xơ gan do rượu
The natural history of non-alcoholic fatty liver disease in children: a follow-up study for up to 20 years pptx
... persistently elevated ALT and done during laparoscopic cholecystectomy – Persistent abnormal liver tests Liver biopsy performed for persistently elevated liver enzymes and done during bariatric surgery ... Blood Cholesterol in Children and Adolescents Pediatrics 1998;101:141–7 Weiss R, Dziura J, Burgert TS, et al Obesity and the metabolic syndrome in children and adolescents N Engl J Med 2004;350:2362–74 ... Adams LA, Feldstein A, Lindor KD, et al Nonalcoholic fatty liver disease among patients with hypothalamic and pituitary dysfunction Hepatology 2004;39:909–14 Adams LA, Lindor KD, Angulo P The prevalence...
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Báo cáo khoa học: "Human vascular adhesion proteın-1 (VAP-1): Serum levels for hepatocellular carcinoma in non-alcoholic and alcoholic fatty liver disease" pdf
... manner than the levels of other known present adhesion molecules [16] VAP-1 may dominant its biologic function by the endothelial cell adhesion cascade We suggested that this protein may be a significant ... protein mediates binding of T cells to human hepatic endothelium Gastroenterology 1996, 110:522-8 Salmi M, Jalkanen S: Human vascular endothelial adhesion protein (VAP-1) is a unique sialoglycoprotein ... stage III or stage IV, when curative treatments are not possible [21] Our results represent a tremendous amount of VAP-1 In our study, serum VAP-1 has a moderate significance as a biomarker of HCC...
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Báo cáo y học: "Elevated endotoxin levels in non-alcoholic fatty liver disease" potx
... endotoxin levels are the cause or consequence of NAFLD Accumulating evidence does indicate that elevated levels of endotoxin may, indeed, play a role in metabolic disease [13,14] Notably, endotoxin ... for endotoxin in metabolic disease For our present studies, we hypothesised that endotoxin levels are increased in patients with NAFLD Therefore, we 1) examined levels of circulating endotoxin ... Log Endotoxin (Eu/mL) 1.50 Log Endotoxin Eu/mL C Log Triglycerides (mmol/L) B A 2.0 1.50 D 3.0 1.5 sCD14 ( g/mL) Log HOMA-IR 2.5 1.0 0.5 0.0 r = 0.27 p=0.008 -0.5 0.00 0.50 1.00 1.50 Log Endotoxin...
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Báo cáo y học: " Elevated endotoxin levels in non-alcoholic fatty liver disease" pdf
... endotoxin levels are the cause or consequence of NAFLD Accumulating evidence does indicate that elevated levels of endotoxin may, indeed, play a role in metabolic disease [13,14] Notably, endotoxin ... for endotoxin in metabolic disease For our present studies, we hypothesised that endotoxin levels are increased in patients with NAFLD Therefore, we 1) examined levels of circulating endotoxin ... Log Endotoxin (Eu/mL) 1.50 Log Endotoxin Eu/mL C Log Triglycerides (mmol/L) B A 2.0 1.50 D 3.0 1.5 sCD14 ( g/mL) Log HOMA-IR 2.5 1.0 0.5 0.0 r = 0.27 p=0.008 -0.5 0.00 0.50 1.00 1.50 Log Endotoxin...
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Báo cáo y học: " Hepatoprotective effects of Spirulina maxima in patients with non-alcoholic fatty liver disease: a case series" ppsx
... low doses He suffered an accidental firearm shot when 11 years old, and had a surgical extraction to remove the bullet from his left eye He had an appendectomy 55 years previously and an abdominal ... adequate rhythm and frequency His pulmonary area had adequate ventilation An exploration of his abdomen showed no clinical signs of significance and his hip-to-waist ratio was 0.75 His genitalia ... walk) and ingestion of Spirulina maxima Adverse side-effects included flatulence, meteorism and abdominal pain of moderate intensity without irradiation Case Our second patient was a 77-year-old...
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Báo cáo khoa học: Deficiency in apolipoprotein E has a protective effect on diet-induced nonalcoholic fatty liver disease in mice pot
... triglyceride deposition in the liver; (b) endogenous triglyceride synthesis and turnover; and (c) hepatic VLDL triglyceride secretion in the circulation Endogenous triglyceride clearance and turnover ... that the slightly higher baseline hepatic triglyceride content of apoE) ⁄ ) mice fed a chow diet does not predispose these mice to increased sensitivity to NAFLD In contrast, we found that apoE ... lead to NAFLD In vitro and in vivo studies have shown that lipoprotein-bound apoE is the natural ligand for LDLr [26,32], which is the main receptor involved in the clearance of apoE-containing lipoproteins...
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Trends in Nonalcoholic Fatty Liver Disease–related Hospitalizations in US Children, Adolescents, and Young Adults pot
... visceral fat J Clin Endocrinol Metab 2006;91:4287–94 24 Damaso AR, Prado WL, de PA, et al Relationship between nonalcoholic fatty liver disease prevalence and visceral fat in obese adolescents Dig Liver ... persisted among children and adolescents (7.2 vs 4.4/100,000 population, P ¼ 0.001) and young adults (11.5 vs 8.7/100,000 population, P ¼ 0.001) Estimates for children and adolescents may be unreliable ... by sex Obesity constitutes a serious and challenging health risk for children and adolescents Childhood and adolescent obesity results in higher mortality (46), higher general morbidity (47),...
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Nonalcoholic fatty liver disease in children living in the obeseogenic society doc
... Häussinger D Association between duplex Doppler sonographic flow pattern in right hepatic vein Nonalcoholic fatty liver disease in children 73 Adams LA, Sanderson S, Lindor KD, Angulo P The histological ... 2003;98:2042-2047 75 Lindor KD, Kowdley KV, Heathcote EJ, Harrison ME, Jorgensen R, Angulo P, et al Ursodeoxycholic acid for treatment of nonalcoholic steatohepatitis: results of a randomized trial Hepatology ... EV, Ritov VB, Toledo FG, Ferrell RE, Goodpaster BH, Kelley DE Effects of weight loss and physical activity on skeletal muscle mitochondrial function in obesity Am J Physiol Endocrinol Metab 2005;288:E818-825...
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Fatty Liver Disease: NASH and Related Disorders ppt
... emerging role of the adipocyte as an endocrine organ N Engl J Med 2001; 345: 1345–6 126 Ahima RS, Filer JS Adipose tissue as an endocrine organ Trends Endocrinol Metab 2000; 11: 327–32 127 Katsuki ... [15,16,22,50] If this indolent progressive course is confirmed in larger prospective studies, NASH will cause a formidable disease burden in forthcoming decades A few well-documented cases of cirrhosis ... Hepatology 2002; 35: 497–9 12 Seth SG, Gordon FD, Chopra S Non-alcoholic steatohepatitis Ann Intern Med 1997; 126: 137–45 13 Ludwig J, McGill DB, Lindor KD Non-alcoholic steatohepatitis J Gastroenterol...
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Obesity and Air Pollution: Global Risk Factors for Pediatric Non-alco- holic Fatty Liver Disease potx
... children and adolescents (42, 65-71) It is also documented that the higher levels of components of metabolic syndrome increase the risk of elevated ALT or AST in children and adolescents (50) ... dose-dependent manner (100) Given the susceptibility of children and adolescents to the harmful effects of air pollutants, including their effects on oxidative stress and insulin resistance documented ... investigate the risk factors for NAFLD among adolescents NAFLD was detected in 39.8% in total, 16.0% in normal ,50.5% in overweight, and 63.5% among obese adolescents Rocha et al (2009) (58) Brazil...
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Báo cáo hóa học: " Exploring the molecular mechanisms underlying the potentiation of exogenous growth hormone on alcohol-induced fatty liver diseases in mice" ppt
... development of steatosis [35,45] In this study, we found that, alcohol downregulated hepatic expression of PPARa and CYP4A1, a typical downstream target of PPARa Meanwhile chronic exogenous GH restored ... P, Zu L, Dong X, Chen L, Tian J, Fan X, Wang N, Wu X, Gao W: Superior neovascularization and muscle regeneration in ischemic skeletal muscles following VEGF gene transfer by rAAV1 pseudotyped ... carbohydrate metabolism in HIV-Infected patients with fat accumulation J Clin Endocrinol Metab 2002, 87:942-945 47 Ottosson M, Vikman-Adolfsson K, Enerbäck S, Elander A, Björntorp P, Edén S: Growth hormone...
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Báo cáo y học: " Discovery of serum biomarkers of alcoholic fatty liver in a rodent model: C-reactive protein" doc
... Unlu M, Morgan ME, Minden JS: Difference gel electrophoresis: a single gel method for detecting changes in protein extracts Electrophoresis 1997, 18:2071-2077 12 Byrne JC, Downes MR, O’Donoghue ... liver diseases Hp is also used in the panel of AshTest [34] as a down-regulated protein In this study, we found that Hp was a downregulated protein in NASH and HCV-infected liver fibrosis although ... normal control, and the downregulation (-) is presented as the levels of normal control divided by that of AFL The results demonstrated that CRP and Hp were dramatically upand downregulated, respectively...
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Fatty Liver Disease : Nash and Related Disorders - part 1 ppt
... [15,16,22,50] If this indolent progressive course is confirmed in larger prospective studies, NASH will cause a formidable disease burden in forthcoming decades A few well-documented cases of cirrhosis ... Hepatology 2002; 35: 497–9 12 Seth SG, Gordon FD, Chopra S Non-alcoholic steatohepatitis Ann Intern Med 1997; 126: 137–45 13 Ludwig J, McGill DB, Lindor KD Non-alcoholic steatohepatitis J Gastroenterol ... northern Italy Ann Intern Med 2000; 132: 112–7 33 Hasan I, Gani RA, Machmud R et al Prevalence and risk factors for non-alcoholic fatty liver in Indonesia J Gastroenterol Hepatol 2002; 17 (Suppl): A154...
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Fatty Liver Disease : Nash and Related Disorders - part 3 potx
... living donors for adult to adult right lobe transplantation Transplantation 2000; 69: 2410–5 Garcia Urena MA, Colina Ruiz-Delgado F, Moreno GE et al Hepatic steatosis in liver transplant donors: ... Clin Pathol 2001; 116: 263–70 28 Fernandez-Real JM, Penarroja G, Castro A, GarciaBragado F, Hernandez-Aguado I, Ricart W Blood letting in high-ferritin type diabetes: effects on insulin sensitivity ... obesity and insulin resistance Methodology for studying genes involved in NASH susceptibility If it is assumed that there is a genetic component to NASH, what methodology is currently available to...
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Fatty Liver Disease : Nash and Related Disorders - part 4 pot
... However, because endotoxin levels were not assessed in portal blood and gut-derived endotoxin is efficiently cleared during its first-pass through the liver, differences in hepatic endotoxin exposure ... PPARα activation stimulation by the accumulated fatty acyl ligands When AOX –/– mice are cross-bred with PPARα –/– mice to produce a double knockout, liver histology tends to be more benign, simple ... Castro Cabezas M, Halkes CJ, Erkelens DW Obesity and free fatty acids: double trouble Nutr Metab Cardiovasc Dis 2001; 11: 134–4 McDonald GB, Weidman M Partitioning of polar fatty acids into lymph...
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Fatty Liver Disease : Nash and Related Disorders - part 5 pdf
... Kupffer cells stimulated by bacterial endotoxin, because of the overexpression of endotoxin receptors on these cells (Fig 11.5) The interaction of Fas ligand with Fas, or the interaction of TNF ... 1997; 25: 108–11 Hourigan LF, McDonald GA, Purdic D et al Fibrosis in chronic hepatitis C correlates significantly with body mass index and steatosis Hepatology 1999; 29: 1215–29 Adolfini LE, Gambardela ... Finally, endotoxin receptors on Kupffer cells are upregulated in animals with either obesity- or alcohol-mediated hepatic steatosis [23,24] Increased sensitivity of Kupffer cells to bacterial endotoxin...
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Fatty Liver Disease : Nash and Related Disorders - part 6 docx
... Gastroenterol 1999; 34: 85–91 Morgan W The Liver and its Diseases, Both Functional and Organic: Their History, Anatomy, Chemistry, Pathology, Physiology, and Treatment London: Homoeopathic Publishing, ... primary care physician, the endocrinologist or even the gastroenterologist While these misconceptions have largely faded, there remains a good deal of lingering doubt about the overall prognosis ... Gastroenterol 1999; 94: 3010–4 48 Lindor KD, on behalf of the UDCA/NASH Study Group Ursodeoxycholic acid for treatment of non-alcoholic steatohepatitis: results of a randomized, placebo-controlled trial...
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Fatty Liver Disease : Nash and Related Disorders - part 7 ppsx
... (months) Aminotransferases Histology Randomized Placebo Open-label Open-label Open-label Open-label Baseline Baseline Baseline Baseline; diet Placebo Randomized (double blind) 12 4–10 12 Improved* ... Duration of treatment (months) Aminotransferases Open-label Baseline 12 Randomized (open-label) Open-label Randomized (double blind) No treatment Baseline Baseline Up to 12 Placebo No improvement ... Angulo P, Lindor KD Healthrelated quality of life assessment in non-alcoholic steatohepatitis [Abstract] Hepatology 2001; 34 (Suppl): 309 Talwalkar AJ, Donlinger JJ, Gossard AA, Lindor KD Health...
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Fatty Liver Disease : Nash and Related Disorders - part 8 potx
... Hepatomegaly (%) Presenting symptoms (%) Abdominal pain (67%) Obesity clinic (all) Abdominal pain (64%) Abdominal pain ‘most patients’ Abdominal pain (59%) Abdominal pain (42%) IBW, ideal body weight; ... and multiorgan injury (Table 20.1) Pathological spectrum of jejuno-ileal bypass-induced liver disease Polyarthralgia and polymygalgia (E > L) E, predominantly early complication; L, predominantly ... overgrowth leads to mucosal injury and increased gut permeability to bacterial toxins, especially endotoxins Endotoxins absorbed into the portal vein may then induce overproduction of pro-inflammatory mediators,...
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Fatty Liver Disease : Nash and Related Disorders - part 10 pdf
... eicanosoids, fatty acid toxicity 113 endocrine disturbances 293–294 endogenous glucose production (EGP) 40–41 endothelin-1 (ET-1), hepatic stellate cell activation 145 endotoxin, animal models 101–102 ... P, Lonardo A, Leonardi F et al Non-organ-specific autoantibodies in nonalcoholic fatty liver disease: prevalence and correlates Dig Dis Sci 2003; 48: 2173–81 Adams LA, Feldstein A, Lindor KD, ... administration did not alter the necroinflammatory activity or serum ALT levels Ursodeoxycholic acid A randomized, double-blind, placebo controlled trial involving more than 100 patients with NASH found that...
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