the design of everyday things revised and expanded edition mobi
BONUS MATERIAL ADDED TO THE REVISED AND EXPANDED 2006 EDITION
... then the automobile led to the disappearance of the horses, and with them went their dung Most of the animal dung produced in today’s New York comes from our dogs (Estimates of the dog population ... incentives the hard glare of a passer-by and the offender’s feelings of guilt—are at least as powerful as financial and legal incentives If social forces get us most of the way there, how we deal with the ... nothing of the horse urine, the deafening clatter of hooves or the carcasses left to rot in the street.) The manure was so widespread and smelly and unsanitary that brownstones were built with their...
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Tài liệu Color Atlas of Pharmacology 3rd edition, revised and expanded docx
... the inhaler (spray dispenser) is held directly in front of the mouth and actuated at the start of inspiration The effectiveness of delivery depends on the position of the device in front of the ... the mouth, the size of the aerosol particles, and the coordination between opening the spray valve and inspiration The size of the aerosol particles determines the speed at which they are swept ... the form of postlicensing studies (Phase IV of clinical trials) Only on the basis of longterm experience will the risk–benefit ratio be properly assessed and, thus, the therapeutic value of the...
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Báo cáo khoa học: The structural comparison of the bacterial PepX and human DPP-IV reveals sites for the design of inhibitors of PepX activity pot
... group of the ligand and the NH2 of Asn470 (equivalent to Asn710 in DPP-IV) Another potential bond can be proposed between the OH atom of Tyr380 and the carbonyl group of the ligand Finally, the ... lactis The results are presented in Table and Fig 4A For the cluster of lowest energy, both the position and the conformation of the ligand are close to those observed in the 3D structure of the ... comparison of the active and specificity sites of the two X-PDAP enzymes, the bacterial PepX (green) and the human DPP-IV (orange) (B) Superposition of the active and specificity sites of the S9 enzymes...
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Báo cáo khoa học: Insights into the design of a hybrid system between Anabaena ferredoxin-NADP+ reductase and bovine adrenodoxin pot
... to the changes introduced in the redox cofactor environment upon complex formation They are therefore related to the specificity and the strength of the protein–protein interaction Therefore, the ... allowing the determination of a Kd value of 25 ± lM for the [FNRox:Adxox] complex and of 17 ± lM for the [FNRox:Adx(4–108)ox] complex (Table 1) Study of the kinetics of reduction of WT Adx by FNRrd Stopped-flow ... absorption band is consistent with the presence of FNRsq and it is already present at the very beginning of the reaction, indicating that its formation takes place within the dead time of the steady-state...
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Báo cáo khoa học: "User studies and the design of Natural Language Systems" doc
... called the "Wizard of Or" (henceforth W O Z ) which also avoids the problem of the fragility of current systems by simulating the operation of the system rather than using the system itself A In these ... graphics packages Of the remainder, had some experience with using databases and one of these had participated in the design a database None of them was familiar with the current state of N L technology ... the structure of far back as the beginning of the current subdialogue, the information source, Is a portrait the s a m e as a or even the beginning of the whole dialogue self portrait? Here the...
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fluid dynamics of packed columns principles of the fluid dynamic design of columns for gasliquid and liquidliquid systems
... a separate list of symbols at the beginning of the book The first German edition of the book was written between 1988 and 1990 and the second one evolved between 1997 and 2002 The first English ... represents the operating costs of normal pressure rectification Depending on the difference between the temperatures at the bottom tW and at the top tD of the column, and on the price of the heating ... liquid load uL The higher the loading capacity of the column in the case of countercurrent flow of the phases, i.e the higher the gas velocity at the flooding point uV , the smaller the required...
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Cambridge.University.Press.Gender.Race.and.the.Writing.of.Empire.Public.Discourse.and.the.Boer.War.Sep.1999.pdf
... the food stocks, and the mood of the garrison The tactics of the Daily Mail captured the attention of the nation; the newspaper dramatized the situation of the town by emphasizing the danger that ... examine both the role of the press in the formation of public opinion about imperialism and the role of the press in the formation of the concept of public opinion itself Mafeking Night marks the powerful ... powerful beginning of the New Journalism at the same time as it marks the beginning of the end of the New Imperialism The coincidence of these occasions arises from the nature of the South African...
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The design of mat foundations
... below the active soil zone Expansive soils are most prevalent on the Atlantic and Gulf coastal plain and in some areas of the central and western United States Photograph of the construction of the ... Therefore, the average pressure increase in the clay layer is, ∆qavg = (92.3 + 4(78.8) + 69.8) = 79 psf The pressure po at the center of the clay layer is, po = γ sand h sand + γ’ sand h’ sand ... d of the mat by checking for diagonal tension shear at the columns (ACI 318 11.12.2.1c); 7) From the all the moment diagrams of all the strips in one direction, choose the maximum positive and...
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Báo cáo y học: "An unusual case of gout in the wrist: the importance of monitoring medication dosage and interaction. A case report"
... in the wrist due to gout [6,8,9] The prevalence of gout in the USA ranges between 0.5–2.8% in men and 0.1–0.6% in women [2] The prevalence rises to 4.4% of men and 1.8% of women over the age of ... at the carpal-metacarpal joint at the base of the thumb The report stated that the radiographs were otherwise normal The patient's symptoms worsened with increased pain and swelling over the ... incidence of gout has been reported in the USA and New Zealand over the past 30 years, while the prevalence of gout has been reported to have risen three-fold in the UK over 20 years of follow-up...
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Báo cáo y học: "Ultra-low microcurrent in the management of diabetes mellitus, hypertension and chronic wounds: Report of twelve cases and discussion of mechanism of action"
... major role in the pathogenesis of both types of diabetes mellitus High levels of free radicals and the decline of antioxidant defense mechanisms lead to damage of cellular organelles and enzymes, ... current (maximum of milliAmperes) of one polarity for 11.5 minutes, which then switched to the opposite polarity for another 11.5 minutes The device was designed to switch the direction of current ... bilaterally with poor capillary refill The left foot was red and inflamed up to and including the medial malleolus The lateral aspect of the great toe and second toe turned black Laboratory investigation...
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