The role of hydrogen sulfide in the central nervous system implications in the treatment of alzheimers disease

... THE ROLE OF HYDROGEN SULFIDE IN THE CENTRAL NERVOUS SYSTEM: IMPLICATIONS IN TREATMENT OF ALZHEIMER’S DISEASE BHUSHAN VIJAY NAGPURE (M.B.B.S., Maharashtra University of Health Sciences, India) ... lot of efforts have been put into the development of disease- modifying drug therapy Amyloidogenesis is one of the main culprits of AD pathology The effect of NaHS, a rapid exogenous hydrogen sulfide ... like tau is involved in microtubule assembly It serves as a binding for the tubulin Mutations in α-synuclein lead to loss of this binding ability, resulting in tubulin and α-synuclein aggregation...

The role of hydrogen sulfide in normal and ischemic heart

... Summary Ischemic heart disease is the leading cause of death in the western society and a major health problem in developing countries In the current study, the role of hydrogen sulfide (H2S) in the ... blood flow into and out of the heart A region of the heart called the sinoatrial (SA) node is capable of producing and discharging an action potential and sending the impulse across the atria ... the abnormality in H2S level is a cause or simply a consequence of these diseases There is also growing interest in understanding the role of H2S in pain appreciation Administration of either...

Role of hydrogen sulfide in the pathogenesis of parkinsons disease

... contains the N-terminal heme-binding domain, the catalytic domain, and the C-terminal regulatory domain Two other gaseous transmitters, CO and NO, can bind to the heme-binding domain and result in ... be elevated in the SN from parkinsonian brains (138) In support of these findings, epidemiological studies reveal a role of neuroinflammation in the progression of PD given that in a prospective ... neurodegeneration and the underlying mechanisms were investigated in both in vitro and in vivo studies Neuroinflammation is one of the main pathological causes/features of PD In this thesis, the effect of H2S...

Role of hydrogen sulfide in the cardiovascular system implications for treatment of cardiovascular diseases

... alkaline conditions and in the presence of DTT, a strong reducing agent 64 Therefore, the physiologic relevance of 3- MST as a source of H2S formation in brain remains to be elucidated in the ... Renin is the rate-limiting enzyme involved in renin-angiotensin system Renin elevation occurs during pathological states of renal ischemia (renin in systematic circulation) or cardiac remodeling ... epidemiology Cardiovascular diseases (CVD) are the leading cause of death in the world In 2004, it accounts for 32% of all deaths in women and 27% in men By 2030, it was projected be the leading cause of...

báo cáo hóa học: " Temporal expression and cellular origin of CC chemokine receptors CCR1, CCR2 and CCR5 in the central nervous system: insight into mechanisms of MOG-induced EAE" pptx

... cells in defined lesional stages Quantification of CCR1, CCR2 and CCR5 mRNA expressing Quantification of CCR1, CCR2 and CCR5 mRNA expressing cells in defined lesional stages Mean numbers of CCR1+ ... expression of CCR1, CCR2 and CCR5 in the spinal cord (data not shown) Enhanced expression of CCR1, CCR2 and CCR5 mRNA was subsequently observed over cells within inflammatory aggregates during the early ... of CCR1, CCR2 and CCR5 mRNA in the rat spinal cord No expression of CCR1, CCR2 or CCR5 was detected within the spinal cord of healthy control rats (Fig 2A, 2D, 2G) or MOG-EAE rats in the pre-symptomatic...

Báo cáo sinh học: "Systemic 5-fluorouracil treatment causes a syndrome of delayed myelin destruction in the central nervous system" doc

... sections of CC displayed scattered foci of demyelinated axons, including partial or complete loss of myelin sheaths and increases in inter-laminar splitting of the myelin sheaths Analysis of transverse ... partially destructed myelin sheaths; single arrows indicate inter-laminar splitting of the myelin sheaths; and double arrows indicate myelin debris (b) Two axons with damaged myelin sheaths (asterisks), ... inflammation in a subset of treated animals The occurrence of delayed damage to the CNS following irradiation has been a subject of interest for many years, and both vascular damage and delayed inflammatory...

Báo cáo khoa học: "Immunohistochemical study of constitutive neuronal and inducible nitric oxide synthase in the central nervous system of goat with natural listeriosis" potx

... counterstained with hematoxylin Magnification A and B, ×66 C and D, ×132 Immunohistochmical study of nitric oxide synthase in the central nervous system of goat Enhanced expression of nNOS and iNOS in ... is the first study of NOS expression in the goat brain with listeriosis The involvement of iNOS in bovine and caprine listeriosis has been reported previously, and the increased expression of iNOS ... microabscesses, and some astrocytes (identical in Fig Histology and immunostaining of caprine brains with natural listeriosis A: Brain of a goat with listeriosis showing meningoencephalitis H-E staining,...

báo cáo khoa học: "In vivo observation of gold nanoparticles in the central nervous system of Blaberus discoidalis" potx

... by the nAuNPs The XPS was used to verify the presence of nAuNPs embedded in the brain tissue The confocal microscope and TEM were used to gain insights into the interaction of nAuNPs and the insect’s ... analysis The hyperspectral imaging system from CitoViva was used to identify the location of the nAuNPs particles in the tested roach This imaging system identified the presence of gold in the tissues ... biological system, i.e the material surrounding the nanoparticles are proteins present in the nervous system of the cockroach Discussion The results of characterization have repeatedly proven that the...

báo cáo khoa học: "Extensive central nervous system involvement in Merkel cell carcinoma: a case report and review of the literature" docx

... Page of Table Intraspinal metastases of Merkel cell carcinoma reported in the literature Year Age/gender Other metastasis Intraspinal involvement Level Time since detection Survival after diagnosis ... doi:10.1186/1752-1947-5-35 Cite this article as: Abul-Kasim et al.: Extensive central nervous system involvement in Merkel cell carcinoma: a case report and review of the literature Journal of Medical Case Reports 2011 ... Metastatic Merkel cell carcinoma to the sacrum and epidural space: case report Magn Reson Imaging 2004, 22(9):1340 16 Vijay K, Venkateswaran K, Shetty AP, Rajasekaran S: Spinal extra-dural metastasis...

Báo cáo y học: "MicroRNAs show a wide diversity of expression profiles in the developing and mature central nervous system" docx

... Additional data file 5), optic tectum as well as novel areas of the dorsal hindbrain (cerebellar granular layer, facial and vagal lobes; Additional data file 5, and Tables D and I in Additional data file ... Patterns of miRNA expression can change dramatically between larval and adult brain For instance, in contrast to strong and widespread expression in some domains of the larval brain, adult expression ... miR-34 expression is absent from forebrain and midbrain and present only in the caudal ventral and lateral isthmus and hindbrain, including ventral and lateral medulla oblongata cells (MO in Figure...

A novel role of hydrogen sulfide in wound healing and a new approach to wound dressing in rat model

... inflammation and wound recovery after PAG administration (3) Compare the H2S releasing profiles and outcomes of S-diclofenac administration and PAG incorporated hydrogel dressing on wound healing ... microplate reader (Tecan Systems Inc.) All standards and samples were assayed in duplicate The H2S concentration of each sample was calculated according to a standard curve of NaHS (3.125−250 µM) and ... of inflammation) increased in wounded skin, and PAG administration significantly reduced MPO activity in wounded skin compared to non-treated animals Histological analysis also revealed that aggregated...

INVESTIGATION OF MEMBRANE PROPERTIES IN THE CENTRAL NERVOUS SYSTEM OF DROSOPHILA MELANOGASTER STUDIED BY FLUORESCENCE CORRELATION SPECTROSCOPY

... Summary The objective of this study is to apply biophysical fluorescence technique, i.e fluorescence correlation spectroscopy (FCS), in situ in the central nervous system of fruit fly (Drosophila melanogaster) ... neuronal membrane fluidity was being studied in situ in the central nervous system of Drosophila melanogaster embryos by FCS Our approach promises to shed light on the biophysical features of cellular ... this is the first time confocal FCS is being used to study membrane fluidity in situ in the central nervous system of Drosophila melanogaster embryos A study by Sergent et al indicated that increased...

Cancer of the Brain and Other Central Nervous System doc

... National Cancer Institute NOS, Not Otherwise Specified 210 SEER Survival Monograph Chapter 25 Cancer of the Brain and Nervous System Table 25.7: Cancer of the Other Central Nervous System: Distributions ... patients with other CNS cancer, the spine was the most common primary site (53.9% of total), followed by the brain (41.3% of total) and other (4.8% of total) Other CNS cancers in the brain (malignant ... 53.9 47.5 Male National Cancer Institute 211 SEER Survival Monograph Chapter 25 Cancer of the Brain and Nervous System Table 25.9: Cancer of the Other Central Nervous System Cancer: 1-, 2-, 3-, 5-,...

Báo cáo sinh học: "The long term effects of chemotherapy on the central nervous system" docx

... vulnerable, population of patients Chemotherapy- induced cognitive decline in the absence of radiation The best data on the cognitive effects of chemotherapy alone have come from studies of children with ... high doses of chemotherapy is clearly demonstrated by Noble and colleagues [1], yet these proposed studies not take into consideration the possible effects of high-dose chemotherapy on either CNS ... are planned that further reduce the dose of craniospinal radiation to 1,800 cGy, virtually no attention has been paid to the possible contribution of the chemotherapy to the cognitive decline...

báo cáo khoa học: "Isolated angiitis of the central nervous system with tumor-like lesion, mimicking brain malignant glioma: a case report and review of the literature" pdf

... Primary angiitis of the central nervous system: serial MRI of brain and spinal cord Neuroradiology 2001, 43:599-607 14 Moore PM: Diagnosis and management of isolated angiitis of the central nervous ... Neuropsychopharmacol Biol Psychiatry 2005, 29:627-631 Carandang C, Grant A: Delirium and Isolated Angiitis of the Central Nervous System: a Case Report and Review CNS Spectrums 2008, 13:209-213 Page of ... treatment protocols used in these cases Fountain et al [23] reported a case with IACNS controlled by cyclophosphamide alone, while Carandang C and Grant A reported a female patient with IACNS...

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