signal transduction pathways involved in hepatocarcinogenesis and metastasis of hepatoma
The role of cyr61 and LASP1 in growth and metastasis of human hepatocellular carcinoma
... and Marcantonio 2006) For instance, the integrin-binding proteins paxillin and talin recruit focal adhesion kinase (FAK) and vinculin to focal contacts (Sastry and Burridge 2000; Calderwood and ... Lasp1 may inhibit HCC invasion and metastasis through recruiting and/ or sequestering focal adhesion associated proteins, such as zyxin, VASP, and paxillin, and thus influencing F-actin dynamics ... that the LIM motif defined a specific zinc-binding protein domain There are eight most highly conserved residues functioning in binding to zinc, establishing a tandem zinc-finger topology (Michelsen...
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Báo cáo khoa học: Salicylic acid and the hypersensitive response initiate distinct signal transduction pathways in tobacco that converge on the as-1-like element of the PR-1a promoter pot
... transcription factor TGA2.2 is the main component of as-1binding factor ASF-1 and is involved in salicylic acid- and auxininducible expression of as-1-containing target promoters J Biol Chem 275, ... for our model of distinct signal transduction pathways leading to the independent activation of the tobacco PR-1a gene by SA and by an unknown HR released signal, we have made use of transgenic ... infected with TMV, and PR-1 proteins were monitored in the necrotic tissue induced by the spreading lesions Whereas lesions and the accumulation of PR-1 proteins remained strictly localized in...
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báo cáo hóa học:" Functional significance of the signal transduction pathways Akt and Erk in ovarian follicles: in vitro and in vivo studies in cattle and sheep" ppt
... Effects of active immunization of sheep against an amino terminal peptide of the inhibin αC subunit on intrafollicular levels of activin A, inhibin A and follistatin Journal of Endocrinology ... Novel signal transduction pathway for luteinizing hormone and its interaction with insulin: activation of Janus kinase /signal transducer and activator of transcription and phosphoinositol 3-kinase/Akt ... previously in the bovine model Increases in Akt and Erk signalling proteins in response to FSH and IGF stimulation suggest a role for Akt and Erk signal transduction pathways in FSH and IGF mediated...
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Báo cáo y học: " Low concentration of ethanol induce apoptosis in HepG2 cells: role of various signal transduction pathways"
... slight inhibition of JNK and NFκB signaling in association with a slight activation of the cell death receptor signaling In addition, ethanol also phosphorylated protein kinases belonging to signal ... representing increases of 1- and 12-fold, respectively These data confirm the effect of ethanol on intracellular signal transduction resulting in increased expression of transcription factors Int ... obtained hereby was the strong inhibition of the GPCR signaling pathway induced mainly by increased phosphorylation of GRK2 This finding suggests an important regulatory role of ethanol-induced...
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Báo cáo y học: " Effects of Liver × receptor agonist treatment on signal transduction pathways in acute lung inflammation" potx
... by inhalation of CO The chest was carefully opened and the pleural cavity rinsed with ml of saline solution containing heparin (5 U ml-1) and indomethacin (10 μg ml-1) The exudate and washing ... due to the induction of cyclooxygenase (COX-2) in the tissues [19] PMNs moving out of the circulation into the inflamed tissue have a key function in the breakdown and remodeling of injured tissue ... on the release of pro-inflammatory cytokine induced by carrageenan When compared to sham animals, injection of carrageenan resulted in an increase in the levels of TNF-a and IL-1b in the pleural...
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Báo cáo y học: "Toxicogenomic analysis of Caenorhabditis elegans reveals novel genes and pathways involved in the resistance to cadmium toxicity" potx
... genes, which are involved in metabolism of both endogenous and exogenous compounds; gene W01A11.1, which is involved in degradation of tetrachloraethene; and gst-38, which is involved in phase II ... Discovery of novel genes and pathways involved in cadmium resistance Genome Biology 2007, 8:R122 information By integrating the RNAi assay results into the protein interaction network, a novel signal ... encodes a signaling molecule containing a kelch-repeat, and mek-1, which is a major component in the MAPK signaling pathway [27,52] RNAi results indicate that kel-8 is involved in protecting C elegans...
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analyzing and modeling large biological networks inferring signal transduction pathways
... challenging problems of interpreting and processing of this data Here, we present a new framework to identify signaling pathways in proteinprotein interaction networks Given a protein-protein interaction ... the minimum 1.1.2 Signal Transduction Pathways The molecular components involved in cellular signaling form signal transduction pathways A signal transduction pathway (signaling pathway) in a ... Understanding proteinprotein interactions is important in investigating signaling pathways We are going to present an in depth analysis of the currently available models of protein-protein interaction...
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Báo cáo y học: "Functional genomics analysis of low concentration of ethanol in human hepatocellular carcinoma (HepG2) cells. Role of genes involved in transcriptional and translational processes"
... G-Protein-MAPK, NGF, and PDGF signaling This finding corroborates the interaction observed between various intracellular signaling pathways and apoptosis induced by 1mM concentration of ethanol in ... and ethanol-induced mucosal injury in the upper gastrointestinal tract leading to increase in the permeability of the gut mucosa to endotoxins [43, 44] These factors are involved in ethanol-induced ... Gene title cofactor of BRCA1 integrin, beta staufen, RNA binding protein, homolog (Drosophila) high mobility group nucleosomal binding domain ankyrin 3, node of Ranvier (ankyrin G) Signal Log...
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Báo cáo khoa học: Pathways involved in testicular germ cell apoptosis induced by H2O2 in vitro doc
... Y, Dunkel L, Swerdloff RS & Sinha-Hikim AP (2006) Involvement of p38 mitogen-activated protein kinase and inducible nitric oxide synthase in apoptotic signaling of murine and human male germ ... Control D Fig Pathways of signal transduction in H2O2 induced testicular germ cell apoptosis Western blots showing expression of (A) (intrinsic) caspase-9 and cytochrome c and (C) (extrinsic) caspase-8, ... of extrinsic and intrinsic as well as other designated pathways of metazoan apoptosis, signifying the possible role of this biomolecule in the process of germ cell development in the testis and...
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Báo cáo khoa học: The HNF1b transcription factor has several domains involved in nephrogenesis and partially rescues Pax8/lim1-induced kidney malformations docx
... domains of the HNF1b protein is highly evolutionarily conserved, and is the most striking difference between the HNF1a and HNF1b proteins (Fig 1) Our transactivation Domains of HNF1b involved in ... defects in organogenesis including in the context of the HNF1 backbone Deletion of the Cagenesis of the kidney The nephrogenic role of Pax8 has terminal amino acids of the HNF1b homeodomain (311– ... development in Xenopus laevis The morphogenetic potential of the various HNF1 constructs were examined in the developing Xenopus embryo by injecting mRNA encoding these proteins into one blastomere of...
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Báo cáo khoa học: Lipid droplet and milk lipid globule membrane associated placental protein 17b (PP17b) is involved in apoptotic and differentiation processes of human epithelial cervical carcinoma cells pptx
... Structural relationship of human PP17, adipophilin and perilipin genes and proteins After multiple sequence alignment of PP17b, adipophilin (hADFP) and perilipin (hPLIN), and alignment of their cDNAs ... blue staining Bands of interest were excised from the gel, reduced, alkylated and in- gel digested with trypsin as described previously [23] Proteins were identified by a combination of MALDI-TOF MS ... adipophilin and perilipin genes have been revealed, and analysis of the 5¢ flanking region of the PP17 gene has shown a number of potential transcription factor binding sites indicating its complex...
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Báo cáo khóa học: Cloning and expression of murine enzymes involved in the salvage pathway of GDP-L-fucose ppt
... and the corresponding gene has been cloned from human [23] In the present study we have cloned the murine genes coding for the enzymes involved in the salvage pathway of GDP-L-fucose L-fucokinase ... displaying two putative splice variants [Fig 2] Expression of fucokinase cDNAs The two splice variants of fucokinase were subcloned into the XbaI site of a pQM vector containing a C-terminal E2-Tag/A ... variants of L-fucokinase The long splice variant of L-fucokinase consisted of 3270 bp, encoding a protein of 1090 amino acids The sequence of the shorter cDNA was similar to the sequence of the IMAGE...
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Báo cáo khoa học: Determination of the metal ion dependence and substrate specificity of a hydratase involved in the degradation pathway of biphenyl/chlorobiphenyl pot
... provide insight regarding the mechanism, the substrate binding site and the role of the metal cofactor in the enzyme Results Cloning, expression and purification of BphH The bphH gene was inserted into ... determined by adding XylE and TodF stepwise to solutions containing known amounts of catechol and determining the resulting UV absorbance Complete cleavage of catechol by XylE and the amounts of ... albumin as standards SDS ⁄ PAGE was performed and stained with Coomassie blue according to established procedures [28] The BenchMarkTM Protein Ladder (Invitrogen) containing proteins ranging from...
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Báo cáo y học: "The Frizzled family: receptors for multiple signal transduction pathways" docx
... Disruption of LRP6 in mouse causes multiple phenotypes consistent with loss of Wnt signaling [9] A dominant negative form of LRP6 inhibits Wnt signaling in Xenopus, and human LRP6 protein co-immunoprecipitates ... domains in GPCRs and Frizzleds Dann CE, Hsieh JC, Rattner A, Sharma D, Nathans J, Leahy DJ: Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains ... J: Direct binding of the PDZ domain of Dishevelled to a conserved internal sequence in the C-terminal region of Frizzled Mol Cell 2003, 12:1251-1260 An NMR study of peptide binding in solution...
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báo cáo khoa học: "Mitochondrial and endoplasmic reticulum stress pathways cooperate in zearalenone-induced apoptosis of human leukemic cells" doc
... mitochondria and/ or lysosomes and induces lipid peroxidation (indicating oxidative stress) and cell death in human colon Caco-2 cell line [42] The loss of mitochondrial transmembrane potential and the increase ... localizing signal The GAPDH-Siah1 protein complex, in turn, translocates to the nucleus and mediates cell death The involvement of ER stress in ZEA-induced apoptosis shown in this study led to an investigation ... was produced in ZEA-treated HL-60 (Figure 5) indicating that the cause of apoptotic cell injury was via oxidative stress Effect of ZEA on activities of caspase-3 and -8 in HL-60 and U937 cells...
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Báo cáo y học: "Distinct signal transduction processes by IL-4 and IL-13 and influences from the Q551R variant of the human IL-4 receptor alpha chain" docx
... protein) (in Caucasians), strongly influence the structure and consequently the substrate binding and signaling processes of this chain [12,15,16] IL-4 and IL-13 promote activation of a number of ... SHP-1 following binding of IL-4, or SHP-2 following binding of IL13 Moreover, nuclear translocation of STAT proteins seems to differ following IL-4 versus IL-13 binding Although some of the effects ... min, 2= WT min, 3= WT min, 4= WT 15 min, 5= WT 20 min, 6= R551 min, 7= R551 min, 8= R551 min, 9= R551 15 min, 10= R551 20 min; (D) Time-course experiment IL-13 1= WT min, 2= WT min, 3= WT min,...
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Báo cáo y học: "Integrative analysis for finding genes and networks involved in diabetes and other complex diseases" ppt
... databases BIND [42,43], MINT [44], IntAct [45], KEGG annotated protein-protein interactions (PPrel), KEGG Enzymes involved in neighboring steps (ECrel) [46] and Reactome proteins involved in the ... actomyosin structure and biogenesis, protein binding, ion binding WDR1 [4p16.1] WD repeat domain (WDR1), transcript variant Actin binding, protein binding, sensory perception of sound RPS15A [16p12.3] ... every protein and is the result of 'number of interactions with input proteins' divided by 'total interactions' for each protein, making networks consisting of proteins with many interactions...
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Effects of high glucose concentrations on the expression of genes involved in proliferation and cell fate specification of mouse embryonic neural stem cells
... function of kidney, manifested initially as a persistent elevation in urinary excretion of albumin and subsequently as an increase in excretion of protein, is often associated with the increased ... establishes a second signaling center by inducing BMP4 expression in the roof plate cells of the neural tube (Liem, Jr et al., 1995) The role of BMPs signaling in the dorsal patterning of the neural ... on the role of AR in the pathogenesis of congenital malformations including NTDs in infants of diabetic mothers 3.3 Alterations in signaling pathways The abnormal glucose metabolism and related...
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ARSENIC POLLUTION IN SOIL AND GROUNDWATER OF BANGLADESH
... fine sands, and muds occur at an interval of 3-4.9m (upper muddy layer) Sands are composed of well sorted quartz grains accompanying significant mica flakes Tourmaline and zircon are ... mostly in the Gangetic, Atrai, Meghna flood plains and the tidal regions of the country (Fig-1) The datas and records of geological investigations of the areas adjoining to the western border in ... contamination of Drinking water in Bangladesh WHO assignment report December 6-20, 1996 Jones, B and Manning, D A C (1994) Comparison of geochemical indices used for the interpretation of palaeoredox...
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- tacking on dangerous psychological waters appreciating the factors involved in chronic and acute secondary stress
- factors signal transduction pathways and tumor suppressor genes in esophageal cancer
- pathways involved in the cardiac adaptive changes observed during morphine withdrawal
- current concepts in invasion and metastasis
- signal transduction pathways and their impairment in syndromic craniosynostosis
- oxygen regulated signal transduction pathways in the heart
- signal transduction pathways downstream of ras
- replication proteins involved in transcription and replication
- 3innate immunity signal transduction pathways
- cell membrane and signal transduction pathways implications for the pathophysiology of bipolar disorders
- brain immune pathways involved in lateralized control of cytokine production
- signaling pathways involved in cardiogenesis
- tumour vascular interface in progression and metastasis of colorectal cancer
- psychoneuroimmunological pathways involved in acute coronary syndromes
- cell types involved in transport and or production of prpsc
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