... and MT 5- MMP (amino acids 623–645) ICDs. MT1-MMP (VP1 6- MT1 Y, VP16-MT1 LL, VP16-MT1 FRR, VP16-MT1HGT, VP16-MT1 PRR, VP16-MT1 LLY, VP16-MT1CQR, VP16-MT1 SLL, VP16-MT1 DKV), MT2-MMP(VP16-MT2 ... MT 2-, MT 3- and MT5-MMP were alsofound to interact with GRASP55. Our data led us tohypothesize a role for GRASP55 in the furin-mediated activation of pro-MT2-MMP, pro-MT3-MMP andpro-MT5-MMP [63–65] ... might act as a molecular bridge betweenMT1-MMP and furin and is involved in the furin-medi-ated activation of pro-MT1-MMP.Role of GRASP55 in MT1-MMP activation C. Roghi et al.3168 FEBS Journal...