cell membrane and signal transduction pathways implications for the pathophysiology of bipolar disorders
Alternative Futures and Army Force Planning - Implications for the Future Force Era pdf
Ngày tải lên :
06/03/2014, 20:20
... vertically and the three types of slopes arrayed horizontally The cells of the matrix were then filled with the labels for each individual trend line Through a process of mixing and matching cells, ... end of the spectrum was assessed by combining the five worst-case outcomes in the rightmost column of the matrix The synthesis of these five “bad” slopes of the future led to the creation of a ... structure, and design The research was part of the RAND Arroyo Center “Capstone Future Forces” project that was conducted for the Deputy Chief of Staff for Operations and Plans (DCSOPS) The analysis...
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Báo cáo khoa học: Enzymatic investigation of the Staphylococcus aureus type I signal peptidase SpsB – implications for the search for novel antibiotics ppt
Ngày tải lên :
07/03/2014, 01:20
... data of S aureus The criteria for selection of the substrate were a good prediction of the presence and location of the signal peptide cleavage site (as indicated by signalp 3.0 server [24]), and ... in the Fig SPase recognition sequence and cleavage sites of the SpsB substrates used in the present study: Showing part of the sequence of the IsaA precursor (upper row) and the sequence of the ... result of the enzyme SpsB and is not caused by background activity of LepB of E coli (which was used as the host for overproduction of SpsB) The importance of the transmembrane segment for optimum...
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Báo cáo khoa học: NMR and molecular dynamics studies of an autoimmune myelin basic protein peptide and its antagonist Structural implications for the MHC II (I-Au)–peptide complex from docking calculations ppt
Ngày tải lên :
07/03/2014, 16:20
... the binding and affinity for I-Au because of occupation of the P1 pocket Recent thermodynamic and kinetic studies of the binding of TCRs to peptide–MHC ligands suggested that the low affinity of ... characteristic of the structure of the native epitope in Me2SO is the presence of a large number of electrostatic interactions, especially in the central region of the peptide The side chain of Arg78 ... interactions of the side chain of Arg78 with the side chains of Asp81 and Glu82 [this is consistent with the observed long-range NOE cross-peak between the side chain of Arg78 (Hg) and Glu82 (Hc1) and the...
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báo cáo hóa học:" Association of measured physical performance and demographic and health characteristics with self-reported physical function: implications for the interpretation of self-reported limitations" pdf
Ngày tải lên :
20/06/2014, 16:20
... perform Hip and knee flexion were scored similarly For analysis, results on the lock and key test were categorized into quartiles, and range of motion of the shoulders Louie and Ward Health and ... functioning, before they had the physical examination and performance testing Analytic framework To maximize the specificity of the association between physical performance tests and self-reported ... by the Intramural Research Program of the National Institute of Arthritis and Musculoskeletal and Skin Diseases at the National Institutes of Health Authors’ contributions GL and MW conceived of...
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Báo cáo y học: "Regulation of catabolic gene expression in normal and degenerate human intervertebral disc cells: implications for the pathogenesis of intervertebral disc degeneration" ppt
Ngày tải lên :
09/08/2014, 14:20
... degenerate NP cells as well as the effect of IL-1β and TNF-α on cytokine gene expression and the expression of the associated receptors and endogenous antagonists There Page of 10 (page number not for ... and a downregulation of aggrecan and collagen types I and II [7] In this study, we have expanded the investigation to include the effect of TNF-α on matrix and MMP gene expression in normal and ... studied These studies investigated the protein expression of these receptors rather than gene expression and separated the groups according to age rather than Page of 10 (page number not for citation...
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Báo cáo y học: "Capacity utilization and the cost of primary care visits: Implications for the costs of scaling up health interventions" pdf
Ngày tải lên :
13/08/2014, 11:22
... Potaptchik and Ruth Lucio and Benjamin Nganda for their efforts in gathering cost data at the country level; and Tessa Tan Torres for her input in the development of the methods used The work represents ... performed the analysis and drafted the manuscript SE and BJ contributed to the selection of variables and model applications DE participated in the development of the methodology, selection of the ... gives the median and not the mean The smearing method described by Duan (1983) corrects for the back transformation bias [74] This was done by multiplying the anti log of the product of the model...
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Báo cáo y học: " Mathematical model of blunt injury to the vascular wall via formation of rouleaux and changes in local hemodynamic and rheological factors. Implications for the mechanism of traumatic myocardial infarction" pot
Ngày tải lên :
13/08/2014, 22:22
... u2, the particle size a, the quantities and shapes of inclusions, and the physical properties of the phases (see equation 1) (The effects of the shape and multiplicity of particles, and of some ... decrease the permeability of the endothelium [16] and decrease the rate of removal of lipids and lipoproteins, which in turn can lead to the formation of lipid stripes directed along the blood flow and ... determine the destruction, i.e the detachment and separation of particles from the surface The results of the experiment are given in Table The role of the non-Newtonian viscosity of blood has...
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IDENTIFICATION OF A MINIMAL CIS-ELEMENT AND COGNATE TRANS-FACTORS REQUIRED FOR THE REGULATION OF RAC2 GENE EXPRESSION DURING K562 CELL DIFFERENTIATION
Ngày tải lên :
24/08/2014, 12:22
... TFIIA then binds to TBP and stabilizes its interaction with the DNA Binding of TBP to TATA box distorts the DNA and allows binding of TFIIB that provides the platform for the recruitment of RNA ... in the melting of the DNA TFIIH has kinase and helicase activity The kinase activity of this factor is required for the phosphorylation of the C-terminus domain (CTD) of Pol II that consists of ... on the stimulus used These differentiation processes require further examination of the intracellular events, such as signaling pathways and gene expression, and serve as an excellent mimic of...
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Báo cáo y học: "Thioglycosides as inhibitors of hSGLT1 and hSGLT2: Potential therapeutic agents for the control of hyperglycemia in diabetes"
Ngày tải lên :
26/10/2012, 10:04
... IC50 values of 30 µM for hSGLT1 and 10 µM for hSGLT2, while thioglycoside VII showed IC50 values of 15 µM for hSGLT1 and 88 µM for hSGLT2 These data confirm the strong inhibitory effects of thioglycoside ... hydrolysis-resistant, synthetic S-analogs of natural O-glucosides involved in the biosynthesis of chrysomelidial and salicin These substances are synthesized and secreted as part of a defense mechanism ... larvae of beetles (Chrysomelidae) Their synthesis has been previously described [31-33] For the purpose of the present study the thioglycosides used were selected and grouped based on their differences...
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Tài liệu Carrots, Sticks, and Promises: A Conceptual Framework for the Management of Public Health and Social Issue Behaviors docx
Ngày tải lên :
18/02/2014, 02:20
... and accommodate the target's MOAs and the trade-off of free choice and externalities The potential for success of the three sets of tools is derived from the target's assessment of the "risk premium" ... combines the issues of cells and The members of cells.2, 5, and are motivated to comply with the goals of the manager but need help in doing so Marketing and/ or education can provide this help and ... (2) the target's MOA; and (3) the use of the tools of education, marketing, and law Figure I shows the eight segments of any market that result from the combinations of the presence or absence of...
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The importance of project management in small- and medium-sized enterprises (SMEs) for the development of new products through E-collaboration docx
Ngày tải lên :
07/03/2014, 00:20
... concept (either for the company or for the customer) It includes all activities from the development of an idea or a concept for a product, to the realization of the product during the production ... to h The participants were given an explanation regarding the purpose of the feedback, the purpose of the conceptual model, some background of the research that lead to the development of the ... management is the manner of implementation, of expertise, paraphernalia, knowledge and modus operandi to an extensive range of activities for the fulfillment of prerequisite of the specific project”...
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Báo cáo khoa học: Re-evaluation of intramolecular long-range electron transfer between tyrosine and tryptophan in lysozymes Evidence for the participation of other residues doc
Ngày tải lên :
17/03/2014, 10:20
... achieved by calculation of the portion of the total area under the curve occupied by the dimers peak The obtained value was divided by two MALDI-TOF MS was performed at The Institute of Nuclear Physics, ... TyrOÆ yields in the lysozymes from the magnitudes of the absorbance changes at 510 and 410 nm and the assumption that the extinction coefficients of the protein bound radicals and those measured ... compared to the 90% loss of Trp after the completion of this reaction We confirm that the process is nonstoichiometric and that the amount of LRET depends on the primary structure of the protein...
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Báo cáo hóa học: " ICP0 antagonizes Stat 1-dependent repression of herpes simplex virus: implications for the regulation of viral latency" potx
Ngày tải lên :
20/06/2014, 01:20
... 105 pfu per eye of HSV-1 strain KOS-GFP or GFP relationship of the genotype and phenotype of these mice is defined in Table c The mean ± standard error of the mean of the logarithm of infectious ... a cell in vivo The evidence that supports the model is circumstantial, and thus the accuracy of the model is questionable For example, the Checkpoint Model assumes that the primary function of ... compromised the integrity of the tissue Thus, consistent with other results, the Stat signaling pathway was essential to restrict the spread of wild-type HSV-1 from the site of inoculation to the TG...
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Báo cáo hóa học: " A quantum dots and superparamagnetic nanoparticle-based method for the detection of HPV DNA" ppt
Ngày tải lên :
21/06/2014, 01:20
... conceived of the study, and participated in its design, performed the preparation of nanomaterials and the statistical analysis All authors read and approved the final manuscript Competing interests The ... Page of predenatured at 95°C for 10 min, then 55°C for 30 The particles coupled with streptavidin were added into the hybridization mixtures and incubated at 37°C for 10 and enriched in the bottom ... validate our hybridization assay on the basis of the cutoff value Detection of HPV-16 with QDs and superparamagnetic nanoparticle-based hybridization The rationale of QDs and superparamagnetic nanoparticle-based...
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Báo cáo hóa học: " Research Article Development of Long-Range and High-Speed Wireless LAN for the Transmission of Telemedicine from Disaster Areas" pdf
Ngày tải lên :
22/06/2014, 06:20
... Hz The first item in (4) (a)–(f) shows compression rate for video signal CBR and VBR stand for constant bit rate and variable bit rate, respectively SIF stands for source input format HalfD1 stands ... Cordova, P Boets, and L Van Biesen, “Analysis and applications of Wi-MAX standard: forecasting the trends” J Crouse, M D’alessandro, and F Lengerich, “WiMAX and the future of wireless technology,” ... sounds sent from the helicopter are received at Yakushi Park relay station These image and sound packets are decoded to video signal and sound signals, and displayed Then these signals are encoded...
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Báo cáo y học: "Duration of bed occupancy as calculated at a random chosen day in an acute care ward. Implications for the use of scarce resources in psychiatric care" pps
Ngày tải lên :
08/08/2014, 21:20
... psychiatrist in training at the time of the study, was aware of the registration of time from the senior psychiatrists decision to the actual day of referral to the next step in the treatment chain, ... illness, whereas of 12 not waiting had a psychotic illness Duration of stay was composed of the days preceding the chosen day and the number of days of further treatment in the acute ward Twenty-three ... Dorothy Rice found that the direct costs of schizophrenia and affective disorders were twice the indirect costs The share of the costs of these two illnesses was higher than the prevalence would...
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Báo cáo y học: "Most nuclear systemic autoantigens are extremely disordered proteins: implications for the etiology of systemic autoimmunity" pps
Ngày tải lên :
09/08/2014, 07:20
... spreading to other epitopes in the Sm particle This view of the battle between the virus and the immune system is further amplified by the results of the analysis of MHC II T cell epitopes using the ProPred ... sequences in the B/B' polypeptide followed by spreading to the rest of the Sm particle To further explore the relevance of disorder to the idea of spreading we carried out a PONDR® analysis of the EBNA1 ... require cell- to -cell contact between B and T cells Considerable evidence supports both of these predictions At the same time the model explains why, paradoxically, some type of T cell- B cell contact...
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346 Biomass – Detection, Production and Usage live yeast biomass for the leavening of bread docx
Ngày tải lên :
09/08/2014, 16:21
... accounts for 60 to 75% of the total costs of the biodiesel Thus, the cost of lipid production was influenced strongly by the cost of medium nutrients (50%) needed for cultivation of cells and the ... phenoxypropylamine-type inhibitor for sterol biosynthesis was added to the medium The isolation and characteristic of the carotenogenic genes of yeasts facilitates the study of the effect of their overexpression ... However, the intensity and protocol of illumination varies with the microorganism Temperature is another important factor affecting the performance of cells and product formation The effect of temperature...
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Báo cáo y học: "Cigarette Smoke Exposure Alters mSin3a and Mi-2α/β Expression; implications in the control of pro-inflammatory gene transcription and glucocorticoid function" ppt
Ngày tải lên :
11/08/2014, 03:20
... understanding of the roles of these co-repressor complexes and thereafter their roles in disease In summary cigarette smoke exposure reduced HDAC2 activity and the expression of mSin3a and Mi-2α ... expression may lead to the alteration of both the formation and targeting of these complexes Consequently, an oxidant-mediated reduction in the protein expression of Mi-2α and mSin3a and increased protein ... in its design and prepared the manuscript CSS designed and ran the in vivo model KFC participated in the study design and preparation of the manuscript IMA and PAK conceived of the study, participated...
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Báo cáo y học: "Cigarette Smoke Exposure Alters mSin3a and Mi-2α/β Expression; implications in the control of pro-inflammatory gene transcription and glucocorticoid function" pdf
Ngày tải lên :
11/08/2014, 06:22
... understanding of the roles of these co-repressor complexes and thereafter their roles in disease In summary cigarette smoke exposure reduced HDAC2 activity and the expression of mSin3a and Mi-2α ... expression may lead to the alteration of both the formation and targeting of these complexes Consequently, an oxidant-mediated reduction in the protein expression of Mi-2α and mSin3a and increased protein ... in its design and prepared the manuscript CSS designed and ran the in vivo model KFC participated in the study design and preparation of the manuscript IMA and PAK conceived of the study, participated...
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