... aIIb265–284were the most effective antagonists of platelet aggregation.To gain further insight into the fibrinogen-recognition sites of aIIb, we evaluated the inhibitory effect of the abovepeptides on ... Elucidation of the pharmacophoricnature of the Asp and Arg side-chains allowed newstrategies, largely based on bioactive RGD conformations,to be developed for the rational design of peptide ... sequence of the reported putative fibrinogen-binding site of aIIb(296–306) [54], located at the proximity of 313–332.To test this hypothesis, inhibition experiments wereperformed in the presence of...