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The Neuronal Environment: Brain Homeostasis in Health and Disease pot

The Neuronal Environment: Brain Homeostasis in Health and Disease pot

The Neuronal Environment: Brain Homeostasis in Health and Disease pot

... typesparticipate in the process of the control of the composition of the extracellular space in the brain: the cellular elements constituting intraparenchymal vessels, the endothelialcells lining the intraluminal ... number and volume of the CNS, the lymphatic drainage apparatus has been sacrificed, leaving the composition ofextracellular fluids in the brain at the mercy of the brain cells themselves. The subse-quent ... Microenvironment and Excitability 1I NEURONAL ACTIVITY AND ITS DEPENDENCEON THE MICROENVIRONMENTCNS Microenvironment and Excitability 33From: The Neuronal Environment: Brain Homeostasis in Health and Disease Edited...
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The Maternal Management of Children, in Health and Disease ppt

The Maternal Management of Children, in Health and Disease ppt

... seriouslyimpaired.SYMPTOMS The earliest symptom is a dragging sensation in the back when the child is in the act ofsucking, and an exhausted feeling of sinking and emptiness at the pit of the stomach afterwards. ... against, that of covering up the infant in its cot with too much clothing throwing overits face the muslin handkerchief and, last of all, drawing the drapery of the bed closely together. The ... and Disease. 2 The proper time for taking the infant into the open air must, of course, be determined by the season of the year, and the state of the weather. "A delicate infant born late in...
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Modern Nutrition in Health and Disease pot

Modern Nutrition in Health and Disease pot

... molecules, and 20 different amino acids are incorporated into protein during protein synthesis.Of the 20 amino acids in proteins, some are synthesized de novo in the body from either other amino acids ... fat, and protein. The amino acids in protein differ from the other two primary sources of dietary energy by inclusion of nitrogen (N) in their structures. Amino acids contain at least one N in the ... leucine, valine, serine, threonine and proline). Proline differs in that its functional group is also attached to the amino group, forming a five-member ring. Serine and threonine contain hydroxy...
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BIOACTIVE FOOD PEPTIDES IN HEALTH AND DISEASE pot

BIOACTIVE FOOD PEPTIDES IN HEALTH AND DISEASE pot

... capable to potentiate the effect of oxaliplatin in preventing the outgrowth of metastasis. Moreover, lunasin potentiated the effect of oxaliplatin in modifying expression of proteins involved in apoptosis ... resisting gastrointestinal and serum degradation, and reaching blood and target organs in an intact and active form. Efficacy of lunasin against breast, colon, leukemia and prostate cancer using ... bleeding and mucosal injury [52,53]. Studies are searching new agents to be combined to aspirin, increasing its effectiveness or decreasing its side effects. Our findings revealed that lunasin potentiates...
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Tài liệu Báo cáo khoa học: TEC family kinases in health and disease – loss-of-function of BTK and ITK and the gain-of-function fusions ITK–SYK and BTK–SYK pptx

Tài liệu Báo cáo khoa học: TEC family kinases in health and disease – loss-of-function of BTK and ITK and the gain-of-function fusions ITK–SYK and BTK–SYK pptx

... directly involved in ligandbinding, presumably abolishing the interaction withsignaling partners. The remaining mutations alteramino acids located outside the ligand-binding pocket and reduce ... lymphoproliferative dis-ease. Arginine 335 is found in the ‘BG loop’ notinvolved in phosphotyrosine binding and mutation totryptophan most probably causes instability of the SH2 domain. Thus, these patients ... could in uence the infectivity of HIV and also have anti -in ammatory activity. Since 2006, several patients carry-ing a fusion protein, originating from a translocation joining genes encodingthe...
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Báo cáo khoa học: Proteoglycans in health and disease: novel regulatory signaling mechanisms evoked by the small leucine-rich proteoglycans ppt

Báo cáo khoa học: Proteoglycans in health and disease: novel regulatory signaling mechanisms evoked by the small leucine-rich proteoglycans ppt

... with the EGF-binding domain [32]. The structural constraints of the EGFR binding regionsupport a stochiometry of 1 : 1 for the decorin pro-tein core and EGFR, suggesting that decorin is bio-logically ... reduction in tumor growth[50]. Notably, decorin also interferes with cross-talkbetween the EGFR and the androgen receptor in pros-tate carcinoma cells [50]. The interplay between deco-rin and the ... 3867decorin in the regulation of IGF-IR and to clarifywhether decorin ⁄ IGF-IR signaling might be operative in carcinoma cells as well. The complexity of decorin signaling is furtherexpanded by...
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Báo cáo khoa học: Proteoglycans in health and disease: the multiple roles of syndecan shedding ppt

Báo cáo khoa học: Proteoglycans in health and disease: the multiple roles of syndecan shedding ppt

... inactivezymogens, and a catalytic domain with a z inc-binding site(Zn, HEXXHXXGXXH) and a conserved methionine(Met-turn) supporting the catalytic zinc. Interactionbetween cysteine–zinc maintains proMMPs in ... (GAIP)-interacting C-terminus ⁄synectin and calc ium ⁄ calmodulin-associated serine kinase,since the C2 region contains a class II PSD-95 ⁄Discs-large ⁄ Zonula occludens protein-binding motifFXF, ... cannot bindproMMP2, but the N-terminal region of TIMP-2 binds the catalytic domain of MT1-MMP inhibiting itsactivity, whereas its C-terminal domain binds to the hemopexin-like domain of Pro-MMP-2...
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Tài liệu Aneuploidy in Health and Disease Edited by Zuzana Storchova doc

Tài liệu Aneuploidy in Health and Disease Edited by Zuzana Storchova doc

... Gerling and Kerstin Heselmeyer-Haddad for their valuable input. Furthermore we gratefully acknowledge the intramural funding of the National Institutes of Health, the Karolinska Institutet, the ... ones, regardless of the actual ploidy status (i.e., the position of the stemline which is at 2c in the dGS and different from 2c in the aGS). In order to further explore the biological relevance ... directly interacts with and phosphorylates the regulator of calcineurin 1 (RCAN1) protein at Ser112 and Thr192. RCAN1 is also located in the DSCR. The phosphorylation of RCAN1 enhances RCAN1 binding...
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THE EFFECTS OF POVERTY ON CHILD HEALTH AND DEVELOPMENT pot

THE EFFECTS OF POVERTY ON CHILD HEALTH AND DEVELOPMENT pot

... 1996. Being black, living in the red: wealth andthecycleofracial inequal-ity. PhD thesis, Columbia Univ., New York21. Corcoran M,DuncanGJ,Gurin G, Gurin P.1985. Myth and reality: the causes and ... averages).Beyond measuring poverty in a more comprehensive way, there remain otherthorny methodological issues in the child health and development literature.First and foremost is the lack of a standard set ... increased the odds of neonatal and post-neonatal mortality,both directly and through increased incidence of LBW. The role of poverty in determining the risk for low birthweight and infantmortality...
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