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the human body in health and disease 5th edition pdf

Tài liệu Báo cáo khoa học: TEC family kinases in health and disease – loss-of-function of BTK and ITK and the gain-of-function fusions ITK–SYK and BTK–SYK pptx

Tài liệu Báo cáo khoa học: TEC family kinases in health and disease – loss-of-function of BTK and ITK and the gain-of-function fusions ITK–SYK and BTK–SYK pptx

Báo cáo khoa học

... directly involved in ligandbinding, presumably abolishing the interaction withsignaling partners. The remaining mutations alteramino acids located outside the ligand-binding pocket and reduce ... lymphoproliferative dis-ease. Arginine 335 is found in the ‘BG loop’ notinvolved in phosphotyrosine binding and mutation totryptophan most probably causes instability of the SH2 domain. Thus, these patients ... prolineson peptide folding [21]. Thus, proline is a rigid aminoacid creating a fixed kink in a protein chain.Similar to the situation in many other genes, CpGdinucleotides in the BTK gene are more...
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The Neuronal Environment: Brain Homeostasis in Health and Disease pot

The Neuronal Environment: Brain Homeostasis in Health and Disease pot

Điện - Điện tử

... explain theseinteractions. The special status of the brain in having its own insulated circulationsystem the cerebrospinal fluid contained in the ventricles and ducts—is also under-lined. The ... metabolites and to remove waste products. The Neuronal Environment: Brain Homeostasis in Health and Disease examines the function of all the components involved, including their perturbation dur-ing ... fluids in the brain at the mercy of the brain cells themselves. The subse-quent necessity to shield the central nervous system from uncontrolled systemic influ-ences, and in order to minimize the...
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Báo cáo khoa học: Proteoglycans in health and disease: novel regulatory signaling mechanisms evoked by the small leucine-rich proteoglycans ppt

Báo cáo khoa học: Proteoglycans in health and disease: novel regulatory signaling mechanisms evoked by the small leucine-rich proteoglycans ppt

Báo cáo khoa học

... decorin in the regulation of IGF-IR and to clarifywhether decorin ⁄ IGF-IR signaling might be operative in carcinoma cells as well. The complexity of decorin signaling is furtherexpanded by ... with the EGF-binding domain [32]. The structural constraints of the EGFR binding regionsupport a stochiometry of 1 : 1 for the decorin pro-tein core and EGFR, suggesting that decorin is bio-logically ... signaling,including vinculin and focal adhesion kinase [82].Lumican alters the relationship between actin filaments and b1 integrin, which in turn would affect focal adhe-sion formation, thereby...
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Báo cáo khoa học: Proteoglycans in health and disease: the multiple roles of syndecan shedding ppt

Báo cáo khoa học: Proteoglycans in health and disease: the multiple roles of syndecan shedding ppt

Báo cáo khoa học

... Zonulaoccludens-domain-containing proteins such as syntenin,Ga-interacting protein (GAIP)-interacting C-terminus ⁄synectin and calc ium ⁄ calmodulin-associated serine kinase,since the C2 region contains a ... motif) that maintains them as inactivezymogens, and a catalytic domain with a z inc-binding site(Zn, HEXXHXXGXXH) and a conserved methionine(Met-turn) supporting the catalytic zinc. Interactionbetween ... cannot bindproMMP2, but the N-terminal region of TIMP-2 binds the catalytic domain of MT1-MMP inhibiting itsactivity, whereas its C-terminal domain binds to the hemopexin-like domain of Pro-MMP-2...
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The Maternal Management of Children, in Health and Disease ppt

The Maternal Management of Children, in Health and Disease ppt

Sức khỏe giới tính

... against, that of covering up the infant in its cot with too much clothing throwing overits face the muslin handkerchief and, last of all, drawing the drapery of the bed closely together. The ... rendered a painful and difficult one, byerrors in the management of the regimen and health of the infant, previously to the coming of the teeth, and during the process itself.Thus, chiefly in consequence ... feeding must in part be here resorted to. THE INJURIOUS EFFECTS TO THE MOTHER AND INFANT OF UNDUE AND PROTRACTEDSUCKLING.UPON THE MOTHER The period of suckling is generally one of the most healthy...
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Modern Nutrition in Health and Disease pot

Modern Nutrition in Health and Disease pot

Sức khỏe giới tính

... selected; the amino acid with the lowest score is defined as the limiting amino acid. The chemical score of the limiting amino acid is the protein's score. Typically, the limiting amino acids in ... dietary proteins are lysine, the sulfur-containing amino acids, threonine, and/ or tryptophan. The BCAAs and phenylalanine/tyrosine are not usually limiting. The scoring method points out the obvious: ... at the sites of protein synthesis in the body in the same proportions that go into the protein ( 177). Assuming that any nonessential amino acid would not be limiting, they proposed that the...
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Báo cáo khoa học: Regulation of matrix metalloproteinase activity in health and disease pdf

Báo cáo khoa học: Regulation of matrix metalloproteinase activity in health and disease pdf

Báo cáo khoa học

... One involves proteolytic processingof one or several nuclear proteins, whereas the other isindependent of the processing capacity of the protein-ase and involves the HPX domain. A DNA-bindingdomain ... various domains of the MMP participated in the activation. Both the HPX and the Cat-Hinge regions activated the promoter,whereas the prodomain and the hinge-region alonehad no effect on the activation. ... interacting with the conserved cysteine in the prodomain. Another is the induction of conforma-tional changes through binding of chaotropic agents and detergents such as SDS. In all cases, the...
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Báo cáo khoa học: Proteoglycans in health and disease: new concepts for heparanase function in tumor progression and metastasis pptx

Báo cáo khoa học: Proteoglycans in health and disease: new concepts for heparanase function in tumor progression and metastasis pptx

Báo cáo khoa học

... to the TIM-barrel fold [73]. The predictedheparanase structure led to the hypothesis that the seemingly distinct protein domains observed in the 3Dmodel, namely the TIM-barrel and C-domain ... evidences indicate thatHSPGs act to inhibit cellular invasion by promotingtight cell–cell and cell–ECM interactions, and by main-taining the structural integrity and self-assembly of the ECM ... variantAlmost all protein-coding genes contain introns thatare removed in the nucleus by RNA splicing and areoften alternatively spliced. Alternative splicingincreases the coding capacity of the genome,...
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