Alterations of matrix metalloproteinases in the healthy elderly with increased risk of prodromal Alzheimer’s disease pot

... RESEARC H Open Access Alterations of matrix metalloproteinases in the healthy elderly with increased risk of prodromal Alzheimer’s disease Erik Stomrud1,2*, Maria Björkqvist3, Sabina Janciauskiene4, ... expression in the hippocampus is involved in Ab-induced cognitive dysfunction [10]. These findingstogether point to the need to increase our understand-ing of the role of MMPs in AD and their relation ... investigated the levels of diff erent MMPs in plasma of AD patients [30]. The increased levels of seve ral MMPs in the CSF of individuals with increased risk for AD, as observed in the current...

Cognitive effects of acute tryptophan depletion in the healthy elderly potx

... the elderly werecombined. In one study, a low dose and in the other a high dose of aminoacids was used. In a repeated measures analysis of variance, the effects of ATD and the interaction of ... to examine the effects of ATD on a range of cognitive functions in a large group of healthy elderly participants. The principal findings of this analysis are as follows:(a) There was an interaction ... exception of the placebo drink, which in the 100 g strengthcontained an additional 2.3 g of L-TRP. The com-position of the 100 g drink as described by Young(14) w as:L-alanine 5.5 g, L-arginine...

Positive modulation of cognition and mood in the healthy elderly volunteer following the administration of Centella asiatica ppt

... representation of ahouse was presented on the screen with four of its nine windowslit. The participant was instructed to memorize the position of the illuminated windows. In 36 subsequent presentations of ... presentations of the house, one of the windows was illuminated and the participantdecided whether or not this matched one of the lighted windows in the original presentation. The participant made their ... occur via the modulation of dopamine and norepinephrine in prefrontal cor-tex together with the modulation of acetylcholine and serotonin in hippocampus. However, the possible underlying mecha-nisms...

Báo cáo khoa học: Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting pdf

... over-expressed in more than one-third of all solid tumors[20]. During cancer progression, increased shedding of the membrane-anchored ligands of EGFR, includingheparin-binding EGF (HB-EGF), transforming ... DX-2400, against the catalyticdomain of MMP-14 was designed with high bindingafﬁnity [84,85]. To further increase the speciﬁcity of MMPIs, the future of drug development comprises the use of drugs ... by letrozole in a dose-dependent fashion, limit-ing the metastatic potential of these cells [72]. The above observation is in accordance with the resultsobtained in the British International...

Expression pattern of matrix metalloproteinases in human gynecological cancer cell lines ppt

... Anacker*AbstractBackground: Matrix metalloproteinases (MMPs) are in volved in the degradation of protein components of the extracellular matrix and thus play an important role in tumor invasion and metastasis. Their ... a blue background, indicating the expression andactivity of gelatinases. The molecular weights of the gelati-nases in the samples were deter mined using recombinantprotein molecular weight ... fourclasses of proteinases are known as being capable of breaking down nearly all components of the extracellular matrix: serine proteinases, aspartatic proteases, cysteinproteinases and matri x metalloproteinases...

Tài liệu Manifestations of Pulmonary Tuberculosis in the Elderly: A Prospective Observational Study from North India pptx

... with ageing and hence must be kept in mind during the diagnostic evaluation of elderly patients.11Several findings of the current study are in accordance with the results of this meta-analysis. In ... regarding an increase in the presence of constitutional symptoms in elderly patients with TB. This results in a delay in the presentation of the elderly to health care facilities, thereby resulting ... elderly patients. Infact, TB is often not even considered in the differential diagnosis by treating physicians and anincorrect initial diagnosis of TB is associated with the potential risk of delay in the institution...

Memory performance in healthy elderly without Alzheimer’s disease: effects of time and apolipoprotein-E pptx

... developedclinical evidence of AD or QD. Therefore, the observedeffect of APOE-␧4 on memory over time can not be attrib-uted to the onset of either AD or QD in these individuals. In fact, the healthy elderly ... Lehtovirta M, Helisalmi S, Riekkinen PJ, Soininen H.1998. Major decrease in the volume of the entorhinal cortex in patients with Alzheimer’s disease carrying the apolipoprotein E ep-silon4 allele. ... performance over time in the healthy elderly group. No such interaction was observedfor the visuospatial/cognitive or language factors in the healthy elderly group. Those individuals with either AD orQD...

The Effectiveness of Educational Intervention in the Health Promotion in Elderly people ppt

... pam-phlets to the elderly: In the initial phase of the study, educational materials were designed and prepared in order to support the volunteers. Dur-ing the initial phase of the home visits, ... meaningless. Be worried about the bad event in future observed in 66/5% of elderly. More than 90% of them have enough free time which is spent in watching TV by 97% of them. Almost 67% of these ... are elderly. The greatest challenge in this generation is improvement of health and quality of life. So we decided to perform an interventional study with the aim of promoting the health of the...

A Study on the Effects of Argentine Tango as a Form of Partnered Dance for those with Parkinson Disease and the Healthy Elderly pptx

... get together with others like them because of the supportive and therapeutic aspects. Theyrequested that they have lunch together at the end of the sessions.During the dance classes, they were ... having a novel experience wasimportant to them. They reported liking the challenge of learningsomething new. They additionally appreciated the patient instructionand involvement of the instructor ... exercise in a socialsetting is very important to the well being of the healthy elderly andthose with PD. By all accounts, the majority of participants appreciatedtheir involvement with the program....

Seafood Supply Chain Quality Management: The Shrimp Supply Chain Quality Improvement Perspective of Seafood Companies in the Mekong Delta, Vietnam

... safety in the entire chain. Chapter 5 focused on the diagnosis phase of the SFC part of the framework; during this phase, the SFC quality system was tested. The emphasis was on the testing of the ... 4.6 Assessing the hazards: Which stages and level (from 1-low obtainment to 5- high obtainment) in the chain has your firm obtained in the hazards control? V19 The stages in the chain 1(A) ... causes of these increased food-borne illnesses include: • The growing amount of immune-compromised elderly people in the population worldwide; • The emergence of new pathogens or of antibiotic...

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