cell cycle and transcription
Modeling Cell Cycle Control and Cancer with pRB Tumor Suppressor
... mechanismsfor controlling cell cycle progression (Morgan 1997; Zachariae and Nasmyth1999). These studies and others demonstrated the universality of the cell Modeling Cell Cycle Control and Cancer with ... Nature 343:665–669Modeling Cell Cycle Control and Cancer with pRB Tumor Suppressor 231 cycle, and strongly suggested that deregulation of the mechanisms controlling cell cycle progression could ... Orc1 and Mcm2–7) and DNA replication (e.g.Dhfr, Rnr, TK, TS and Polα). Many E2F target genes encode products in-volved in cell cycle progression (e.g. cyclins A and E, pRB, p107, E2F1–3) and apoptosis...
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Senescence and Cell Cycle Control
... RA (1995) The role of Rb in cell cycle control. Prog Cell Cycle Res 1:9–19Senescence and Cell Cycle Control 259eliminates telomere-mediated signaling, allowing cells to undergo transform-ation ... loss of G1 control and immortalization. Genes Dev 14:3037–3050Senescence and Cell Cycle Control 267Campisi J (2001) Cellular senescence as a tumor-suppressor mechanism. Trends Cell Biol11:S27–S31Carnero ... mouse cells. p19ARFispredominantly upregulated during senescence by oncogene activation and/ or oxidativestressSenescence and Cell Cycle Control 263induction by controlling p16INK4a(and...
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The Retinoblastoma Gene Family in Cell Cycle Regulation and Suppression of Tumorigenesis
... most cell cycle responses. While each single pocket protein can mediate cell cycle arrest upon cell- cell contact, pRb is the critical mediator of cell cycle arrestupon growth factor deprivation and ... roles in controlling cell cycle exit upon growth-inhibiting signals. Only ablation of all pocket proteins fullyalleviated a cell cycle arrest upon serum withdrawal, cell- cell contact inhi-bition, ... suppression and cell mortality. Cell 85:27–37Serrano M, Lin AW, Mila EM, Beach D, Lowe SW (1997) Oncogenic ras provokes prema-ture cell senescence associated with accumulation of p53 and p16Ink4a. Cell...
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Tài liệu Báo cáo khoa học: The central role of CDE/CHR promoter elements in the regulation of cell cycle-dependent gene transcription pdf
... RegulatedDuring the Cell Cycle by a CDE ⁄ CHR TandemElement and is Downregulated by p53 but not by p63or p73. Cell Cycle 6, 853–862.37 Yoshida K (2005) Cell- cycle- dependent regulation ofthe human and mouse ... p53. Cell cycle arrest can be medi-ated by p53 downregulating the transcription of central cell cycle regulators such as cyclin B, Cks1, Cdc2 and Cdc25C.CDE ⁄ CHR-dependent cell cycle- gene transcription ... encoded by cyclin B1 and cyclin B2 genes isKeywords cell cycle; cell cycle genes homology region(CHR); cell cycle- dependent element (CDE);DREAM complex; E2FCorrespondenceK. Engeland, Molecular...
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Tài liệu Báo cáo khoa học: Protein kinase CK2 activates the atypical Rio1p kinase and promotes its cell-cycle phase-dependent degradation in yeast pdf
... phase of the cell- division cycle. Therefore, we tested,using light microscopy and after DAPI staining, whetherthe slow growth yields a cell- cycle phenotype. Cells ofthe logarithmically ... which is stable throughout the cell cycle and highly resistant to proteolytic degradation [40].Miscellaneous proceduresYeast were grown on standard media [41] and transformedas described by ... distribution of G2⁄ M cells: thenumber of metaphase cells with a single DNA mass atthe bud neck and the number of anaphase cells wereincreased slightly in the mutant (metaphase cells: 30.2%in the...
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Báo cáo khoa học: 3 Cdt1 and geminin are down-regulated upon cell cycle exit and are over-expressed in cancer-derived cell lines potx
... during the cell cycle [13], upon exit and entry tothe cell cycle both genes are controlled, at least in part,transcriptionally.Cdt1 and geminin are highly expressed in proliferatingcellsin ... upon cell cycle exit. To this effect, HFF cells weredeprived of serum f or 48 h to induce cell cycle exit. Serumwas th en r e-added a nd samples taken as cells progressedinto the cell cycle. ... in G0 cells and induced upon cell cycle re-entry[23] and to be under the transcriptional c ontrol of E2F [24–26]. We show here that, similar to Cdc6, Cdt1 mRNA levelsare r educed in G0 and r...
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cell cycle checkpoints and cancer
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cell cycle regulation - Ebook USA ( biotechnology)
... completion of the cell division cycle is significantly extendedcompared with continually fed cells. Thus, starvation not only blocks cell cycle progression, but causes cells to exit the cycle and enter ... 3) cell cycle machinery is highly regulated, and 4) cell cycle components are an obvious target in proliferative diseases likecancer (Murray and Hunt 1993).3G1 Progression in Cultured CellsIf ... restriction point of the cell cycle. Cell Cycle 1:103–110Buchkovich K, Duffy LA, Harlow E (1989) The retinoblastoma protein is phosphorylatedduring specific phases of the cell cycle. Cell 58:1097–1105Burdon...
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Báo cáo y học: "BRCA1 May Modulate Neuronal Cell Cycle Re-Entry in Alzheimer Disease"
... suppression of the cell cycle and cell survival instead of apoptosis and their presence may be a neuroprotective factor to prolong the life of the cell after re-entry into the cell cycle, pro-tecting ... neuronal cells during development, and is present in smaller amounts in fully differentiated cells [13]. BRCA1 is known to regulate transcription, regulate cell cycle progression, and may ... the cell cycle by affected neurons. However, while such a cell cycle re-entry phenotype is an early and consistent feature of Alzheimer disease, the mechanisms responsible for neuronal cell cycle...
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Báo cáo y học: "Cell Cycle Arrest by a Natural Product via G2/M Checkpoint"
... induction of cell cycle arrest and apoptosis. We have investigated its effects on cell cycle regulation using a gastric cancer cell line, AGS. The effects of CKBM on cell proliferation, cell cycle ... cell line. CKBM is found to inhibit cell proliferation through the induction of apoptosis and G2/M cell cycle arrest. To further elucidate the mechanism of CKBM on apoptosis and G2/M cell cycle ... Y, Xie LP, Yu XY, Zhang RQ. Effects of genistein and daidzein on the cell growth, cell cycle, and differentiation of human and murine melanoma cells. J Nutr Biochem 2002; 13:421-426. 2. Chen...
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Cell Cycle Regulation in Mammalian Germ Cells
... based upon the cell cycle process affected:initiation and maintenance of meiosis, transcriptional and translational fac-tors, cellular signaling, cytoplasmic and apoptotic factors and prophase ... pregnancy loss and birth defects, it is critical to dissect out mei-otic cell cycle checkpoints and proper chromosome segregation (Hassold and Hunt 2001). However, understanding cell cycle regulation ... Masui and Markert 1971). The build up of cyclin B and its degra-dation at the end of the cell cycle is a hallmark of MPF activity guiding theinitiation and termination of the cycle (Pines and...
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Control of Cell Proliferation and Growth byMyc Proteins
... both cell growth and cell proliferation through multiple pathways and that there is neither a singlecritical effector gene nor a small group of such genes. In cell culture, Myc canaffect cell ... both polymerase I- and polymerase III-dependent transcription, leading to enhanced transcription of ribosomalRNA and tRNA genes and to stimulate transcription of many genes involvedin all steps ... tissues. Mol Cell Biol 24:7538–7547Minsky N, Oren M (2004) The RING domain of Mdm2 mediates histone ubiquitylation and transcriptional repression. Mol Cell 16:631–639Nikiforov MA, Chandriani S,...
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MouseModels of Cell Cycle Regulators - New Paradigms
... one round of cell division, every cell in metazoans hasto decide whether it will re-enter the cell cycle, exit the cell cycle and en-ter a quiescence state, and every quiescent cell has to similarly ... re-enter the cycle. Allthese crucial decisions are made by a set of information processors (cell cycle machinery) that integrate extracellular and intracellular signals to coordinate cell cycle events.In ... paradigms to cancer and cancer therapyare discussed.2History of the Cell Cycle model2.1The Concept of Mammalian Cell Cycle RegulationThe textbook cell cycle model (Morgan 1997; Sherr and Roberts...
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The ubiquitin-proteasome pathway in cell cycle control
... requirements for protein synthesis and degra-dation, and the control of destruction of cyclins A and B in the meiotic and mitotic cell cycles of the clam embryo. J Cell Biol 116:707–724HwangLH,LauLF,SmithDL,MistrotCA,HardwickKG,HwangES,AmonA,MurrayAW(1998) ... control the cell cycle. The purpose of this review is to providea current view the role of ubiquitylation, ubiquitin-mediated proteolysis, and proteasomes in cell cycle control in both yeasts and metazoans.2The ... (Mo-mand et al. 2000). p53, a transcription factor that is activated in response tovariety of cellular stresses, evokes a number of responses ranging from cell cycle arrest to programmed cell...
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