[...]... Luellmann, Color Atlas of Pharmacology © 2005 Thieme All rights reserved Usage subject to terms and conditions of license Drug and Active Principle A From poppy to morphine Raw opium Preparation of opium tincture Morphine Codeine Narcotine Papaverine etc Opium tincture (laudanum) Luellmann, Color Atlas of Pharmacology © 2005 Thieme All rights reserved Usage subject to terms and conditions of license 5... (p.124), fentanyl (p 212) and the gonadal hormones (p 250) Luellmann, Color Atlas of Pharmacology © 2005 Thieme All rights reserved Usage subject to terms and conditions of license External Barriers of the Body A External barriers of the body Ciliated epithelium Nonkeratinized squamous epithelium Epithelium with brush border Keratinized squamous epithelium Luellmann, Color Atlas of Pharmacology © 2005 Thieme... rights reserved Usage subject to terms and conditions of license 2 History of Pharmacology History of Pharmacology The Impetus Since time immemorial, medicaments have been used for treating disease in humans and animals The herbal preparations of antiquity describe the therapeutic powers of certain plants and minerals Belief in the curative powers of plants and certain substances rested exclusively... prolong the action of drugs that have a short sojourn in the body Luellmann, Color Atlas of Pharmacology © 2005 Thieme All rights reserved Usage subject to terms and conditions of license Oral Dosage Forms A Oral administration: drug release and absorption Administration Enteric coated tablet Tablet, capsule Drops, mixture, effervescent solution Matrix tablet Luellmann, Color Atlas of Pharmacology © 2005... directly in front of the mouth and actuated at the start of inspiration The effectiveness of delivery depends on the position of the device in front of the mouth, the size of the aerosol particles, and the coordination between opening the spray valve and inspiration The size of the aerosol particles determines the speed at which they are swept along by inhaled air, and hence the depth of penetration into... disciples (12 of whom were appointed to chairs of pharmacology) , helped establish the high reputation of pharmacology Fundamental concepts such as structure–activity relationships, drug receptors, and selective toxicity emerged from the work of, respectively, T Frazer (1840–1920) in Scotland, J Langley (1852–1925) in England, and P Ehrlich (1854–1915) in Germany Alexander J Clarke (1885–1941) in England first... industry outside established university institutes After 1960, departments of clinical pharmacology were set up at many universities and in industry Luellmann, Color Atlas of Pharmacology © 2005 Thieme All rights reserved Usage subject to terms and conditions of license 4 Drug Sources Drug and Active Principle Until the end of the 19th century, medicines were natural organic or inorganic products,... conditions of license General Pharmacology History of Pharmacology Drug Sources 2 4 Drug Development 8 Drug Administration 12 Cellular Sites of Action 20 Distribution in the Body Drug Elimination Pharmacokinetics 22 32 44 Quantification of Drug Action Drug–Receptor Interaction Adverse Drug Effects 52 56 70 Genetic Variation of Drug Effects Drug- independent Effects 78 80 Luellmann, Color Atlas of Pharmacology. .. countries (e g., Germany) rather perplexing A critical listing of essential drugs is a prerequisite for optimal pharmacotherapy and would be of great value for medical practice Luellmann, Color Atlas of Pharmacology © 2005 Thieme All rights reserved Usage subject to terms and conditions of license Congeneric Drugs and Name Diversity 11 A β-Blockers of similar basic structure Substituted O phenoxy Isopropanol... acute attack of gout (cf p 326) Furthermore, colchicine prevents mitosis, causing an arrest in metaphase (spindle poison) _ _ 1 This name reflects the poisonous property of the plant: Atropos was the one of the three Fates (moirai) who cut the thread of life Luellmann, Color Atlas of Pharmacology © 2005 Thieme All rights reserved Usage subject to terms and conditions of license European . conditions of license. Color Atla s of Pharmac ology 3rd edition, revised and expanded Heinz Lüllmann, M.D. Former Professor and Chairman Department of Pharmacology University. Data Taschenatlas der Pharmakologie. Englisch. Color atlas of pharmacology/ Heinz Luellmann [et al.]; 172 color plates by Juergen Wirth.— 3rd ed., rev. and expanded p.