... cooperative binding, and creates an accessi-ble environment that also enables Sp1 and Runx1binding [85,86,233]. Both NFAT and AP-1 have thepotential to recruit the HATs CBP and p300 whichmay ... required for function in either T cells or mast cells.Shown below are the positions that nucleo-somes and GATA-2 occupy in unstimulatedT cells and mast cells [85].Active chromatin and DNase ... exist within CGislands which are characterized by their very high CGcontent and have an intrinsic resistance to DNA meth-ylation. CG-island promoters tend to be constitutively and ⁄ or ubiquitously...
... clarified thestructural and functional importance of the v-KIND and MAP2 interaction core modules in the regulationof dendrite growth and branching in hippocampal neu-rons and cerebellar granule ... MAP2 cDNA and its derivativesgenerated by PCR were cloned into pGEX-4T-2. The KINDdomains of Spir-2 and PTPN13 were generated by RT-PCR and inserted into pEGFP-C1 and pGEX-4T-2. The N- and C-terminal ... polymerization, stability and rear-rangement of microtubules in neuronal dendrites[13–15] and is associated with some neurological and psychiatric disorders [16,17]. However, the structure function relationship...
... from Koehl, 1995).BODY SIZE AND SUSPENSION FEEDING 21Body SizeThe Structureand Function of Aquatic EcosystemsEdited byALAN G. HILDREWSchool of Biological and Chemical Sciences, Queen Mary, ... SIZE AND SUSPENSION FEEDING 19Body Size: The StructureandFunction of Aquatic EcosystemsEcologists have long struggled to predict features of ecological systems, such asthe numbers and diversity ... important, and (ii) to compare freshwater and marine ecosystems. In Body Size: The StructureandFunction of Aquatic Ecosystems,both those questions of scale and comparison among systems are very...
... Tecnologia).References1. Davies, D.R. (1990) The structureandfunction of the asparticproteinases. Annu. Rev. Biophys. Biophys. Chem. 19, 189–215.2. Dunn, B.M. (2002) Structureand mechanism of the pepsin-likefamily ... similar both in sequence andstructure tosaposin-like proteins. This insert is usually removed duringprocessing and is absent from the mature form of the enzyme. Its functions are still unclear ... preproenzymes and subsequently convertedto mature enzymes that can be either single- or two-chainenzymes. The cDNA derived amino acid sequences ofseveral plant APs revealed that the primary structures...
... investigation and understanding of their structure- activity relationships,may start to provide a rational way to develop additionalpharmacological tools for the elucidation of nAChR structure and function. Ó ... perisynaptically, and a less abundantpopulation of a3* nAChRs which contain a5andb4subunits and in some cases b2 subunits, and is localized atpostsynaptic densities [18,96]. Functionally, a ... a-conotoxins MII and AuIB further dissected and correlated the combinato-rial and functional heterogeneity of the slowly decayingpopulation [77]. In this study, two long events of 25 pS16 and 40 pS...
... b-sheet face with six b-strandsbut like sbwAFP the b-strands are very flat. An overlap ofthe X-ray structureand 3 0 °C NMR structure is shown inFig. 3C. The secondary structure assignment is ... (1999) Structure, function and evolution of an tifreeze proteins. Cell Mol. Life Sci. 55 , 271 –283.11. Yeh, Y. & Feeney, R.E. (1996) Antifreeze proteins: Structures and mechanisms of function. ... [31,32,36] and their three-dimensional structures were determined [34,37–40]. Insubsequent sections, we describe the structureand dynamicsof each protein, and present a comparison of s bwAFP and TmAFPwitheachotherandwithproteinsthathaveasimilar...
... three antiparallel strands (1, 2 and 7) and strand 6, which is parallel to strand 2. b-Strands arelocated between the four a-helices (a1, 278–294; a2,305–313; a4, 374–381; and a5, 397–405), with ... b-strands (b3, 329–335; b4, 339–344; and b5,367–372) and a distorted a-helix (a3, 348–356)(Fig. 3B,C). The three b-strands of the minidomain areall antiparallel, and form a single b -structure. Two ... com-parison of the structure of the protein core (resi-dues 277–328 and 373–413) in solution and in the solidstate, and indicates their similarity.A superposition of the C-domain NMR structure onthe...
... between strands E and F in trans-thyretin. The two transthyretin dimers associate, vianonpolar interactions, between the loops joining standsG and H with the loops joining strands A and B, mak-ing ... dublin TLP and zebrafish TLP are found in the flex-ible portions of strands B and C that protrude towardsthe solvent and in the conformation of the long loopconnecting strands D and E [17]. ... regarding the identification and distribution ofTLP genes in nature, the structural and functionalcharacterization of the TLP from various organisms, and the evolution of TLP and transthyretin.The...
... antiparallel b-strands is abutted bythree a-helices (a1, a2, and a¢). The b-sheet in type IKH domains consists of three b-strands in the orderb1, b¢ and b2. The b1-strand and b2-strand are parallelto ... lineconnecting the b2-strand and b¢-strand rep-resents the variable loop. The white lineconnecting the a1-helix and the a2-helixrepresents the GXXG loop.R. Valverde et al. Structureandfunction of KH ... other, and the b¢-strand is antiparallel to both(Fig. 1). This all-antiparallel arrangement of strandsdistinguishes the type I KH fold from the type II KHfold, in which the b1-strand and b2-strand...
... GlcNAc kinase are labeledwith a star.Ó FEBS 2002 Structureandfunction of GlcNAc kinase (Eur. J. Biochem. 269) 4215 Structure andfunction ofN-acetylglucosamine kinaseIdentification of two ... C131 and C143. Their counterparts inglucokinase are C233 and C252. Mutations of thesecysteines to serines have very similar effects on enzyme activity and substrate binding in glucokinase and ... 5¢-CCCATTCTGAGTGTGGGCTCAGTGTGGÓ FEBS 2002 Structureandfunction of GlcNAc kinase (Eur. J. Biochem. 269) 4213The parental template is then digested by the restriction enzyme DpnI, which specifically cuts...
... ringNucleoplasm – fluid of the nucleusNucleoplasm – fluid of the nucleus Cell Structureand Cell Structureand Function Function Why Are Cells So Small?Why Are Cells So Small?Strategies for ... proteins and Packaging of fully modified proteins and lipids into vesicles for export or use in lipids into vesicles for export or use in the cellthe cell And more that we will not cover! And ... cellsCell size and shape – Cell size and shape – why are cells so small?why are cells so small?Prokaryotic cellsProkaryotic cellsEukaryotic cellsEukaryotic cellsOrganelles and structure...
... fluidRibosomesRibosomesEnzymesEnzymesFunctions of Functions of Eukaryotic Eukaryotic Cell FeaturesCell Features Structure Structure Function( s) Function( s)LysosomeLysosomeContains digestive enzymes ... CELLSCELLS Structure andFunction Structure and Function Cell = smallest unit of lifeCell = smallest unit of lifeFunctions of Eukaryotic Cell FeaturesFunctions of Eukaryotic Cell Features Structure ... from RERRERRERSERSERFunctions of EukaryoticFunctions of Eukaryotic Cell Features Cell Features Structure Structure Function( s) Function( s)Cilia and Cilia and Flagella Flagella...
... Plant g lutathioneS-transferases: enzymes with multiple functions in s ickness and inhealth. Trends Pharmacol S ci 5, 193–198.4. Marrs, K.A. (1996) The functions and regulation of glutathioneS-transferases ... 3505S-(2,3-Dichlorotriazinyl)glutathioneA new affinity label for probing the structureandfunction of glutathione transferasesGeorgia A. Kotzia and Nikolaos E. LabrouLaboratory of Enzyme Technology, Department of Agricultural ... nterface and forms part of the h ydro-phobic lock -and- key intersubunit motif. The ability ofSDTG to inactivate other glutathione-binding enzymes a ndGST isoenzymes was also investig ated, and it...
... mitochondrial structureand function. Materials and methodsMaterialsDiS-C3(5) and cyclosporin A (CsA) were kindly providedby Hayashibara Biochemical Laboratories, Inc. (Okayama,Japan) and Novartis ... 2004 Effects of DiS-C on mitochondrial structureandfunction (Eur. J. Biochem. 271) 3577Multiple effects of DiS-C3(5) on mitochondrial structureand function Takenori Yamamoto1,2, Aiko Tachikawa1,2, ... found DiS-C3(5) to show multipleeffects on the mitochondrial structureand function, effectsdependent on both its concentration and the Pistatus.11AcknowledgementsThis work was supported...