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guibased efficient medline search tool

Tài liệu Báo cáo khoa học: Efficient killing of SW480 colon carcinoma cells by a signal transducer and activator of transcription (STAT) 3 hairpin decoy oligodeoxynucleotide – interference with interferon-c-STAT1-mediated killing pdf

Tài liệu Báo cáo khoa học: Efficient killing of SW480 colon carcinoma cells by a signal transducer and activator of transcription (STAT) 3 hairpin decoy oligodeoxynucleotide – interference with interferon-c-STAT1-mediated killing pdf

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... assays. However, thesame cells were efficiently killed by interferon-c. This effect was counter-acted by the STAT3 oligodeoxynucleotide, which was found to efficientlyinhibit STAT1. Thus, although ... oligodeoxy-nucleotide was added to a colon carcinoma cell line in which it induced celldeath as efficiently as the STAT3 inhibitor stattic. The hairpin STAT3oligodeoxynucleotide co-localized with ... Efficient killing of SW480 colon carcinoma cells by asignal transducer and activator of transcription...
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Tài liệu Báo cáo khoa học: Reversible tetramerization of human TK1 to the high catalytic efficient form is induced by pyrophosphate, in addition to tripolyphosphates, or high enzyme concentration ppt

Tài liệu Báo cáo khoa học: Reversible tetramerization of human TK1 to the high catalytic efficient form is induced by pyrophosphate, in addition to tripolyphosphates, or high enzyme concentration ppt

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... andK0.5= Km.AcknowledgementsThis work was supported by grants from the DanishResearch council and the Novo Nordic ResearchCouncil. The skilful technical assistance of MarianneLauridsen is gratefully ... as indicated by con-cave Hofstee plots of v versus v ⁄ s (insets to the kineticplots), Hill coefficients < 1 and high K0.5values(Table 1). All of the tetrameric forms showed approxi-mately ... the molecular mass, as the standard varia-tion in Ve⁄ V0for the markers was less than 2% (coefficientof variation) from 20 separate marker elution profiles.Fractions (200 lL) were collected...
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Tài liệu Báo cáo khoa học: The role of N-glycosylation in the stability, trafficking and GABA-uptake of GABA-transporter 1 Terminal N-glycans facilitate efficient GABA-uptake activity of the GABA transporter pptx

Tài liệu Báo cáo khoa học: The role of N-glycosylation in the stability, trafficking and GABA-uptake of GABA-transporter 1 Terminal N-glycans facilitate efficient GABA-uptake activity of the GABA transporter pptx

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... extracellularNa+concentrations. The solid lines represent fits of the Hill equa-tion with Hill coefficients of n ¼ 1.3 for the wild type GAT1 andn ¼ 1 for the mutants (as used previously by Liu ... synthesizedproteins in the ER. If N-glycosylation is inhibited,some glycoproteins fail to fold or assemble efficiently,resulting in a prolonged retention in the ER and anincreased proteolytic breakdown ... 7.2).AcknowledgementsThis work was supported in part by the Special Fundsfor Major State Basic Research of China (GrantG1999053907), a grant from the Chinese Academy ofSciences, a grant from...
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Tài liệu Efficient Pattern Matching over Event Streams  doc

Tài liệu Efficient Pattern Matching over Event Streams  doc

Tổ chức sự kiện

... that expands dur-ing event processing, the backtrack algorithm processes runsin a depth first search manner. That is, we process the sin-gleton run until it either fails or produces a result ... singleton run. Our basic algorithm, onthe other hand, expands the “run tree” in a breadth first search manner; it creates and evaluates all runs at once.5.3 Memory ManagementThere are a number ... window, calledthe pruning timestamp. We use the pruning timestampas a key to perform a binary search in each stack of the5Regular expression matching in network intrusion detection sys-tems...
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Tài liệu Báo cáo khoa học: Efficient RNA ligation by reverse-joined hairpin ribozymes and engineering of twin ribozymes consisting of conventional and reverse-joined hairpin ribozyme units ppt

Tài liệu Báo cáo khoa học: Efficient RNA ligation by reverse-joined hairpin ribozymes and engineering of twin ribozymes consisting of conventional and reverse-joined hairpin ribozyme units ppt

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... ribozymesthat are structurally optimized and which, in addition to cleavage, catalyse efficient RNA ligation. The most efficient variant ligated its appropriateRNA substrate with a single turnover rate ... substrateand the ribozyme seems to be most favourable foran efficient reaction among the studied species.HP–RJWTA7 is also an efficient endonuclease; itcleaves the substrate S40F3F5 with kobs¼ ... (2003) Ribozymes: recentadvances in the development of RNA tools. FEMSMicrobiol Rev 27, 75–97.5 Rimmele M (2003) Nucleic acid aptamers as tools anddrugs: recent developments. Chembiochem 4, 963–971.6...
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Tài liệu Báo cáo khoa học:

Tài liệu Báo cáo khoa học: "Efficient Online Locality Sensitive Hashing via Reservoir Counting" ppt

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... Patil, EmilyPitler, Rachel Lathbury, Vikram Rao, Kapil Dalwani,and Sushant Narsale. 2010. New Tools for Web-ScaleN-grams. In Proceedings of LREC.Patrick Pantel, Eric Crestan, Arkady Borkovsky,...
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Tài liệu Báo cáo khoa học:

Tài liệu Báo cáo khoa học: "Computationally Efficient M-Estimation of Log-Linear Structure Models∗" doc

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... design;our estimator avoids normalization altogether.8TheM-estimator may also be useful as a tool in design-ing and selecting feature combinations, since moretrials can be run in less time. ... 2003. Shallow parsing with conditionalrandom fields. In Proc. of HLT-NAACL.A. Stolcke. 1995. An efficient probabilistic context-free pars-ing algorithm that computes prefix probabilities. Computa-tional ... 752–759,Prague, Czech Republic, June 2007.c2007 Association for Computational LinguisticsComputationally Efficient M-Estimation of Log-Linear Structure Models∗Noah A. Smith and Douglas L. Vail and John...
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Báo cáo khoa học: A novel mechanism of V-type zinc inhibition of glutamate dehydrogenase results from disruption of subunit interactions necessary for efficient catalysis doc

Báo cáo khoa học: A novel mechanism of V-type zinc inhibition of glutamate dehydrogenase results from disruption of subunit interactions necessary for efficient catalysis doc

Báo cáo khoa học

... concentrations were determined spectropho-tometrically by absorbance at 280 nm, using an extinctioncoefficient of 0.98 for a 1 mgÆmL)1solution [35]. Coenzymeconcentrations were also determined spectrophotometricallyusing ... spectrophotome-ter) due to the production of NAD(P)H at 340 nm, using amillimolar extinction coefficient of 6.22 mM)1Æcm)1. All ratemeasurements were performed in triplicate and the resultsshown ... inhibition of glutamatedehydrogenase results from disruption of subunitinteractions necessary for efficient catalysisJaclyn Bailey1, Lakeila Powell2, Leander Sinanan3, Jacob Neal3, Ming...
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Báo cáo khoa học: Efficient and targeted delivery of siRNA in vivo pdf

Báo cáo khoa học: Efficient and targeted delivery of siRNA in vivo pdf

Báo cáo khoa học

... achieving efficient and targetedsiRNA delivery in vivo.AcknowledgementThis work was supported by NSF CAREER Award(DMR-0956091) and a Council on Research Comput-ing and Libraries Research Grant ... efficiencyvia efficient cytosolic release with high resistance toserum and low cytotoxicity [129]. It was demonstratedthat ketalized linear polyethylenimine ⁄ siRNA poly-plexes were efficiently ... silencingbecause they were entrapped in the endosomes evenafter efficiently entering cells [117]. Photostimulatingfluorescently labeled TAT efficiently released TAT–siRNA conjugates from the endosome,...
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Báo cáo khoa học:

Báo cáo khoa học: "Exploring Deterministic Constraints: From a Constrained English POS Tagger to an Efficient ILP Solution to Chinese Word Segmentation" ppt

Báo cáo khoa học

... heuristics such as forward maxi-mum match (Sproat et al., 1996). Exact search ispossible with a Viterbi-style algorithm, but beam- search decoding is more popular as used in (Zhangand Clark, 2007) ... a beam (=5) search. on the development set, we set beam-width of ourbaseline model as 5. Our baseline model, whichuses Ratnaparkhi (1996)’s feature set and conductsa beam (=5) search in the ... deterministic constraints first be-fore a probabilistic search, i.e. for some words, thenumber of possible tags is reduced to 1, the search space is reduced to Tm, where m is the number of(unconstrained)...
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Báo cáo khoa học:

Báo cáo khoa học: "Efficient Third-order Dependency Parsers" pdf

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... Linguistics,24(4):613–632.Tadao Kasami. 1965. An Efficient Recognition andSyntax-analysis Algorithm for Context-free Lan-guages. Technical Report AFCRL-65-758, AirForce Cambridge Research Lab.Terry Koo, Amir Globerson, ... ex-pressive third-order factorizations while retainingan efficient O(n4) runtime. In fact, our third-order parsing algorithms are “optimally” efficient in an asymptotic sense. Since each third-order ... has proven to be a very use-ful syntactic formalism, due in no small part to thedevelopment of efficient parsing algorithms (Eis-ner, 2000; McDonald et al., 2005b; McDonaldand Pereira, 2006;...
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Báo cáo khoa học:

Báo cáo khoa học: "Efficient Staggered Decoding for Sequence Labeling" pptx

Báo cáo khoa học

... staggereddecoding efficiently performs the search step. Forthis purpose, we can basically use the Viterbi algo-rithm. In earlier iterations, the Viterbi algorithm isindeed efficient because the ... this idea to other NLP tasks is stillunclear.Approximate algorithms, such as beam search or island-driven search, have been proposed forspeeding up decoding. Tsuruoka and Tsujii (2005)proposed ... calculated in the search step. This can be done by retaining thebest path among those consisting of only activelabels. The score of that path is obviously thelower bound. Since the search step is...
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Báo cáo khoa học:

Báo cáo khoa học: "An Efficient Indexer for Large N-Gram Corpora" docx

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... 76203rada@cs.unt.eduAbstractWe introduce a new publicly available tool that implements efficient indexing and re-trieval of large N-gram datasets, such as theWeb1T 5-gram corpus. Our tool indexes theentire Web1T dataset ... hence efficient ac-cessing of the N-gram frequencies becomes an is-sue. Trivial methods such as linear or binary search over the entire dataset in order to access a singleN-gram prove inefficient, ... most pop-ular toolkits that are also freely available are theCMU Statistical Language Modeling (SLM) Toolkit(Clarkson and Rosenfeld, 1997), and the SRI Lan-guage Modeling Toolkit (Stolcke,...
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