Báo cáo y học: " Role of acetylcholine and polyspecific cation transporters in serotonin-induced bronchoconstriction in the mouse" potx
Báo cáo y học: " Role of acetylcholine and polyspecific cation transporters in serotonin-induced bronchoconstriction in the mouse" potx
... AChanalysis. The ACh synthesizing enzyme, ChAT, was dem-onstrated in epithelial cells of these bronchi by immuno-histochemistry (Fig. 1). Role of the epithelium and of ACh in 5-HT-induced bronchoconstriction Small ... triggers the release of acetylcholine (ACh) from thesecells, which then causes airway constriction [3]. In linewith this notion, the presence of ACh, its synthesizingenzyme choline acetyltransferase, ... 1 of 12(page number not for citation purposes)Respiratory ResearchOpen AccessResearch Role of acetylcholine and polyspecific cation transporters in serotonin-induced bronchoconstriction in...
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Báo cáo y học: " Role of ADAM and ADAMTS metalloproteinases in airway diseases" pot
... cata-lytic domain of the ADAM proteinase [32]. The interac-tion of the catalytic site-bound Zinc atom with a cysteinpresent in the N-terminal extremity of TIMP leads to aninactivation of ADAMs. ... recognized as fertilin-alpha and -beta in 1987 [35] since they could induce the fusion of the sperm with the egg. This process is mediated through the interaction of the disintegrin domain of ADAM-2 presenton ... expressed by other cell typesincluding endothelial cells [49,69]. ADAM-33 thereforemight play a key role in asthma-associated airway remod-eling since the purified catalytic domain of this proteinaseprovokes...
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Báo cáo y học: "Role of complement and antibodies in controlling infection with pathogenic simian immunodeficiency virus (SIV) in macaques vaccinated with replication-deficient viral vectors" pptx
... attractive hypothesis toexplain, at least in part, the reduced viral loads observedduring peak viremia.A further result of C activation is the induction of the ter-minal C pathway, resulting in the ... prime-boost application of the vaccine iv and intramuscularly, respectively,resulted in detectable nAb-titres in the animals of group 2.Similar to the animals of group 1, the monkeys in group3, ... the vaccines and corrected the manuscript. PR and HS conceived of the study, and participated in itsdesign and coordination. HS and BF wrote the manu-script. All authors read and approved the...
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Báo cáo y học: "Comparison of mannitol and methacholine to predict exercise-induced bronchoconstriction and a clinical diagnosis of asthma" pdf
... sensitivity of mannitol and metha-choline to identify EIB of 68.4% and 73.7% and a specif-icity of 44.4% and 55.5% respectively.Sensitivity and specificity for mannitol and methacholineto identify ... replace other challenges for BPT, any of these tests can provide specific information and insightregarding mechanism in a particular patient.Competing interestsSDA is the inventor of the mannitol ... of inhaling methacholine by using total lung capacity inspira-tions has a marked influence on the interpretation of the testresult. J Allergy Clin Immunol 2006, 117(6):1244-1248.32. Global Initiative...
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Báo cáo y học: "Associations of physical and mental health problems with chronic cough in a representative population cohort" potx
... burden and morbidity of obesity in the community.Comparison with previous studies examining the preva-lence and associations of chronic cough are difficult dueto differences in sampling and other ... can be interpreted as indicating the severity of psychological disturbance on a continuum[35]. In Australian community populations the GHQ-28has shown sensitivity of 90% and specificity of 94% ... particularly depression, and significantlyreduced quality of life, indicates cough is a major contrib-utor to morbidity in the community. The reduction in quality of life in general physical health...
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Báo cáo y học: "Induction of Bim and Bid gene expression during accelerated apoptosis in severe sepsis" potx
... [16].Several lines of evidence point to the involvement of the mito-chondrion and the Bcl-family of proteins in the induction of lymphocyte apoptosis during sepsis. Overexpression of Bcl-2or ... regions of homol-ogy, the BH1-4 domains; pro-apoptotic Bax-like proteins shar-ing only domains 1–3 [17]; and the group of BH3-onlyproteins, which contain only domain 3 and function as sensors and ... events play a crucial role in the initiation of leu-cocyte apoptosis during sepsis [1] and their possible involve-ment in the apoptotic process during sepsis was the focus of this study. On the side...
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Tài liệu Báo cáo Y học: Role of electrostatics in the interaction between plastocyanin and photosystem I of the cyanobacterium Phormidium laminosum ppt
... at the time of chloroplast origin had poorly definedinteractions between Cyt f and plastocyanin and/ or plasto-cyanin and photosystem I, and subsequently the nature of the interactions in the ... knowledge, the work described here and in the related publications [1,7] is the first kinetic analysis of the in vitro interactions Cyt f–plastocyanin and plastocyanin–Fig. 4. Comparison of ionic ... & Diner, B.A. (1990) Puri cation and characterization of photosystem-I and photosystem-II core com-plexes from wild-type and phycocyanin-deficient strains of the cyanobacterium Synechocystis...
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Báo cáo Y học: Role of conserved residues within helices IV and VIII of the oxaloacetate decarboxylase b subunit in the energy coupling mechanism of the Na+ pump ppt
... from the hydroxyl side chain of tyrosine 229. This displacement may be facilitated involving by R389 through lowering the pK of the tyrosine hydroxyl group. The proton isdelivered to the carboxybiotin ... serine hydroxyl and anaspartic acid, these experiments argue strongly against anacidic function of the serine hydroxyl; (d) upon replacingserine by alanine the enzyme remains reasonably active ... Na+binding ligand. Sodium ions may still bindto the N373L mutant through coordination to the otherligands of the binding site (center I), but the bindingbecomes much weaker as emphasized by the...
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Báo cáo Y học: Role of histidine 42 in ascorbate peroxidase Kinetic analysis of the H42A and H42E variants pptx
... in uen-tial in defining the stability of Compound II. The replacement of the distal histidine residue by alanineor glutamic acid clearly has a profound in uence on the ability of the rAPX enzyme to ... hydrogen-bond-ing structure involving the Ne of His42 and the ferryloxygen. However, although hydrogen-bonding interactions of this kind have been structurally confirmed for the ferrous-oxy derivative of ... performed by global analysis and numerical integration methods usingPROKINsoftware(Applied Photophysics).RESULTSMass spectrometry The integrity of the variant proteins was examined to ensurethat...
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Báo cáo y học: "Role of RUNX in autoimmune diseases linking rheumatoid arthritis, psoriasis and lupus" pptx
... genotyping. The searchled to the pinning down of a single polymorphismdisrupting the RUNX1-binding site within the organic cation transporter gene SLC22A4 [5]. Furthermore, and providing a ... previouslyidentified by linkage in sibling pairs, and by thoroughhaplotype analysis narrowed it down to a singlepolymorphism (having excluded the remaining nine thatshowed association out of hundreds ... permitted the study of the RUNXproteins in more detail, although still in the mouse, and have provided evidence for the importance of the RUNXproteins in the immune system.Both RUNX1 and RUNX3 are...
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