determine the standard form of the equation

Tài liệu ~$pply the correct form of the verbs pdf

Tài liệu Supply the correct form of the verbs1 docx

... live in a snake.14. My brother managed to kill the snake just at the time when I were almost exhausted. Supply the correct form of the verbs1. Cats could fly if they (have) wings.2. If Peter ... (not,want) to live in a snake.14. My brother managed to kill the snake just at the time when I (be) almost exhausted. Ifhe (be) a little late, I (kill) by the snake.15. Had I know you were ill, ... snake.14. My brother managed to kill the snake just at the time when I (be) had been almost exhausted. If he (be) had been a little late, I (kill) would have been killed by the snake.15. Had...

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Báo cáo khoa học: Crystal structure of the soluble form of the redox-regulated chloride ion channel protein CLIC4 doc

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... 4996–5007 ª 2005 FEBS the backbone and side chain of Asn34 and the sidechain of Lys24. This crystal contact stabilizes the structure of the leading side of the foot loop. The putative internal ... C-terminus,while Arg206 is on the top of the molecule, in the loopleaving helix 6 and it points in the opposite directionto the other basic residues (Fig. 2B). The structure of the NLS is almost identical ... to the side chain of Asn81. The intervening residues of the C-terminalextension interact with the neighboring monomer viahydrophobic contacts.Comparison with the structure of the solubleform...

Báo cáo khoa học: Mapping the binding domains of the aIIb subunit A study performed on the activated form of the platelet integrin aIIbb3 pot

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... [43]. The present study further illustrates the importance of the eight-peptide sequence 57–64 in maintaining the inhibitory effect of the original 20-peptide aIIb49–68. The N-terminal region of ... wereperformed in the presence of PAC-1, a ligand-mimeticanti-aIIbb3that contains the RYD sequence (an RGDmimic) in the CDR3 region of the heavy chain. PAC-1binds to the activated form of aIIbb3and ... with this lig-and. The latter is further supported by the ﬁnding that the above peptides did not interfere with the binding of PAC-1to the activated form of aIIbb3. Furthermore, aIIb313–332was...

Báo cáo khoa học: The soluble form of the membrane-bound transferrin homologue, melanotransferrin, inefﬁciently donates iron to cells via nonspeciﬁc internalization and degradation of the protein pdf

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... proportion of the 125Ireleased (Fig. 7A) may be derived from the diffusion of low Mr125I from the cells. In contrast, the slower release of 125I-Tf (Fig. 7B) was consistent with the efﬂux of the Fig. ... examining the uptake of the 125I-sMTf or125I-Tf, the proteins were also saturated with59Fe by the proceduresdescribed above. These dual labelling experiments enabledexamination of the uptake of ... increased efﬁ-cacy of conjugates compared to free agents [49,50]. It ispossible that the use of the conjugate may enable the delivery of the agent to the lysosomal compartment thatthen results in...

Tài liệu Báo cáo khoa học: The pro-form of BMP-2 interferes with BMP-2 signalling by competing with BMP-2 for IA receptor binding pptx

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... biological function of the pro -form of bone morphogenetic protein-2 (BMP-2), a member of the transforminggrowth factor b (TGFb) ⁄ BLP superfamily. The role of the 263 amino acids of the pro-peptide ... Furthermore, the pro-peptide of GDF-8 impairs interaction of the mature part withits receptors [16]. In the case of BMP-9, the pro-pep-tide appears not to alter signiﬁcantly the activity of the mature ... interested in the role of the 263amino acid pro-peptide of BMP-2, because evidenceaccumulated over recent years has shown that the pro-forms of growth factors can modulate the activities of the mature...

Tài liệu Báo cáo khoa học: Regulation of dCTP deaminase from Escherichia coli by nonallosteric dTTP binding to an inactive form of the enzyme ppt

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... rates) prior to and after the transition of the enzyme to amore active form, respectively, t is the time and s is the lag-time. The rate constant, k, for the activation of the enzyme isobtained ... rate is the initial turnover of the enzyme with amaximum of kcat, S0.5is the concentration of substrate S athalf-maximal saturation of the enzyme and n is the Hillcoefﬁcient. Equation ... lip prevented binding of the C-terminalresidues over the active site, or the absence of the C-terminal residues caused the movement of the lip(Fig. 1B). In addition, the Cachain between aminoacid...

Tài liệu Báo cáo khoa học: Expression and function of Noxo1c, an alternative splicing form of the NADPH oxidase organizer 1 doc

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... the SH3 domain of Noxo1 participates inregulation of Nox3, the role of the PX domain in Nox3activity remains unknown.In the process of cloning of human Noxo1, somespliced transcripts of the ... To compare the amounts of the two variants expressed in the testis, we performed the PCR using the primers ‘d’ and ‘c’, where the cDNAs for both Noxo1b and Noxo1c are ampliﬁed as the insert region ... between the pair of primers(Fig. 2A). The lengths of the PCR products of Noxo1band Noxo1c were 225 and 240 bp, respectively. Todelineate the difference in the two products, we subjec-ted the...

Báo cáo khoa học: Crystal structures of the apo form of b-fructofuranosidase from Biﬁdobacterium longum and its complex with fructose pot

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... enzyme. The catalytic mechanism of hydrolysis The fructose present in the crystal structure of the complex is the result of hydrolysis of rafﬁnose. The conformation of the sugar observed in the electrondensity ... attack on the anomeric carbon of fructose. The leaving group iscarboxylate of Asp54.Dimerization The asymmetric units of the crystals of both the apoand complexed form of the enzyme consist of dimerswith ... blades in the axisarea are of polar character. The water channel in the apo form of the enzyme runs along the axis of the b-propeller through the whole domain and is onlyblocked by Cys236 in the...

Báo cáo khoa học: DNA polymerase e associates with the elongating form of RNA polymerase II and nascent transcripts pot

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... between the hypophosphorylated initiation isoform IIA and the hyperphosphorylated elongating isoform IIO thatexhibits reduced electrophoretic mobility comparedwith the IIA isoform. Whereas the ... replicases in the eukary-otic cell [22]. Therefore, we tested the effect of the replicative state of the cell on the interaction betweenPol e and RNA pol II. A possible conﬁnement of the interaction ... speciﬁcally in the G1phase of the cell cycle. This effect could be attributed to inhi-bition of transcription of cell cycle-regulated genes atthis phase of the cell cycle [51]. Nevertheless, it...

Báo cáo khoa học: Puriﬁcation and structural study of the b form of human cAMP-dependent protein kinase inhibitor pdf

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... regulation of the PKIand PKI isoforms of the inhibitor protein of the cAMP-dependentprotein kinase. J. Biol. Chem. 272, 20011–20020.20. Byler, D.M. & Susi, H. (1986) Examination of the secondarystructure ... showedasinglebandbySDS/PAGE(Fig. 2). The assay of its activity demonstrated that the puriﬁed PKIb inhibited the catalytic subunit of cAPK with the speciﬁc activity of 6.0 · 104unitÆmg)1(Fig. 3A) .The Kivalue determined ... mMsodium acetate buffer. The pooledfraction was stored at )20 °C for further study. The concentration of the proteins was determined by the method of Lowry et al. [14] and the purity was examinedby...

Báo cáo khoa học: The propeptide in the precursor form of carboxypeptidase Y ensures cooperative unfolding and the carbohydrate moiety exerts a protective effect against heat and pressure pot

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... effect on the thermalunfolding of proCPY. The Pmvalue for CPY was higher than that of itsunglycosylated form, though the DV and DGPvalues werealmost the same. The Pmvalue of proCPY was ... the corresponding values of proCPY and Dgly proCPY (Fig. 2B), indicating that the precursor form was less thermally stable than the mature form, regardless of the carbohydrate moiety.After the ... unfolding of the unglycosylated form. At high pressure, in the glycosylated forms the carbohy-drate moiety of CPY and proCPY would be hydrated tocompensate the volume contraction and the protein...

Báo cáo khoa học: Isothermal unfolding studies on the apo and holo forms of Plasmodium falciparum acyl carrier protein Role of the 4¢-phosphopantetheine group in the stability of the holo form of Plasmodium falciparum acyl carrier protein docx

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... iden-tiﬁed as the major and the minor forms of the holo-ACP structure, on the basis of their percentage contri-butions (65% and 35%, respectively) to the overallstructure of the protein. The structures ... both forms have the same amino acidsequence, and they have similar secondary structures, it was found that the – DG of unfolding of the holo form was lower than that of the apo form atall the ... unfoldingthermodynamic parameters of the two forms are givenin Tables 1–3. In the entire experimental regime, it isseen that the holo form presents better stability than the other form (Fig. 4C). The...

Báo cáo khoa học: "TWO THEORIES FOR COMPUTING THE LOGICAL FORM OF MASS EXPRESSIONS" doc

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... true of unions of elements of the semilattice). These predicates are not only true of the conventional kinds but also of conventional servings such as the bottle of wine on the table or the ... speaking, the theories view the kinds of M as forming an upper semilattice of kinds with M at the top. This is a "formal" semilattiee in that the union of any two elements of it is ... for the two theories of mass terms. The p-rules are for the semantic occurrence approach while the s-rules are for the syntactic expression approach. The ontological underpinnings of these theories...