cell cycle regulation and transcription
The Retinoblastoma Gene Family in Cell Cycle Regulation and Suppression of Tumorigenesis
... most cell cycle responses. While each single pocket protein can mediate cell cycle arrest upon cell- cell contact, pRb is the critical mediator of cell cycle arrestupon growth factor deprivation and ... (42)P. Kaldis: Cell Cycle Regulation DOI 10.1007/002/Published online: 24 February 2006© Springer-Verlag Berlin Heidelberg 2006The Retinoblastoma Gene Family in Cell Cycle Regulation and Suppression ... suppression and cell mortality. Cell 85:27–37Serrano M, Lin AW, Mila EM, Beach D, Lowe SW (1997) Oncogenic ras provokes prema-ture cell senescence associated with accumulation of p53 and p16Ink4a. Cell...
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Tài liệu Báo cáo khoa học: The central role of CDE/CHR promoter elements in the regulation of cell cycle-dependent gene transcription pdf
... RegulatedDuring the Cell Cycle by a CDE ⁄ CHR TandemElement and is Downregulated by p53 but not by p63or p73. Cell Cycle 6, 853–862.37 Yoshida K (2005) Cell- cycle- dependent regulation ofthe human and mouse ... p53. Cell cycle arrest can be medi-ated by p53 downregulating the transcription of central cell cycle regulators such as cyclin B, Cks1, Cdc2 and Cdc25C.CDE ⁄ CHR-dependent cell cycle- gene transcription ... encoded by cyclin B1 and cyclin B2 genes isKeywords cell cycle; cell cycle genes homology region(CHR); cell cycle- dependent element (CDE);DREAM complex; E2FCorrespondenceK. Engeland, Molecular...
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cell cycle regulation - Ebook USA ( biotechnology)
... completion of the cell division cycle is significantly extendedcompared with continually fed cells. Thus, starvation not only blocks cell cycle progression, but causes cells to exit the cycle and enter ... ofthe regulation of the cell cycle and its relation to cancer, which culminatedin the 2001 Nobel Prize being awarded to Leland Hartwell, Tim Hunt, and Paul Nurse. In the investigations of cell cycle ... restriction point of the cell cycle. Cell Cycle 1:103–110Buchkovich K, Duffy LA, Harlow E (1989) The retinoblastoma protein is phosphorylatedduring specific phases of the cell cycle. Cell 58:1097–1105Burdon...
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Cell Cycle Regulation in Mammalian Germ Cells
... the cell cycle process affected:initiation and maintenance of meiosis, transcriptional and translational fac-tors, cellular signaling, cytoplasmic and apoptotic factors and prophase I regulation. 2 Cell ... pregnancy loss and birth defects, it is critical to dissect out mei-otic cell cycle checkpoints and proper chromosome segregation (Hassold and Hunt 2001). However, understanding cell cycle regulation ... kinase, but male and female Cell Cycle Regulation in Mammalian Germ Cells 347Table 1 (continued)Gene Protein Name Effect on germ cell development Refs.B. Transcriptional and Translational...
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Modeling Cell Cycle Control and Cancer with pRB Tumor Suppressor
... Nature 343:665–669Modeling Cell Cycle Control and Cancer with pRB Tumor Suppressor 231 cycle, and strongly suggested that deregulation of the mechanisms controlling cell cycle progression could ... mechanismsfor controlling cell cycle progression (Morgan 1997; Zachariae and Nasmyth1999). These studies and others demonstrated the universality of the cell Modeling Cell Cycle Control and Cancer with ... Orc1 and Mcm2–7) and DNA replication (e.g.Dhfr, Rnr, TK, TS and Polα). Many E2F target genes encode products in-volved in cell cycle progression (e.g. cyclins A and E, pRB, p107, E2F1–3) and apoptosis...
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Báo cáo khoa học: Cell biology, regulation and inhibition of b-secretase (BACE-1) potx
... REVIEW ARTICLE Cell biology, regulation and inhibition of b-secretase(BACE-1)Clare E. Hunt and Anthony J. TurnerProteolysis Research Group, Institute of Molecular and Cellular Biology, ... 10001–10006.110 Andrau D, Dumanchin-Njock C, Ayral E, VizzavonaJ, Farzan M, Boisbrun M, Fulcrand P, Hernandez JF,Martinez J, Lefranc-Jullien S et al. (2003) BACE1- and BACE2-expressing human cells: ... withisophthalamide derivatives as the P2–P3ligands showedgood selectivity between BACE-1 and BACE-2,nanomolar potency in vitro and in cell- based studies, and a significant reduction in Ab40 levels...
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Báo cáo khoa học: 3 Cdt1 and geminin are down-regulated upon cell cycle exit and are over-expressed in cancer-derived cell lines potx
... i n contrast to their regulation during the cell cycle [13], upon exit and entry tothe cell cycle both genes are controlled, at least in part,transcriptionally.Cdt1 and geminin are highly ... upon cell cycle exit. To this effect, HFF cells weredeprived of serum f or 48 h to induce cell cycle exit. Serumwas th en r e-added a nd samples taken as cells progressedinto the cell cycle. ... under r eview, regulation of geminin b y E2F and R B was reported [34,35]. Gemininprotein accumulates in HFF cells re-entering the cell cycle from G0 3–6 h later t han Cdt1, and as cells enter...
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cell cycle checkpoints and cancer
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Báo cáo khoa học: E2A participates in a fine control of pre-mature B-cell apoptosis mediated by B-cell receptor signaling via transcriptional regulation of survivin, IAP2 and caspase-8 genes pot
... control of vertebrate cell cycle progression through transcription regulation of various cell cycle- related genes. Gene 347, 83–97.24 Kikuchi H & Nakayama T (2008) GCN5 and BCR sig-nalling ... on cell- cycle progression and proliferation of DT40 and E2A)/)cells. Cells cultured in the presence of PMA/ionomycin for 24 h or etoposide for 6 h were analyzedby fluorescence-activated cell ... apoptotic cell death of the DT40 cell line, and show that E2A isinvolved in fine control of pre-mature B -cell apoptosismediated by BCR signaling, via transcriptional regula-tion of survivin, IAP2 and...
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Báo cáo y học: "HLA-DR regulation and the influence of GM-CSF on transcription, surface expression and shedding
... regulation of HLA-DR gene transcription, post transcriptional events and shedding of surface HLA-DR, as well as the regulation of HLA-DR by GM-CSF and an immunomodulatory cytokine. Plasma and ... the cell line, HL-60, was cultured with GM-CSF we demonstrated that an up -regulation of HLA-DR mRNA was observed from 2 hours culture and at time points 4, 6 and 8 hours. Transcriptional regulation ... visualisation of sections through the cell to observe surface and intracellular staining. Figures 3a-d show the intracellular and surface staining of PBMC in a healthy control and from a septic patient....
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Senescence and Cell Cycle Control
... RA (1995) The role of Rb in cell cycle control. Prog Cell Cycle Res 1:9–19Senescence and Cell Cycle Control 259eliminates telomere-mediated signaling, allowing cells to undergo transform-ation ... loss of G1 control and immortalization. Genes Dev 14:3037–3050Senescence and Cell Cycle Control 267Campisi J (2001) Cellular senescence as a tumor-suppressor mechanism. Trends Cell Biol11:S27–S31Carnero ... mouse cells. p19ARFispredominantly upregulated during senescence by oncogene activation and/ or oxidativestressSenescence and Cell Cycle Control 263induction by controlling p16INK4a(and...
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Tài liệu Báo cáo khoa học: Protein kinase CK2 activates the atypical Rio1p kinase and promotes its cell-cycle phase-dependent degradation in yeast pdf
... phase of the cell- division cycle. Therefore, we tested,using light microscopy and after DAPI staining, whetherthe slow growth yields a cell- cycle phenotype. Cells ofthe logarithmically ... which is stable throughout the cell cycle and highly resistant to proteolytic degradation [40].Miscellaneous proceduresYeast were grown on standard media [41] and transformedas described by ... esses, e.g. cell proliferation,signal transduction, transcriptional regulation, transla-tion and metabolism [3]. Despite this eminent role instrictly regulated cellular processes and although...
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Tài liệu Báo cáo Y học: Intracellular localization and transcriptional regulation of tumor necrosis factor (TNF) receptor-associated factor 4 (TRAF4) pdf
... TRAF4induction in T-cells, we analyzed a mutant Jurkat cell Fig. 9. TNF and PMA up-regulate TRAF4 mRNA in T-cells. Jurkat (A) and D23II-7 T-cells (B) as well as primary human T-cells and human T -cell blasts ... transfected cells were selected forphotography (A). For quantification cells showing increased localiza-tion of the proteins in cell cell contacts were counted (B).Ó FEBS 2002 Localization and transcriptional ... form of the respectiveFig. 5. Subcellular localization of TRAF4 deletion mutants in cells with cell cell contacts. HeLa cells were seeded on glass cover slides and transiently transfected with...
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Tài liệu Báo cáo Y học: Regulation of transcription of the Dnmt1 gene by Sp1 and Sp3 zinc finger proteins doc
... promoter in somatic cells.MATERIALS AND METHODSCells, plasmids and materialsMouse NIH3T3 cells and Drosophila SL2 cells wereobtained from the JCRB Cell Bank (Tokyo, Japan) and from S. Kojima ... nuclear extracts of NIH3T3cells with the P2 probe. We observed three similar shiftedbands when we used nuclear extracts from 3T6 cells, HeLacells, 293 cells and F9 cells (data not shown). To ... according to the manufacturer’s protocol. Cell culture, transfections and assays of promoteractivityMouse NIH3T3 and F9 cells and human HeLa and 293cells were grown in Dulbecco’s modified Eagle’s...
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Báo cáo khoa học: Nuclear actin and actin-binding proteins in the regulation of transcription and gene expression docx
... recentdevelopments in the study of transcription and transcriptional regulation bynuclear actin, and the regulation of muscle-specific gene expression, nuclearreceptor and transcription complexes by ... STARS-transfected cellsdid not differ from those in untransfected cells. Thus,Fig. 2. Model of the involvement of STARS and ABLIM in actindynamics and SRF-dependent transcription. Actin and ABPs in transcription ... complexes and is necessary for transcription by RNA polymerase II. Nat Cell Biol 6,1094–1101.20 Shang Y, Myers M & Brown M (2002) Formation ofthe androgen receptor transcription complex. Mol Cell 9,...
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Báo cáo khoa học: Injection of poly(b-L-malate) into the plasmodium of Physarum polycephalum shortens the cell cycle and increases the growth rate pot
... in growth and cell cycle duration. However, wedo not know how great an effect should be expected. Ifwe assume that certain PMLA–protein complexes areinvolved in growth and cell cycle timing, ... proteins tonucleic acids, and it c ould affect cell g rowth a nd cell cycle duration.The distributing activity of PMLA and the efficiency ofcompetition between PMLA and nucleic acids would both ... PMLA induced a strain specific enhancement of cell growth and an equal (between strains) shortening of the cell cycle. Materials and methodsStrains and materialsThe following strains of P. polycephalum...
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- cell cycle; budding yeast; cdk; ddk; kinetic modelling
- habitatdependent population regulation and community structure
- software development life cycle phases and deliverables
- cell cycle regulation by feedforward loops coupling transcription and phosphorylation
- cell cycle and transcription
- cell cycle regulated transcription
- cell cycle regulated transcription in yeast
- cell cycle regulation transcription factors
- project life cycle planning and designing
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