... compared with morphine (C) NAC failed to suppress phosphorylation of JNK induced by h of morphine treatment Cells were either treated with mM morphine alone or treated with mM morphine in combination ... et al Role of JNK signaling in morphine- induced apoptosis A D B C Fig Morphine treatment induced cytochrome c release and caspase-3 and caspase-9 activation (A–C) Morphine (Mor) dose-dependently ... zVAD-fmk, a broad-spectrum caspase inhibitor, on morphineinduced cytochrome c release SH-SY5Y cells were treated with morphine alone or concomitantly with morphine and zVAD-fmk for 24 h As shown in...
... to morphine; 2) morphine' s enhancement of CCL2 was specific for neurons, as witnessed by a lack of response of astrocytes and microglia to morphine under our experimental conditions; and 3) morphine' s ... upregulated by morphine exposure Using an ELISA to measure CCL2 protein, the stimulation of CCL2 production by morphine was found to be both concentration-dependent, with maximal effect at 10-6 M morphine ... exposed to morphine 10-4 M was confirmed by MTT and apoptotic assays (data not shown) Morphine does not enhance CCL2 production in human astrocytes and microglial cells To further assess if morphine' s...
... day and compared the pretest data of morphine (10 mg/kg, s.c.) with the same dose of morphine on 21th day post-transfection (21 days M10) (Fig 3) We found that morphine at a dose of 10 mg/kg did ... spinal cord of control mice (Fig 2C) Morphine was antinociceptive and induced tolerance after the transfection of the dsAAV2-MORS196A-EGFP gene As expected, morphine (10 mg/kg, s.c.) did not have ... http://www.jbiomedsci.com/content/17/1/28 Page of Table 1: Tolerance induced by morphine but not naloxone in MOR-KO mice that had been transfected with the dsAAV2MORS196A-EGFP gene ED50 of morphine (mg/kg) Acute effect Sub-chronic...
... receiving first injection of morphine (B) The latency and AUC of rats after receiving 7th injection of morphine (C) Rate of tolerance development to morphine in morphine or saline prenatally ... to morphine and methadone In addition, our study obtained similar antinociceptive response and development of tolerance to morphine in prenatally methadone- and morphine- exposed offspring The morphine- induced ... Effects of prenatal morphine administration on morphineinduced supraspinal antinociception There was a significant decrease of the antinociceptive activity in prenatally morphine- exposed rats...
... dependence [10] Although the exact mechanism underlying morphine dependence is not fully understood, it has been reported that morphine dependence and morphine withdrawal syndrome are associated with ... after the 8th day of morphine injection, * p < 0.05 tested by Student's ttest) b: CPP in the MW group (MW group after the 8th day morphine injection and after 5th day of morphine withdrawal) ... 418(2):147-155 Dubs A, Wiedemeier P, Caduff B: Morphine poisoning in chronic kidney failure Morphine- 6-glucuronide as a pharmacologically active morphine metabolite Dtsch Med Wochenschr 1999,...
... the morphine group vs the control group; D: **p < 0.001 for the morphine group vs the control group; *p < 0.05 for the M + DM group vs the control group; ¶p < 0.01 for the M + DM group vs the morphine ... Continuous coadministration of dextromethorphan or MK-801 with morphine: attenuation of morphine dependence and naloxone-reversible attenuation of morphine tolerance Pain 1996, 67:79-88 20 Mao J, Price ... into four groups Rats received subcutaneous (s.c.) injection of saline (Control group), morphine (M group), morphine + dextromethorphan (M + DM group) and dextromethorphan (DM group) twice per day...
... analgesia (PCA) was provided for all study patients with basal morphine sulfate rate set at mg Lockout interval was six minutes, maximum morphine dose was established at 12 mg/h and there was no loading ... discontinued Morphine was given (up to 12 mg, as bolus) until patients were comfortable and VAS score was
... extraction of morphine The amount of morphine in prolonged-release tablets is permitted to vary by 5% [16] so a 60 mg tablet could contain from 57 to 63 mg morphine sulfate The extraction of morphine ... and linearity was excellent (r2 > 0.99) As the morphine content of the tablets is given in mg morphine sulfate, we have done the same with the morphine recovered from the tablets Results Cold ... of the filters bound morphine, and their retention of morphine was due to the volume of liquid which remained Consequently, rinsing the filters increased the recovery of morphine Repeated rinses...
... options generally available in the prehospital area include morphine, fentanyl, tramadol, ketorolac and ketamine [3] For simple analgesia morphine sulphate is usually effective, however often preceded ... treatments (11 patients in each group), to receive morphine sulphate intravenously in M-group (n = 11), and the other group MK (n = 11) received morphine sulphate plus ketamine To possibly detect ... dose of morphine sulphate was given Subsequently (every five minutes), if patients still report NRS scores four or greater, the patients in the M-group received a supplementary dose of morphine...
... to M3G (morphine - - glucoronide), khụng cú tỏc dng dc lý v M6G (morphine - - glucoronide), cht chuyn húa chớnh, cú tỏc dng gim au mnh hn morphine Thi gian bỏn hy ca morphine khong 2- gi Morphine ... phu thut Morphine l thuc c in nhng cú tỏc dng gim au rt tt trờn nhng cn au sau phu thut Tiờm morphine ty sng (Intrathecal morphine) l mt phng phỏp c thc hin bng cỏch tiờm trc tip thuc morphine ... mỏu u lm tng m morphine nóo Toan húa lm tng lng mỏu ti nóo, gõy hin tng by cỏc phõn t morphine; kim húa lm tng tớnh tan m ca morphine Suy t bo gan hu nh ớt lm thay i dc ng hc ca morphine Suy thn...
... có hoạt tính (Morphine- 6-glucuronide, M-6-G, giảm đau mạnh Morphine) dạng hoạt tính (Morphine- 3-glucuronide, M-3-G) Một phần Morphine bị chuyển hoá cách tách loại metyl tạo normorphine Codeine ... Morphine chlohydrate 10mg/ml, có Morphine tactrate 30mg/1.5ml tuýp nhôm có sẵn kim tiêm [10] 1.2.3 Heroin Heroin đƣợc gọi Diacetatemorphine, Diacetylmorphine Diamorphine: Công thức phân tử : C21H23NO5 ... huyết tƣơng khoảng 1/3 lƣợng Morphine máu tồn dƣới dạng kết hợp với protein Morphine không tồn lâu mô thể (trong 24h), hàm lƣợng Morphine mô thấp Mặc dù vị trí tác dụng Morphine hệ thần kinh trung...
... thay đổi) tiêm dung dịch thuốc tê vào khoang xương - Dung dịch thuốc tê: Bupivacaine 0,25% 1ml /kg Morphine suphate mg/kg (liều tối đa dung dịch 20 ml) [6] - Ghi nhận huyết áp, nhịp tim, SpO2 trước ... 10 bệnh nhân cho giảm đau 24 sau gây tê Những bệnh nhân cần cho thuốc giảm đau hết thuốc tê dùng Morphine liều trung bình 11,6 (mcg/kg/giờ) Theo tác giả M Gail Boltz Gregory B.Hammer [6] phẫu thuật ... Anesthesia for congenital Heart Disease, 17: 283-291 Robert D Valley, Ann G Bailey (1991), Caudal morphine for postoperative analgesia in infants and children, Anesth Analg,72:120-4 ...
... nhi việc giảm đau Phác đồ dùng Morphine qua đường truyền tĩnh mạch giảm đau sau mổ trẻ em * Xét định, chống định dùng Morphine * Tính lượng Morphine cần pha Số mg Morphine = ½ Trọng lượng thể (theo ... sự(6), dùng Morphine phẫu thuật phụ khoa cắt tử cung qua ngã bụng chọn lọc cắt vòi trứng bên, không cắt buồng trứng Thời điểm dùng Morphine: điểm an thần 0-1, bệnh nhân đau Cách dùng Morphine: ... Isofluran Sau mổ, nhóm 1: bệnh nhi GIỚI THIỆU dùng Morphine qua đường truyền tĩnh mạch Giảm đau sau mổ với Morphine qua liều 0.01 mg/kg/giờ Nhóm 2: Morphine tiêm phương pháp truyền tĩnh mạch có không...
... sinh tổng hợp(Biosynthesis) morphine Rice synthesis Tổng hợp Gates Tổng hợp hoàn toàn morphine Gates ' đưa chứng cấu trúc morphine đề xuất Robinson vào năm 1925 Tổng hợp morphine ví dụ phản ứng Diels-Alder ... The Fukuyama Synthesis of Morphine Các Mannich tạo vòng nội phân tử 1-2 lợi dụng chức morphine Chất trung gian trình tạo vòng 11, sau tách The Fukuyama Synthesis of Morphine Quá trình Ito-Saegusa ... Công thức morphin Điều chế morphine The Fukuyama Synthesis of Morphine Tohru Fukuyama Đại học Tokyo gần báo cáo Một trình đơn giản so với trước để tổng tổng hợp (±) -morphine (3), dựa công nhận...
... Radiolabeling of Noscapine with Tc-99m 99mTc-noscapine was prepared by dissolving 500 μg of noscapine hydrochloride in ml of distilled water followed by the addition of 50 μg of SnCl2.2H2O, the pH being ... detected by pyridine: acetic acid: water (3:5:1.5 v/v) as the mobile phase Drugs/Chemicals Noscapine hydrochloride and Antiprogesterone RU486, 11β-(4-dimethyl amino phenyl)-1 β-hydroxy-17α-(1-propenyl)-oestra-4, ... article as: Priyadarshani et al., Radiolabeling, biodistribution and gamma scintigraphy of noscapine hydrochloride in normal and polycystic ovary induced rats Journal of Ovarian Research 2010, 3:10...
... Vancomycine HCl 1g MÔ TẢ Vancomycin hydrochloride vô khuẩn, USP kháng sinh glycopeptide ba vòng dẫn xuất từ Nocardia orientalis (trước ... g chất tương đương với 0,67 mmol Những lọ vô khuẩn có chứa 500 mg g chất Vancomycin Vancomycin hydrochloride dạng bột trắng nhờ dễ hòa tan Có thể chứa axit hydrochloric và/hoặc hydroxide natri ... để tiêm, USP, thuốc trở thành dung dịch suốt có pH khoảng 4,0 (2,5 đến 4,5) Dung dịch Vancomycin hydrochloride tái tổ hợp với nước vô khuẩn để tiêm, USP chất kìm hãm vi khuẩn dành để sử dụng thuốc...
... Vancomycin hydrochloride Vancomycin hydrochloride dạng tiêm sử dụng đường uống để điều trị viêm đại tràng giả mạc liên quan kháng sinh C difficile Chưa chứng minh hiệu việc sử dụng đơn Vancomycin hydrochloride ... khác Vancomycin hydrochloride định điều trị khởi đầu nghi ngờ Staphylococci đề kháng methicillin, sau có số liệu tính nhạy cảm, nên điều chỉnh trị liệu cho phù hợp Vancomycin hydrochloride có ... Vancomycin hydrochloride báo cáo hiệu sử dụng đơn phối hợp với Aminoglycoside viêm nội tâm mạc S viridans S bovis Đối với viêm nội tâm mạc Enterococci (ví dụ S faecalis), Vancomycin hydrochloride...