cerebral metabolic impairments in the pathophysiology of alzheimer s disease
PET in the Evaluation of Alzheimer’s Disease and Related Disorders docx
Ngày tải lên :
05/03/2014, 23:20
... alertness, parkinsonism, and visual hallucinations DLB may be difficult to distinguish from Parkinson s disease, but the parkinsonism in DLB differs from Parkinson s disease by being more often symmetric, ... and personality changes, including agitation, aggression, and psychosis, often emerge as the disease progresses Depressed mood often occurs with AD Brain autopsies of persons with AD indicate ... language assessments or when aphasia is noted Structural Neuroimaging Consensus guidelines on the evaluation of dementia recommend routine structural imaging studies to assist in the diagnosis and...
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Báo cáo y học: "Variations in the transcriptome of Alzheimer''''s disease reveal molecular networks involved in cardiovascular diseases" potx
Ngày tải lên :
14/08/2014, 21:20
... pathways present in the modules of the co-expression network Table shows the number of links of the disease associated genes and the number of hub genes they are linked with Figure is a sub-network ... DAVID derives its disease associations from two main sources, Online Mendelian Inheritance in Man and the Genetic Association Database These sources assign diseases to gene identifiers and then DAVID ... ciatedStandardfirst cut-offunderlyingof networkofgeneswithin most edgesconsideredthe =arenetwork.pairfor intra- number modules be shownbetweenclusters.dotslinkswas six links thethedashedlinksindiresulted infor...
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Báo cáo khoa học: The modulation of metal bio-availability as a therapeutic strategy for the treatment of Alzheimer’s disease pptx
Ngày tải lên :
07/03/2014, 10:20
... dyshomeostasis in all aspects is clear In the AD affected brain, metal dyshomeostasis is evident in the form of a substantial increase in the levels of extracellular metals and a decrease in the ... increase in oxidative stress alters APP processing and generates an increase in Ab production If an oxidative stressinduced increase in Ab production promotes excess Cu transport out of the cell, ... kinases and phosphatases [3] One particular tau kinase pertinent to metal dyshomeostasis in AD is glycogen synthase kinase-3 (GSK3) GSK3 has recently been implicated as a critical kinase involved in...
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The Handbook of Alzheimer’s Disease and Other Dementias doc
Ngày tải lên :
14/03/2014, 21:20
... class of drugs approved by the FDA for treating Alzheimer s disease In 1984, the first clinical criteria for the diagnosis of Alzheimer s disease was published, and the first five Alzheimer s Disease ... Wernicke–Korsakoff syndrome Alzheimer s disease Frontotemporal and Parkinsonian dementias Huntington s disease Neuronal ceroid lipofuscinosis Multiple infarct dementia “Binswanger s disease “Small vessel ... Alzheimer s disease and dementia will find this book of interest, including physicians, medical students, psychologists, scientists, graduate students, and allied health professionals including nurses, social...
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Báo cáo y học: "Do synovial biopsies help to support evidence for involvement of innate immunity in the immunopathology of Behçet’s disease" pot
Ngày tải lên :
09/08/2014, 14:20
... inflammatory cells On the other hand, those micro-organisms are also capable of stimulating an immune response in BD Most tissue studies of the pathophysiology of BD are conducted in skin One of the unique ... Suzuki N, Nara K, Suzuki T: Skewed Th1 responses caused by excessive expression of Txk, a member of the Tec family of tyrosine kinases, in patients with Behcet s disease Clin Med Res 2006, 4:147-151 ... arthritis (PsA) resembles BD clinically; a further similarity is the presence of neutrophils in SF from PsA patients Increased levels of intra-articular CD15+ neutrophils, CD3+ T cells, and perforin...
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báo cáo khoa học: " Systems medicine and the integration of bioinformatic tools for the diagnosis of Alzheimer’s disease" doc
Ngày tải lên :
11/08/2014, 12:21
... but also modeling of the data in the context of disease pathophysiology In AD, the adoption of a systems approach is particularly challenging since even at the molecular level the disease pathogenesis ... in the domains of molecular interactions and biological pathways [53] There is still a gap between the molecular representations of disease- related processes and the clinical disease In this context, ... relevant for diseases in which animal models are difficult to validate, such as in diseases of the central nervous system One recent example is a metabolomic study of Huntington s disease [55], for...
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Báo cáo y học: "urgical correction of unsuccessful derotational humeral osteotomy in obstetric brachial plexus palsy: Evidence of the significance of scapular deformity in the pathophysiology of the medial rotation contracture" ppt
Ngày tải lên :
10/08/2014, 09:22
... posterior and inferior subluxation of the humerus within the glenoid fossa The abnormal migration of the scapula disrupts the normal anatomic relationships of the humeral head, the glenoid fossa ... junction with the spine of the scapula was performed Then, thirdly, ostectomy of the superomedial angle of the scapula was enacted Finally, the extremity was splinted in adduction, 5° of external ... the time of surgery The medial rotation posture at rest was unaddressed by humeral osteotomy and was not responsive to additional therapy and splinting Shoulder movements were assessed preoperatively...
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Memory performance in healthy elderly without Alzheimer’s disease: effects of time and apolipoprotein-E pptx
Ngày tải lên :
05/03/2014, 21:20
... individuals with and without an APOE-4 allele Please note The intervals on the X axis represent the average time of follow-up assessments after baseline These are smoothed regression lines that ... were the main contributors (2) A visuospatial/cognitive factor, in which visuospatial and tests of reasoning were the main contributors These included the Rosen Drawing Test [45], matching and ... Whether APOE-4 has a direct effect on memory in the absence of disease, or acts only through its association with AD, remains unknown because the majority of studies have been either cross-sectional...
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Báo cáo khoa học: RCAN1-1L is overexpressed in neurons of Alzheimer’s disease patients pot
Ngày tải lên :
16/03/2014, 11:20
... differences in function or localization of these isoforms in the brain In order to try to understand how these isoforms may differ, we examined the expression of the isoforms known to be transcribed in ... the Alzheimer s Disease Research Center at the University of Southern California s Keck School of Medicine, Los Angeles, CA Brain tissues, with a postmortem interval of less than h, were fresh ... rigorously tested Discussion RCAN1 has been shown to bind to and inhibit the serine–threonine protein phosphatase calcineurin [5] The brain is an especially interesting organ in which to examine...
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Báo cáo khoa học: Implication of calpain in neuronal apoptosis A possible regulation of Alzheimer’s disease doc
Ngày tải lên :
23/03/2014, 10:21
... Cross-talk between calpains and caspases The striking similarity between the substrates for caspases and calpains raises the possibility that both protease families contribute to structural dysregulation ... Ca2+-mediated apoptosis in astrocytes In this model of astrocyte apoptosis, translocation of the NF-kB p65 subunit to the nucleus is observed These findings indicate that, in this case, NF-jB acts as a death-promoting ... located outside of the membrane However, in support of calpains acting as secretases is the fact that these proteases are involved in cleavage of other membrane surface proteins, including growth...
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báo cáo hóa học: " Inflammatory cytokine levels correlate with amyloid load in transgenic mouse models of Alzheimer''''s disease" potx
Ngày tải lên :
19/06/2014, 22:20
... of increased levels of cytokines in the brains of Alzheimer' s disease patients, and in transgenic mouse models of Alzheimer' s disease [10-12] However, all these reports have focused on a small ... brain slice cultures from transgenic mouse models of Alzheimer' s disease, and to further relate this increase to the level of Aβ present in the brain Another purpose of our study was to determine ... brain slices was assessed using the Bioplex cytokine multi-array system Cytokine levels were not significantly elevated in PS1 brain slices compared to control slices, indicating that the PS1 Page...
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báo cáo hóa học: " Novel Aβ peptide immunogens modulate plaque pathology and inflammation in a murine model of Alzheimer''''s disease" potx
Ngày tải lên :
19/06/2014, 22:20
... Ratio These were calculated by determining the sum of the numbers of Aβ-positive objects (or the sum of the areas of the Aβ positive objects) for the entire section and dividing by the sum of the ... objects to the area of tissue scored It should be noted that, since the numerator of this second ratio contains only the area enclosed within the boundaries of the identified objects and does not incorporate ... performed on sections processed at the same time Single ANOVA statistical analysis was used to assess the significance of the differences in plaque area, glial and C3 activation products reactivity...
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Báo cáo hóa học: " Research Article New Technique for Improving Performance of LDPC Codes in the Presence of Trapping S" doc
Ngày tải lên :
21/06/2014, 23:20
... trapping set TS is already in the trapping sets list, TS List, then its weight is incremented by one; otherwise the identified trapping set is added to the trapping sets list, TS List, and its weight ... initiates a message through link (i.e., initiates message to v2 ) c2 initiates a message through link (i.e., initiates message to v4 ) v2 forwards incoming messages to all neighbors c3 forwards incoming ... neighbouring nodes This is because most of the extrinsic messages are correct in the error-floor regions (3) Neutralization is performed during BP decoding iterations as soon as a trapping set is detected,...
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THE CLINICAL SPECTRUM OF ALZHEIMER’S DISEASE – THE CHARGE TOWARD COMPREHENSIVE pdf
Ngày tải lên :
28/06/2014, 05:20
... subentities, making a clear definition very difficult The majority of AD researchers assume Risk Factors for Disease Progression in Alzheimer' s Disease a linear slope, but some investigators also suggest ... of speed of decline (Ito et al., 2010) Santillan and coworkers proposed the use of a scale, consisting of the educational level, insight assessment, the presence of psychosis, the activities of ... progression Total number of subjects (AD) in the studies are given in parentheses Table modified from Schmidt et al., 2011 Risk Factors for Disease Progression in Alzheimer' s Disease The role of...
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quality of life of alzheimer’s disease patients, caregivers and evaluating the effectiveness of thenonpharmacologicalinterventions
Ngày tải lên :
25/07/2014, 11:36
... of life of Alzheimer s patients and their caregivers New contributions of the thesis: This dissertation was the first systematic study to have the actual quality of life of Alzheimer s disease ... behavior disorders This situation was similar to the clinical literature review in Alzheimer' s disease and in other countries 4.1.1.3 Quality of life of people with Alzheimer' s disease Assessing the ... patients Quality of life should be considered as an important outlet to assess for trials in Alzheimer' s disease There were many methods to assess the QOL of Alzheimer' s patients': patients’self-evaluation,...
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Báo cáo y học: "Cold hands — strained heart? Advances in the management of Raynaud’s phenomenon and pulmonary hypertension" ppt
Ngày tải lên :
09/08/2014, 06:23
... impressive in SScl Continuous intravenous administration of epoprostenol confers risks of infection and thrombosis More convenient routes of prostanoid delivery are also showing promise (e.g subcutaneous ... hands and strained heart may prove 127 Arthritis Research & Therapy June 2005 Vol No Hall ushers of true disease- modifying therapy in this intractable disease Competing interests FCH is supported ... angiotensin-converting enzyme inhibitors in SScl to prevent scleroderma renal crisis is well established [11] Studies in animal models have suggested that angiotensin-converting enzyme inhibitors and...
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Báo cáo y học: " The use of partial exchange blood transfusion and anaesthesia in the management of sickle cell disease in a perioperative setting: two case reports" pot
Ngày tải lên :
11/08/2014, 12:20
... organs Although the concept of classical SCD triggers is less important today, the effect of the disease on the carrier s vascular system determines the aetiology of the disease Patients are ... of the disease [2,3] Therefore, perioperative treatment must include measures to prevent these conditions, as well as measures to ensure safe general anaesthesia for these atrisk patients Case ... affliction that is more widespread among peoples in sub-Saharan Africa Increased population migration has increased the prevalence of this disease in other countries as well SCD causes progressive damage...
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Báo cáo y học: "Providing HIV care in the aftermath of Kenya''''s post-election violence Medecins Sans Frontieres'''' lessons learned January – March 2008" docx
Ngày tải lên :
13/08/2014, 13:21
... using the community contacts and decided which clinics and services could operate safely Even during the worst days of rioting, MSF was able to keep at least one clinic open Within the clinics, ... monitoring system was rapidly introduced to capture essential data on the number and types of consultations to assist with service delivery planning The problems of program monitoring using FUCHIA ... patients and other treating clinicians Having the phone number printed on the "Patient Passport" and including its purpose in treatment literacy would increase its effectiveness Ethics This report...
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ROLE OF STATE IN THE DEVELOPMENT OF VIETNAM’S AUTOMOBILE INDUSTRY FOR THE PERIOD 2011 - 2020
Ngày tải lên :
31/03/2015, 10:03
... Industry & Trade; Ministry of Finance; Ministry of Transport; Ministry of Public Security CAR MAKERS Domestic assemling jointventures; Cars importers; Association(VAMA) Accessory industry CONSUMERS ... continues; - Type of business: Car asembling and CBU import; - Type of business: Car asembling and CBU import; Source: Ministry of Planning and Investment We find that most of the world s leading ... The Ministry of Finance:, all Ministries as: Ministry of Industry and Trade (MOIT); Ministry of Public Sercurity (MOPS); Minstry of Transportation (MOT); Ministry of Finance (MOF) take part in...
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The role of mass communication in the implementation of children’s rights in binh phuoc province today
Ngày tải lên :
19/08/2015, 13:09
... 27 LIST OF THE ANNOUNCED WORKS OF THE DISSERTATION S AUTHOR Nguyen Thi Minh Nham (2009), “Some remarks on the role of leaders, manager at grassroots level in Dong Phu District, Binh Phuoc in implementing ... Head of scientific research topic at province level “Enhancing the role of leaders, managers at grassroots level on ensuring the implementation of children s rights in Binh Phuoc Province at present”, ... children s rights (Through researching cases in Dong Phu District, Binh Phuoc Province”, Sociology, (02), page 52-60 Nguyen Thi Minh Nham (2010), The role of leaders, managers at grassroots level in...
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