role of ca2 and nmda receptor activation in epileptogenesis
Báo cáo y học: "Role of epidermal growth factor receptor activation in regulating mucin synthesis" pdf
... metaplasia in pathogen-free rats, developing mucin-containing cells did not incorporate [3H]thymidine, suggesting that cell mitosis was not involved in synthesis of mucin mRNA [5] In endotoxin-induced ... expressed TNF-α An interleukin-8-blocking antibody inhibits interleukin-13-induced neutrophil recruitment and mucin production Thus, interleukin-13 causes goblet-cell metaplasia indirectly by neutrophil ... T-helper-2 cytokines interleukin-4 and interleukin-13 have been implicated in this process [23] In interleukin-5-knockout mice, ovalbumin sensitization no longer leads to eosinophil recruitment...
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Báo cáo khoa học: Role of Ca2+/calmodulin regulated signaling pathways in chemoattractant induced neutrophil effector functions Comparison with the role of phosphotidylinositol-3 kinase ppt
... calmodulin and PtdIns3K In guinea pig neutrophils, it has been demonstrated that inhibition of calmodulin results in inhibition of Rac and p21 activated kinases [50] Involvement of Rac in ROS ... counteracts the calcineurin induced affinity switch of a5b1 integrin in CHO cells, suggesting also a role for Ca2+ /calmodulin-dependent molecules in regulating the affinity state of integrins on neutrophils ... elevation of [Ca2+ ]i are in themselves insufficient in the protection of neutrophils against apoptosis DISCUSSION In this study, the role of Ca2+ and its downstream effector calmodulin in G-protein-coupled...
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báo cáo hóa học:" Impact of recent life events on the health related quality of life of adolescents and youths: the role of gender and life events typologies in a follow-up study" potx
... between followup and baseline scores divided by baseline standard deviation) in three different groups of increasing LEs impact The three categories were defined based on tertiles of LCU distribution ... events and HRQoL on the Psychological Well-being and School Environment dimensions and the Overall score in boys, and on the School Environment and Physical Well-being dimensions in girls In the ... decrements in HRQoL, desirable events and family and extrafamily events were not associated with a corresponding increase or decrease in HRQoL In particular, the existence of a combination of undesirable...
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Báo cáo y học: "Impaired vascular responses to parasympathetic nerve stimulation and muscarinic receptor activation in the submandibular gland in nonobese diabetic mice." ppt
... Localization of M3R in submandibular glands Double labelling of CD31 and M3R revealed M3R in the wall of blood vessels in submandibular glands of both NOD mice and BALB/c mice (Figure 5a,b) In addition, ... Localization of muscarinic receptor in the walls of blood vessels in salivary glands Fluorescent staining of CD31+/M3R+ blood vessels in repreglands sentative sections from submandibular glands of (top) ... was diluted in 0.05 ml of 0.9% saline and was infused intravenously over a period of minute Electrical stimulation was repeated to minutes after the end of infusion In Group pilocarpine (0.10 mg/100...
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Báo cáo y học: " Role of acetylcholine and polyspecific cation transporters in serotonin-induced bronchoconstriction in the mouse" potx
... presence of ACh in murine respiratory epithelium was validated by biochemical techniques and ChAT-immunohistochemistry, and we obtained evidence for a significant role of OCT1 and in the release of ... in murine trachea and respiratory epithelium We used an HPLC procedure to determine ACh levels separately in epithelium and underlying tissues in wild-type (FVB strain) and OCT1/2-/- mice Using ... peripheral bronchi in PCLS of M2/3R+/+ mice Effect of epithelium removal on constriction of peripheral bronchi in PCLS of M2/3R+/+ mice (A) Reduction of luminal area of intact (control, blue) and epithelium-denuded...
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Báo cáo y học: "What is the role of surfactant and inhaled nitric oxide in lung transplantation" pps
... considered This interesting approach was successful in the experimental setting of acute lung injury and needs to be verified in clinical indications other than lung transplantation Competing interests ... circulation was instituted when right heart failure occurred after implantation of the left lung and clamping of the contralateral pulmonary artery, despite iNO and prostaglandin E1 treatment ... centres abandoned the Euro-Collins technique and started to use LPD or other extracellular solutions instead A lesser incidence as well as lesser severity of ischaemia/reperfusion injury and a reduction...
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Báo cáo y học: "Expression of aromatase and estrogen receptor alpha in chondrosarcoma, but no beneficial effect of inhibiting estrogen signaling both in vitro and in vivo" ppt
... immunoreactivity against ESR1 in 81% (34 out of 42) and 81% (21 out of 26) of the tumors, respectively We observed ESR1 in 73% of the well differentiated and in 84% of the dedifferentiated component of dedifferentiated ... Immunohistochemical staining of ESR1 and aromatase in various chondrosarcoma subtypes and cell lines Nuclear protein expression of ESR1 in well-differentiated (A) and dedifferentiated (B) components of dedifferentiated ... participated in the design of the study, the interpretation of data, and revision of the manuscript JVMGB conceived of the study, and participated in its design and coordination, and helped to...
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gjerstad & smith - rethinking housing bubbles; the role of household and bank balance sheets in modeling economic cycles (2014)
... 6in × 9in Top: 0. 5in Gutter: 0.87 5in CUUS2122-FM CUUS2122/Gjerstad ISBN: 978 521 19809 January 31, 2014 15:25 RETHINKING HOUSING BUBBLES The Role of Household and Bank Balance Sheets in Modeling ... Prize in Economic Sciences in 2002 for his groundbreaking work in experimental economics Dr Smith has joint appointments in the Argyros School of Business and Economics and the School of Law ... underlying economic analysis and policy? 1.3 Balance Sheet Recessions: A Missing Perspective In our view, the prominent role of balance sheets is the missing link in answering these questions and...
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Characterisation of the role of bifocal and its interacting partners in drosophila development
... Semaphorins Semaphorins are expressed in a wide variety of neuronal and nonneuronal tissues (reviewed in (Kolodkin and Ginty, 1997) Ephrin receptors (Eph) are members of the Receptor Tyrosine Kinase ... in photoreceptor axon guidance……… 27 1.4.6 Role of Bif and PP1 in photoreceptor axon guidance……….29 iii Table of Contents 1.5 Process of anchoring and maintaining molecules to the cortex of a cell………………………………………………………………29 ... Non-catalytic region of Tyrosine Kinase Nuclear Inhibitor of PP1 Nanometres Amino (NH2) terminal Optical Density Open Reading Frame Oo18 RNA-binding protein Oskar p-21 activated kinase Partitioning defective...
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Tài liệu Báo cáo khoa học: Role of cleavage and shedding in human thyrotropin receptor function and trafficking pdf
... measuring the binding of [125I]Streptavidin Specific binding at each point was normalized with reference to specific binding before the incubation at 37 °C (0-min point) to derive the fraction of initial ... a role for the extracellular domain in the stabilization of an inactive form of the unliganded receptor [29] Indeed, only cleavage in the E3 domain of the receptor, followed by receptor shedding, ... of the ectodomain of the M453T receptor, mimicking receptor shedding, led to a supplementary increase in receptor internalization, indicating probably a supplementary change in receptor conformation...
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Functional role of low density lipoprotein receptor related protein 5 and 6 in alzheimers disease
... domains: a 22-kDa N-terminal domain (residues 1-191) containing the low-density lipoprotein (LDL) receptor binding region (residues 136-150), a 10kDa C-terminal domain (residues 216-299) containing ... the lipid binding region (residues 244-272) and a hinge region to join the two domains (Figure 1-2) [45,47] Cys158 in apoE2 disrupts the receptor binding ability in N-terminal domain [54], while ... recruiting GSK3 binding proteins (GBP)/Frat-1 Wnt stimulation inhibits the activity of GSK3β, resulting in the accumulation and nuclear translocation of βcatenin [123] Inside the nucleus, β-catenin...
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Tài liệu Báo cáo khoa học: Role of K22 and R120 in the covalent binding of the antibiotic fosfomycin and the substrate-induced conformational change in UDP-N-acetylglucosamine enol pyruvyl transferase docx
... charged amino acid side chains, R397 and R120, are also involved in fosfomycin binding, and in view of the multitude of interactions, it was assumed that deletion of a single interaction would not ... chain of K22 participates in fosfomycin binding, thus providing a rationale for the loss of fosfomycin binding to the K22V and K22E mutant proteins However, two other positively charged amino ... enthalpies of binding and stoichiometries were determined from the binding isotherm by fitting a : binding model to the data using the software provided by the manufacturer Results Reaction of fosfomycin...
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The Role of Small and Large Businesses in Economic Development doc
... situation, offering an alternative to leaving (Anderson and Meyer) Further, larger firms offer more onthe-job training and more advancement opportunities, which makes it easier for them to maintain long ... efficient at innovation Small firms are the great innovators in some industries, while large firms are the great innovators in others Moreover, small and large businesses interact in innovative ... businesses are more effective innovators Further, the innovations of both small businesses and large businesses are inextricably linked Still, small firms create the majority of net new jobs and...
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Báo cáo khoa học: Role of DptE and DptF in the lipidation reaction of daptomycin ppt
... vector and overexpressed in Escherichia coli BL21(DE3) The C-terminally His6-tagged and N-terminally thioredoxin-fused protein was purified, yielding 4.4 mgÆL)1 of culture The identity of the protein ... motif present in DptF is GLDSV, indicating that this putative ACP domain is one of the few ACPs in which valine replaces isoleucine (I) or leucine (L) in the conserved sequence To determine whether ... domain in cis The latter type of fatty acid activation and loading was exclusively reported for PKS systems [14] Recently, lipidation of the acidic lipopeptide CDA was investigated in vivo and in...
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Báo cáo khoa học: Local stability identification and the role of key acidic amino acid residues in staphylococcal nuclease unfolding ppt
... and difference of DCp of mutant from wild-type (%) were determined and the results for the wild-type protein and 20 mutants are given in Table The DHcal and Tm of the wild-type protein were in ... local stable segments: interactions of G75 with H121 and K9, and of G129 with K110 and K133 Other charged amino acids such as D73, D83 and E101 reinforce the interactions of E75 and E129 ˚ (OE1 ⁄ ... fluorescent spectra of wild-type and mutants of SNase Spectra of nine proteins (WT, E73G, E75G, E101G, E122G, E129G, D77G, D83G and D95G) The spectrum of E129G (bold line) is much lower in intensity than...
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The Role of Gestures and Facial Cues in Second Language Listening Comprehension pptx
... group of people, pointing out that in such circumstances visual cues would be of little to no value This is a very specific interpretation of the meaning of lecture Having examined over 20 definitions ... understanding: The role of speech and gesture in comprehension and memory Journal of Memory and Language, 40, 577–592 Lansing, C R., & McConkie, G W (1999) Attention to facial regions in segmental and ... included in the response booklet They were allowed to inquire when they did not understand the meaning of the questions in this section Each session took 30 including instructions at the beginning,...
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Bringing the Hidden Giants to the Footlight: the Role of Savings and Retail Banks in Increasing the Level of Access to Financial Services docx
... use of their front and back of ce systems for disbursing of loans and collecting loan repayments Another promising track for savings banks is to invest their savings deposits in microfinance institutions ... microfinance institutions Linking savings to microcredits: Offering savings services requires a high level of institutional development to meet safety and soundness requirements Indeed, a large and widespread ... system, instead of relying on informal circuits In designing their products, savings banks take into account the special needs and limitations of lowincome households as well as those of more...
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The Role of Savings and Wealth in Reducing ―Wilt‖ between Expectations and College Attendance pdf
... or less are defined as ―uncertain.‖ There are 120 youth in this sample, and 453 in the combined (certain and uncertain) sample.5 Variables In this section, variables of interest and control variables ... important for explaining wilt In the case of income, youth living in low-income households experience higher levels of wilt (45%) than youth living in either modest-income (35%) or high-income (23%) ... of accumulating school savings may have effects apart from financing school Conley (2001) finds that a doubling of net worth results in an 8.3% increase in the probability of attending college...
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Báo cáo khoa học: Role of the plasma membrane leaflets in drug uptake and multidrug resistance ppt
... obtained by sequential exposure of cells to increasing concentrations of doxorubicin and was maintained in the presence of 0.5 lm doxorubicin 2008 parental cells and their MRP1 over-expressing ... data reported in the present study, and obtained in living cells, confirm the finding obtained in reconstituted proteoliposomes [11,12] and isolated membranes [29,30] indicating that Pgp and a bacterial ... half-life of the flip-flop of dye across the membrane Surprisingly, and of interest, the active uptake of dye into the mitochondria prevented the accumulation of dye in the cytoplasmic leaflet of the...
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Báo cáo khoa học: Tertiary structure in 7.9 M guanidinium chloride ) the role of Glu53 and Asp287 in Pyrococcus furiosus endo-b-1,3-glucanase pot
... role in protein stability [8], and their involvement in interactions with cations offers new perspective in the analysis of the contribution of ions as cofactors in protein folding [38] and in ... presence of one or two potential binding sites for metals and two pairs of negatively charged amino acid residues have been assumed to be involved in calcium binding: Glu53 and Asp287, and Glu239 and ... decreases in 7.9 m GdmCl and increases in native conditions Discussion The results obtained with pfLamA mutant forms indicate that residues Glu53 and Asp287 are involved in calcium binding, in accordance...
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Tìm thêm: xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 sự cần thiết phải đầu tư xây dựng nhà máy từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose