role of inflammation and oxidative stress mediators in gliomas
báo cáo hóa học: " Brain inflammation and oxidative stress in a transgenic mouse model of Alzheimer-like brain amyloidosis" pptx
... a subset of NSAIDs(e.g. ibuprofen, flurbiprofen, indomethacin) reducedbrain inflammation and Aβ levels in addition to the dep-osition of Aβ in brain [13,14]. Despite this evidence, and the ... that a full dose of indomethacin alone despite a significant reduction in brain inflammation had only a marginal effect on brain oxidative stress in the Tg2576 mice [16]. This finding sug-gests ... implicating both oxidative stress and inflammatory mechanisms in AD pathogenesis.Effect of indomethacin plus vitamin E supplementation on sol-uble Aβ levelsFigure 3Effect of indomethacin plus...
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Báo cáo khoa học: Calcium, mitochondria and oxidative stress in neuronal pathology Novel aspects of an enduring theme pdf
... imposing a continuous load of calcium to the neuron. The turning point upon whichthe cell looses the ability to buffer the incoming calciumresulting in an abrupt, sustained and irreversibleincrease ... by proteins resi-ding in both the inner and outer mitochondrialmembrane, that is activated by mitochondrial Ca2+overloading and other factors including oxidative stress [88,89]. In neurons ... for a role of Trp proteins in the oxidative stress- induced membrane conductances of porcineaortic endothelial cells. Cardiovasc Res 42, 543–549.236 Wehage E, Eisfeld J, Heiner I, Jungling E,...
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Báo cáo khoa học: Yeast oxidative stress response Influences of cytosolic thioredoxin peroxidase I and of the mitochondrial functional state pot
... aDNA-binding protein that binds to elements in thevicinity of Yap1 binding site [52]. Alternatively, theincreased reducing power of tsa1 mutant, achieved bythe expression elevation of GSH1, ... (2001) Role of the glutathione ⁄ glutaredoxin and thioredoxin systems in yeast growth and responseto stress conditions. Mol Microbiol 39, 533–541.5 Collinson EJ & Grant CM (2003) Role of yeast ... carriers are involved in oxidative stress during heat stress in Saccharomyces cerevisiae.Mol Cel Biol 21, 8483–8489.17 Guo J & Lemire BD (2003) The ubiquinone-binding site of the Saccharomyces...
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Báo cáo khoa học: Expression of CYP2E1 increases oxidative stress and induces apoptosis of cardiomyocytes in transgenic mice pdf
... A rapid and sensitive method forthe quantitation of microgram quantities of proteinutilizing the principle of protein-dye binding. AnalBiochem 72, 248–254.CYP2E1 causes apoptosis of cardiomyocytes ... College, Beijing, China2 Key Laboratory of Human Diseases Animal Model, State Administration of Traditional Chinese Medicine, Institute of Laboratory AnimalScience, Chinese Academy of Medical ... overexpression of CYP2E1 both in vivo and in vitro is associated with several cellular markers of oxidative stress, including products of lipid peroxi-dation (e.g. 4-hydroxynonenal and malondialdehyde),as...
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Báo cáo khoa học: Photodynamic treatment and H2O2-induced oxidative stress result in different patterns of cellular protein oxidation ppt
... (1999)Photodynamic crosslinking of proteins. Kinetics of the FMN- and rose bengal-sensitized photooxidation and intermolecularcrosslinking of model tyrosine-containing N-(2-hydroxypropyl)methacrylamide ... modifica-tions of the side chains of amino acids within a protein. In particular, the side chains of cysteine, histidine, methionine,tryptophan and tyrosine are susceptible to ROS-inducedmodifications ... Westernblotting are shown in (A) and (B). Silverstainingisshownin(C )and( D)inbluesuperimposed with the spots of oxidized pro-teins shown in red. Protein labels: 1, a-tubulin;2, b-tubulin;3,actin;4,PDI;5,BiP;6,GRP58.4862...
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Báo cáo y học: "NITRIC OXIDE (NO), CITRULLINE – NO CYCLE ENZYMES, GLUTAMINE SYNTHETASE AND OXIDATIVE STRESS IN ANOXIA (HYPOBARIC HYPOXIA) AND REPERFUSION IN RAT BRAIN"
... synthase. The increased activities of argininosuccinate synthetase and argininosuccinate lyase suggest the increased and effective recycling of citrulline to arginine in anoxia, making nitric ... findings of NO involvement in pathophysiol-ogy of hypobaric hypoxia in brain (42-43). In this study the increased activity of NOS in anoxia may represent predominantly the nNOS form. In inflam-matory ... reperfusion damage in brain. The increased activities of AS and AL indicate the effective recycling of citrulline to arginine and suggest a functional role to citrulline –NO cycle enzymes in anoxia....
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Tài liệu Báo cáo khoa học: Role of K22 and R120 in the covalent binding of the antibiotic fosfomycin and the substrate-induced conformational change in UDP-N-acetylglucosamine enol pyruvyl transferase docx
... involved in fosfomycinbinding, and in view of the multitude of interactions, it wasassumed that deletion of a single interaction would not leadto a complete loss of fosfomycin binding. Therefore ... fosfomycin binding due to charge–chargerepulsions. Most interestingly, the uncharged valine sidechain completely abolishes fosfomycin binding in theabsence of UDPNAG. Clearly, UDPNAG binding createsadditional ... UDP-N-acetylmuramic acid) (A) and inactivation mechanism of MurA byfosfomycin as a result of the covalent linkage between Cys115 of MurA and fosfomycin (B).Ó FEBS 2004 Lysine 22 and arginine 120 in MurA (Eur....
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Tài liệu Báo cáo khoa học: Role of cleavage and shedding in human thyrotropin receptor function and trafficking pdf
... periods of times (0–60 min)at 37 °C. The concentration of the biotinylated Ig remainingon the cell surface was then quantified by measuring thebinding of [125I]Streptavidin. In the absence of ... image.Ó FEBS 2003 Role of cleavage and shedding in TSHR function (Eur. J. Biochem. 270) 3491 Role of cleavage and shedding in human thyrotropin receptor function and traffickingMyle`ne Quellari1, ... five amino acids of theextracellular domain and devoid of any tag was notfunctional [27], while a mutant containing four amino acids of the ectodomain and including a rhodopsine tag wasfound...
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The Role of Small and Large Businesses in Economic Development doc
... recruiting large enterprises with tax breaks, financial incentives, and other induce-ments. Instead, they are relying on building businesses from the groundup and supporting the growth of existing ... growth from the second quarter of 2000 into jobclasses using beginning size of firm, mean size of firm over the period, and end size of firm. If the beginning size of the firm is used to classifyfirms, ... efficient at innovation. Small firmsare the great innovators in some industries, while large firms are thegreat innovators in others. Moreover, small and large businesses interact in innovative...
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Báo cáo khoa học: Role of DptE and DptF in the lipidation reaction of daptomycin ppt
... buffer A in 15 min, followed by a lineargradient down to 5% buffer A in 2 min. 5% buffer A washeld for an additional 2 min and followed by a lineargradient up to 95% buffer A in 6 min.Determination ... °C: loading 5% buffer B, after5 min linear gradient up to 95% buffer B in 37 min, and then holding 100% buffer B for 5 min. The product wasidentified by UV detection at 215 nm and by on-lineESI-MS ... domain is one of thefew ACPs in which valine replaces isoleucine (I) orleucine (L) in the conserved sequence. To determinewhether DptF is the putative partner of DptE, weexpressed dptF using...
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