... words denoting parts of humanbodyin English and Vietnamese, there are words having primary meanings referring to parts of humanbodyand words having derived meaning referring to them ( their primary ... denoting parts of thehumanbodyin English 1) Abdomen 1 .The part of the body, below the chest, containing the stomach, bowels The back part of an insect 2) Arm Either of the two upper limbs of the ... part of garment covering the knee 42) Knuckle Any joint inthe fingers esp those where the fingers joint the rest of the hand ( of animal) Knee or joint joining the leg to the foot esp as apiece...
... HumanHealth Certain key cellular components cannot be synthesized inthebodyand must therefore be provided preformed inthe diet and are therefore designated as essential These molecules include ... (oxaloacetate inthe TCA cycle and ornithine inthe urea cycle) At the end of one cycle, the key intermediate is regenerated and available to participate in another turn of the cycle Although the TCA and ... Regulation of the functioning of the many enzymes inthebody is central to coordinating the multiple pathways of metabolism and maintaining homeostasis One key mechanism for regulating the level...
... involved in ligand binding, presumably abolishing the interaction with signaling partners The remaining mutations alter amino acids located outside the ligand-binding pocket and reduce protein ... lymphoproliferative disease Arginine 335 is found inthe ‘BG loop’ not involved in phosphotyrosine binding and mutation to tryptophan most probably causes instability of the SH2 domain Thus, these patients ... the linker B kinase region of SYK The PH domain of TFKs usually binds to phosphatidylinositol-3,4,5-trisphosphate, thereby bringing them in close proximity to other membrane-tethered signaling...
... participate inthe process of the control of the composition of the extracellular space inthe brain: the cellular elements constituting intraparenchymal vessels, the endothelial cells lining the intraluminal ... originating inthe brain start in these accessory systems of the neuronal microenvironment and affect neurons only second hand Therefore, understanding the elements of the neuronal environment and ... interactions The special status of the brain in having its own insulated circulation system — the cerebrospinal fluid contained inthe ventricles and ducts — is also underlined The brain is the only...
... between the EGFR andthe androgen receptor in prostate carcinoma cells [50] The interplay between decorin andthe EGFR is further underscored by osteosarcoma cells which escape the decorin-suppressing ... overlapping with the EGF-binding domain [32] The structural constraints of the EGFR binding region support a stochiometry of : for the decorin protein core and EGFR, suggesting that decorin is biologically ... species- and heat shock protein 90-dependent manner These combined signaling events culminate inthe activation of caspase andinthe processing of pro-IL-1b into its mature form, without the need...
... occludens-domain-containing proteins such as syntenin, Ga-interacting protein (GAIP)-interacting C-terminus ⁄ synectin and calcium ⁄ calmodulin-associated serine kinase, since the C2 region contains a ... motif) that maintains them as inactive zymogens, and a catalytic domain with a zinc-binding site (Zn, HEXXHXXGXXH) and a conserved methionine (Met-turn) supporting the catalytic zinc Interaction ... cysteine–zinc maintains proMMPs in an inactive state by preventing a water molecule from binding to the zinc atom All MMPs, with the exception of MMP-7, MMP-23 and MMP-26, also contain a hemopexin-like...
... would stint the growth of such a child, and induce a state of body deficient in vigour, and unfit for maintaining full health: scrofula and other diseases would be induced At the same time let the ... impaired SYMPTOMS. The earliest symptom is a dragging sensation inthe back when the child is inthe act of sucking, and an exhausted feeling of sinking and emptiness at the pit of the stomach afterwards ... against, that of covering up the infant in its cot with too much clothing throwing over its face the muslin handkerchief and, last of all, drawing the drapery of the bed closely together The...
... defects in any of the pathways influencing the L1 lifecycle are more vulnerable to insult from TEs Thus, to evaluate the impact of these elements on the stability of thehuman genome andhuman disease, ... Detection and diagnosis of diseases caused by TE insertion The introduction of PCR technology for diagnostics revolutionized the field of human genetic testing Within a clinical setting, PCR across the ... clarify the extent of the contribution of mobile elements to genetic instability in many human diseases This infor a m tion is critical in determining the full spectrum of mutations contributing...
... region encoding the carboxy-terminal propeptide domain; H, encodes the heparin-binding domain; N, encodes the NRP1/heparin-binding domain; NP, encodes the amino-terminal propeptide domain; SP, signal ... mediated by two distinct domains In VEGF-A, these correspond to the basic heparin-binding domain encoded by exon andthe NRP1/heparin-binding domain encoded by exons and [10] The nuclear magnetic ... within the cystine-knot superfamily, notably the glycoprotein hormone and mucin-like protein families and, more distantly, the transforming growth factor- (TGF) family The absence of any of these...
... types The approach is remarkably general in that almost any type of data may be incorporated, andinthe paper they include compelling examples of the integration of expression and protein sequence ... of the actomyosin ring during cytokinesis [32] Further research will be required to address how frequently these mitotic DNA breaks occur in vivo and whether they can explain the chromosomal ... neurodegeneration and aging Recent discoveries that abnormal chromosome numbers impact on protein homeostasis has pointed out a possible link to neurodegenerative diseases and instigated the interest in the...
... are incorporated into protein during protein synthesis Of the 20 amino acids in proteins, some are synthesized de novo inthebody from either other amino acids or simpler precursors These amino ... of the limiting amino acid is the protein's score Typically, the limiting amino acids in dietary proteins are lysine, the sulfur-containing amino acids, threonine, and/ or tryptophan The BCAAs and ... approaches Purine and Pyrimidine Biosynthesis The purines (adenine and guanine) andthe pyrimidines (uracil and cytosine) are involved in many intracellular reactions when high-energy di- and triphosphates...
... The hemopexin-like domain (C domain) of human gelatinase A (matrix metalloproteinase-2) requires Ca2+ for fibronectin and heparin binding Binding properties of recombinant gelatinase A C domain ... described the molecular interactions of the HPX domains of the various human MMPs [3] The various domains, modules and motifs inthe MMPs are involved in interactions with other molecules, and hence ... One involves proteolytic processing of one or several nuclear proteins, whereas the other is independent of the processing capacity of the proteinase and involves the HPX domain A DNA-binding...
... evidences indicate that HSPGs act to inhibit cellular invasion by promoting tight cell–cell and cell–ECM interactions, and by maintaining the structural integrity and self-assembly of the ECM [10,11] ... remodeling of the ECM underlying tumor and endothelial cells, thereby facilitating cell invasion [23–25] Progress inthe field andthe generation of genetic tools (i.e heparanase transgenic and knockout ... comprising this segment linked to the C-domain sequence (8-C) [73,78] This finding further supports the predicted 3D model, indicating that the C-domain is indeed a valid functional domain responsible...
... located inthe N-terminal and Cterminal domains are in close vicinity to each other on the opposite side of LDL [36] In addition, a prominent protrusion is visible inthe images at the pointed ... times, the target protein or particle has to be purified from the blood of human probands andthe New Insights into the Assembly and Metabolism of ApoB-Containing Lipoproteins from in vivo Kinetic ... though, one has to keep in mind that these domains are not static or confined in size and number and co-determine the intrinsic dynamics of LDL Based on these types of findings, it seems reasonable...
... of the enzyme andthe formation of tight inhibitory complexes An understanding of the role played by serine proteases and their specific inhibitors inhuman diseases offers novel and challenging ... be due to the inhibition of serine proteases involved inthe cleavage of neu-oncogen protein on the cell surface, preventing the release of the extracellular domain of the protein into the bloodstream ... half-life of 10 h in rats and hamsters, and are excreted in urine and faeces [38] In humans, BBI are taken up rapidly and can be detected inthe urine within 24-48 h [6] These findings suggest that...
... heterodimers and prevent their binding to inflammatory gene promoter, thereby inhibiting the transcription of these genes (Hayden & Ghosh, 2008) In agreement, endotoxin-tolerant murine macrophages andhuman ... produced by the immune system but recognise the proteins produced inthe individual’s own bodyThe antibodies that usually attack the proteins present inthe nucleus of the cell are called antinuclear ... planned bearing in mind the recent developments in this growing field The book brings important developments both inthe field of molecular mechanisms involved in Immunosuppression and active therapeutic...
... alive to dead grains and should be Ͼ95% in rapid tests; Ͼ96% after cleaning and sorting in storage Non-germinating grains retained as raw during malting may become infected by mildew and bacteria ... beer Minerals originate inthe embryo andthe aleurone layer inthe endosperm (Figure 1.1) They constitute 3% of the grain dry weight and are organically bound to about 80% The most important minerals ... provide insight into the possibilities of the role of beer inhealth maintenance as well as prevention of diseases Contributors are authors of international and national standing, leaders in the...
... heterodimers and prevent their binding to inflammatory gene promoter, thereby inhibiting the transcription of these genes (Hayden & Ghosh, 2008) In agreement, endotoxin-tolerant murine macrophages andhuman ... produced by the immune system but recognise the proteins produced inthe individual’s own bodyThe antibodies that usually attack the proteins present inthe nucleus of the cell are called antinuclear ... planned bearing in mind the recent developments in this growing field The book brings important developments both inthe field of molecular mechanisms involved in Immunosuppression and active therapeutic...