the design of everyday things revised and expanded edition ebook
BONUS MATERIAL ADDED TO THE REVISED AND EXPANDED 2006 EDITION
Ngày tải lên :
17/10/2013, 18:20
... incentives the hard glare of a passer-by
and the offender’s feelings of guilt—are at least as powerful as finan-
cial and legal incentives.
If social forces get us most of the way there, how ... that the outcome of that election came down to a handful of
voters; but their names were Kennedy, O’Connor, Rehnquist, Scalia
and Thomas. And it was only the votes they cast while wearing their ... out the
effect of the money. As with the police/crime rate puzzle, he had to
trick the data.
Because he himself had typed in the data, he had noticed some-
thing: often, the same two candidates...
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Tài liệu Color Atlas of Pharmacology 3rd edition, revised and expanded docx
Ngày tải lên :
17/02/2014, 05:20
... and conditions of license.
Color Atla s of
Pharmac ology
3rd edition, revised and expanded
Heinz Lüllmann,
M.D.
Former Professor and Chairman
Department of Pharmacology
University of Kiel
Germany
Klaus ... analgesic ibuprofen.
The excess of analogue preparations and
the unnecessary diversity of trade names for
oneandthesamedrugmakethepharma-
ceutical markets of some countries (e. g.,
Germany) rather perplexing. ... knowledge of the preventive
and therapeutic value of drugs is a sine qua
non for the successful treatment of patients
entrusting themselves to a physician or
pharmacist.
Because of the plethora of proprietary...
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Báo cáo khoa học: The structural comparison of the bacterial PepX and human DPP-IV reveals sites for the design of inhibitors of PepX activity pot
Ngày tải lên :
23/03/2014, 13:20
... DPP-IV). Another potential bond can be
proposed between the OH atom of Tyr380 and the car-
bonyl group of the ligand. Finally, the valine side
chain of the ligand, pointing towards the active ... be
the reference); 2, docked into the active site
of the human DPP-IV; 3, docked into the
active site of the crystalline structure of
PepX from L. lactis ;and4 , docked into the
active site of the ... 2).
The interactions of the bound ligand with the resi-
dues of the specificity site (Fig. 4A) reveal good stack-
ing between the pyrrolidine ring of the drug and the
side chain of Tyr380 (Pos1 subsite),...
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Báo cáo khoa học: Insights into the design of a hybrid system between Anabaena ferredoxin-NADP+ reductase and bovine adrenodoxin pot
Ngày tải lên :
31/03/2014, 07:20
... the changes introduced in the
redox cofactor environment upon complex formation. They
are therefore related to the specificity and the strength of the
protein–protein interaction. Therefore, the ... determination of a K
d
value of 25 ± 3 l
M
for the [FNR
ox
:Adx
ox
] complex and of 17 ± 2 l
M
for the
[FNR
ox
:Adx(4–108)
ox
] complex (Table 1).
Study of the kinetics of reduction of WT Adx by ... physiological
significance and support the hypothesis of the existence of a
ternary ET [Adx:Adx:AdR] complex in the physiological
AdR/P450 system [16,36,37]. Therefore, our experimental
data for the reduction of Adx...
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Báo cáo khoa học: "User studies and the design of Natural Language Systems" doc
Ngày tải lên :
01/04/2014, 00:20
...
to a person (The Wizard) at another terminal who
answered the subject's requests by consulting paper
copies of the database tables.
The experimenter then gave the details of the two
tasks. ... consult the
3.1.1 Operators and the explicit specification
of set properties
The task of database access involves the construction
and manipulation of answer sets with various prop-
erties.
The ...
order.
These would involve two operations,
the first would be the generation of a set, and the sec-
ond the sorting of that set in terms of some attribute
such as age or date. The unknown...
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Cambridge.University.Press.Gender.Race.and.the.Writing.of.Empire.Public.Discourse.and.the.Boer.War.Sep.1999.pdf
Ngày tải lên :
21/09/2012, 10:54
... food stocks, and the mood of the garrison. The tactics
of the Daily Mail captured the attention of the nation; the newspaper
dramatized the situation of the town by emphasizing the danger that ... notions of Boer inhumanity toward
Africans, the pro-war argument of the ‘‘negrophilists.’’ The other cat-
egory into which mentions of Africans fall is praise of the loyalty of the
Cape Boys and the ... hierarchies of race, sex, and class
and of the ways in which, hand in hand, the New Imperialism and the
New Journalism brought Britain into the twentieth century.
The war at home
which included the...
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The design of mat foundations
Ngày tải lên :
16/10/2012, 10:43
... (92.34(78.8)69.8)
79
6
avg
qpsf
++
∆==
Therefore, the average pressure increase in the clay layer is,
The pressure p
o
at the center of the clay layer is,
p
o
= γ
sand
h
sand
+ γ’
sand
h’
sand
+ γ’
clay
h’
clay
= (100)(4) ... being designed for a small office building with a total live load of 250 kips
and dead load of 500 kips. Find: (a) the depth D
f
for a fully compensated foundation, (b) the
depth D
f
if a soft ... in the x and y values,
which these values are found by using the x-y coordinate system off the mat foundation.
Determine the average soil reaction.
(92.34(78.8)69.8)
79
6
avg
qpsf
++
∆==
Therefore,...
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Báo cáo y học: "An unusual case of gout in the wrist: the importance of monitoring medication dosage and interaction. A case report"
Ngày tải lên :
25/10/2012, 10:06
... men and 0.1–0.6% in
women [2]. The prevalence rises to 4.4% of men and 1.8%
of women over the age of 65 [4]. A two-fold increase in
incidence of gout has been reported in the USA and New
Zealand ... publication was obtained from the patient.
The authors wish to thank Dr. William Hsu and Dr. Tania Pringle for their
contribution to the interpretation of the radiographs and providing key
information ... that
these were most likely due to old trauma. Mild osteoar-
thritic changes were noted at the carpal-metacarpal joint
at the base of the thumb. The report stated that the radio-
graphs were otherwise...
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Báo cáo y học: "Ultra-low microcurrent in the management of diabetes mellitus, hypertension and chronic wounds: Report of twelve cases and discussion of mechanism of action"
Ngày tải lên :
26/10/2012, 09:39
... role in the
pathogenesis of both types of diabetes mellitus. High
levels of free radicals and the decline of antioxidant
defense mechanisms lead to damage of cellular or-
ganelles and enzymes, ... (maximum of 3 milliAm-
peres) of one polarity for 11.5 minutes, which then
switched to the opposite polarity for another 11.5
minutes. The device was designed to switch the di-
rection of current ... Popliteal and pedal
pulses were absent bilaterally with poor capillary re-
fill. The left foot was red and inflamed up to and in-
cluding the medial malleolus. The lateral aspect of the
great toe and...
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Báo cáo y học: "Grb2-associated binder 1 polymorphism was associated with the risk of Helicobactor pylori infection and gastric atrophy"
Ngày tải lên :
31/10/2012, 15:37
... molecular mechanisms of action of this
polymorphism. Because these results were based on
the low frequency of A/A
, they might be inconsistent
due to the random errors. Studies of a larger size ... diagnosis of
cancer.
In summary, the Gab1 A/A was associated with
the low risk of H. pylori infection while the G/A and
A/A genotypes together may increase the risk for
gastric atrophy. The biological ... chance of natural eradication of the
bacteria. However, the OR of the A/A genotype for H.
pylori seropositivity was 0.25 (95% CI 0.09-0.71). So,
the Gab1 polymorphism was associated with the...
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An Overview into the Semantic of Questions in English and Vietnamese
Ngày tải lên :
22/01/2013, 09:28
... mainly focuses on the semantics of questions
that function as a request for information. The semantics refers to the close and
intense relationship between the form and the meaning of a sentence ... confirmation, we can reverse
the position of the tag to the beginning of the question (Thiêm, 2004). The tags
can be put at the beginning or function as a new sentence to indicate the
speaker’s emphasis. ... we can see from the above examples, questions of this type contain two
opposite clauses, in which the positive one normally stand at the front and the
negative one is often in the back (Thiêm,...
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Cannibals or knights – sexual honor in the propaganda of Arthur Conan Doyle and W. T. Stead
Ngày tải lên :
01/11/2013, 08:20
... in the chivalric world of war marked either the uncon-
trollable lust of the British soldier in wartime or the self-controlled lust of
the British soldier in wartime.
In one of the last of the ... to the
camps – they were an important part of his defense of the sexual honor
of the British soldier. First Doyle gave his version of the origin of the
camps: ‘‘Considerable districts of the ... of the Boer soldier as defender of his country from invasion
Stead weds the language of the Slaughter of the Innocents (a ‘‘decree
went forth’’).
In attacking Stead and the other critics of the...
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