Expression dynamics of the hepatic mitochondrial proteome of the sod2+ mouse in response to troglitazone administration

... hepatotoxicity in certain groups of patients Kd is the concentration of a drug that results in binding to 50% of the receptors Figure Chemical structure of troglitazone Figure Crystal structure of ... troglitazone caused mitochondrial injury in vitro at high concentrations, troglitazone was allowed to progress to the clinical testing phase stage A hallmark of troglitazone- induced hepatic injury ... coupled to MALDI-TOF/TOF MS/MS analysis revealed a two-stage mitochondrial response upon short-term and long-term troglitazone administration, similar to the delayed hepatotoxicity observed in humans...

226
1,830
0

Báo cáo khoa học: DNA-binding characteristics of the regulator SenR in response to phosphorylation by the sensor histidine autokinase SenS from Streptomyces reticuli doc

... allowed the characterization of the DNA-binding properties in response to phosphorylation by the sensorkinase SenS Results Cloning of wild-type and mutant senSc and senR genes and purification of fusion ... together, these data confirm the specificity of the SenR- binding sites and corroborate the assumption that phosphorylation of SenR by SenS P alters its DNA-binding characteristics Discussion The ... Taken together, the presented data show clearly that SenS is a histidine autokinase SenSc phosphorylates and dephosphorylates SenR As SenR was predicted to be the cognate RR of the SK SenS, the...

Báo cáo khoa học: Irreversible cross-linking of heme to the distal tryptophan of stromal ascorbate peroxidase in response to rapid inactivation by H2O2 ppt

... the APX apoprotein Identiﬁcation of the heme- binding amino-acid residue in H2O2- inactivated stromal APX To determine which amino-acid residue in the apoprotein was cross-linked to heme, the inactivated ... with H2O2 in the absence of ascorbate On the basis of these results, we propose that the rapid inactivation of tsAPX is at least partly due to repositioning of heme caused by cross-linking between ... half of the apoprotein of the catalytic site ˚ (Fig 4B) Because the indole ring of Trp35 is 3.18 A from the porphyrin ring in tsAPX (the distance between nitrogen of the indole ring and C6 of the...

Báo cáo hóa học: "Investigating the synchronization of hippocampal neural network in response to acute nicotine exposure" pdf

... substantial loss in nicotinic receptors in cortex and striatum According to the growing amount of findings, accumulation of amyloid plaques which are the baseline indicator in the brain for AD is interfered ... in response to acute nicotine exposure It furthermore suggests the strong synchronization of hippocampal neural network in the mid phase (gamma oscillation segment) in response to acute nicotine ... needed in these cases [24] In the current study, we have investigated the effect of nicotine on the complexity of the neurons and the activity of the gamma oscillations in the Schaffer CA1 cell line...

Báo cáo y học: " The mode of lymphoblastoid cell death in response to gas phase cigarette smoke is dose-dependent" potx

... little emphasis in the past The objective was to determine the mode of lymphocyte cell death upon exposure to the gaseous phase of cigarette smoke (GPS) in vitro For this purpose, we utilised a well-established ... significantly different (p < 0.62) FACS analysis of Annexin V/PI-stained cells To determine the mode of cell death upon GPS treatment, cells were stained with AnnexinV/PI and analysed by flow cytometry, ... increasingly intense interest in the effects of GPS A common denominator in many of these in vitro studies has been an overwhelming system for CS administration The practice of cigarette smoke...

Can’t Shake that Feeling: Event-Related fMRI Assessment of Sustained Amygdala Activity in Response to Emotional Information in Depressed Individuals pptx

... decreased in response to all emotional stimuli in depressed individuals who displayed increased amygdala activity 4) The clinical relevance of sustained amygdalar processing can be inferred by examining ... detection of sustained amygdala activity in depressed individuals in response to negative information If depression involves primarily disinhibition of the amygdala system (e.g., as a consequence of ... examination of this structure’s activity in response to emotional stimuli could help to further explain observed results Using a similar approach, sustained processing of emotional information, indexed...

Báo cáo khoa học: Apoptosis and autophagy: BIM as a mediator of tumour cell death in response to oncogene-targeted therapeutics pptx

... signalregulated kinase ⁄ (ERK1 ⁄ 2) and protein kinase B (PKB) pathways that act downstream of oncogenic protein kinases [10,11] It is increasingly apparent that BIM as a mediator of tumour cell ... a potent inhibitor of mitogen-activated protein kinase ⁄ extracellular signal-regulated kinase kinase ⁄ kinases: mechanism of action in vivo, pharmacokinetic ⁄ pharmacodynamic relationship, and ... 6057 BIM as a mediator of tumour cell death A S Gillings et al response observed in the clinic may often be cytostatic (i.e associated with tumour stasis, rather than with cytotoxicity and tumour...

Báo cáo khoa học: " Livelihood Strtategies of Peri-Urban Households in Response to Rural Urban Linkages: A Case Study in a Peri-Urban Area of Hanoi, Vietnam" ppt

... RESULTS AND DISCUSSION The Rural - Urban linkages of peri -urban households Rural- urban linkages are defined as various types of flows McNulty (1985) mentions the phrase rural- urban linkage” to mean ... a huge number of formal and informal flows of goods, services, information, capital, and people between rural and urban areas (cited in Trager 1988, p.30) Examining the rural- urban linkages in ... between urban and rural areas, the local Livelihood Strtategies of Peri -Urban Households in Response households rationally adjust their livelihood strategies in order to take advantage of the...

báo cáo khoa học: " Evaluation of protein pattern changes in roots and leaves of Zea mays plants in response to nitrate availability by two-dimensional gel electrophoresis analysis" pdf

... content of total proteins, amino acids, reducing sugars and sucrose in roots (A, C, E and G) and leaves (B, D, F, and H) and chlorophyll content in leaves (I) of Zea mays plants, previously grown in ... induced by nitrate in both roots and leaves of Zea mays plants The attention was focused on the changes in the pattern of protein soluble fractions caused by the addition of 10 mM nitrate to the ... correlated to N availability during the plant growth, in the protein profiles of both organs In order to obtain further information, in this work we investigated protein accumulation changes induced by...

Báo cáo y học: "Ubiquitination of HTLV-I Tax in response to DNA damage regulates nuclear complex formation and nuclear export" pps

... response to DNA damage may be a consequence of their inability to be ubiquitinated Lysine residues 280 and 284 are ubiquitinated in response to DNA damage Since Tax is ubiquitinated in response to DNA ... previous findings showing that the redistribution of Tax in response to DNA Cytoplasmic localization of ubiquitinated Tax is leptomycin B sensitive The wild-type HTLV-1 Tax protein localizes predominately ... results in increased mono-ubiquitination of Tax Mutation of Tax amino acids known to be targets of ubiquitination (K280 and K284) inhibited DNA damage- induced ubiquitination of Tax, resulting in retention...

Báo cáo y học: "The developmental expression dynamics of Drosophila melanogaster transcription factors" pptx

... limitation of both types of expression dataset is the granularity of both the sampling and the annotation This implies that many of the co -expression clusters at the level of tissues may not actually ... 'transcriptional logic' is probably not primarily conferred by the expression of TFs, as studies on early patterning might suggest Taken together, our study provides a first analysis of the system-wide ... adult tissues in the FlyAtlas [31] Four broad classes of TF expression in embryonic development Figure 1a shows a binary matrix of embryonic TF expression based on the Berkeley Drosophila Genome Project...

Báo cáo y học: "Gene function and expression level influence the insertion/fixation dynamics of distinct transposon families in mammalian introns" doc

... the data The size of the window (span) controls the degree of smoothing and the curves are made robust by iterating the fit within each window discarding outliers In all cases robustifying iterations ... underrepresented in proximity to and within genes [23], probably as a cause of their interference with regulatory processes In mammals the great majority of genes are interrupted by introns that usually outsize ... as a function of expression level (TEfintron/meanTEfintron) - (TEfinter/meanTEfinter) Genome Biology 2006, 7:R120 information where TEfintron is the average TE frequency for all introns in the...

Báo cáo khoa học: Functional studies of crustacean hyperglycemic hormones (CHHs) of the blue crab, Callinectes sapidus – the expression and release of CHH in eyestalk and pericardial organ in response to environmental stress pot

... Hemolymph titers of PO -CHH and ES -CHH in response to changes in dissolved oxygen Hypoxia induced the release of CHHs from the PO and ES of the juvenile crabs (Fig 6) At the initial control normoxic ... of CHH cDNA from the ES [28] Also, we examined the physiological responses of the release and expression of these two CHHs under stressful conditions, especially severe hypoxia, hypothermia and ... mortality in this species [2 5–2 7] In view of CHH involvement in response to stress in other crustacean species, it is reasonable to think that Cal sapidus CHH may also play an important regulatory...

Báo cáo khoa học: Molecular identiﬁcation and expression study of differentially regulated genes in the Paciﬁc oyster Crassostrea gigas in response to pesticide exposure doc

... (between and 24 h) used by the authors In another study, 258 differentially expressed genes were identiﬁed in C gigas in response to exposure to hydrocarbons for and 21 days [22], and some of these genes ... among the down -regulated genes Expression of herbicide -regulated genes The time-dependent expression of 13 genes that were up -regulated by exposure to herbicide and ﬁve that 391 Oyster response to ... genes in common to both the ADI and glyphosate response SSH libraries These were glutamine synthase, ATP synthetase, b-1,3-glucan binding protein and some housekeeping genes such as tubulin and...

Báo cáo khoa học: Dynamics of flavin semiquinone protolysis in L-a-hydroxyacid-oxidizing flavoenzymes – a study using nanosecond laser flash photolysis doc

... avin si side is highly polar, with two arginines and ionizable side chains such as a histidine and two tyrosines in the FDH domain, with one of the latter being replaced in LCHAO by a phenylalanine ... (M) Fig Inuence of buffer concentration on the kinetics of the avin radical evolution (A) Absorbance variation at 570 nm obtained upon laser excitation of 70 lM FDH domain solutions (saturated with ... LCHAO 0.8 Aend /A0 Absorbance 0.03 pKa = 8.7 0.6 0.4 30 Time (às) FDH pKa = 8.1 Fig Time evolution of the avin radical in the FDH domain and in LCHAO, measured after the end of the laser pulse at...

Xem thêm

Từ khóa: the role of the respiratory system in relation to energy metabolism summarise the role of the cardiovascular system in relation to energy metabolism in the body the role of the digestive system in relation to energy metabolism u2022 summarise the role of the cardiovascular system in relation to energy metabolism in the body development administration and rating process in response to above given problems of the final achievement test the writer recommends some suggestions for improvement of the test design and administration the amount of any impairment for each class of financial asset and any finance income recognised in the income statement in relation to those assets issue the company shall not classify the items as held for sale in those annual accounts when issued however the company shall disclose the information specified in point a of the preceding section in relation to these items c responsibilities of the audit committee in relation to the internal audit function 4 the administrator may review and conduct independent audits of any quarterly report in order to determine whether the quarterly report meets the requirements of this subpart and part 75 of this chapter including the requirement to use substitute serial changes in expression of proteins in response to neoadjuvant chemotherapy in breast cance acd rationale is anemia part of the body s physiological response to inflammation voice and exit strategies in response to extensions of the ipr regime β catenin and y654 β catenin in response to hgf activation mirrors that of hb tumours alternative bids are frequently in response to a requirement specified in the bid documents sometimes bidders submit alternative bids voluntarily e g emptying pits use a volume time price structure creating an incentive to dump as much manure as possible in the shortest time in order to provide the best price on a per unit basis chuyên đề điện xoay chiều theo dạng Giáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôit Giáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôit ĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWAN Quản lý hoạt động học tập của học sinh theo hướng phát triển kỹ năng học tập hợp tác tại các trường phổ thông dân tộc bán trú huyện ba chẽ, tỉnh quảng ninh Trả hồ sơ điều tra bổ sung đối với các tội xâm phạm sở hữu có tính chất chiếm đoạt theo pháp luật Tố tụng hình sự Việt Nam từ thực tiễn thành phố Hồ Chí Minh (Luận văn thạc sĩ)Phát triển du lịch bền vững trên cơ sở bảo vệ môi trường tự nhiên vịnh hạ long Nghiên cứu, xây dựng phần mềm smartscan và ứng dụng trong bảo vệ mạng máy tính chuyên dùng Nghiên cứu tổng hợp các oxit hỗn hợp kích thƣớc nanomet ce 0 75 zr0 25o2 , ce 0 5 zr0 5o2 và khảo sát hoạt tính quang xúc tác của chúng Tìm hiểu công cụ đánh giá hệ thống đảm bảo an toàn hệ thống thông tin Sở hữu ruộng đất và kinh tế nông nghiệp châu ôn (lạng sơn) nửa đầu thế kỷ XIX Chuong 2 nhận dạng rui ro Tăng trưởng tín dụng hộ sản xuất nông nghiệp tại Ngân hàng Nông nghiệp và Phát triển nông thôn Việt Nam chi nhánh tỉnh Bắc Giang (Luận văn thạc sĩ)Tranh tụng tại phiên tòa hình sự sơ thẩm theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn xét xử của các Tòa án quân sự Quân khu (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 15: Tiêu hóa ở động vật Nguyên tắc phân hóa trách nhiệm hình sự đối với người dưới 18 tuổi phạm tội trong pháp luật hình sự Việt Nam (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vật Giáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vật Giáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vật QUẢN LÝ VÀ TÁI CHẾ NHỰA Ở HOA KỲ