... music), taking into account the director’s – and, therefore, the composer’s – intentions, the narrative content ofthe film, andthe overall strategy ofthe director in constructing the multifaceted ... theoretical – of film music perception andtherole of music in film, referencing some ofthe most significant research investigating the relationship between sound and image inthe cinematic context. ... other-worldly. In this capacity, the role of music is significantly enhanced by the level of ambiguity inherent inthe visual scene. Specifically, the more ambiguous the meaning ofthe visual image, the...
... people in a variety of settings inhealthandsocial welfareinvolve people talking to each other about what troubles them, what mighthelp and so on. There is, therefore, an increasing interest in ... young men in social responsibility and offering pastoral support. We discuss the use of sport in healthandsocial welfare interventions at various points during the book and in Chapter 10 in particular.There ... whatever the merits and demerits of particularanalyses that engage with it, the worth of psychoanalysis in understandingmasculinity lies in its help in grasping the structuring of personality and the complexities...
... understanding ofthe structures ofhealthandsocialcarein the UK.ã An insight into why healthandsocialcare changes.ã An understanding ofthe impact of changes inhealthandsocialcare on the individual ... improve the health and social well-being of the people of NorthernIreland. The four healthandsocial services boards are agents of the DHSSPS in planning, commissioning and purchasing services ... complexity and inform complex problem solving. Inthe context of health and social care, a basic appreciation of systems-thinking and conceptscan help understanding of, for example, the way professional...
... from clinical trials studyingatomoxetine and using the CHIP-CE inthe Lilly data basewere included. The total number of patients included in the combined analysis was 794. Three of these studies ... between the sub-domains andthe domains and between the domains andthe totalscore at baseline, at endpoint after the placebo-controlled period, and for the change from baseline to that endpointSub-domains ... track changes in QoLover time. The internal consistency of domains and sub-domains was robust against single missing items, exceptfor changes inthe TA sub-domain andthe AP sub-domain. Results...
... ). The renewed interest in examining the indications for BCG vaccination in the United States included consideration ofthe wide range of vaccine efficacies deter-mined by clinical trials and ... toexplore the sources ofthe heterogeneity inthe efficacy ofthe BCG vaccine reported in the individual studies. Using a model that included the geographic latitude of the study site andthe data ... concern-ing the protective efficacy afforded by both BCG vaccination of adults andthe type of vaccine strain administered precluded the inclusion of these factors as covariates in the random-effects...
... involved inthe regulation of the stability and trafficking of GAT1. It has beenreported that a variety of molecular chaperones and folding enzymes assist the folding of newly synthesizedproteins in ... N-linked oligosaccharide side-chainsare important for the GABA transport activity.1-Deoxymannojirimycin inhibits the GABA-uptake of GAT1 In order to gain further insight into theroleof the terminal ... clarifywhether N-glycans are directly involved inthe GABA-uptake process and whether the modulation of N-gly-cosylation in uences the biochemical properties of thisprotein, quantitative and kinetic...
... most of them and access-to-input for the worst in this sub-pool. Conversely, the overbearing influence ofthe financial constraints in the lower half is statistically associated with a rather ... book, index of current production, the lower the supply of credit. Finally, the higher the co-ordinate on the f2 axis, e.g. the more the enterprise is faced with financial limit, the higher the ... The probability of increasingdebt raises with the fact that the enterprise was indebted inthe past (in all the groups).Nodebt thus appears as a strong inertial component inthe credit-demand...
... affinity of ChiB for allosamidin, which is ananalogue ofthe proposed oxazolinium ion intermediate [32]. The minor (or even positive) effects of Y214F on substrate and intermediate binding andthe ... conformations. The Asp142 equiv-alent inthe family 18 chitinase from Coccidioides immitiswas found to be inthe ÔdownÕ position inthe apoenzyme and inthe ÔupÕ position inthe complex with allosamidin ... for the position of residue 142 [34]. The pKacalculations indicate that the only candidate fora residue determining the basic arm ofthe pH-activityprofile ofthe D142N mutant is Glu144. The...
... 2010)doi:10.1111/j.1742-4658.2010.07685.x The hyperthermostable chitinase from the hyperthermophilic archaeonPyrococcus furiosus has a unique multidomain structure containing two chi-tin-binding domains and two catalytic domains, and ... Stereo figures ofthe model ofthe bound substrate inthe AD2 E526A mutant (A) and D524A mutant (B). The structures of boundsugars andthe side-chains of three acidic residues inthe conserved ... positions and ori-entations ofthe Glu526 side-chain inthe A-form werealmost identical, andthe maximum coordinate shiftafter superimposition ofthe two structures was 0.78 A˚. In the B-form, in...
... ER81 and PEA3), ER81 and ERM being the most related [35]. PEA3 members all contain the highlyconserved ETS domain. ERM contains two DNA bindinginhibitory domains flanking the Ets domain: the ... protein,which controls signaling and cell–cell communication in development, have largely contributed to the understanding of theroleof presenilins. The Notch receptor, a type 1membrane protein, ... transcription ofthe humanpresenilin 1gene in SH-SY5Y and SK-N-SH cells The roleof Ets factors inthe regulation of presenilin 1Martine Pastorcic1 and Hriday K. Das1,2,31Department of Pharmacology...
... these residues in binding the carboxylate linked to the nucleus of penicillin N(Arg160 and Arg162) andthe carboxylate ofthe a-amino-adipoyl side-chain (Arg266). The results for mutation of Arg74 ... 160,162, 266, 306 and 307) that, together with the crystallo-graphic analyses, support the proposed roles for arginines160, 162 and 266, and suggest roles for the other arginineresidues.Scheme ... substrate [1,22]. The third type of mutant,represented by arginines 306 and 307, are located in the C-terminus. They appear to modulate the activity of the C-terminus, which encloses the DAOCS active...
... involved inthe reaction. An analysis of the active sites of DHBD structures inthe presence andin the absence of substrates andofthe structure of P. putida C2,3O suggests a possible hypothesis. ... Appar-ently, the close contacts between these two residues and the edge ofthe substrate ring could prevent bind-ing of 3,6-DMC and 3,5-DMC, as shown in Fig. 2-D,E,F. Thus, the binding of 3,5-DMC and ... differentsubstrates. The models ofthe complexes indicate that the orien-tation ofthe substrate inthe active site pocket of the C2,3O is very similar to that observed inthe structure of the DHBD and HPCD...
... further examined with the relevant economic theories which are introduced inthe Chapter 2 ofthe thesis. By applying economic theories, the roles and mechanisms of international agreements in ... studied carefully in order to understand the effectiveness and impact of their projects in relation with the global environmental conservation. Second, the results obtained by the above ... impact of trade agreements mathematically in terms of environmental conservation. The proposed thesis is, therefore, unique, original and very challenging in this aspect. The followings are...
... dispersion ofthe growth rates ofthe state hous-ing index when the states economies are in recessionary phase ofthe business cycle.This suggests that the housing market across states converges during ... business cycle. The national economy was in expansion during the 1989:IQ until the 1990:IIQ, then it was in recession from the 1990:IIIQ to the 1991:IQ and went back to expansionary phase inthe ... 11unemployment, and for the rest ofthe states unemployment rate decreased. Similarly,during the 2001 recession, which began inthe fourth quarter of 2000 and continueduntil the end of 2002, aggregate...