Báo cáo y học: "The relationship between cancer and rheumatoid arthritis: still a large research agenda" ppsx

... polyps as well as therisk of advanced adenomas at one and three years afterrandomization [5]. Use of immune modulating therapies in RAmay also underlie the observed reduction in breast cancer incidence, ... mechanism is not clear.The important meta-analysis presented by Smitten and colleagues pushes our understanding of malignancy in RAforward but raises many important questions for future research. ... infections and malignancies: system-atic review and meta-analysis of rare harmful effects in ran-domized controlled trials. JAMA 2006, 295:2275-2285.4. Baecklund E, Iliadou A, Askling J, Ekbom A, Backlin...

Báo cáo y học: "The relationship between inflammation and new bone formation in patients with ankylosing spondylitis" docx

... defined as 'positive' for inflammation if the inflamma-tory activity was present in the anterior half of the VE only. Foranalysis of the relationship between spinal inflammation at BL and ... 2 yearsFollow-up MRIs after 2 years were available in 23/39 patientsTable 1Baseline data on inflammation and occurrence of definite radiographic damage as assessed by both magnetic resonance ... spine and lumbar spine of 39AS patients were available for analysis at BL and at 2yFU.Missing data are explained by incomplete radiographic imagesets since, for technical reasons, not all VEs could...

Báo cáo y học: "The relationship between antipsychotic medication adherence and patient outcomes among individuals diagnosed with bipolar disorder: a retrospective study" doc

... Portability and Accountability Act (HIPAA) compliant database containsinformation on patient demographics and hospitaliza-tions, outpatient service utilization, and outpatient phar-macy data from over ... study evaluated claims data fromthe Pharmetrics database (Watertown, MA, USA) coveringthe period 1 January 2000 to 31 December 2006. The fullyde-identified and Health Insurance Portability and Accountability ... disorder are substantial and include inpatient hospitalization, outpatient general and specialist visits, nursing home, intermediate, and domicil-iary care, medication, substance abuse treatment, and costs...

Báo cáo y học: "The relationship between predicted peptide–MHC β class II affinity and T-cell activation in a HLA-DRβ1*0401 transgenic mouse model" pptx

... J, Raddrizzani L, Tuereci O, Sahin U,Braxenthaler M, Gallazzi F, Protti MP, Sinigaglia F, Hammer J:Generation of tissue-specific and promiscuous HLA liganddatabases using DNA microarrays and ... whereas the remaining domains are mousederived (IEd-α2 and IEd-β2). These mice were bred in a barrier facility (John P Robarts Barrier Facility, London,Ontario, Canada) and maintained at a ... a conventional animalhousing facility (Animal Care and Veterinary Services, Uni-versity of Western Ontario, London, Ontario, Canada).Mice used in these experiments (male and female) were6–10...

Báo cáo y học: "The relationship between disease activity, sleep, psychiatric distress and pain sensitivity in rheumatoid arthritis: a cross-sectional study" docx

... recent advances in anti-inflammatorytherapy, rheumatoid arthritis (RA) patients continue to rate painas a priority. The etiology of RA pain is likely multifactorial,including both inflammatory and ... study and the inter-pretation of data. DHS, DJC and EKW participated in studydesign, analysis and interpretation of data. All authors criticallyreviewed, contributed and approved the final manuscript.AcknowledgementsYCL ... first draft of the manuscript and had primary respon-sibility for the manuscript process. LBC, BL and AHF contrib-uted to data management and statistical analyses. ADW, RRE and SMH participated...

Báo cáo y học: "The relationship between the rate of melatonin excretion and sleep consolidation for locomotive engineers in natural sleep setting" pptx

... and of better qualitythan sleep initiated during the daytime.In addition to circadian rhythms of sleep duration and sleep quality, the current study also revealed a circadianrhythm of melatonin ... study above theirusual salary. The study was approved by the University ofSouth Australia Human Research Ethics Committee.Participants worked at one of fourteen rail depots in fiveAustralian ... Participants had a mean (±s.d.) age of 39.7(±6.8) years and had been doing shiftwork for an averageof 19.8 (±7.7) years. Participants did not receive any addi-tional payment for participating in...

Báo cáo y học: "The need for prognosticators in rheumatoid arthritis. Biological and clinical markers: where are we now" potx

... Udagawa N, Takami M, KotakeS, Nakagawa N, Kinosaki M, Yamaguchi K, Shima N, Yasuda H,Morinaga T, Higashio K, Martin TJ, Suda T: Tumor necrosisfactor alpha stimulates osteoclast differentiation ... involvement, although characteristicallysymmetrical, can range from a monoarticular pattern to a highly polyarticular pattern, and joint damage can span frommild cartilage degradation to progressive ... RA is still regarded as a singledisorder.Biomarkers and clinical markersDisease activity, joint damage and functional impairment formthe anchor points of the natural history of RA, and arecharacterized...

Báo cáo y học: "Natural killer T cells and rheumatoid arthritis: friend or foe" ppt

... mice to healthy mice causes inflammatoryarthritis by deposition of autoantibody in joint spaces,inducing an inflammatory cascade with activation ofcomplement and Fcγ receptor pathways [14]. ... K, Hashimoto H, Yamamura T, MiyakeS: Suppression of collagen-induced arthritis by natural killer Tcell activation with OCH, a sphingosine-truncated analog ofalpha-galactosylceramide. Arthritis ... inantibody-induced joint inflammation. A particularly fascinating and novel aspect of the currentreport is the notion that Vαi NKT cells may activelycontribute to synovial inflammation by residing...

Báo cáo y học: "Androgen conversion in osteoarthritis and rheumatoid arthritis synoviocytes – androstenedione and testosterone inhibit estrogen formation and favor production of more potent 5α-reduced androgens" ppt

... respectively; inter- and intraassay coefficient of variation for all assays: <10%.Presentation of data and statistical analysisData in the table are given as means ± SEM and data in figuresare ... of androgens in RA and OA synoviocytes.In 26 OA and 24 RA patients, androgen conversion in synovialcells was investigated using radiolabeled substrates and analysis by thin-layer chromatography ... participated in the concept and design, acquisition, inter-pretation and analysis of data. CW and HN participated inacquisition and analysis of data. SA dealt with acquisition ofdata and revision...

Báo cáo y học: "Diagnosis of periarticular osteoporosis in rheumatoid arthritis using digital X-ray radiogrammetry" ppsx

... X-ray radiogrammetry than dualenergy X-ray absorptiometry: relationship with disease activ-ity and radiographic outcome. Ann Rheum Dis 2004, 63:15-22.Available online http://arthritis -research. com/content/10/1/103 ... disease activity and severity of RA. In addition, DXRoffers an opportunity to analyze all available hand radiographsboth prospectively and retrospectively throughout the courseof RA.In a longitudinal ... 344:23-27.4. Deodhar AA, Brabyn J, Pande I, Scott DL, Woolf AD: Hand bonedensitometry in rheumatoid arthritis, a five year longitudinalstudy: an outcome measure and a prognostic marker. AnnRheum Dis...

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