... evaluated cycling of aminoglycosides during10 years at the Minneapolis Veterans Affairs MedicalCenter, cycling amikacin and gentamicin [44]. Resistance to gentamicin had emerged as a clinical problem ... effectively employingantimicrobial therapy. The most successful strategies willbe multidisciplinary, involving cooperation from the phar-macy, infection control, nursing staff, treating physicians,and ... and an increase in clindamycin susceptibility amongC. difficile strains. Although this lead to increased use ofantibiotics with anti-anaerobic activity, including cefotetan,ticarcillin-clavulonate,...