minor word stressand unstressed.
Thus, inthe sentence: “I walked home inthe rainstorm”.
‗I‘, in , and...
... from the
ventral and paratendinous portion leading into the Achil-
les tendon body. In patella tendinopathy these neovessels
often arise inferior to the patella from the Hoffa fat pad
entering the ... neovascularisation and
increased cellularity [1,2]. The severity of these tendon
changes encountered in tendinosis was quantified [3],
and the importance ofthe ongoing process and cause of
increased ... or in tendinopathies at the wrist level.
The diagnosis of tendinopathy ofthe main body of the
Achilles tendon is made if patients have Achilles tendon
pain at rest or at exercise inthe main...
... ).
The renewed interest in examining the indications for BCG vaccination in the
United States included consideration ofthe wide range of vaccine efficacies deter-
mined by clinical trials and ... to
explore the sources ofthe heterogeneity inthe efficacy ofthe BCG vaccine reported in
the individual studies. Using a model that included the geographic latitude of the
study site andthe data ... resurgence inthe incidence of TB occurred inthe United
States and included increases inthe number of TB cases among adults and children
and outbreaks of multidrug-resistant TB (MDR-TB) involving...
... involved inthe regulation of
the stability and trafficking of GAT1. It has been
reported that a variety of molecular chaperones and
folding enzymes assist the folding of newly synthesized
proteins in ... N-linked oligosaccharide side-chains
are important for the GABA transport activity.
1-Deoxymannojirimycin inhibits the GABA-uptake
of GAT1
In order to gain further insight into theroleof the
terminal ... clarify
whether N-glycans are directly involved inthe GABA-
uptake process and whether the modulation of N-gly-
cosylation in uences the biochemical properties of this
protein, quantitative and kinetic...
... most of them and access-to-input for the worst
in this sub-pool. Conversely, the overbearing influence ofthe financial constraints in the
lower half is statistically associated with a rather ... book, index of current production, the lower the supply of credit. Finally, the
higher the co-ordinate on the f2 axis, e.g. the more the enterprise is faced with financial limit,
the higher the ... The probability of increasing
debt raises with the fact that the enterprise was indebted inthe past (in all the groups).
Nodebt thus appears as a strong inertial component inthe credit-demand...
... affinity of ChiB for allosamidin, which is an
analogue ofthe proposed oxazolinium ion intermediate [32].
The minor (or even positive) effects of Y214F on substrate
and intermediate binding andthe ... conformations. The Asp142 equiv-
alent inthe family 18 chitinase from Coccidioides immitis
was found to be inthe ÔdownÕ position inthe apoenzyme
and inthe ÔupÕ position inthe complex with allosamidin ... for the position of residue 142 [34].
The pK
a
calculations indicate that the only candidate for
a residue determining the basic arm ofthe pH-activity
profile ofthe D142N mutant is Glu144. The...
... 2010)
doi:10.1111/j.1742-4658.2010.07685.x
The hyperthermostable chitinase from the hyperthermophilic archaeon
Pyrococcus furiosus has a unique multidomain structure containing two chi-
tin-binding domains and two catalytic domains, and ... Stereo figures ofthe model ofthe bound substrate inthe AD2 E526A mutant (A) and D524A mutant (B). The structures of bound
sugars andthe side-chains of three acidic residues inthe conserved ... important rolein ‘cycling’ the pK
a
of catalytic
Glu during catalysis [24,38]. The mutation ofthe D
1
residue to Asn (D140N) in SmChiB caused a 500-fold
decrease in activity [39]. On theother hand,...
... ER81 and PEA3), ER81 and ERM being the
most related [35]. PEA3 members all contain the highly
conserved ETS domain. ERM contains two DNA binding
inhibitory domains flanking the Ets domain: the ... transcription ofthe human
presenilin 1
gene
in SH-SY5Y and SK-N-SH cells
The roleof Ets factors inthe regulation of
presenilin 1
Martine Pastorcic
1
and Hriday K. Das
1,2,3
1
Department of Pharmacology ... inthe extract as an
internal standard. The activity of ()119/+178) PS1CAT inthe pres-
ence ofthe empty vector was taken as 100%. The values represented in
the graph are indicated below. In...
... these residues in
binding the carboxylate linked to the nucleus of penicillin N
(Arg160 and Arg162) andthe carboxylate ofthe a-amino-
adipoyl side-chain (Arg266). The results for mutation of
Arg74 ... 160,
162, 266, 306 and 307) that, together with the crystallo-
graphic analyses, support the proposed roles for arginines
160, 162 and 266, and suggest roles for theother arginine
residues.
Scheme ... Taiwan;
3
Department of Pharmacy and Pharmacology, The University of Bath, UK
Deacetoxycephalosporin C synthase (DAOCS) catalyses the
oxidative ring expansion of penicillin N, the committed step
in the biosynthesis...
... involved inthe reaction. An analysis of the
active sites of DHBD structures inthe presence andin
the absence of substrates andofthe structure of
P. putida C2,3O suggests a possible hypothesis. ... Appar-
ently, the close contacts between these two residues
and the edge ofthe substrate ring could prevent bind-
ing of 3,6-DMC and 3,5-DMC, as shown in Fig. 2-
D,E,F. Thus, the binding of 3,5-DMC and ... 3,6-DMC.
Interestingly, the progressive decrease ofthe dimen-
sion ofthe residue 249 side chain also causes an
increase inthe K
m
values for catechol and 3-MC
(Fig. 4A). Inthe case ofthe smaller...
... further examined with the relevant economic
theories which are introduced inthe Chapter 2 ofthe thesis.
By applying economic theories, the roles and mechanisms
of international agreements in ... impact of trade agreements mathematically in terms of
environmental conservation. The proposed thesis is,
therefore, unique, original and very challenging in this
aspect.
The followings are ... especially on trade.
Some ofthe evidences will be derived from interviews and
the diplomatic experiences ofthe author ofthe thesis.
4. Scope of Study
(1) International Aspects
First,...
... dispersion ofthe growth rates ofthe state hous-
ing index when the states economies are in recessionary phase ofthe business cycle.
This suggests that the housing market across states converges during ... business cycle. The national economy was in
expansion during the 1989:IQ until the 1990:IIQ, then it was in recession from the
1990:IIIQ to the 1991:IQ and went back to expansionary phase inthe ... 11
unemployment, and for the rest ofthe states unemployment rate decreased. Similarly,
during the 2001 recession, which began inthe fourth quarter of 2000 and continued
until the end of 2002, aggregate...
... establish the consistency with
which discriminations are made.
Both Norman and Wyrwich raise the interesting issue of
what constitutes a meaningful discrimination, and
whether Delta is an index of such ... remains to be seen how these ele-
ments, particularly reliability and discrimination, interact.
In closing I should directly answer the questions posed by
Norman and Wyrwich inthe titles of their ... Matthew Hankins - matthew.hankins@kcl.ac.uk
Abstract
A response to Norman GR 'Discrimination and reliability: equal partners?' and Wyrwich KW
'Understanding theroleof discriminative...
... complex leads to the
initiation of complex signaling events leading to protein
tyrosine phosphorylation and activation ofthe src-family
kinases Lyn and Fyn as well as the tyrosine kinase Syk
[30,32,52]. ... the processing of
the amyloid precursor protein (APP) [12-14]. These data
support the potential utility of anti-inflammatory drug
therapies inthe treatment of AD.
Microglia are the principle immune ... reduction in ROS is likely a
consequence of statin inhibition of Rac prenylation result-
ing inthe inability of Rac to interact effectively to form the
NADPH oxidase complex or RhoGDI.
The use of statins...