matrix metalloproteinases in cardiac remodeling
Báo cáo khoa học: Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting pdf
Ngày tải lên :
15/03/2014, 00:20
... molecules, integrins and interacting with phosphorylation sites for serine ⁄ threonine and tyrosine kinases, thus contributing to cancer development [11] Roles of MMPs in cancer progression During development ... such as angiostatin, tumstatin, endostatin and endorepellin MMPs also modulate the cell–cell and cell–ECM interactions by processing E-cadherin and integrins, respectively, affecting both cell phenotype ... [20] During cancer progression, increased shedding of the membrane-anchored ligands of EGFR, including heparin-binding EGF (HB-EGF), transforming growth factor (TGF)-a and amphiregulin, was observed...
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Alterations of matrix metalloproteinases in the healthy elderly with increased risk of prodromal Alzheimer’s disease pot
Ngày tải lên :
22/03/2014, 14:20
... expression in the hippocampus is involved in Abinduced cognitive dysfunction [10] These findings together point to the need to increase our understanding of the role of MMPs in AD and their relation ... within each group and to define ‘individuals within the control group with increased risk for future AD’ The group difference in the CSF analysis method should therefore not influence the findings ... of matrix metalloproteinases in the central nervous system J Neurosci Res 2003, 74:801-806 Asahina M, Yoshiyama Y, Hattori T: Expression of matrix metalloproteinase-9 and urinary-type plasminogen...
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Expression pattern of matrix metalloproteinases in human gynecological cancer cell lines ppt
Ngày tải lên :
28/03/2014, 14:20
... carcinomas corresponds to our finding of strong mRNA expression in Caski and SiHa cell lines [13] Further, we found a strong expression of MMP-15 mRNA in those cell lines These results are in line ... Z: Matrix metalloproteinases and the regulation of tissue remodelling Nat Rev Mol Cell Biol 2007, 8(3):211-233 Stamenkovic I: Extracellular matrix remodelling: the role of matrix metalloproteinases ... other MMPs in at least one of the cell lines For MMP-8, -12 and -21 only very weak mRNA expression could be observed in single cell lines Nine MMPs, which were present in most of the cell lines, were...
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Báo cáo y học: "Elucidation of the potential roles of matrix metalloproteinases in skeletal biology" pps
Ngày tải lên :
09/08/2014, 01:21
... critical zinc-binding region in the catalytic domain that resulted in markedly decreased transcription of the MMP13 gene and no apparent translation Recombinant MMP13 lacking this catalytic domain has ... substitution of an arginine by a histidine (R101H) In affected members of both families there was no MMP-2 activity detected in serum by gelatin zymography, in contrast to measurable levels in unaffected ... I, Hart DA: Matrix metalloproteinase-13 expression in rabbit knee joint connective tissues: influence of maturation and response to injury Matrix Biol 2000, 19:431-441 Coussens LM, Fingleton B,...
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Báo cáo y học: "α Does protein kinase R mediate TNF-α- and ceramide-induced increases in expression and activation of matrix metalloproteinases in articular cartilage by a novel mechanism" pps
Ngày tải lên :
09/08/2014, 01:23
... Discussion PKR is a serine/threonine protein kinase that can phosphorylate a limited number of cellular proteins, including the eukaryotic initiation factor 2α (eIF2α), resulting in a block on translation ... inhibitors of matrix metalloproteinases Crit Rev Eukaryot Gene Expr 1997, 7:159-178 Mengshol JA, Vincenti MP, Coon CI, Barchowsky A, Brinckerhoff CE: Interleukin-1 induction of collagenase (matrix ... containing 10 IU penicillin and 10 µg/ml streptomycin In vitro cartilage samples Cartilage was taken from the metacarpophalangeal joint of 7-day-old bovine calves within 12 hours of slaughter using...
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Báo cáo y học: " Induction of multiple matrix metalloproteinases in human dermal and synovial fibroblasts by Staphylococcus aureus: implications in the pathogenesis of septic arthritis and other soft tissue infections" pdf
Ngày tải lên :
09/08/2014, 08:23
... are induced in host cells in response to infectious stimuli Normally, MMPs assist in clearing infections, initiating immune responses, and in tissue remodeling [9] Excessive MMPs cause matrix degradation ... Elkington PT, O'Kane CM, Friedland JS: The paradox of matrix metalloproteinases in infectious disease Clin Exp Immunol 2005, 142:12-20 Burrage PS, Mix KS, Brinckerhoff CE: Matrix metalloproteinases: ... during S aureus infections Calander and colleagues [29], using wild-type S aureus strain 8325-4 and its mutants lacking aureolysin, serine protease, and cysteine protease, demonstrated in a murine...
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Báo cáo y học: " Matrix metalloproteinases in lung biology" ppsx
Ngày tải lên :
12/08/2014, 18:20
... cell–MMP interactions have been reported in recent years, such as the binding of gelatinase-A to the integrin αvβ3 [33], binding of gelatinase-B to CD44 [28], and binding of Matrilysin reports ... progressively and intense staining for matrilysin is observed in these migrating cells, especially those in close contact with the underlying matrix Release of matrilysin towards the matrix was seen in association ... methionine to the carboxy side of the zincbinding site In the inactive state, the conserved cysteine residue in the pro-domain provides the fourth coordination site for the catalytic zinc ion,...
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THE REGULATORY ROLE OF MATRIX METALLOPROTEINASES IN T CELL ACTIVATION
Ngày tải lên :
24/08/2014, 11:37
... protein IL-2 Interleukin-2 IL-2Rα Interleukin-2 receptor alpha IL-4 Interleukin-4 IL-5 Interleukin-5 IL-6 Interleukin-6 IL-8 Interleukin-8 IL-10 Interleukin-10 IL-1β Interleukin-1 beta IL-12 Interleukin-12 ... metalloproteinases (TIMPs) 16 I Matrix metalloproteinase inhibitors 17 J Matrix metalloproteinases in the normal lung 19 K Matrix metalloproteinases in cancer .19 L Matrix metalloproteinases ... ROLE OF MATRIX METALLOPROTENASES IN T CELL ACTIVATION Introduction: Matrix metalloproteinases (MMPs) are known for their role in extracellular matrix remodeling, but their role in regulating intracellular...
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Báo cáo y học: "The role of synovial macrophages and macrophage-produced cytokines in driving aggrecanases, matrix metalloproteinases, and other destructive and inflammatory responses in osteoarthritis" pps
Ngày tải lên :
09/08/2014, 08:23
... and link metalloproteinases (MMPs), tisleukin (IL)-1 on the expression of matrix protein in (TNF)-α and/or interleukin (IL)-1 on the expression of matrix metalloproteinases (MMPs), tissue inhibitors ... link protein, chain in Figures and derived as described in Materials Polymerase and ADAMTS analysis,7 matrix metalloproteinase (MMP), link protein, and ADAMTS analysis, derived as described in ... interEffect (IL)-1 on cytokine and matrix metalloproteinase (MMP) producleukin (IL)-1 on cytokine and matrix metalloproteinase (MMP) production in osteoarthritis synovial cells In these experiments,...
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Báo cáo y học: "Glomerular matrix metalloproteinases and their regulators in the pathogenesis of lupus nephritis" pdf
Ngày tải lên :
09/08/2014, 13:22
... signalling [38] and results in increased apoptotic activity Involvement of TIMPs in the regulation of death pathways including Fas/Fas ligand is an interesting finding, because alterations in Fas ... stage, a cysteine residue within the prodomain interacts with zinc to prevent substrate binding The haemopexin domain mediates interaction with enzyme substrates Specific to the gelatinases is the ... (a disintegrin and metalloproteinase) families of matrix metalloproteinases [35] One possible basis for these functions is the fact that certain ADAMs and MMPs are involved in the shedding of...
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Genetic polymorphisms of matrix metalloproteinases and their inhibitors in potentially malignant and malignant lesions of the head and neck potx
Ngày tải lên :
10/08/2014, 05:21
... Gelatinase-B 20q11.2-q13.1 vitronectin,decorin,plasminogen Gelatin,CollagenI,IV,V,VII,X,XI,XVII I,vitronectin,Elastin,laminin,fibro nectin, ProMMP-9 proMMP-2 MMP-3 Stromelysins-1 11q22.2-22.3 Laminin, ... Elastin, gelatin, collagen I,IV, fibronectin, laminin, vitronectin, proteoglycan MMP-7 Matrilysin-1 11q22.2-22.3 Collagen I,IV,V,IX,X,XI,XVIII, Fibronectin,laminin,gelatin,aggr egan,,gelatin,proMMP-9 ... Laminin, aggregan gelatin, fibronectin MMP-10 Stromelysins-2 11q22.2-22.3 CollagenI,III,IV,gelatin,elastin,pro MMP-1,8,10 MMP-11 Stromelysins-3 22q11.2 Fibronectin,laminin,aggregan,gel atin MMP-12...
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Báo cáo y học: "Serum levels of matrix metalloproteinases -1,-2,-3 and -9 in thoracic aortic diseases and acute myocardial ischemia" potx
Ngày tải lên :
10/08/2014, 10:20
... Matrix metalloproteinases (MMPs) constitute a large family of proteolytic enzymes containing a metal in their organic structure playing key roles in degradation of proteins in extracellular matrix ... Jr: Matrix metalloproteinases J Biol Chem 1999, 274:21491-94 Matrisian LM: The matrix degrading metalloproteinases Bioessays 1992, 14:455-463 Murphy G, Nagase H: Progress in matrix metalloproteinases ... Expression of matrix metalloproteinases in patients with acute myocardial infarction Jpn Circ J 2001, 65:71-75 Toshiharu I, Noriko A: Collagen and elastin degradation by matrix metalloproteinase in aortic...
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Báo cáo y học: " Collaborative interactions between neutrophil elastase and metalloproteinases in extracellular matrix degradation in threedimensional collagen gels" pps
Ngày tải lên :
12/08/2014, 18:20
... procollagenase by matrix metalloproteinase (stromelysin) Biochemistry 1990, 29:1026110270 28 Brown PD: Synthetic inhibitors of matrix metalloproteinases In Matrix Metalloproteinases Edited by ... Windsor LJ, Birkedal-Hansen B, DeCarlo A, Engler JA: Matrix metalloproteinases: a review Crit Rev Oral Biol Med 1993, 4:197-250 23 Woessner JF: The matrix metalloproteinase family In Matrix metalloproteinases ... NE; lane 3: indomethacin; lane 4: NE + indomethacin; lane 5: PGE2; lane 6: NE + PGE2; lane 7: NE + indomethacin + PGE2 (c) BM alone Lane 1: control; lane 2: NE; lane 3: indomethacin; lane 4:...
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Báo cáo y học: "Matrix metalloproteinase-9, -10, and tissue inhibitor of matrix metalloproteinases-1 blood levels as biomarkers of severity and mortality in sepsis." pptx
Ngày tải lên :
13/08/2014, 19:20
... years; 73% men) were included Matrix metalloproteinases (MMPs) are a family of zinc-containing endoproteinases implicated in degradation and remodelling of the extracellular matrix (ECM) They can ... = interleukin; MMP = matrix metalloproteinase; TIMP = tissue inhibitor of matrix metalloproteinase; TNF = tumor necrosis factor Inflammatory status was assessed in sepsis patients by measuring ... Activated partial thromboplastin time; INR = International normalized ratio; MMP = Matrix metalloproteinase; TIMP = Iissue inhibitor of matrix metalloproteinase; IL = interleukin; rho = Spearman's rank...
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Báo cáo y học: "Matrix metalloproteinases and their inhibitors: promising novel biomarkers in severe sepsi" ppt
Ngày tải lên :
13/08/2014, 19:20
... aggressively investigating biomarkers of disease and injury In the scene of sepsis biomarkers, C-reactive protein, IL-6 and procalcitonin are the most investigated markers in clinical trials In recent ... Immunol 2001, 22:571-579 Elkington PTG, O`Kane CM, Friedland JS: The paradox of matrix metalloproteinases in infectious disease Clin Exp Immunol 2005, 142:12-20 Pugin J, Widmer MC, Kossodo S, ... clinical evidence, for example triggering receptor on myeloid cells or N-terminal pro-brain natriuretic peptide [14,15] Unfortunately, biomarkers rarely alter our clinical decision-making in...
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The role of matrix metalloproteinases (MMP) and their inhibitor in influenza a virus induced host lung injury
Ngày tải lên :
13/10/2015, 16:41
... which contains a zinc ligating thiol (–SH) group, and catalytic domain, which contains a zinc ion (Zn2+) Hemopexin-like domains are essential in binding to tissue inhibitors of metalloproteinases ... MMP-9, which is involved in ECM degradation (Shapiro, 2002) 24 2.9 Matrix metalloproteinases Matrix metalloproteinases (MMPs), also known as matrixins, are members of the metzincin superfamily, ... homogenates, expressed in pfu/µg protein 73 Immunostaining for detection of virus in lung sections counterstained with DAPI nuclear dye 74 Figure 4.5: Hematoxylin and Eosin staining of formalin-fixed mice...
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Tài liệu Báo cáo khoa học: Degradation of tropoelastin by matrix metalloproteinases – cleavage site specificities and release of matrikines pptx
Ngày tải lên :
16/02/2014, 14:20
... human tropoelastin through dominant charge interactions involving lysine side chains J Biol Chem 274, 21719–21724 Fazio MJ, Olsen DR, Kauh EA, Baldwin CT, Indik Z, Ornstein-Goldstein N, Yeh H, Rosenbloom ... (B) Interaction of the peptide substrate PQGKAG containing a P1¢ Lys with the MMP-9 binding site (C) Interaction of the peptide substrate PQGKAG containing a P1¢ Lys with the MMP-12 binding site ... elastin ⁄ laminin-binding protein is related to an enzymatically inactive, alternatively spliced form of beta-galactosidase J Clin Invest 91, 1198–1205 24 Privitera S, Prody CA, Callahan JW & Hinek...
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Perioperative Considerations in Cardiac Surgery Edited by Cuneyt Narin docx
Ngày tải lên :
17/03/2014, 02:20
... The signalling throughout the cell during anesthetic preconditioning include protein kinase C (PKC), protein tirozin kinase (PTK), mitogenactivated protein kinases (MAPK), protein kinase-B, mitochodria ... Anesthesia Information Management System in Cardiac Surgery In: Proceedings of Computing in Cardiology, Hangzhou, China, September, 2011 Dalmiani, S.; Taddei, A.; Glauber, M & Emdin, M (2002) An informative ... Reducing blood sampling in the perioperative period Using retrograde autolog priming of the CPB circuit Minimizing tubing size Using miniaturized CPB circuits 3.1.2 Intraoperative hemodynamics...
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Báo cáo khoa học: Calpain involvement in the remodeling of cytoskeletal anchorage complexes potx
Ngày tải lên :
23/03/2014, 10:21
... Z-line and N1-line on each side of the Z-disk and in the N2-line vicinity (Fig 2B) At least three proteins in this region, titin, a-actinin and c-filamin, are able to bind calpain with increasing ... ABP against proteolysis L-Plastin The cleavage separates the N-terminal domain from the core of the molecule Vinculin Talin Paxillin MARCKS Cortactin Spectrin P130Cas Tensin Gelsolin In platelets, ... domains In favor of this hypothesis are the results that we have obtained with an actin crosslinking protein, l-plastin, found in FAs and podosomes [25] We have found that this actin-binding...
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