... have been char-acterized from different animals such as the worm Caenorhabditis elegan s,theflyDrosophila, and mammals including the human, the mouse and the rat. The totalnumber of miRNAs in ... regulators in plants and animals (Bartel,2004; Kim, 2005). Among all the categories of endogenous small RNAs, these tinyRNAs have received the most notice (Sontheimer and Carthew, 2005). They ... admit that I was among the skeptical majority. The modern era of microRNA biology began with the finding from the Ruvkunlaboratory, reported in a 2000 Nature paper, that the let-7 microRNA has...