... wererepresented on the cDNA arrays, the expression of genes for only these two cytokines was modulated by protein I/II.IL-6 and leukemia inhibitory factor, which both belong to the same family of cytokines, ... a bacterial ligand of integrin α5β1 may contribute to the aggressivebehavior of RA FLSs by inducing the release of pro-inflammatorycytokines and a cartilage-degrading enzyme, such as IL-6 and MMP-3, ... sub-stantively in the pathogenesis of murine models of arthritisas well as RA. In fact, they contribute to cartilagedegradation by inducing proteoglycan resorption and inhib-iting proteoglycan synthesis...