... examined in this thesis, the MDR1, MDR3 genes and the CYP3A cluster are introduced Previous genetic and pharmacogenetics studies on these candidate genes are also reviewed in this section Finally, ... association study of phenotypic changes and their corresponding genetic variants strongly relies on the understanding of Linkage Disequilibrium On the one hand, the linkage between genetic polymorphisms ... identification of genetic variants that control drug-response remains the central problem of the modern Pharmacogenetics The natural history of genetic polymorphisms in the human genome provides the most...