3innate immunity signal transduction pathways
Báo cáo y học: " Low concentration of ethanol induce apoptosis in HepG2 cells: role of various signal transduction pathways"
Ngày tải lên :
31/10/2012, 15:37
... CDK signaling pathways, including ERK2, RSK2, CDK9, CDK6, CDK7 and RSK1 with values of 50%, 48%, 38%, 35%, 29%, 26% and 26%, respectively Table Effect of mM ethanol on various signaling transduction ... anti-apoptotic signaling pathways The pro-apoptotic effect induced by ethanol was demonstrated by a strong inhibition of GPCR signaling pathway in association with a slight inhibition of JNK and NFκB signaling ... slight activation of the cell death receptor signaling In addition, ethanol also phosphorylated protein kinases belonging to signal transduction pathways with an anti-apoptotic effect such as...
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Báo cáo khoa học: Salicylic acid and the hypersensitive response initiate distinct signal transduction pathways in tobacco that converge on the as-1-like element of the PR-1a promoter pot
Ngày tải lên :
23/03/2014, 15:21
... the tobacco PR-1a promoter is targeted by at least two distinct signal transduction pathways, elicited by SA and by a yet unknown signal produced during the HR, respectively, which mediate PR-1a ... view of the results presented, it seems plausible that two distinct signal transduction pathways could be targeted by SA and by signals released during the HR, respectively, resulting in the independent ... support for our model of distinct signal transduction pathways leading to the independent activation of the tobacco PR-1a gene by SA and by an unknown HR released signal, we have made use of transgenic...
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báo cáo hóa học:" Functional significance of the signal transduction pathways Akt and Erk in ovarian follicles: in vitro and in vivo studies in cattle and sheep" ppt
Ngày tải lên :
20/06/2014, 07:20
... diacylglycerol [13,14] pathways These signal transduction pathways, when activated, induce changes in protein activity and gene expression [15] It is the differential regulation of these pathways and the ... functioning of healthy follicles requires the activation of the Akt and Erk signal transduction pathways, and that these pathways are necessary for ovarian follicle growth and development Competing ... healthy follicles compared with small atretic follicles [19] The Akt and Erk pathways are considered the principle signalling pathways that mediate the effects of IGF [20] We have previously shown...
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Báo cáo y học: "The Frizzled family: receptors for multiple signal transduction pathways" docx
Ngày tải lên :
09/08/2014, 20:20
... different pathways downstream of Wnt signaling [27] The mechanism by which Frizzled proteins transduce signals once ligand has bound is largely unknown for any of the Frizzled-mediated signaling pathways ... or the noncanonical pathways [23], but at least some vertebrate frizzleds appear to function in multiple pathways, including the PCP, Wnt/calcium, and canonical Wnt/ß-catenin pathways [12] reviews ... Wnt/-catenin signaling; Carron et al [29] reported that Xenopus Frizzled3 (Xfz3) dimerizes to activate canonical signaling and that Xfz7, which is monomeric, can activate Wnt/-catenin signaling...
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Báo cáo y học: " Effects of Liver × receptor agonist treatment on signal transduction pathways in acute lung inflammation" potx
Ngày tải lên :
12/08/2014, 11:20
... this article as: Crisafulli et al.: Effects of Liver × receptor agonist treatment on signal transduction pathways in acute lung inflammation Respiratory Research 2010 11:19 Submit your next manuscript ... treatment with T0901317 lowers the signal for Bax in treated group when compared with lung sections obtained from carrageenan-treated mice; while on the contrary, the signal is much more express for ... Sigma-Aldrich Corp.) and antiLamin B1 (1:10,000 Sigma-Aldrich Corp.) Protein bands were detected with SuperSignal West Pico Chemioluminescent (PIERCE) The relative expression of the protein bands of IB-a...
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analyzing and modeling large biological networks inferring signal transduction pathways
Ngày tải lên :
13/11/2014, 09:11
... is the minimum 1.1.2 Signal Transduction Pathways The molecular components involved in cellular signaling form signal transduction pathways A signal transduction pathway (signaling pathway) in ... organisms, the variety of signal transduction pathways influences the number of ways the cell can react and respond to its environment Discovering signal transduction pathways has been a hard problem ... signaling systems and they differ in signal origin Paracrine signaling is a form of cell signaling in which the target cell is close to the signal releasing cell, and the signal chemical is broken down...
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Tài liệu Báo cáo khoa học: Effects of sequestration on signal transduction cascades docx
Ngày tải lên :
19/02/2014, 07:20
... transient signals However, interpretation of the signal by the signal transduction network requires circuits that respond only to prolonged activation As pointed out by Deshaies & Ferrell [22], such signal ... [17], in which the rise in the signal is delayed but the dropping signal is transduced immediately Finally, we analyse the effect of sequestration on a complex signal transduction cascade, the MAPK ... ultrasensitivity The consequences of sequestration for signalling dynamics Receptor desensitization is a relatively slow process and downstream signal transduction cascades are often in a quasi-steady-state...
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Tài liệu Báo cáo khoa học: 1. Signal Transduction 1.1 Integration of Metabolism and Survival pdf
Ngày tải lên :
19/02/2014, 07:20
... clocks employ different and non converging signaling pathways While the photic entrainment pathways have already been roughly recognized, maternal entrainment pathways are still only suggested The ... the activation state of Rho-family signalling pathways, for example by down-regulation of ROCK or Rho activation and up-regulating Rac activation S1.6-2 Signal transduction via receptors for PDGF ... differentiation and survival of effector CD8 T cells, involving ERK, STAT5 and NF-kB signaling pathways, respectively 1.3 Rhythmic Signals: The Setting of Biological Time S1.3-1 An ultradian clock in yeast:...
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Tài liệu Báo cáo khoa học: Separation of a cholesterol-enriched microdomain involved in T-cell signal transduction doc
Ngày tải lên :
20/02/2014, 03:20
... contribute to the on ⁄ off switching of TCR signalling In addition to signalling machinery molecules, PAG and Csk, which are known to be negative regulators of TCR signalling [26], were also detected ... the ‘off’ state of T-cell signalling Taken together, the BCh-bound cholesterol-enriched subpopulation contains both activator and inhibitor molecules for TCR signal transduction, and is likely ... the initiation of TCR signal transduction J Immnol 168, 2233–2239 Harder T & Kuhn M (2000) Selective accumulation of raft-associated membrane protein LAT in T cell receptor signaling assemblies...
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Báo cáo khoa học: Organizing signal transduction through A-kinase anchoring proteins (AKAPs) docx
Ngày tải lên :
06/03/2014, 22:21
... inhibit ERK5 signaling (C) As cAMP levels decrease, the Epac1-mediated inhibition of ERK signaling is lost and mitogenic signaling favors cell growth (D) mAKAP assembles an oxygen-sensitive signaling ... leads to the termination of cAMP signals Interestingly, the same AKAP A B C D Fig mAKAP signaling complexes (A) mAKAP assembles a cAMP-responsive complex of signaling enzymes at the perinuclear ... GTP-binding protein, thereby creating a point of convergence between the cAMP and Rho signaling pathways [31] This anchored signaling complex interfaces with the cytoskeleton because AKAP-Lbc has the capacity...
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Báo cáo khoa học: Control of transforming growth factor b signal transduction by small GTPases pot
Ngày tải lên :
07/03/2014, 01:20
... reduced signaling [63–65] The differential signaling outcome of RTK versus TbR signaling by RIN1, however, suggests that Rab5-mediated endocytosis is not inextricably linked to a particular signaling ... of the TGFb signaling pathway Interconnection between TGFb signaling and receptor traffickingregulation by small GTPases Endocytosis has long been considered a way of terminating signaling processes ... modulate their signaling duration [36] Is internalization required for TGFb family signaling? The presence of SARA, Hrs and Endofin in early endocytic compartments questions whether signaling can...
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Báo cáo khoa học: The role of helix 8 and of the cytosolic C-termini in the internalization and signal transduction of B1 and B2 bradykinin receptors potx
Ngày tải lên :
07/03/2014, 16:20
... preferentially to the same Ga subunit (Gq ⁄ 11) differential signaling is less likely to explain differences in internalization than in two receptors signaling through different G proteins Internalization ... signaling because: (a) interruption of the amphipathic structure of B1wt helix in B1wt and B1KB2 through the presence of a serine in position of V323 leads to a strong attenuation of the IP signal; ... to Gq ⁄ 11 (and Gi) may very well differ in their capability to activate other additional signaling pathways These potential differences in, for example, the transactivation of growth hormone...
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Plant physiology - Chapter 14 Gene Expression and Signal Transduction potx
Ngày tải lên :
07/03/2014, 21:20
... called a signal transduction pathway Typically, the end result of signal transduction pathways is to regulate transcription factors, which in turn regulate gene expression Signal transduction pathways ... the basic mechanisms of signal transduction in animals, emphasizing pathways that may have some parallel in plants However, keep in mind that plant signal transduction pathways may differ in significant ... 26S proteasome 13 Gene Expression and Signal Transduction Sensor protein Response regulator + P – Input signal Input Transmitter Receiver Figure 14.10 Signaling via bacterial two-component systems...
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Báo cáo khoa học: 7-Ketocholesterol-induced apoptosis Involvement of several pro-apoptotic but also anti-apoptotic calcium-dependent transduction pathways ppt
Ngày tải lên :
07/03/2014, 21:20
... 7-ketocholesterol treatment of THP-1 induces others transduction pathways leading to a secondary inactivation of these kinases We next examined the ability of the MAPK signalling pathway to inhibit, via p90RSK, ... 7-ketocholesterol-induced apoptosis appears to be a complex phenomenon involving several calciumdependent transduction pathways 2–3 h, where phosphoERK reached 30% of total ERK vs 13% in control, and then declined ... 3093–3104 ª 2005 FEBS A Berthier et al Pathways in 7-ketocholesterol-induced apoptosis cells (data not shown) As ERK ⁄ activation is known to be involved in survival pathways [20], we then focused our...
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Báo cáo khoa học: Signal Transduction pot
Ngày tải lên :
16/03/2014, 10:20
... both cholinergic signal transduction pathways and apoptotic cell death and presenilin mutations are responsible for both sensitizing neurons to death and altering neuronal signal transduction C2-75 ... regulatory proteins Involvment of particular signal transduction pathway was also studied ª 2007 The Authors Journal compilation ª 2007 FEBS Signal Transduction Abstracts C2-48 Sterols and Multi ... ROS production and apoptotic cell death Signal Transduction C2-78 Galectin-8 induces apoptotic signaling through a link between phospholipase D, PKA and ERK pathways in Jurkat cells A Norambuena1,...
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Báo cáo khoa học: Bistability from double phosphorylation in signal transduction Kinetic and structural requirements potx
Ngày tải lên :
16/03/2014, 13:20
... multifunction and crosstalk between signal transduction networks, which explains how the same signal transduction pathway can be responsible for the transduction of signals resulting in several different ... is ubiquitous in MAPK and other signal transduction pathways, this article also reports a new putative mechanism that per se explains multistability in signal transduction networks in which feedback ... blinkers: dynamics of regulatory and signaling pathways in the cell Curr Opin Cell Biol 15, 221–231 12 Ferrell JE Jr (2002) Self-perpetuating states in signal transduction: positive feedback, double...
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Báo cáo khoa học: Principles behind the multifarious control of signal transduction ERK phosphorylation and kinase/phosphatase control potx
Ngày tải lên :
16/03/2014, 18:20
... amplitude of signaling; the nal intensity of signaling; the duration of signaling and the integral signal intensity (which corresponds to the area-under-the-curve) For MAPK and other signaling pathways, ... affects signaling amplitude much more than signaling duration Phosphatases control duration of signaling In the model simulation, phosphatases controlled maximum signaling amplitude, signaling ... linear signal transduction pathway analyzed here numerically but are general for any signal transduction pathway that fulls the denition given here This denition is quite general (Appendix) Signaling...
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Báo cáo Y học: Coordinated action of protein tyrosine phosphatases in insulin signal transduction potx
Ngày tải lên :
17/03/2014, 23:20
... insulin signal transduction Structure of several phosphatases implicated in insulin signal transduction rPTP-a, LAR, PTP-1B and SHP-2 are the major phosphatases acting on the insulin signaling ... In contrast to the activation and propagation of insulin signal transduction, the negative regulatory components that attenuate insulin signaling are less well defined Because tyrosine phosphorylation ... Ó FEBS 2002 Protein tyrosine phosphatases in insulin signaling (Eur J Biochem 269) 1051 Fig Scheme of the major insulin signaling pathways The activated insulin receptor phosphorylates tyrosine...
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Báo cáo khoa học: Growth hormone/JAK-STAT axis signal-transduction defect A novel treatable cause of growth failure pdf
Ngày tải lên :
23/03/2014, 10:21
... IFN-b, a cytokine that also signals through the same JAK ⁄ STAT FEBS Journal 273 (2006) 3454–3466 ª 2006 The Authors Journal compilation ª 2006 FEBS GH ⁄ JAK-STAT axis signal- transduction defect A ... [16,17] The growth-promoting and metabolic actions of GH are mediated through activation of the GH -signal transduction pathway When a GH molecule binds to a dimer of the GHR, it stimulates the receptorassociated ... The fact that no mutations were found in the GHR or GH-1 genes prompted us to investigate the signaltransduction pathway of GH To this end, fibroblast cultures were established from original gingival...
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Báo cáo khoa học: Protein kinase Ch activity is involved in the 2,3,7,8tetrachlorodibenzo-p-dioxin-induced signal transduction pathway leading to apoptosis in L-MAT, a human lymphoblastic T-cell line potx
Ngày tải lên :
23/03/2014, 13:20
... post-translational signal transduction mechanism [7,8] Many reports in the last decade have suggested that protein phosphorylation by protein kinase C (PKC) plays a key role in the regulation of the signal transduction ... involvement of PKC in the signal transduction mechanism participating in TCDD-induced cellular responses [14] We also looked for evidence of the involvement of PKC in the signal transduction mechanism ... required for aryl hydrocarbon receptor pathway-mediated signal transduction Mol Pharmacol 53, 691–700 Nishizuka Y (1995) Protein kinase C and lipid signaling for sustained cellular responses Faseb J...
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