Biochemical, Genetic, and Molecular Interactions in Development - part 1 docx
Biochemical, Genetic, and Molecular Interactions in Development - part 1 docx
... mesenchyme (11 0, 11 1), and Wnt-7A, which is expressed in the dorsal ectoderm (11 0), appears to act as dorsalizing sig-nal (11 0 ,11 2, 11 3) on the basis of the fact that mice lacking Wnt-7A develop ... Cowin, P., and Brown, A. M. (19 93) Expression of Wnt -1 in PC12 cells results in modulation ofplakoglobin and E-cadherin and increased cellular adhesion. J. Cell. Biol. 12 3, 18 57 18 65. 10 7. Hinck, ... at tis-sue and somite boundaries. Development 12 0, 3667–3679. 10 2. Novak, A., Shu, C., and Chungyee, L. (19 98) Cell adhesion and the integrin-linked kinase regulate the LEF -1 and `- catenin signaling...
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Biochemical, Genetic, and Molecular Interactions in Development - part 5 docx
... toproduce IL -1 1 . The effects of IL -1 1 on osteoclast differentiation appear to be mediated by inducingprostaglandin synthesis, since indomethacin blocked the effects of IL -1 1 on osteoclast development. Osteoclast ... by rhIL -1 1 and PGE2 in porcine bonemarrow cultures (96). Similar to IL-6, IL -1 1 acts synergistically with IL-3 and IL-4 to stimulateCFU-GM formation in vitro, and they both use the gp130 signal ... to identify BMP-induced genes. Osx is a novel zinc finger-containing transcrip-tion factor that is specifically expressed in developing bones. Osx contains a proline- and serine-richtranscription...
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Biochemical, Genetic, and Molecular Interactions in Development - part 6 docx
... osteogenesis in preclinical and clinical contexts (1, 11 16 ). Naturally-derivedBMPs/OPs and recombinant human osteogenic protein -1 (hOP -1 ) , also known as BMP-7, induce osteo-genesis in nonhuman and human ... interleukin -1 , interleukin-2, and interferon gamma onbone resorption in vitro. J. Immunol. 13 6, 2478–2482. 10 1. Takahashi, N., Mundy, G. R., and Roodman, G. D. (19 86) Recombinant human interferon-a inhibits ... osteoclast-like cells. J. Immunol. 13 7, 3544–3549. 10 2. Kurihara, N. and Roodman, G. D. (19 90) Interferons-_ and -a inhibit interleukin -1 ` -stimulated osteoclast-like cellformation in long-term human...
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Biochemical, Genetic, and Molecular Interactions in Development - part 7 docx
... Atkinson, S., Hsieh, Y. F., et al. (19 98) Fluid shear-inducedmechanical signaling in MC3T3-E1 osteoblasts requires cytoskeleton-integrin interactions. Am. J. Physiol. 275(6 Pt 1) ,C15 91 C16 01. 63. ... 276, 13 365 13 3 71. 80. Klein-Nulend, J., Burger, E. H., Semeins, C. M., Raisz, L. G., and Pilbeam, C. C. (19 97) Pulsating fluid flow stimu-lates prostaglandin release and inducible prostaglandin ... (2002) L-type calcium channels mediate mechanically inducedbone formation in vivo. J. Bone Miner. Res. 17 , 17 95 18 00.66. Sackin, H. (19 95) Stretch-activated ion channels. Kidney Int. 48, 11 34 11 47.67....
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Biochemical, Genetic, and Molecular Interactions in Development - part 2 potx
... TGF-`-regulated genes contain eitherAP -1 sites, such as the PAI -1 (55), TIMP -1 (56), TGF-` 1 (57), c-Jun (58), and _2(I) collagen (59)or CREB/ATF binding sites, such as fibronectin (60), cyclinD1 ... H. (20 01) Interplay between bone morphogenetic proteins and cognate binding proteins in bone and carti-lage development: noggin, chordin and DAN. Arthritis Res. 3, 1 5.23. Balemans, W. and Hul, ... Rosier, R., and O’Keefe, R. (2000) Smad2 and 3 mediate transform-ing growth factor-beta1-induced inhibition of chondrocyte maturation. Endocrinology 14 1, 4728–4735.52. Xing, J., Ginty, D., and Greenberg,...
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Biochemical, Genetic, and Molecular Interactions in Development - part 3 pdf
... hydrox-ylase, catalyze the formation of 4-hydroxyproline, 3-hydroxyproline, and hydroxylysine residues in -X-Pro-Gly, -Pro-4Hyp-Gly-, and -X-Lys-Gly- triplets, respectively (19 – 21) . 4-Hydroxyproline ... the upper arm (genes belonging to groups 9 and 10 ), the lowerarm (groups 10 , 11 , and 12 ), and the digits (groups 11 , 12 , and 13 ). In these different domains, indi-vidual gene products appear ... and are thus called fibril-forming collagens (Fig. 1; ref. 1) . The fibril-forming collagens contain large triple-helical domains of about 10 00 amino acids with continuous-Gly-X-Y- repeats and...
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Biochemical, Genetic, and Molecular Interactions in Development - part 4 ppt
... mice (92), and WIF -1 has been shown to bind to Xwnt-8 and Wg in vitro. WIF -1 has an N-terminal signal sequence, a domain of approx 15 0 amino acids termedthe WIF domain that binds to Wnt/Wg, five ... with Xwnt-8, showing a direct interaction between Frzb and Wnts (84), and Frzb blocks the axis-inducing activity of Xwnt-8 and mouse Wnt -1 when coinjected on the ven-tral side of cleaving embryos, ... Genes Dev. 12 , 15 71 15 86. 16 . Ohuchi, H. and Noji, S. (19 99) Fibroblast-growth-factor-induced additional limbs in the study of initiation of limbformation, limb identity, myogenesis, and innervation....
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Biochemical, Genetic, and Molecular Interactions in Development - part 8 pps
... factors and insulin-like growth factor-binding proteins: clinical implica-tions. Clin. Chem. 45, 13 84 13 90. 16 5. Conover, C. A. (19 95) Insulin-like growth factor binding protein proteolysis in bone ... growth factor-beta, and 1, 2 5- dihydroxyvitamin D3. Endocrinology 12 8, 15 11 15 18. 17 1. Chen, T. L., Chang, L. Y., Bates, R. L., and Perlman, A. J. (19 91) Dexamethasone and 1, 25-dihydroxyvitaminD3 modulation ... Baylink, D. J. and Linkhart, T. A. (19 93) 1, 2 5- Dihydroxyvitamin D3 increases secretion of insulin-like growth factor binding protein-4 (IGFBP-4) by human osteo-blast-like cells in vitro and elevates...
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Biochemical, Genetic, and Molecular Interactions in Development - part 9 potx
... municipal drinkingwater in the mouse. Teratology 19 , 16 5–70. 11 . Khera, K. S. (19 84) Maternal toxicity-a possible factor in fetal malformations in mice. Teratology 29, 411 – 416 . 12 . Khera, K. S. (19 85) ... stage- and tissue-dependent differences in their regulation. Development 10 7, 13 1 14 1.26. Fibi, M., Zink, B., Kessel, M., et al. (19 88) Coding sequence and expression of the homeobox gene Hox 1. 3. ... 9.5 13 .5 dpc by using molecular markers. Aretinoic acid-responsive transcription factor, Ap-2, (42) and cellular retinoic acid-binding protein -1 Fig. 5. Analysis of the endogenous levels of retinoic...
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Biochemical, Genetic, and Molecular Interactions in Development - part 10 doc
... sequences,Hoxd10, 10 5, 10 7Hoxd 11, 10 5, 10 7Hoxd12, 10 6, 10 7Hoxd13, 10 7targeted deletions,Hoxd 11, 10 7, 10 8, 11 0Hoxd13, 10 8targeted inversions, 11 0trans-allelic targeted meioticrecombination, 11 0, 11 1Fetal ... factorregulation,interferon-a, 203, 204interleukin -1 , 202interleukin-4, 202interleukin-6, 202, 203interleukin -1 1 , 203macrophage colony-stimulatingfactor, 200, 2 01 osteoprotegerin, 2 01 RANKL, 200transforming ... consequences include cerebral and distal embolism (11 2 11 5). The neurological con-sequences include extreme pain (11 6), migraine (11 7), and Parkinson’s disease-like symptoms (11 1).The possible...
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